An Update on the Clinical Pipelines of New Antibacterial Drugs Developed in China

Antibacterial resistance is a global health threat that requires further concrete action on the part of all countries.In this context,one of the biggest concerns is whether enough new antibacterial drugs are being discovered and developed.Although several high-quality reviews on clinical antibacterial drug pipelines from a global perspective were published recently,none provides comprehensive information on original antibacterial drugs at clinical stages in China.In this review,we summarize the latest progress of novel antibacterial drugs approved for marketing and under clinical evaluation in China since 2019.Information was obtained by consulting official websites,searching commercial databases,retrieving literature,asking personnel from institutions or companies,and other means,and a considerable part of the data covered here has not been included in other reviews.As of June 30,2023,a total of 20 antibacterial projects from 17 Chinese pharmaceutical companies or developers were identified and updated.Among them,two new antibacterial drugs that belong to traditional antibiotic classes were approved by the National Medical Products Administration(NMPA)in China in 2019 and 2021,respectively,and 18 antibacterial agents are in clinical development,with one under regulatory evaluation,five in phase-3,six in phase-2,and six in phase-1.Most of the clinical candidates are new analogs or monocomponents of traditional antibacterial pharmacophore types,including two dual-acting hybrid antibiotics and a recombinant antibacterial protein.Overall,despite there being 17 antibacterial clinical candidates,our analysis indicates that there are still relatively few clinically differentiated antibacterial agents in stages of clinical development in China.Hopefully,Chinese pharmaceutical companies and institutions will develop more innovative and clinically differentiated candidates with good market potential in the future research and development(R&D)of original antibacterial drugs.

An Analysis of Innovative Contributions to the Important Discourse on the Development of New Quality Productivity

The discourse on developing high-quality productivity marks a significant theoretical innovation,which is conducive to the modernization and sinicization of Marxism.It refines our understanding of“new quality productivity,”defining it as an advanced form driven by innovation,embodying“high technology,efficiency,and quality,”with the aim of comprehensively enhancing productivity.It elucidates the necessity of cultivating such forces,asserting that they are crucial for achieving high-quality development,securing a leading position in global technology,and fulfilling the aspirations for a better life.Moreover,it outlines a new implementation route,emphasizing strategies such as fostering technological autonomy,nurturing emerging industries,integrating education and talent in technology,adopting a“build through challenges”approach,adjusting solutions locally,and providing categorized guidance,all of which are based on the ongoing comprehensive reforms.

Research on the Internal Talent Training Path and Performance Evaluation Mechanism of New R&D Institutions in Zhejiang Province

New research and development(R&D)institutions are an important part of the national innovation system,playing an important role in promoting the transformation of scientific and technological achievements.In recent years,new R&D institutions have gradually become the driving force of innovation-driven development in China.Taking new R&D institutions in Zhejiang Province as the research object,this paper studies the internal talent training path and performance evaluation mechanism of new R&D institutions in Zhejiang Province by using the literature research method,comparison method,case verification method,and other methods.The investigation results show that there are problems such as lack of material and spiritual support and neglect of the absorption of local talents in the internal talent training,and there are problems such as unclear standards,insufficient data,and opaque processes in the performance evaluation mechanism,which greatly affect the establishment and improvement of the performance evaluation mechanism.Given the above problems,this paper puts forward a forward-looking,oriented,flexible,and compatible talent training path and performance evaluation mechanism,hoping to optimize the effective internal talent training path of new R&D institutions,improve the evaluation performance,and promote healthy development of new R&D institutions in Zhejiang Province.

Innovative Strategies for Financial Investment Management Strategies of Enterprises in the New Era

With the in-depth development of economic globalization and the continuous emergence of new technologies,the importance of enterprise financial investment management strategy is becoming more and more prominent.The traditional financial investment management strategy can no longer meet the needs of enterprises in the new era and needs to be innovated with the times.For enterprises,the effectiveness and scientificity of financial investment management strategy will directly affect the competitiveness and long-term development of enterprises.Therefore,this study chooses the innovation based on the financial investment management strategy of enterprises in the new era as the research theme,aiming at exploring the innovative strategy to adapt to the needs of enterprises in the new era.

Analysis of Innovative Paths for Enterprise Marketing Management Development Strategy under the Background of New Media

From the perspective of enterprise marketing strategy planning,innovative research should be conducted based on the current trends in new media.The findings should be applied to practical activities within enterprises to achieve innovation in marketing strategy decision-making in the new media environment.Enterprises should adopt advanced communication transmission technologies and big data processing capabilities to effectively leverage the hidden value and promotional planning advantages of network media platforms.This approach can enhance customer loyalty and increase demand for new products.Enterprises should integrate into the continuously evolving new media landscape,explore their potential business characteristics,and innovate promotional methods.By effectively combining product information with digital media content,companies can ultimately achieve significant increases in corporate interests.

Research on the Mechanism and Strategy of Equity Investment Driving the Transformation of New Material Innovation Achievements

Under the wave of global technological revolution,the new materials industry is facing difficulties in innovation and transformation.Equity investment has become a key driving force due to its flexible mechanism,risk sharing,and deep participation.Based on introducing the current development status of China’s new materials industry,this article reveals the mechanism of equity investment in financial support,risk management,incentive constraints,and resource integration.The article proposes optimization strategies,such as building an information-sharing mechanism and a diversified investment fund system,to promote the high-quality development of the new materials industry driven by innovation and provide strategic guidance for policymakers,investors,and enterprises.

Influencing Factors of Cultivation and Improvement of College Students Innovation and Entrepreneurship Ability under the New Normal

The cultivation of innovative and entrepreneurial talents is an effective guarantee to meet the strategic needs of national development under the new normal,promote the construction of an innovative country and the development of universities themselves.Combined with the questionnaire survey of colleges and universities in Heilongjiang Province,this paper analyzed factors such as the understanding of the connotation of innovation and entrepreneurship,the thinking and awareness of innovation and entrepreneurship,the demand for training methods of innovation and entrepreneurship,and the approaches to acquire knowledge and capabilities of innovation and entrepreneurship.On this basis,it came up with recommendations for promoting the cultivation of innovative and entrepreneurial talents in colleges and universities,to provide an objective basis for the construction of innovative and entrepreneurial talent training models,so as to promote the effective cultivation of innovative and entrepreneurial talents in colleges and universities.

Government subsidies, dual-credit policy, and enterprise performance: Empirical evidence from Chinese listed new energy vehicle companies

The development of the new energy vehicle industry has become a key force driving the goals of carbon peak and carbon neutralization.To better guide future strategies,this study investigates the dual impact of subsidy and dual-integral policies on the performance of new energy vehicle enterprises.This study first theorizes the influential mechanism according to the institutional-based approach and technical innovation theory,and then collects data from listed companies in the new energy vehicle industry from 2016 to 2020.The hypotheses are examined using a two-way fixed-effects model.The findings show that:(1)subsidy policies are can still improve enterprise performance,but not through green technology innovation;(2)the dual-credit policy can improve enterprise performance through green technology innovation;and(3)under current policy conditions,with subsidies declining annually,the interaction effects between the subsidy and dual-integral policies will also decrease.Thus,this study suggests that non-monetary industrial policy,represented by the dual credit policy is a more effective alternative to government subsidies.

A new type of internal solitary waves with a re-appearance period of 23 h observed in the South China Sea

The South China Sea （SCS）, in particular the northern SCS, is one of ocean areas where energetic internal solitary waves （ISWs）occur most frequently （Cai et al., 2012; Zheng, 2017）. Based on the re-appearance period （RP） at an observation station, Ramp et al.（2004） divided the ISWs into two types：Type-a and Type-b. Type-a ISWs arrive regularly at the same time every day, i.e., the RP is about 24 h, and Type-b ISWs arrive about one hour late every day, i.e., the RP is about 25 h.

Investigation Into the Market-Orientated New Product Development Performance

The effect that the market orientation brings to product innovation performance is reported and the degree of product innovativeness is explored. The interdepartmental integration inside the company is also investigated. A series of hypotheses were developed aiming at presenting a conceptual framework to clarify how market orientation contributes to product innovation performance-moderated by the degree of product innovativeness and affected by the interdepartmental integration. Survey data from 36 business units were analyzed based on the respondents in the research. The statistic results suggest a substantial positive effect of market orientation on product innovation performance. Under the condition of incremental innovativeness among the samples, the more innovative the product is, the more improvements in product innovation performance would be achieved. A variety of particular interdepartmental integration mechanisms have been certified to lend more supports to establishing market orientation and improving product innovation performance.

The Countermeasures and Researches on Improving Farmers' Incomes of Shaanxi Province in the New Period

Combining the relative agricultural statistics from 2000 to 2009, the paper selects 20 major variables to carry out the analyses of factors. Through the component matrix, 3 common factors can be gained. They are investment on agricultural production, development of the second and the third agricultural industries and policies. On the basis of these 3 common factors, the paper suggests on how to improve farmers' incomes. Such as improving farmers' agricultural management incomes, improving farmers' salary and strengthening the construction of policies and so on.

Research on the Cultivation of Innovative Talents in Software Engineering Based on the OBE Concept

Under the background of New Engineering,focusing on talent cultivation,this article explores the teaching reform and innovation of software engineering majors.Starting from the goal of cultivating software engineering talents in the context of New Engineering,the concept of outcome-based education is introduced to study and explore the construction of innovative talent training models for software engineering majors in universities.Through recent years’application practice,initial results have been achieved,which can provide feasible methods and ideas for the cultivation of innovative talents in other majors.

Review of Agricultural Insurance Development in the New Period in China

Agricultural insurance is a great support for agricultural modernization in the new period. It plays a role of " stabilizer" in consecutive increase of yield and constant increase of farmers' income. This paper elaborated current situation of agricultural insurance development in China in the new period,analyzed existing problems,and came up with pertinent recommendations.

Diversity of New Three-Wave Solutions and New Periodic Waves for the (3 + 1)-Dimensional Kadomtsev-Petviashvili-Boussinesq-Like Equation

Based on the generalized bilinear method, diversity of exact solutions of the (3 + 1)-dimensional Kadomtsev-Petviashvili-Boussinesq-like equation is successfully derived by using symbolic computation with Maple. These new solutions, named three-wave solutions and periodic wave have greatly enriched the existing literature. Via the three-dimensional images, density images and contour plots, the physical characteristics of these waves are well described. The new three-wave solutions and periodic solitary wave solutions obtained in this paper, will have a wide range of applications in the fields of physics and mechanics.

Causes of Corruption in China's Rural Areas in the New Period and Countermeasures

In the new period,corruption in China's rural areas is becoming increasingly prominent. There is frequent occurrence of violation of laws and disciplines,such as the use of power for personal gain,and corruption and bribery. Main causes for the corruption in China's rural areas include imperfect rural supervision mechanism,imperfect financial system,and low crime cost. How to deal with the increasingly serious corruption situation is a topic faced at present and in the future. It is required to continue to reinforce the democratic supervision and education of village cadres,improve the comprehensive quality of villagers,and increase the crackdown and punishment of corrupt practices,so as to guarantee healthy operation of rural authorities.

Innovation of Moral Education Mode in Agricultural and Forestry Colleges and Universities in the New Period

The moral quality of students in agricultural and forestry colleges and universities in the new period has a positive mainstream tendency,but at the same time there are some unavoidable problems. The instrumentalization of traditional moral education mode,mechanical preaching and the characteristics of knowledge education are the important reasons for the emergence of problems. The agricultural and forestry colleges and universities must realize the transformation and innovation of moral education mode,reshape the main position of moral education of college students,rebuild the core value of moral education which pays close attention to the growth of individual life,and reconstruct the way of realization of moral education in colleges and universities.

Construction of the Style of Study in Colleges and Universities in the New Period

The Nineteenth National Congress of the Communist Party of China has defined the mission of educating people for our educators.The style of study reflects the education philosophy,culture and spirit of a university from the inside to the outside. Starting from the present situation and existing problems of the construction of the style of study in colleges and universities in the new period,this paper puts forward some recommendations for the construction of the style of study in colleges and universities in the new period.

AR Brought New Opportunities to the Innovation Industry

The data forecast from 2018shows that Chinese AR and VR industries will boast a profit of USD 120 billion in the next 5 years. The AR business will account for 75%. Shi Xiaogang,founder and CEO of Beijing Xloong Technologies Co., Ltd., recently commented that the integration between AR technology and innovation economy is at the early phase of reform and in a key phase of exploration.Innovation industries rise in emerging economies In the past decade, the export of the innovation industry has increased by 8%each year.

The New Normal of China's Macroeconomic Policy

This paper summarizes the theoretical background and realistic considerations for the emergence of the new normal of macro policy. The characteristics of the new normal of macro policy are as follows: 1) a supply-side approach in response to growth slowdown; 2) understanding economic heterogeneity and growth disequilibrium and paying attention to structural regulation; 3) highlighting strategic planning and broadening the horizon of macro policy; 4) re-establishing a benchmark of macro policy and re-initiating local competition; 5) balancing the interests of various stakeholders and understanding the political economy of macro policy; 6) respecting the spillover effects of major countries and implementing responsible macro policies; 7) respecting "market determinism" and recognizing the limitations of macro policy; and 8) propelling institutional developments and creating a basic framework of macro policy. This paper concludes that the new normal of macro policy is not simply a passive adjustment to the new normal of economy but represents an initiative of proactive response that steers the economy towards a more advanced form. In particular, the following issues should be clarified in current macro policy: some of the characteristics will be corrected or phased out, some that coincide with the new normal will be abreast with the times, and some require that a new trail be explored through innovation of macro policy. These components will constitute the basic framework for China's macro policy to transition towards the new normal.

Swiss Innovation Week 2019:Home of Drones,the New High Flyer of Swiss Industry

Following the successful Swiss Innovation Week(SIW)held in July 2018,the Embassy of Switzerland in China launches its 2nd edition from 12 to 14of June 2019.With Swiss drones as the brand-new theme,Switzerland’s drone ecosystem and innovation in the field of flying robots were present.According to various rankings,Switzerland is one of the most innovative countrie s in the world and also one of the most competitive co untries.