A numerical study of fluid injection and mixing under near-critical conditions

Nitrogen injection under conditions close vicinity of the liquid-gas critical point is studied numerically. The fluid thermodynamic and transport properties vary drasti- cally and exhibit anomalies in the near-critical regime. These anomalies can cause distinctive effects on heat-transfer and fluid-flow characteristics. To focus on the influence of ther- modynamics on the flow field, a relatively low injection Reynolds number of 1 750 is adopted. For comparisons, a reference case with the same configuration and Reynolds number is simulated in the ideal gas regime. The model accommodates full conservation laws, real-fluid thermody- namic and transport phenomena. Results reveal that the flow features of the near-critical fluid jet are significantly differ- ent from their counterpart. The near-critical fluid jet spreads faster and mixes more efficiently with the ambient fluid along with a more rapidly development of the vortex pairing pro- cess. Detailed analysis at different streamwise locations in- cluding both the flat shear-layer region and fully developed vortex region reveals the important effect of volume dilata- tion and baroclinic torque in the near-critical fluid case. The former disturbs the shear layer and makes it more unstable. The volume dilatation and baroclinic effects strengthen the vorticity and stimulate the vortex rolling up and pairing pro- cess

Postmarketing studies on safety of Dengfeng~ shenmai injection

OBJECTIVE: To systematically research the postmarketing safety of Dengfeng shenmai injection, identify potential risk factors, and ensure its clinical safety. METHODS: We investigated a comprehensive series of studies on the production process, quality standards, pharmacology, postmarketing clinical studies, and safety evaluation of Shenmai injection, including literature analysis of adverse drug reaction(ADR) case analysis and systematic review. Data from the hospital information system(HIS) and spontaneous reporting system(SRS) were also analyzed. RESULTS: The approximate dosage leading to death in dogs is 45.0-67.5 g raw drug/kg and the toxic reactions are restlessness, skin irritation, salivation, and vomiting. The results of chronic toxicity tests in mice and dogs, and the other tests such as 6-month toxicity, drug safety, genetic toxicity, and reproductive toxicity of rats and dogs, were positive or qualified. Patient ADR history and ADR family history were closely associated with itching based on the data analysis from SRS. There was no damage to renal function from Shenmai injection use at a dosage and a treatment course outside the recommended dosage and treatment course as specified based on data analysis from HIS. The most common ADR from Shenmai injection are difficulty breathing, facial flushing, nausea, vomiting, chest tightness, skin itching, rash, and back pain. CONCLUSION: This study includes complete information on Shenmai injection ADR incidence rate. We found that Shenmai injection is safe and this study can provide clinical, research, and production institutions with an objective, reliable, and scientific basis for use of Shenmai injection.