Diabetes mellitus (DM) is marked as global health care challenge with almost 10% of the United States population being diagnosed with DM. A sizeable percentage of patients are oblivious of their disease, in spite of e...Diabetes mellitus (DM) is marked as global health care challenge with almost 10% of the United States population being diagnosed with DM. A sizeable percentage of patients are oblivious of their disease, in spite of easily accessibility knowledge about its early signs and symptoms and rapid diagnostic modalities. Critically ill patients with undiagnosed DM are likely to have an increased mortality as compared to intensive care unit (ICU) patients with diagnosed DM. DM may have adverse effect on ICU patients causing organ failure and complications. Early Screening of patients at the risk of developing disease may prevent long term complications. Early screening and management may be beneficial as controlled DM patients have similar morbidity as non DM patients in ICU. An intense glycaemic and blood pressure control improves retinopathy and albuminuria, but may not affect the macrovascular outcomes.展开更多
目的探讨串联质谱(tandem mass spectrometry,MS/MS)联合气相质谱(gas phase mass spectrometry,GC-MS)在新生儿重症监护病房(neonatal intensive care unit,NICU)遗传代谢病(inherited metabolic disorders,IMD)筛查诊断中的应用价值...目的探讨串联质谱(tandem mass spectrometry,MS/MS)联合气相质谱(gas phase mass spectrometry,GC-MS)在新生儿重症监护病房(neonatal intensive care unit,NICU)遗传代谢病(inherited metabolic disorders,IMD)筛查诊断中的应用价值。方法选取2020年1月至2021年12月解放军总医院第七医学中心NICU收治的3682例新生儿(其中足月儿1794例,早产儿1888例)为观察对象,采集干血斑行MS/MS遗传代谢病筛查。初次筛查阳性者重新采样复查并行尿液GC-MS检测。根据患儿代谢谱结合临床表现进行生化诊断。统计学方法采用χ^(2)检验。结果3682例NICU患儿中初筛阳性率为5.65%(208/3682),复筛阳性率为1.33%(49/3682),共生化诊断IMD患儿14例,总检出率为0.38%(14/3682),其中足月儿检出率高于早产儿[0.67%(12/1794)与0.11%(2/1888),χ^(2)=7.697,P=0.006]。14例IMD中,有机酸代谢异常11例,包括甲基丙二酸血症8例(57.1%)、戊二酸血症2例(14.3%)、3-甲基戊二烯酸尿症1例(7.1%);氨基酸代谢异常3例,包括尿素循环障碍2例(14.3%)、高苯丙氨酸血症1例(7.1%)。MS/MS初筛假阳性率为5.29%(194/3668),阳性预测值为6.73%(14/208)。召回复查后,二次MS/MS复测,假阳性率为0.95%(35/3668),阳性预测值为28.57%(14/49)。在各类MS/MS指标异常中,丙酰肉碱及其比值增高、戊二酰肉碱增高的阳性预测值高于氨基酸类代谢异常。结论NICU人群IMD发病率较高,且存在早产、感染等多种非遗传因素,干扰MS/MS代谢筛查结果。及时进行MS/MS复查及尿GC-MS分析可以提高诊断效率,明确生化诊断。展开更多
目的检测重症监护谵妄筛查量表(Intensive Care Delirium Screening Checklist,ICDSC)的信度和效度,为测评全麻术后麻醉苏醒期患者的谵妄状态提供有效工具。方法根据ISPOR指南,对国际通用的ICDSC进行编译,制定中文版ICDSC,对228例手术...目的检测重症监护谵妄筛查量表(Intensive Care Delirium Screening Checklist,ICDSC)的信度和效度,为测评全麻术后麻醉苏醒期患者的谵妄状态提供有效工具。方法根据ISPOR指南,对国际通用的ICDSC进行编译,制定中文版ICDSC,对228例手术后麻醉恢复室留观患者进行谵妄评估,对中文版ICDSC进行信度和效度分析。结果中文版ICDSC内部一致性Cronbach′sα系数为0.74,评分员间信度为0.90;以DSM-Ⅳ诊断结果为金标准,ICDSC诊断域值≥4分时,敏感度为0.97,特异度为0.83,阳性预测值为0.52,阴性预测值为0.99,ICDSC与DSM-Ⅳ总一致性的Kappa值为0.59(P<0.01)。ROC曲线下面积为0.93。结论中文版ICDSC具有满意的信度和效度,具有较高的诊断效能,可作为麻醉恢复室谵妄筛查工具,但诊断阳性者仍需专科医生进一步鉴别诊断排除其他疾病。展开更多
文摘Diabetes mellitus (DM) is marked as global health care challenge with almost 10% of the United States population being diagnosed with DM. A sizeable percentage of patients are oblivious of their disease, in spite of easily accessibility knowledge about its early signs and symptoms and rapid diagnostic modalities. Critically ill patients with undiagnosed DM are likely to have an increased mortality as compared to intensive care unit (ICU) patients with diagnosed DM. DM may have adverse effect on ICU patients causing organ failure and complications. Early Screening of patients at the risk of developing disease may prevent long term complications. Early screening and management may be beneficial as controlled DM patients have similar morbidity as non DM patients in ICU. An intense glycaemic and blood pressure control improves retinopathy and albuminuria, but may not affect the macrovascular outcomes.
文摘目的探讨串联质谱(tandem mass spectrometry,MS/MS)联合气相质谱(gas phase mass spectrometry,GC-MS)在新生儿重症监护病房(neonatal intensive care unit,NICU)遗传代谢病(inherited metabolic disorders,IMD)筛查诊断中的应用价值。方法选取2020年1月至2021年12月解放军总医院第七医学中心NICU收治的3682例新生儿(其中足月儿1794例,早产儿1888例)为观察对象,采集干血斑行MS/MS遗传代谢病筛查。初次筛查阳性者重新采样复查并行尿液GC-MS检测。根据患儿代谢谱结合临床表现进行生化诊断。统计学方法采用χ^(2)检验。结果3682例NICU患儿中初筛阳性率为5.65%(208/3682),复筛阳性率为1.33%(49/3682),共生化诊断IMD患儿14例,总检出率为0.38%(14/3682),其中足月儿检出率高于早产儿[0.67%(12/1794)与0.11%(2/1888),χ^(2)=7.697,P=0.006]。14例IMD中,有机酸代谢异常11例,包括甲基丙二酸血症8例(57.1%)、戊二酸血症2例(14.3%)、3-甲基戊二烯酸尿症1例(7.1%);氨基酸代谢异常3例,包括尿素循环障碍2例(14.3%)、高苯丙氨酸血症1例(7.1%)。MS/MS初筛假阳性率为5.29%(194/3668),阳性预测值为6.73%(14/208)。召回复查后,二次MS/MS复测,假阳性率为0.95%(35/3668),阳性预测值为28.57%(14/49)。在各类MS/MS指标异常中,丙酰肉碱及其比值增高、戊二酰肉碱增高的阳性预测值高于氨基酸类代谢异常。结论NICU人群IMD发病率较高,且存在早产、感染等多种非遗传因素,干扰MS/MS代谢筛查结果。及时进行MS/MS复查及尿GC-MS分析可以提高诊断效率,明确生化诊断。
文摘目的检测重症监护谵妄筛查量表(Intensive Care Delirium Screening Checklist,ICDSC)的信度和效度,为测评全麻术后麻醉苏醒期患者的谵妄状态提供有效工具。方法根据ISPOR指南,对国际通用的ICDSC进行编译,制定中文版ICDSC,对228例手术后麻醉恢复室留观患者进行谵妄评估,对中文版ICDSC进行信度和效度分析。结果中文版ICDSC内部一致性Cronbach′sα系数为0.74,评分员间信度为0.90;以DSM-Ⅳ诊断结果为金标准,ICDSC诊断域值≥4分时,敏感度为0.97,特异度为0.83,阳性预测值为0.52,阴性预测值为0.99,ICDSC与DSM-Ⅳ总一致性的Kappa值为0.59(P<0.01)。ROC曲线下面积为0.93。结论中文版ICDSC具有满意的信度和效度,具有较高的诊断效能,可作为麻醉恢复室谵妄筛查工具,但诊断阳性者仍需专科医生进一步鉴别诊断排除其他疾病。
