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Direction finding of bistatic MIMO radar in strong impulse noise
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作者 CHEN Menghan GAO Hongyuan +2 位作者 DU Yanan CHENG Jianhua ZHANG Yuze 《Journal of Systems Engineering and Electronics》 SCIE CSCD 2024年第4期888-898,共11页
For bistatic multiple-input multiple-output(MIMO)radar,this paper presents a robust and direction finding method in strong impulse noise environment.By means of a new lower order covariance,the method is effective in ... For bistatic multiple-input multiple-output(MIMO)radar,this paper presents a robust and direction finding method in strong impulse noise environment.By means of a new lower order covariance,the method is effective in suppressing impulse noise and achieving superior direction finding performance using the maximum likelihood(ML)estimation method.A quantum equilibrium optimizer algorithm(QEOA)is devised to resolve the corresponding objective function for efficient and accurate direc-tion finding.The results of simulation reveal the capability of the presented method in success rate and root mean square error over existing direction-finding methods in different application situations,e.g.,locating coherent signal sources with very few snapshots in strong impulse noise.Other than that,the Cramér-Rao bound(CRB)under impulse noise environment has been drawn to test the capability of the presented method. 展开更多
关键词 bistatic multiple-input multiple-output(MIMO)radar impulse noise direction finding lower order covariance quan-tum equilibrium optimizer algorithm(QEOA) maximum likeli-hood estimation method Cramér-Rao bound(CRB)
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Characteristics analysis of muzzle impulse noise based on wavelet energy spectrum
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作者 赖富文 张建宇 胡桂梅 《Journal of Measurement Science and Instrumentation》 CAS CSCD 2015年第2期142-146,共5页
Because muzzle impulse noise could cause damage to or have an intluence on the operator, tiae ettecnve protecnve measures should be taken. Therefore, correct analysis of impulse noise characteristics is very significa... Because muzzle impulse noise could cause damage to or have an intluence on the operator, tiae ettecnve protecnve measures should be taken. Therefore, correct analysis of impulse noise characteristics is very significant. Considering the shortcomings of fast Fourier transform method (FFT) in analysis of muzzle impulse noise frequency characteristics, wavelet energy spectrum method is put forward. Based on specific experiment data, the frequency characteristics and spectral energy dis tribution can be obtained. The experiment results show that wavelet energy spectrum method is applicable in muzzle impulse noise characteristic analysis. 展开更多
关键词 muzzle impulse noise wavelet transform energy spectrum signal processing
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A detail-preserving random-valued impulse noise removal algorithm based on S-ROAD
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作者 朱柱 王庆 +2 位作者 肖彦昌 万雪音 张小国 《Journal of Southeast University(English Edition)》 EI CAS 2012年第4期438-444,共7页
In a random-valued impulse noise corrupted image, in order to remove impulse noise and, meanwhile, efficiently preserve image edges and details, a novel two-phase detail- preserving random-valued impulse noise removal... In a random-valued impulse noise corrupted image, in order to remove impulse noise and, meanwhile, efficiently preserve image edges and details, a novel two-phase detail- preserving random-valued impulse noise removal algorithm is proposed. At the noise detecting phase, an image statistic called S-estimate based rank-ordered absolute difference (S- ROAD) is presented to distinguish image edge and detail pixels from impulse noise pixels in a noise corrupted image. By introducing S-estimate into ROAD statistic, the interference caused by the image edges and details in the ROAD statistic is eliminated. With the S-ROAD statistic, most of the noise pixels, including the noise at edges and details, can be distinguished. At the noise pixels filtering phase, a two-threshold iterative method is used to restore the identified noise pixels and the estimate precision is improved; thus, the image details can be efficiently preserved. Experimental results show that the proposed method provides a significant improvement over many existing filters in terms of both subjective and objective evaluations. 展开更多
关键词 S-estimate rank-ordered absolute difference edges and details impulse noise
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Direction of arrival estimation method based on quantum electromagnetic field optimization in the impulse noise 被引量:1
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作者 DU Yanan GAO Hongyuan CHEN Menghan 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2021年第3期527-537,共11页
In order to resolve direction finding problems in the impulse noise,a direction of arrival(DOA)estimation method is proposed.The proposed DOA estimation method can restrain the impulse noise by using infinite norm exp... In order to resolve direction finding problems in the impulse noise,a direction of arrival(DOA)estimation method is proposed.The proposed DOA estimation method can restrain the impulse noise by using infinite norm exponential kernel covariance matrix and obtain excellent performance via the maximumlikelihood(ML)algorithm.In order to obtain the global optimal solutions of this method,a quantum electromagnetic field optimization(QEFO)algorithm is designed.In view of the QEFO algorithm,the proposed method can resolve the difficulties of DOA estimation in the impulse noise.Comparing with some traditional DOA estimation methods,the proposed DOA estimation method shows high superiority and robustness for determining the DOA of independent and coherent sources,which has been verified via the Monte-Carlo experiments of different schemes,especially in the case of snapshot deficiency,low generalized signal to noise ratio(GSNR)and strong impulse noise.Beyond that,the Cramer-Rao bound(CRB)of angle estimation in the impulse noise and the proof of the convergence of the QEFO algorithm are provided in this paper. 展开更多
关键词 direction of arrival(DOA)estimation impulse noise infinite norm exponential kernel covariance matrix maximum-likelihood(ML)algorithm quantum electromagnetic field optimization(QEFO)algorithm Cramer-Rao bound(CRB)
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Image Filter for Removal of Impulse Noise Based on Directional Derivatives 被引量:2
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作者 KONG Tao, LI Jun-li, CHEN Gang (College of Information Science and Engineering, Ningbo University, Ningbo 315211, China) 《Computer Aided Drafting,Design and Manufacturing》 2008年第2期91-102,共12页
One of the most common image processing tasks involves the removal of noise from images. Noise can be introduced during image capture, during transmission, or during storage. For design purposes, noise sources are fre... One of the most common image processing tasks involves the removal of noise from images. Noise can be introduced during image capture, during transmission, or during storage. For design purposes, noise sources are frequently approximated by random variables with a known probability distribution. One common noise model corrupts a signal by introducing impulses. And the surface of the image disturbed by impulse noise displays many peaks or vales. According to the characteristic of impulse noise, a novel algorithm is proposed to the detection of impulse noise point from images based on directional derivatives. First, the theory of calculus on directional derivatives is introduced in detail. Then it is applied to the field of image to removing noise with the discrete form derived from its continuous mathematical model. And a number of contrasting simulations illustrate that our algorithm not only can preserve the structure information while removing impulse noise but also can mostly save the gray value of the pixels undisturbed by noise. In addition, the comparisons of the filtering performance for removing impulse noise are analyzed in detail in the case of different noise densities, and also show that the algorithm suggested outperforms the conventional filter algorithms such as mean filter, median filter and so on in speed and impulse noise reduction, especially in random-valued impulse noise reduction. So it is a very good alternative to the existing schemes. 展开更多
关键词 level sets directional derivatives impulse noise median filter
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Removing Random-Valued Impulse Noises by a Two-Staged Nonlinear Filtering Method
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作者 Ahmad Ashfaq Lu Yanting 《Transactions of Nanjing University of Aeronautics and Astronautics》 EI CSCD 2016年第3期329-338,共10页
Digital images are frequently contaminated by impulse noise(IN)during acquisition and transmission.The removal of this noise from images is essential for their further processing.In this paper,a two-staged nonlinear f... Digital images are frequently contaminated by impulse noise(IN)during acquisition and transmission.The removal of this noise from images is essential for their further processing.In this paper,a two-staged nonlinear filtering algorithm is proposed for removing random-valued impulse noise(RVIN)from digital images.Noisy pixels are identified and corrected in two cascaded stages.The statistics of two subsets of nearest neighbors are employed as the criterion for detecting noisy pixels in the first stage,while directional differences are adopted as the detector criterion in the second stage.The respective adaptive median values are taken as the replacement values for noisy pixels in each stage.The performance of the proposed method was compared with that of several existing methods.The experimental results show that the performance of the suggested algorithm is superior to those of the compared methods in terms of noise removal,edge preservation,and processing time. 展开更多
关键词 image de-noising random-valued impulse noise nonlinear filter noisy pixel detection two-stage detection and correction method cascaded stages directional differences
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Research of multi-channel impulse noise detection algorithms based on template
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作者 赵薇 Xie Qianli +1 位作者 Wu Yin Zhang Qin 《High Technology Letters》 EI CAS 2015年第2期147-154,共8页
Attenuating the undesired audio noise generated by impulse noise,such as shot and scream of brakes,is specially useful for real-time audio recording of TV or broadcasting live report.On the basis of impulse noise dete... Attenuating the undesired audio noise generated by impulse noise,such as shot and scream of brakes,is specially useful for real-time audio recording of TV or broadcasting live report.On the basis of impulse noise detection algorithms based on template,this paper improves the method of establishing the template by using multiple microphones to pick up noise corrupted signals and impulse noises in the environment.The universal of thresholds is found and a detection algorithm with slope as the characteristic is proposed by comparing a variety of feature extraction algorithms.The proposed algorithm gets a significant improvement in testing speed and accuracy,which means it is suitable for real-time processing of audio signals. 展开更多
关键词 impulse noise detection TEMPLATE MULTI-CHANNEL universal of thresholds slop algorithm (SA)
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Iterative Adaptive Median Filter for Impulse Noise Cancellation
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作者 程学珍 张京钊 曹茂永 《Journal of Measurement Science and Instrumentation》 CAS 2010年第4期326-329,共4页
Based on the characteristics of impulse noises, the authors establish a new filter, Iterative Adaptive Median Filter (IAMF). Acccording to the characteristics of images polluted by impulse noises, they establish wei... Based on the characteristics of impulse noises, the authors establish a new filter, Iterative Adaptive Median Filter (IAMF). Acccording to the characteristics of images polluted by impulse noises, they establish weight function combined with iterative algorithm to eliminate noises. In IAMF filter process, because the noise sixes do not participate in the computation, they do not influence the normal points in the image, therefore IAMF can retain the detail well, maintain the good clarity after processing image, and simultaneously reduce the computation. Experiments showed that IAMF have ideal denoising effect for the images polluted by the impulse noises; especially when the noise rates are more than 0.5, IAMF is mote prominent, even when the noise rotes are more than 0.9, IAMF can achieve a satisfactory results. 展开更多
关键词 iterative adaptive median filter impulse noise image processing
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Localization for mixed near-field and far-field sources under impulsive noise
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作者 GAO Hongyuan ZHANG Yuze +2 位作者 DU Ya’nan CHENG Jianhua CHEN Menghan 《Journal of Systems Engineering and Electronics》 SCIE CSCD 2024年第2期302-315,共14页
In order to solve the problem that the performance of traditional localization methods for mixed near-field sources(NFSs)and far-field sources(FFSs)degrades under impulsive noise,a robust and novel localization method... In order to solve the problem that the performance of traditional localization methods for mixed near-field sources(NFSs)and far-field sources(FFSs)degrades under impulsive noise,a robust and novel localization method is proposed.After eliminating the impacts of impulsive noise by the weighted out-lier filter,the direction of arrivals(DOAs)of FFSs can be estimated by multiple signal classification(MUSIC)spectral peaks search.Based on the DOAs information of FFSs,the separation of mixed sources can be performed.Finally,the estimation of localizing parameters of NFSs can avoid two-dimension spectral peaks search by decomposing steering vectors.The Cramer-Rao bounds(CRB)for the unbiased estimations of DOA and range under impulsive noise have been drawn.Simulation experiments verify that the proposed method has advantages in probability of successful estimation(PSE)and root mean square error(RMSE)compared with existing localization methods.It can be concluded that the proposed method is effective and reliable in the environment with low generalized signal to noise ratio(GSNR),few snapshots,and strong impulse. 展开更多
关键词 source localization far-field source(NFS) near-field source(FFS) impulsive noise Cramer-Rao bound(CRB)
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Efficient Global Threshold Vector Outlyingness Ratio Filter for the Removal of Random Valued Impulse Noise
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作者 J. Amudha R. Sudhakar 《Circuits and Systems》 2016年第6期692-700,共9页
This research paper proposes a filter to remove Random Valued Impulse Noise (RVIN) based on Global Threshold Vector Outlyingness Ratio (GTVOR) that is applicable for real time image processing. This filter works with ... This research paper proposes a filter to remove Random Valued Impulse Noise (RVIN) based on Global Threshold Vector Outlyingness Ratio (GTVOR) that is applicable for real time image processing. This filter works with the algorithm that breaks the images into various decomposition levels using Discrete Wavelet Transform (DWT) and searches for the noisy pixels using the outlyingness of the pixel. This algorithm has the capability of differentiating high frequency pixels and the “noisy pixel” using the threshold as well as window adjustments. The damage and the loss of information are prevented by means of interior mining. This global threshold based algorithm uses different thresholds for different quadrants of DWT and thus helps in recovery of noisy image even if it is 90% affected. Experimental results exhibit that this method outperforms other existing methods for accurate noise detection and removal, at the same time chain of connectivity is not lost. 展开更多
关键词 Image Restoration noise Detection noise Removal Random Valued impulse noise Global Threshold Vector Outlyingness Ratio
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Mixed noise removal for color images using quaternion representation 被引量:2
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作者 王定成 田宇航 +1 位作者 陈北京 舒华忠 《Journal of Southeast University(English Edition)》 EI CAS 2015年第3期347-352,共6页
In order to effectively restore color noisy images with the mixture of Gaussian noise and impulse noise,a new algorithm is proposed using the quaternion-based holistic processing idea for color images.First,a color im... In order to effectively restore color noisy images with the mixture of Gaussian noise and impulse noise,a new algorithm is proposed using the quaternion-based holistic processing idea for color images.First,a color image is represented by a pure quaternion matrix.Secondly,according to the different characteristics of the Gaussian noise and the impulse noise,an algorithm based on quaternion directional vector order statistics is used to detect the impulse noise. Finally,the quaternion optimal weights non-local means filter (QOWNLMF)for Gaussian noise removal is improved for the mixed noise removal.The detected impulse noise pixels are not considered in the calculation of weights.Experimental results on five standard images demonstrate that the proposed algorithm performs better than the commonly used robust outlyingness ratio-nonlocal means (ROR-NLM)algorithm and the optimal weights mixed filter (OWMF). 展开更多
关键词 color image denoising Gaussian noise impulse noise mixed noise QUATERNION
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DOA Estimation Based on Sparse Representation of the Fractional Lower Order Statistics in Impulsive Noise 被引量:8
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作者 Sen Li Rongxi He +1 位作者 Bin Lin Fei Sun 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2018年第4期860-868,共9页
This paper is mainly to deal with the problem of direction of arrival(DOA) estimations of multiple narrow-band sources impinging on a uniform linear array under impulsive noise environments. By modeling the impulsive ... This paper is mainly to deal with the problem of direction of arrival(DOA) estimations of multiple narrow-band sources impinging on a uniform linear array under impulsive noise environments. By modeling the impulsive noise as α-stable distribution, new methods which combine the sparse signal representation technique and fractional lower order statistics theory are proposed. In the new algorithms, the fractional lower order statistics vectors of the array output signal are sparsely represented on an overcomplete basis and the DOAs can be effectively estimated by searching the sparsest coefficients. To enhance the robustness performance of the proposed algorithms,the improved algorithms are advanced by eliminating the fractional lower order statistics of the noise from the fractional lower order statistics vector of the array output through a linear transformation. Simulation results have shown the effectiveness of the proposed methods for a wide range of highly impulsive environments. 展开更多
关键词 α-stable distribution direction of arrival(DOA) fractional lower-order statistics impulsive noise sparse representation
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Minimum geometric power distortionless response beamforming against heavy-tailed noise of unknown statistics 被引量:3
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作者 Wenchang Wang Lei Li +1 位作者 Chunjing Liu Feng Liu 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2011年第5期749-753,共5页
A minimum geometric power distortionless response beamforming approach against impulsive noise (including all α- stable noise) of unknown statistics is proposed. Due to that definite logarithmic moments require no ... A minimum geometric power distortionless response beamforming approach against impulsive noise (including all α- stable noise) of unknown statistics is proposed. Due to that definite logarithmic moments require no priori knowledge of impulsive noise, this new beamformer substitutes the logarithmic moments for the second-order moments and iteratively minimizes the "ge- ometric power" of the beamformer.s output snapshots, subjected to a linear constraint. Therefore, the proposed beamformer can provide significantly higher output geometric signal-to-noise-andinterference ratio. Moreover, the optimum weight vector is obtained by using a new iteration process. The simulation results prove that the new method is effective. 展开更多
关键词 array signal processing BEAMFORMING geometric power impulsive noise logarithmic moments.
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Performance analysis of Turbo-Codes in communication channels with impulsive noise 被引量:3
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作者 Li Chong Deng Weibo Duan Lingjie 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2009年第1期27-31,共5页
Performance of Turbo-Codes in communication channels with impulsive noise is analyzed. First, mathematical model of impulsive noise is presented because it has non-Gaussian nature and is found in many wireless channel... Performance of Turbo-Codes in communication channels with impulsive noise is analyzed. First, mathematical model of impulsive noise is presented because it has non-Gaussian nature and is found in many wireless channels due to impulsive phenomena of radio-frequency interference. Then, with linear Log-MAP decoding algorithm for its low complexity, Turbo-Codes are adopted and analyzed in such communication channels. To confirm the performance of the proposed method, simulations on both static and fully interleaved flat Rayleigh fading channels with impulsive noise have been carried out. It is shown that Turbo-Codes have a better performance than the conventional methods (e.g. convolutionally coded system). 展开更多
关键词 Turbo-Codes impulsive noise LOG-MAP Gaussian mixture distribution universal nobile telecommu-nications system.
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Precoder Design and Impulsive Noise Mitigation Scheme for Industrial Wireless Communications 被引量:2
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作者 Yanjing Sun Xinyan Li +3 位作者 Jiasi Zhou Ruirui Chen BowenWang Yanfen Wang 《China Communications》 SCIE CSCD 2021年第4期182-197,共16页
In industrial wireless scenarios,the impulsive noise(IN)incurred by machine running or operation causes a serious influence on the powerlimited industrial wireless communications.It is challenging to ensure efficient ... In industrial wireless scenarios,the impulsive noise(IN)incurred by machine running or operation causes a serious influence on the powerlimited industrial wireless communications.It is challenging to ensure efficient and reliable transmission with quality of service(QoS)guarantee for machinetype communication devices(MTCDs).Considering the IN in the industrial process,this paper establishes the multiuser multiple-input single-output(MU-MISO)orthogonal frequency division multiplexing(OFDM)system model,which combines transmitter and receiver design.Two precoding schemes are designed to improve communication effectiveness at the transmitter.More specifically,the precoder design scheme which combines semi-definite relaxation(SDR)with difference-of-two-convex-function(D.C.)iterative algorithm,is developed by utilizing the Dinkelbach method to improve the system effectiveness.To decrease the computational complexity,we devise the quadratic-based fractional programming(QFP)algorithm,which decouples the variables by using a quadratic transform method.On this basis,the IN mitigation scheme is studied to reduce the system error rate(SER)at the receiver.With the goal of improving the reliability of industrial wireless communications,we propose a hybrid nonlinear IN mitigation(HNINM)scheme and then derive its closed-form expression of SER.The simulation results show that the proposed QFP algorithm achieves superior performance while the HNINM scheme decreases the SER of industrial wireless communications. 展开更多
关键词 Industrial wireless communications precoder design impulsive noise mitigation
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Receiver design of UWB radio systems for an impulsive noise environment 被引量:1
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作者 贾琳 张中兆 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2004年第1期31-38,45,共9页
The performance of UWB (ultrawide bandwidth) radio systems under an impulsive noise environment is first investigated. In the analysis, the Middleton's class A model is used as a model of the impulsive noise. At f... The performance of UWB (ultrawide bandwidth) radio systems under an impulsive noise environment is first investigated. In the analysis, the Middleton's class A model is used as a model of the impulsive noise. At first, the statistical characteristics of the inphase and quadrature components of the impulsive noise are investigated, and it is proved that unlike Gaussian noise, these components are dependent especially on the impulsive noise with small impulsive indices. The probability that the high amplitude noise is emitted in the inphase component which becomes firstly larger and then smaller for the larger quadrature component of impulsive noise is presented. Next, the performance of conventional UWB radio systems designed for the Gaussian noise under the impulsive noise is evaluated and numerical results show that the performance of the conventional UWB radio systems is much degraded by the effect of the impulsive noise. Using the dependence between the inphase and quadrature components of the impulsive noise, a novel UWB receiver designed for impulsive noise is proposed and the performance improvement achieved by the receiver is evaluated. Numerical results show that the performance of UWB radio systems is much improved by employing the proposed receiver. 展开更多
关键词 ultrawide bandwidth radio time hopping spreadspectrum impulsive noise impulse radio
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Performance analysis of UWB radio systems under cassa impulsive noise environment
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作者 贾琳 张中兆 《Journal of Harbin Institute of Technology(New Series)》 EI CAS 2006年第2期242-250,共9页
The performance of UWB (Ultrawide Bandwidth) radio systems under class A impulsive noise environment is studied in this paper. First, while employing the Middleton’s class A model as a model of impulsive noise, the s... The performance of UWB (Ultrawide Bandwidth) radio systems under class A impulsive noise environment is studied in this paper. First, while employing the Middleton’s class A model as a model of impulsive noise, the statistical characteristics of in-phase and quadrature components of impulsive noise is investigated. It is proven that, unlike Gaussian noise, they are dependent especially due to the fact that impulsive indices are small. Next, using this above dependence, a novel UWB radio receiver designed for impulsive noise is proposed and the exact expression for the average BER (Bit Error Rate) of this receiver as a function of SNR (Signal to Noise Power Ratio) and threshold value is derived. Then, the optimum threshold value is discussed and the performance of UWB radio systems with the proposed receiver designed for impulsive noise and with the conventional receiver designed for Gaussian noise under impulsive noise environment is estimated. Numerical results are compared and show that the influence of impulsiveness index and threshold value on the performance of UWB radio systems is quite large and that the performance achieved by the proposed UWB radio receiver is much superior to that of the conventional UWB radio receiver under class A impulsive noise environment. 展开更多
关键词 ultrawide bandwidth radio time hoooin impulsive noise impulse radio PPM
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Impulsive Noise Cancellation in OFDM System Using Low Density Parity Check
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作者 Attia Irum Abdul Muiz Fayyaz +6 位作者 Sara Ayub Mudassar Raza Majed Alhaisoni Muhammad Attique Khan Abdullah Alqahtani Heebum Kim Byeong-Gwon Kang 《Computer Systems Science & Engineering》 SCIE EI 2023年第7期1265-1276,共12页
An effective communication application necessitates the cancellation of Impulsive Noise(IN)from Orthogonal Frequency Division Multiplexing(OFDM),which is widely used for wireless applications due to its higher data ra... An effective communication application necessitates the cancellation of Impulsive Noise(IN)from Orthogonal Frequency Division Multiplexing(OFDM),which is widely used for wireless applications due to its higher data rate and greater spectral efficiency.The OFDM system is typically corrupted by Impulsive Noise,which is an unwanted short-duration pulse with random amplitude and duration.Impulsive noise is created by humans and has non-Gaussian characteristics,causing problems in communication systems such as high capacity loss and poor error rate performance.Several techniques have been introduced in the literature to solve this type of problem,but they still have many issues that affect the performance of the presented methods.As a result,developing a new hybridization-based method is critical for accurate method performance.In this paper,we present a hybrid of a state space adaptive filter and an information coding technique for cancelling impulsive noise from OFDM.The proposed method is also compared to Least Mean Square(LMS),Normalized Least Mean Square(NLMS),and Recursive Least Square(RLS)adaptive filters.It has also been tested using the binary phase-shift keyed(BPSK),four quadrature amplitude modulation(QAM),sixteen QAM,and thirty-two QAM modulation techniques.Bit error Rate(BER)simulations are used to evaluate system performance,and improved performance is obtained.Furthermore,the proposed method is more effective than recent methods. 展开更多
关键词 Impulsive noise adaptive filter OFDM NLMS RLS
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A preliminary study of the mechanism of compound hearing loss caused by ototoxic drugs combined with impulse noise
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作者 Xin Qiu Qing‐qing Jiang +2 位作者 Wei‐wei Guo Ning Yu Shi‐ming Yang 《iLABMED》 2024年第1期38-52,共15页
Background:Hearing loss(HL)is becoming increasingly common and is more commonly caused by noise,ototoxic substances,or a combination of ototoxic factors.However,so far,few studies have examined the mechanism by which ... Background:Hearing loss(HL)is becoming increasingly common and is more commonly caused by noise,ototoxic substances,or a combination of ototoxic factors.However,so far,few studies have examined the mechanism by which compound factors cause HL.The only relevant study is about occupational ototoxic substances combined with environmental noise at 85-110 dB SPL.In this study,to address the shortcomings of existing research,we innovatively focused on HL induced by loud noise(impulse noise,>160 dB SPL)combined with common ototoxic drugs.The aim of this study was to establish and validate a mature animal model,and then to compare the characteristics of audiology,pathomorphology and molecular features,and to preliminarily predict pathogenesis in compound HL.Materials and Methods:We selected guinea pigs to construct in vivo HL model groups for different extents of exposure,including a blank control group,a single-drug group,a single-impulse noise group,and a compound group.The animal model of the mature compound HL group was established using gentamicin combined with impulse noise.We then performed audio-logical and pathological verification.We analyzed the auditory brainstem response(ABR),pathological morphology of the cochlea,and molecules(including important self-radicals,cytokines,and apoptosis signal trans-duction pathway proteins in the pathogenesis of drug-and noise-induced HL),compared the effect of different extents of exposure on HL,and preliminarily predict the pathogenic mechanism of compound HL.Results:Four groups of animal models were established successfully and verified by audiology and pathology.Regarding audiology,there were no sig-nificant differences in the ABR thresholds before exposure(p>0.05),but differences emerged among the groups after exposure.Notably,after 3,7,and 14 days of exposure,there were significant differences in the ABR thresholds between the compound group and both the drug and noise groups(p<0.01),and after 14 days,the HL of the compound group was much more severe(greater than the linear sum of single-factor HL group).Regarding the patho-morphology,compared with the control group,the cochleae were damaged to different degrees in the factor exposure groups.The drug group had the least severe HL,the noise group had serious HL(p<0.05),and the compound group had the most severe HL(p<0.01).The compound group's damage was greater than the linear sum of the single-factor group in many ways,such as the loss and damage of hair cells and cilia,disturbed morphology and arrangement of hair cells,protein metabolism,cell function,and structural defects on the epidermal plate(p<0.01).From a molecular perspective,the trend was similar to pathology and audiology,and the synergistic effect of ototoxic drugs and impulse noise significantly increased cytokine levels(IL-6,ICAM-1,8-OHDG,IL-1,and TNF-α),free radicals Malondialdehyde([MDA],▪OH,LPO,O•2ˉ),and the apoptosis signal transduction pathway protein.There were significant differences between the compound group and single-factor groups(p<0.05).Conclusion:Gentamicin,impulse noise,and compound factors were used to induce HL in animal models,which were verified by audiology and pathology,laying a foundation for future studies.After constructing the animal models,we found that 50 mg/kg of gentamicin for 10 days was a subinjury dose,and 50�impulse noise caused partial HL,but the two factors combined had a significant synergistic ototoxicity effect,which increased the level of oxidative stress and the waterfall response of inflammatory cytokines in the cochleae and enhanced the expression of apoptosis-related proteins,resulting in syn-ergistic pathomorphological and audiological injury.We preliminarily analyzed the pathogenic mechanism of compound HL,establishing the basis for further study of the mechanism,prevention,and treatment of this increasing global problem. 展开更多
关键词 auditory brainstem response GENTAMICIN hearing loss impulse noise molecular mechanisms PATHOMORPHOLOGY
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EFFICIENT BOX-CONSTRAINED TV-TYPE-l^1 ALGORITHMS FOR RESTORING IMAGES WITH IMPULSE NOISE 被引量:6
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作者 Liyan Ma Michael K. Ng +1 位作者 Jian Yu Tieyong Zeng 《Journal of Computational Mathematics》 SCIE CSCD 2013年第3期249-270,共22页
In this paper, we study the restoration of images simultaneously corrupted by blur and impulse noise via variational approach with a box constraint on the pixel values of an image. In the literature, the TV-l^1 variat... In this paper, we study the restoration of images simultaneously corrupted by blur and impulse noise via variational approach with a box constraint on the pixel values of an image. In the literature, the TV-l^1 variational model which contains a total variation (TV) regularization term and an l^1 data-fidelity term, has been proposed and developed. Several numerical methods have been studied and experimental results have shown that these methods lead to very promising results. However, these numerical methods are designed based on approximation or penalty approaches, and do not consider the box constraint. The addition of the box constraint makes the problem more difficult to handle. The main contribution of this paper is to develop numerical algorithms based on the derivation of exact total variation and the use of proximal operators. Both one-phase and two-phase methods are considered, and both TV and nonlocal TV versions are designed. The box constraint [0, 1] on the pixel values of an image can be efficiently handled by the proposed algorithms. The numerical experiments demonstrate that the proposed methods are efficient in computational time and effective in restoring images with impulse noise. 展开更多
关键词 Image restoration impulse noise Total variation Nonlocal total variation Proximal Operators.
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