INADEQUATE(Incredible Natural Abundance DoublE QUAntum Transfer Experiment)is one of the most important techniques in revealing the carbon skeleton of organic solids in solid-state NMR spectroscopy.Nevertheless,its us...INADEQUATE(Incredible Natural Abundance DoublE QUAntum Transfer Experiment)is one of the most important techniques in revealing the carbon skeleton of organic solids in solid-state NMR spectroscopy.Nevertheless,its use for structural analysis is quite limited due to the low natural abundance of^(13)C-^(13)C connectivity(~0.01%)and thus low sensitivity.Particularly,in semi-solids like rubbers,the sensitivity will be further significantly reduced by the inefficient cross polarization from 1H to^(13)C due to molecular motions induced averaging of^(1)H-^(13)C dipolar couplings.Herein,in this study,we demonstrate that transient nuclear Overhauser effect(NOE)can be used to efficiently enhance^(13)C signals,and thus enable rapid acquisition of two-dimensional(2D)^(13)C INADEQUATE spectra of rubbers.Using chlorobutyl rubber as the model system,it is found that an overall signalto-noise ratio(SNR)enhancement about 22%can be achieved,leading to significant timesaving by about 33%as compared to the direct polarization-based INADEQUATE experiment.Further experimental results on natural rubber and ethylene propylene diene monomer(EPDM)rubber are also shown to demonstrate the robust performance of transient NOE enhanced INADEQUATE experiment.展开更多
BACKGROUND No consensus has been reached in patients suspected of having inadequate bowel preparation regarding optimal salvage methods, which negatively affects the efficacy and quality of colonoscopy. The most ideal...BACKGROUND No consensus has been reached in patients suspected of having inadequate bowel preparation regarding optimal salvage methods, which negatively affects the efficacy and quality of colonoscopy. The most ideal and reasonable rescue option involves early suspicion and identification of patients with inadequate preparation before sedation, additional oral ingestion of a suitable preparation formulation, and same-day colonoscopy.AIM To compare 0.5-L and 1-L polyethylene glycol containing ascorbic acid(PEG +Asc) as additional bowel cleansing methods after a 2-L split-dose PEG + Asc regimen in patients with expected inadequate bowel preparation before colonoscopy.METHODS Individuals with expected inadequate bowel preparation based on last stool form, such as turbid liquid, particulate liquid, or liquid with small amounts of feces, were randomized to either a 0.5-L PEG + Asc group or a 1-L PEG + Asc group. The primary endpoint was bowel preparation as assessed using the Aronchick bowel preparation scale(ABPS) and Boston bowel preparation scale(BBPS) scores. The secondary endpoints were cecal intubation time, withdrawal time, polyp detection rate(PDR), adenoma detection rate(ADR), individual compliance with additional PEG + Asc, and patient satisfaction.RESULTS Initially, 98 patients were included, but 8 were later excluded due to withdrawal of consent to participate in the study. Adequate bowel preparation(as assessed by ABPS) was observed in 80.9%(38/47) of subjects in the 0.5-L group and in88.4%(38/43) of subjects in the 1-L group(P = 0.617). Mean total BBPS was 6.7 points in the 0.5-L group and 7.0 points in the 1-L group(P = 0.458). ADRs and PDRs were similar in the two groups, and cecal intubation and withdrawal times were not significantly different. However, mean patient satisfaction score was significantly higher in the 0.5-L group(P = 0.041).CONCLUSION The bowel cleaning efficacy of additional 0.5-L PEG + Asc was not inferior to that of 1-L PEG + Asc. Additional 0.5-L PEG + Asc is worthwhile when inadequate bowel preparation is expected before colonoscopy.展开更多
Six new indole alkaloids,named alstoniascholarines L–Q(1–6),together with nineteen known analogues were isolated from the inadequately dried leaves of Alstonia scholaris.Their structures were elucidated on the basis...Six new indole alkaloids,named alstoniascholarines L–Q(1–6),together with nineteen known analogues were isolated from the inadequately dried leaves of Alstonia scholaris.Their structures were elucidated on the basis of extensive analysis of spectroscopic data and by comparison of their physical and spectroscopic data with the literature values.In addition,the new alkaloids were tested for their cytotoxic and neurite outgrowth-promoting activities.展开更多
Objective The Gaoligongshan oblique collisional orogen is located in the southern section of the Hengduan Mountains, and belongs to one of the main Late Yanshanian-Himalayan oblique collisional orogens in the Sanjiang...Objective The Gaoligongshan oblique collisional orogen is located in the southern section of the Hengduan Mountains, and belongs to one of the main Late Yanshanian-Himalayan oblique collisional orogens in the Sanjiang area. Many researchers have studied the geology, geochemistry and geophysics of this region, and many research achievements have been obtained from deep geophysical exploration of the region, especially using the magnetotelluric （MT） sounding technique. However,展开更多
目的:探讨德谷门冬双胰岛素联合达格列净治疗血糖控制不佳2型糖尿病患者的临床疗效。方法:选取2023年4月—2023年9月射阳县人民医院内分泌科收治的60例血糖控制不佳的2型糖尿病患者,随机分为门冬30组(给予门冬胰岛素30皮下注射联合口服...目的:探讨德谷门冬双胰岛素联合达格列净治疗血糖控制不佳2型糖尿病患者的临床疗效。方法:选取2023年4月—2023年9月射阳县人民医院内分泌科收治的60例血糖控制不佳的2型糖尿病患者,随机分为门冬30组(给予门冬胰岛素30皮下注射联合口服达格列净治疗)和德谷门冬组(给予德谷门冬双胰岛素皮下注射联合口服达格列净治疗),每组各30例。比较两组患者早空腹、午餐前、晚餐前及晚睡前各时间点的血糖水平、平均血糖、血糖标准差、血糖波动幅度、血糖控制达标时间及胰岛素使用剂量。结果:两组患者血糖控制达标后,德谷门冬组患者的早空腹血糖[(6.17±1.71) mmol/L vs (6.78±0.23) mmol/L]、血糖标准差[(1.48±0.31) mmol/L vs (1.64±0.28) mmol/L]、血糖波动幅度[(3.04±0.82) mmol/L vs (3.88±0.67) mmol/L]及血糖控制达标时间[(6.00±2.00)天vs (7.13±1.66)天]均显著低于门冬30组患者(均P<0.05)。结论:德谷门冬双胰岛素联合达格列净对血糖控制不佳的2型糖尿病患者治疗效果较好,值得临床推广应用。展开更多
基金support of National Natural Science Foundation of China(No.22173033,and 22241501)Natural Science Foundation of Guangdong Province,China(No.2023A1515011395).
文摘INADEQUATE(Incredible Natural Abundance DoublE QUAntum Transfer Experiment)is one of the most important techniques in revealing the carbon skeleton of organic solids in solid-state NMR spectroscopy.Nevertheless,its use for structural analysis is quite limited due to the low natural abundance of^(13)C-^(13)C connectivity(~0.01%)and thus low sensitivity.Particularly,in semi-solids like rubbers,the sensitivity will be further significantly reduced by the inefficient cross polarization from 1H to^(13)C due to molecular motions induced averaging of^(1)H-^(13)C dipolar couplings.Herein,in this study,we demonstrate that transient nuclear Overhauser effect(NOE)can be used to efficiently enhance^(13)C signals,and thus enable rapid acquisition of two-dimensional(2D)^(13)C INADEQUATE spectra of rubbers.Using chlorobutyl rubber as the model system,it is found that an overall signalto-noise ratio(SNR)enhancement about 22%can be achieved,leading to significant timesaving by about 33%as compared to the direct polarization-based INADEQUATE experiment.Further experimental results on natural rubber and ethylene propylene diene monomer(EPDM)rubber are also shown to demonstrate the robust performance of transient NOE enhanced INADEQUATE experiment.
文摘BACKGROUND No consensus has been reached in patients suspected of having inadequate bowel preparation regarding optimal salvage methods, which negatively affects the efficacy and quality of colonoscopy. The most ideal and reasonable rescue option involves early suspicion and identification of patients with inadequate preparation before sedation, additional oral ingestion of a suitable preparation formulation, and same-day colonoscopy.AIM To compare 0.5-L and 1-L polyethylene glycol containing ascorbic acid(PEG +Asc) as additional bowel cleansing methods after a 2-L split-dose PEG + Asc regimen in patients with expected inadequate bowel preparation before colonoscopy.METHODS Individuals with expected inadequate bowel preparation based on last stool form, such as turbid liquid, particulate liquid, or liquid with small amounts of feces, were randomized to either a 0.5-L PEG + Asc group or a 1-L PEG + Asc group. The primary endpoint was bowel preparation as assessed using the Aronchick bowel preparation scale(ABPS) and Boston bowel preparation scale(BBPS) scores. The secondary endpoints were cecal intubation time, withdrawal time, polyp detection rate(PDR), adenoma detection rate(ADR), individual compliance with additional PEG + Asc, and patient satisfaction.RESULTS Initially, 98 patients were included, but 8 were later excluded due to withdrawal of consent to participate in the study. Adequate bowel preparation(as assessed by ABPS) was observed in 80.9%(38/47) of subjects in the 0.5-L group and in88.4%(38/43) of subjects in the 1-L group(P = 0.617). Mean total BBPS was 6.7 points in the 0.5-L group and 7.0 points in the 1-L group(P = 0.458). ADRs and PDRs were similar in the two groups, and cecal intubation and withdrawal times were not significantly different. However, mean patient satisfaction score was significantly higher in the 0.5-L group(P = 0.041).CONCLUSION The bowel cleaning efficacy of additional 0.5-L PEG + Asc was not inferior to that of 1-L PEG + Asc. Additional 0.5-L PEG + Asc is worthwhile when inadequate bowel preparation is expected before colonoscopy.
基金The authors are grateful to the Natural Science Foundation of China(81225024)Collaborative Innovation Center of Southwest EthnicMedicine(Guangxi Normal University),(CICSEM 2013-A)+1 种基金the Ministry of Science and Technology of the People’s Republic of China(2014ZX09301307-003)the Chinese Academy of Sciences(KSZD-EW-Z-004-03)for partial financial support。
文摘Six new indole alkaloids,named alstoniascholarines L–Q(1–6),together with nineteen known analogues were isolated from the inadequately dried leaves of Alstonia scholaris.Their structures were elucidated on the basis of extensive analysis of spectroscopic data and by comparison of their physical and spectroscopic data with the literature values.In addition,the new alkaloids were tested for their cytotoxic and neurite outgrowth-promoting activities.
基金the National Natural Science Foundation of China(grants No.41504061 and 41674078)the National Key Research and Development Project of China(grant No. 2016YFC0600302)
文摘Objective The Gaoligongshan oblique collisional orogen is located in the southern section of the Hengduan Mountains, and belongs to one of the main Late Yanshanian-Himalayan oblique collisional orogens in the Sanjiang area. Many researchers have studied the geology, geochemistry and geophysics of this region, and many research achievements have been obtained from deep geophysical exploration of the region, especially using the magnetotelluric （MT） sounding technique. However,
文摘目的:探讨德谷门冬双胰岛素联合达格列净治疗血糖控制不佳2型糖尿病患者的临床疗效。方法:选取2023年4月—2023年9月射阳县人民医院内分泌科收治的60例血糖控制不佳的2型糖尿病患者,随机分为门冬30组(给予门冬胰岛素30皮下注射联合口服达格列净治疗)和德谷门冬组(给予德谷门冬双胰岛素皮下注射联合口服达格列净治疗),每组各30例。比较两组患者早空腹、午餐前、晚餐前及晚睡前各时间点的血糖水平、平均血糖、血糖标准差、血糖波动幅度、血糖控制达标时间及胰岛素使用剂量。结果:两组患者血糖控制达标后,德谷门冬组患者的早空腹血糖[(6.17±1.71) mmol/L vs (6.78±0.23) mmol/L]、血糖标准差[(1.48±0.31) mmol/L vs (1.64±0.28) mmol/L]、血糖波动幅度[(3.04±0.82) mmol/L vs (3.88±0.67) mmol/L]及血糖控制达标时间[(6.00±2.00)天vs (7.13±1.66)天]均显著低于门冬30组患者(均P<0.05)。结论:德谷门冬双胰岛素联合达格列净对血糖控制不佳的2型糖尿病患者治疗效果较好,值得临床推广应用。
