Establishing a reliable electrophysiological recording platform is crucial for cardiology and neuroscience research.Noninvasive and label-free planar multitransistors and multielectrode arrays are conducive to perform...Establishing a reliable electrophysiological recording platform is crucial for cardiology and neuroscience research.Noninvasive and label-free planar multitransistors and multielectrode arrays are conducive to perform the large-scale cellular electrical activity recordings,but the signal attenua-tion limits these extracellular devices to record subthreshold activities.In recent decade,in-cell nanoelectronics have been rapidly developed to open the door to intracellular electrophysi-ology.With the unique three-dimensional nanotopography and advanced penetration strategies,high-throughput and high-fidelity action potential like signal recordings is expected to be realized.This review summarizes in-cell nanoelectronics from versatile nano-biointerfaces,penetration strategies,active/pas-sive nanodevices,systematically analyses the applications in electrogenic cells and especially evaluates the influence of nanodevices on the high-quality intracellular electrophysiological signals.Further,the opportunities,challenges and broad prospects of in-cell nanoelectronics are prospected,expecting to promote the development of in-cell electrophysiological platforms to meet the demand of theoretical investigation and clinical application.展开更多
A novel idea of in-cell iR compensation was proposed by using a four-electrode electrochemical system, which was consisted of two working electrodes, one reference electrode （RE） and one auxiliary electrode （AE）. ...A novel idea of in-cell iR compensation was proposed by using a four-electrode electrochemical system, which was consisted of two working electrodes, one reference electrode （RE） and one auxiliary electrode （AE）. One of the two working electrodes was called the auxiliary working electrode （AWE）, which was directly connected to the ground. Another working electrode was used as a regular working electrode （WE） for electrochemical testing. The reference electrode was set in a frit close to the AWE for potential sampling. The other electrodes, WE, RE and AE, were connected to a conventional potentiostat of three-electrode system for electrochemical measurements. A linear narrow electrochemical cell was designed for setting AE at one end and AWE with RE at another end, and setting WE in between AE and AWE. In this way, a positive feedback potential was generated at the working electrode from the solution resistance and the current flow in the solution. An formal iR compensation over 100%, as high as 500%, had been achieved without potential oscillation. The electrochemical cell design, the principle of the in-cell iR compensation, and the preliminary voltammetric characterization by using the redox reaction of ferrocyanide anions were reported.展开更多
A touch sensor is an essential component in meeting the growing demand for human-machine interfaces.These sensors have been developed in wearable,attachable,and even implantable forms to acquire a wide range of inform...A touch sensor is an essential component in meeting the growing demand for human-machine interfaces.These sensors have been developed in wearable,attachable,and even implantable forms to acquire a wide range of information from humans.To be applied to the human body,sensors are required to be biocompatible and not restrict the natural movement of the body.Ionic materials are a promising candidate for soft touch sensors due to their outstanding properties,which include high stretchability,transparency,ionic conductivity,and biocompatibility.Here,this review discusses the unique features of soft ionic touch point sensors,focusing on the ionic material and its key role in the sensor.The touch sensing mechanisms include piezocapacitive,piezoresistive,surface capacitive,piezoelectric,and triboelectric and triboresistive sensing.This review analyzes the implementation hurdles and future research directions of the soft ionic touch sensors for their transformative potential.展开更多
BACKGROUND Oral implant surgery is an effective procedure for artificial implants in missing tooth areas under local anesthesia.Because patients under local anesthesia are conscious during this procedure,compared with...BACKGROUND Oral implant surgery is an effective procedure for artificial implants in missing tooth areas under local anesthesia.Because patients under local anesthesia are conscious during this procedure,compared with general anesthesia-related operations,they are more likely to experience negative emotions,such as anxiety and tension.These emotional reactions result in shivering and chills in the limbs,leading to poor doctor-patient cooperation and even avoidance of treatment.In traditional Chinese medicine,it is believed that acupoint massage regulates blood and Qi,dredge menstruation,and relieve pain,which is beneficial for patients’emotional adjustment;however,there are few related clinical studies.AIM To observe the changes in anxiety and pain in patients with oral implant after acupoint massage combined with touch therapy.METHODS One hundred patients undergoing oral implantation in our hospital between May 2020 and May 2023 were randomly divided into control and study groups,according to a random number table,with 50 patients in each group.The control group received routine intervention,and the study group received acupoint massage combined with touch on the basis of the control group.Anxiety[assessed using the Modified Dental Anxiety Scale(MDAS)],pain severity,blood pressure,heart rate,and satisfaction were compared between the two groups.RESULTS Before intervention,the difference in MDAS score between the two groups was not significant(P>0.05),while after the intervention,the MDAS scores decreased in both groups compared with those before the intervention(P<0.05);the MDAS score of the study group was lower than that of the control group,with a statistically significant difference(P<0.05).The degree of pain in the intervention group was significantly lower than that in the control group(P<0.05).Before the intervention,there were no significant differences in systolic and diastolic blood pressures or heart rate between the two groups(P>0.05).The systolic and diastolic blood pressures and heart rate in the intervention group,during and after the intervention,were significantly lower than those in the control group(P<0.05).The total degree of satisfaction in the study group was significantly higher than that in the control group(P<0.05).CONCLUSION Acupoint massage combined with touch better relieves anxiety and pain in patients undergoing dental implant surgery,improving the perioperative comfort of these patients and ensuring safety and a smooth operation.展开更多
基金The work is supported in part by the National Natural Science Foundation of China(Grant Nos.82061148011,61771498)Guangdong Basic and Applied Basic Research Foundation(Grant No.2020A1515010665)+2 种基金Department of Science and Technology of Guangdong Province Project(Grant No.2020B1212060030)Foundation of Sun Yat-sen University(Grant Nos.76120-18821104,20lgpy47,20lgzd14)Open Project of Chinese Academy of Sciences(Grant No.SKT2006).
文摘Establishing a reliable electrophysiological recording platform is crucial for cardiology and neuroscience research.Noninvasive and label-free planar multitransistors and multielectrode arrays are conducive to perform the large-scale cellular electrical activity recordings,but the signal attenua-tion limits these extracellular devices to record subthreshold activities.In recent decade,in-cell nanoelectronics have been rapidly developed to open the door to intracellular electrophysi-ology.With the unique three-dimensional nanotopography and advanced penetration strategies,high-throughput and high-fidelity action potential like signal recordings is expected to be realized.This review summarizes in-cell nanoelectronics from versatile nano-biointerfaces,penetration strategies,active/pas-sive nanodevices,systematically analyses the applications in electrogenic cells and especially evaluates the influence of nanodevices on the high-quality intracellular electrophysiological signals.Further,the opportunities,challenges and broad prospects of in-cell nanoelectronics are prospected,expecting to promote the development of in-cell electrophysiological platforms to meet the demand of theoretical investigation and clinical application.
文摘A novel idea of in-cell iR compensation was proposed by using a four-electrode electrochemical system, which was consisted of two working electrodes, one reference electrode （RE） and one auxiliary electrode （AE）. One of the two working electrodes was called the auxiliary working electrode （AWE）, which was directly connected to the ground. Another working electrode was used as a regular working electrode （WE） for electrochemical testing. The reference electrode was set in a frit close to the AWE for potential sampling. The other electrodes, WE, RE and AE, were connected to a conventional potentiostat of three-electrode system for electrochemical measurements. A linear narrow electrochemical cell was designed for setting AE at one end and AWE with RE at another end, and setting WE in between AE and AWE. In this way, a positive feedback potential was generated at the working electrode from the solution resistance and the current flow in the solution. An formal iR compensation over 100%, as high as 500%, had been achieved without potential oscillation. The electrochemical cell design, the principle of the in-cell iR compensation, and the preliminary voltammetric characterization by using the redox reaction of ferrocyanide anions were reported.
基金supported by the National Research Foundation of Korea(NRF)(No.2021R1C1C2009703)the Gachon University Research Fund of 2022(GCU-202300890001).
文摘A touch sensor is an essential component in meeting the growing demand for human-machine interfaces.These sensors have been developed in wearable,attachable,and even implantable forms to acquire a wide range of information from humans.To be applied to the human body,sensors are required to be biocompatible and not restrict the natural movement of the body.Ionic materials are a promising candidate for soft touch sensors due to their outstanding properties,which include high stretchability,transparency,ionic conductivity,and biocompatibility.Here,this review discusses the unique features of soft ionic touch point sensors,focusing on the ionic material and its key role in the sensor.The touch sensing mechanisms include piezocapacitive,piezoresistive,surface capacitive,piezoelectric,and triboelectric and triboresistive sensing.This review analyzes the implementation hurdles and future research directions of the soft ionic touch sensors for their transformative potential.
文摘BACKGROUND Oral implant surgery is an effective procedure for artificial implants in missing tooth areas under local anesthesia.Because patients under local anesthesia are conscious during this procedure,compared with general anesthesia-related operations,they are more likely to experience negative emotions,such as anxiety and tension.These emotional reactions result in shivering and chills in the limbs,leading to poor doctor-patient cooperation and even avoidance of treatment.In traditional Chinese medicine,it is believed that acupoint massage regulates blood and Qi,dredge menstruation,and relieve pain,which is beneficial for patients’emotional adjustment;however,there are few related clinical studies.AIM To observe the changes in anxiety and pain in patients with oral implant after acupoint massage combined with touch therapy.METHODS One hundred patients undergoing oral implantation in our hospital between May 2020 and May 2023 were randomly divided into control and study groups,according to a random number table,with 50 patients in each group.The control group received routine intervention,and the study group received acupoint massage combined with touch on the basis of the control group.Anxiety[assessed using the Modified Dental Anxiety Scale(MDAS)],pain severity,blood pressure,heart rate,and satisfaction were compared between the two groups.RESULTS Before intervention,the difference in MDAS score between the two groups was not significant(P>0.05),while after the intervention,the MDAS scores decreased in both groups compared with those before the intervention(P<0.05);the MDAS score of the study group was lower than that of the control group,with a statistically significant difference(P<0.05).The degree of pain in the intervention group was significantly lower than that in the control group(P<0.05).Before the intervention,there were no significant differences in systolic and diastolic blood pressures or heart rate between the two groups(P>0.05).The systolic and diastolic blood pressures and heart rate in the intervention group,during and after the intervention,were significantly lower than those in the control group(P<0.05).The total degree of satisfaction in the study group was significantly higher than that in the control group(P<0.05).CONCLUSION Acupoint massage combined with touch better relieves anxiety and pain in patients undergoing dental implant surgery,improving the perioperative comfort of these patients and ensuring safety and a smooth operation.
