The title compound has been synthesized and resolved previously by T. M. Kubiak. In our searching of new potent agonists of LH-RH(luteinizing hormone releasing hormone), α-N-t-butyloxycarbonyl-β-3-quinolyl)-D-α-ala...The title compound has been synthesized and resolved previously by T. M. Kubiak. In our searching of new potent agonists of LH-RH(luteinizing hormone releasing hormone), α-N-t-butyloxycarbonyl-β-3-quinolyl)-D-α-alanine and its L-isomer were synthesized. The unprotected.optically active amino acids were obtained by enzymatic hydrolysis of the title compounds, followed by hydrolysis in 6 mol/L hydrochloric acid. The title compound was synthesized initially with 3-quinolinecar-展开更多
文摘The title compound has been synthesized and resolved previously by T. M. Kubiak. In our searching of new potent agonists of LH-RH(luteinizing hormone releasing hormone), α-N-t-butyloxycarbonyl-β-3-quinolyl)-D-α-alanine and its L-isomer were synthesized. The unprotected.optically active amino acids were obtained by enzymatic hydrolysis of the title compounds, followed by hydrolysis in 6 mol/L hydrochloric acid. The title compound was synthesized initially with 3-quinolinecar-