Aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders:progress of experimental models based on disease pathogenesis

Neuromyelitis optica spectrum disorders are neuroinflammatory demyelinating disorders that lead to permanent visual loss and motor dysfunction.To date,no effective treatment exists as the exact causative mechanism remains unknown.Therefore,experimental models of neuromyelitis optica spectrum disorders are essential for exploring its pathogenesis and in screening for therapeutic targets.Since most patients with neuromyelitis optica spectrum disorders are seropositive for IgG autoantibodies against aquaporin-4,which is highly expressed on the membrane of astrocyte endfeet,most current experimental models are based on aquaporin-4-IgG that initially targets astrocytes.These experimental models have successfully simulated many pathological features of neuromyelitis optica spectrum disorders,such as aquaporin-4 loss,astrocytopathy,granulocyte and macrophage infiltration,complement activation,demyelination,and neuronal loss;however,they do not fully capture the pathological process of human neuromyelitis optica spectrum disorders.In this review,we summarize the currently known pathogenic mechanisms and the development of associated experimental models in vitro,ex vivo,and in vivo for neuromyelitis optica spectrum disorders,suggest potential pathogenic mechanisms for further investigation,and provide guidance on experimental model choices.In addition,this review summarizes the latest information on pathologies and therapies for neuromyelitis optica spectrum disorders based on experimental models of aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders,offering further therapeutic targets and a theoretical basis for clinical trials.

基于24Model-D-ISM的地铁站火灾疏散影响因素研究

为预防地铁站火灾事故,深入了解地铁站火灾人员疏散影响因素间的内在联系与层次结构,基于第6版“2-4”模型(24Model)分析63起地铁站火灾疏散事故,充分考虑各个因素之间的交互作用,提取19个影响地铁站人员疏散的关键因素,建立地铁站火灾人员疏散影响因素指标体系;采用算子客观赋权法(C-OWA)改进决策试验与评价实验法(DEMATEL),确定地铁站火灾人员疏散的重要影响因素;在此基础上,采用解释结构模型(ISM)分析各个因素间的层次结构及相互作用路径,构建地铁站火灾人员疏散影响因素的多级递阶结构模型。研究结果表明:疏散引导、恐慌从众行为、人员拥挤为地铁站火灾人员疏散的关键影响因素;地铁站火灾人员疏散受表层因素、中间层因素、深层因素共同作用的影响,其中,疏散教育与培训、设施维护与检查、疏散预案等因素是根源影响因素,重视根源影响因素的改善有利于从本质上预防和控制事故的发生。

24Model与LCM原因因素定义对比研究

为探究损失致因模型(LCM)原因因素定义与事故致因“2-4”模型(24Model)存在的异同和优缺点,梳理2个模型各层面原因和结果的定义,对比定义内容及其对事故原因分析等安全实务的指导作用,并以一起瓦斯爆炸事故为例加以实证分析,获得二者分析结果之间的差异。研究结果表明:LCM是首个将管理因素纳入事故致因分析的一维事件序列模型,可明确各层面原因因素的定义和因素间的逻辑关系,但部分定义存在交叉重复的问题,并没有揭示安全工作指导思想等深层次事故致因因素;24Model作为系统性事故致因模型,对各类因素的定义均以组织为主体,描述事件、事故、安全的概念内涵,划分个体安全动作、安全能力和组织安全管理体系的类别并给出含义解析,探究组织安全文化层面的问题并以32个元素体现;2个模型的事故原因分析方法均建立在对各层级原因因素定义的基础上,并适用于模型理论体系本身。

Role of methoxy and C_(α)-based substituents in electrochemical oxidation mechanisms and bond cleavage selectivity of β-O-4 lignin model compounds

In order to better understand the specific substituent effects on the electrochemical oxidation process of β-O-4 bond, a series of methoxyphenyl type β-O-4 dimer model compounds with different localized methoxyl groups, including 2-(2-methoxyphenoxy)-1-phenylethanone, 2-(2-methoxyphenoxy)-1-phenylethanol, 2-(2-methoxyphenoxy)-1-(4-methoxyphenyl)ethanone, 2-(2-methoxyphenoxy)-1-(4-methoxyphenyl)ethanol, 2-(2,6-dimethoxyphenoxy)-1-(4-methoxyphenyl)ethanone, 2-(2,6-dimethoxyphenoxy)-1-(4-methoxyphenyl)ethanol have been selected and their electrochemical properties have been studied experimentally by cyclic voltammetry, and FT-IR spectroelectrochemistry. Combining with electrolysis products distribution analysis and density functional theory calculations, oxidation mechanisms of all six model dimers have been explored. In particular, a total effect from substituents of both para-methoxy(on the aryl ring closing to Cα) and Cα-OH on the oxidation mechanisms has been clearly observed, showing a significant selectivity on the Cα-Cβbond cleavage induced by electrochemical oxidations.

基于24Model的煤炭企业安全文化提升实践研究

为了发挥安全文化在事故预防中的重要作用,运用基于事故致因“2-4”模型的安全文化水平提升方法研究某煤炭企业的安全文化建设现状并提出改进措施。首先,明确了24Model视域下的安全文化水平提升方法在我国的适用性;然后,从安全文化水平现状和安全理念2方面开展了针对该企业的实践研究;最后,提出改进措施。结果表明:该企业安全文化水平总体上要比国内或同行业的安全业绩较差的企业好,比安全业绩较好的企业差;该企业安全理念涉及32元素的13个方面;一线人员、班组长、专业人员和领导层对部分元素的理解程度不佳,并且这些元素中仅有元素3、元素4、元素6、元素13、元素16的内容在企业的安全理念有所体现。提出了14条改进的安全理念用于提高企业的安全文化水平。

Rain-Flow Modelling Using the GR4J Model for Flood Risk Management in the Oti Watershed (Togo)

In recent years, West Africa has been confronted with hydro-climatic disasters causing crises in both urban and rural areas. The tragedy in the occurrence of such events lies in the recurrent aspect of high water and associated floods. The devastating floods observed in Africa’s major rivers have revealed the need to understand the causes of these phenomena and to predict their behavior in order to improve the safety of exposed people and property. The aim of this study is to reproduce flood flows using the GR4J (Rural Engineering Four Daily Parameters) model to analyze flood risk in the Oti watershed in Togo. Daily data on flows (m3/s), potential evapotranspiration (mm/day) and average precipitation (mm) over the basin from 1961-2022 collected at the National Meteorological Agency of Togo (ANAMET) and the Department of Water Resources in Lome, were used with the R software package airGR. The Data from the West African Cordex program from 1961-2100 were used to analyze projected flows. The results obtained show the GR4J model’s effectiveness in reproducing flood flows, indicating that observed flows are well simulated during the calibration and validation periods, with KGE values ranging from 0.73 to 0.85 at calibration and 0.62 to 0.81 at validation. These KGE values reflect the good performance of the GR4J model in simulating flood flows in the watershed. However, a deterioration in the KGE value was observed over the second validation period. Under these conditions, there may be false or missed alerts for flood prediction, and the use of this model should be treated with the utmost caution for decision-support purposes.

24 Model在道路运输事故成因中的应用

为预防道路运输事故,基于事故致因“2-4”(24 Model)模型,对2015—2021年发生的215起道路运输事故的行为原因进行研究。从个人层面和组织层面分析导致事故发生的直接原因、间接原因、根本原因及其根源原因。结果表明:发生频次最多的不安全动作是驾驶员超速行驶(占10.67%);22.33%的道路运输事故存在管理者违章安排无资质员工上岗作业;管理者和领导者对57.67%的道路运输事故的发生有重要影响;由人为因素产生的不安全物态占比达71.53%;驾驶员、车辆安全生产管理制度欠缺或执行不到位在根本原因中尤为突出(占20.92%)。基于此,提出道路运输事故预防对策并构建出道路运输系统各因素关系图。

IFAM与24Model的对比研究

为完善和推动事故致因理论的发展,提高事故防控水平,在对信息流事故致因模型(IFAM)和事故致因2-4模型(24Model)理论基础、组成要素和分析过程对比研究的基础上,通过实例分析辨识二者之间的异同。研究结果表明:IFAM与24Model都有较强的理论基础,部分组成要素存在对应关系,但原因类别划分存在差异。IFAM以信息流和组织为研究对象,研究过程相对复杂,更适用于分析单起事故;24Model以组织为研究对象,事故原因模块通用性和逻辑性强,适用于分析单起或某类事故。在实际应用中,IFAM与24Model均可用于事故调查分析和事故分级定责,具有一定的理论和实践价值。IFAM通过信息流表征事故致因,直观描述组织外部原因因素,但对个体能力的深入研究欠缺;而24Model认为组织外部因素需要通过组织内部原因模块的欠缺体现,认为个体能力是引发事故的间接原因并进行细致分析,但对组织间相关关系的探究欠缺。研究结果可为事故预防工作提供新视角和理论支撑。

基于24Model的房屋市政工程事故致因组态研究

为探索房屋市政工程事故的影响因素与关联组态路径,依据案例的完整性、代表性与可靠性选取2018—2022年发生的70起较大及以上规模房屋市政工程生产安全事故作为研究对象,运用定性比较分析方法和“2-4”模型寻找该类事故的致因组态。研究结果表明:组织安全管理体系的执行情况是导致事故发生的重要影响因素;安全文化型和不安全动作型是事故的主要发生机制;事故致因与结果之间存在多重并发的因果关系。房屋市政工程生产安全管理需夯实安全管理体系,利用致因组态强化事故预防措施,以改善工程的经济与社会效益。

Calculation of the Standard Model Parameters and Particles Based on a SU(4) Preon Model

This paper describes an extension and a new foundation of the Standard Model of particle physics based on a SU(4)-force called hyper-color, and on preon subparticles. The hyper-color force is a generalization of the SU(2)-based weak interaction and the SU(1)-based right-chiral self-interaction, in which the W-and the Z-bosons are Yukawa residual-field-carriers of the hyper-color force, in the same sense as the pions are the residual-field-carriers of the color SU(3) interaction. Using the method of numerical minimization of the SU(4)-action based on this model, the masses and the inner structure of leptons, quarks and weak bosons are calculated: the mass results are very close to the experimental values. We calculate also precisely the value of the Cabibbo angle, so the mixing matrices of the Standard model, CKM matrix for quarks and PMNS matrix for neutrinos can also be calculated. In total, we reduce the 29 parameters of the Standard Model to a total of 7 parameters.

Research on Track Fastener Service Status Detection Based on Improved Yolov4 Model

As an important part of railway lines, the healthy service status of track fasteners was very important to ensure the safety of trains. The application of deep learning algorithms was becoming an important method to realize its state detection. However, there was often a deficiency that the detection accuracy and calculation speed of model were difficult to balance, when the traditional deep learning model is used to detect the service state of track fasteners. Targeting this issue, an improved Yolov4 model for detecting the service status of track fasteners was proposed. Firstly, the Mixup data augmentation technology was introduced into Yolov4 model to enhance the generalization ability of model. Secondly, the MobileNet-V2 lightweight network was employed in lieu of the CSPDarknet53 network as the backbone, thereby reducing the number of algorithm parameters and improving the model’s computational efficiency. Finally, the SE attention mechanism was incorporated to boost the importance of rail fastener identification by emphasizing relevant image features, ensuring that the network’s focus was primarily on the fasteners being inspected. The algorithm achieved both high precision and high speed operation of the rail fastener service state detection, while realizing the lightweight of model. The experimental results revealed that, the MAP value of the rail fastener service state detection algorithm based on the improved Yolov4 model reaches 83.2%, which is 2.83% higher than that of the traditional Yolov4 model, and the calculation speed was improved by 67.39%. Compared with the traditional Yolov4 model, the proposed method achieved the collaborative optimization of detection accuracy and calculation speed.

基于24model的建筑施工机械伤害事故脆弱性分析

为预防建筑施工机械伤害事故,本研究采用事故致因2-4模型(24model)和复杂网络理论(CN)对施工机械事故进行分析整理。首先采用24model梳理86起典型机械事故报告中各层次事故的致因,对伤害事故中的安全管理体系、习惯性行为、不安全动作和不安全物态进行定性分析;随后根据复杂网络理论构建风险要素网络模型,通过网络攻击的手段找到导致事故的关键要素。研究结果表明:未经允许冒险作业、无相关施工资质、作业环境恶劣是事故关键致因。通过对关键节点的防控,可有效提升建筑施工安全水平。

HFACS与24Model不安全动作因素对应关系研究

不安全动作是导致事故发生的直接原因,为明确和统一不安全动作的定义及判定标准,采用对比分析的方法梳理人因分析与分类系统(HFACS)和24Model中不安全动作的定义和判定标准,建立HFACS与24Model不安全动作因素的对应关系,并以实际事故为例论述对应关系的应用过程。结果表明,HFACS定义的不安全动作可以通过对应关系与24Model定义的不安全动作相对应;所建立的对应关系统一了不安全动作的判定标准。

Effect of pre-deformation on aging creep of Al-Li-S4 alloy and its constitutive modeling

A set of uniaxial tensile creep tests at different pre-deformations, aging temperatures and stress levels were carried out for Al-Li-S4 alloy, and the creep behavior and the effects of pre-deformation on mechanical properties and microstructures were determined under basic thermodynamics conditions of aging forming. The results show that pre-deformation shortens the time of primary creep and raises the second steady-state creep rate. Then, the total creep strain is greater, but in the range of test parameters it is still smaller than that without pre-deformation. In addition, transmission electron microscopy（TEM） observation shows that pre-deformation promotes the formation of T1 phase and θ′ phase and makes them distribute more dispersively, while inhibits the generation of δ′ phase, which leads to the improvement of mechanical properties of the alloy. A unified constitutive model reflecting the effects of aging mechanism, stress levels and different pre-deformations was established. The fitting results agree with the experimental data well.

MATHEMATICAL MODEL OF ~4He QUANTUM INTERFEROMETER GYROSCOPE

The mathematical model of 4He quantum interferometer gyroscope is presented. The model includes the driven equation, the current equation and the position equation. Therefore, it can sufficiently describe the gyro- scope system. The driven equation shows the thermally driven gyroscope can work for a long time but the pres- sure driven one cannot. From the current equation, the superfluid currents passing through the weak link contain the AC currents which show the rotation flux, and other currents caused by drive. As shown in the position equa- tion, the displacement of diaphragm is the only detectable parameter in the gyroscope system. The model is tested by the simulations based on experimental parameters, and can be used to research performance of the gyroscope and analyse the gyroscope error.

A modified Johnson-Cook model for NC warm bending of large diameter thin-walled Ti-6Al-4V tube in wide ranges of strain rates and temperatures

Numerical control（NC） warm bending is a proven strategy to form the large diameter thin-walled（LDTW） Ti-6 Al-4 V tubes, which are typical light-weight and high-performance structural components urgently required in many industries. In virtue of unveiling the thermo-mechanical coupled deformation behaviors, uniaxial tensile tests were conducted on Ti-6 Al-4 V tube within wide ranges of temperatures（25-600 ℃） and strain rates（0.00067-0.1 s～（-1））. Moreover, a modified Johnson-Cook（JC） model is proposed with a consideration of nonlinear strain rate hardening and the interaction between strain hardening and thermal softening. Resultantly, the present model gives more accurate predictions for flow stress over the entire deformation ranges and the maximum error decreases by about 90%. By employing proposed model to NC warm bending, preferable precision is obtained in predicting forming defects including fracture, wrinkling and over thinning. The present work lays foundation for the forming limit prediction and process optimization in NC warm bending of LDTW Ti-6 Al-4 V tubes.

Decomposition of a β-O-4 lignin model compound over solid Cs-substituted polyoxometalates in anhydrous ethanol: acidity or redox property dependence?

Production o f aromatics from lignin has attracted much attention. Because of the coexistence of C-O and C-C bonds and their complex combinations in the lignin macromolecular network, a plausible roadmap for developing a lignin catalytic decomposition process could be developed by exploring the transformation mechanisms of various model compounds. Herein, decomposition of a lignin model compound, 2-phenoxyacetophenone （2-PAP）, was investigated over several ce-sium-exchanged polyoxometalate （Cs-POM） catalysts. Decomposition of 2-PAP can follow two dif-ferent mechanisms： an active hydrogen transfer mechanism or an oxonium cation mechanism. The mechanism for most reactions depends on the competition between the acidity and redox proper-ties of the catalysts. The catalysts of POMs perform the following functions： promoting active hy-drogen liberated from ethanol and causing formation of and then temporarily stabilizing oxonium cations from 2-PAP. The use of Cs-PMo, which with strong redox ability, enhances hydrogen libera-tion and promotes liberated hydrogen transfer to the reaction intermediates. As a consequence, complete conversion of 2-PAP （〉99%） with excellent selectivities to the desired products （98.6% for phenol and 91.1% for acetophenone） can be achieved.

HFACS中组织影响与24Model中组织行为的对应关系研究

HFACS是一种广为接受的事故致因模型,具有复杂的结构和内容,24Model由作者课题组建立,其内容及表达方式符合国内习惯,为深入了解HFACS并完善24Model,对2个模型中均包含的事故组织层面的原因进行对比研究。剖析HFACS中组织影响和24Model中组织行为的具体含义,并应用2个模型分析"8·12"天津港火灾爆炸事故。研究表明:HFACS的组织影响和24Model的组织行为有对应关系,但24Model更便于事故分析,得到的分析结果有利于提出事故预防措施;24Model中安全文化元素表还需完善。

一种基于Inception-V4的车位状态检测方法

针对城市停车难,车位检测环境复杂等情况,研究了一种基于Inception-V4算法的车位状态检测方法。在Inception-V4网络结构基础上使用Leaky_ReLU代替ReLU作为激活函数,解决ReLU激活函数引起的神经元失活问题;在网络分类层前添加FReLU激活函数层和多个全连接层,使其获得有更丰富语义信息的特征向量,防止了网络过拟合问题,提高车位状态检测模型的整体性能。基于PKLot停车场数据集的实验结果表明,该方法对车位状态检测准确率较原模型有较大程度的提升。

基于24Model的高校危化品实验室事故分析及对策

为制定高校危化品实验室安全管理对策和优化实验室安全培训,以某高校危化品实验室爆炸事故为例,采用行为安全“2-4”模型(24Model)的分析方法,分别从个人层面和组织层面深入研究该事故发生的直接原因、间接原因、根本原因和根源原因,进而建立危化品实验室事故行为分析模型,该模型对实验室日常监督检查、实验室风险预控体系建设、实验室事故应急响应体系建设给出具体要求。在此基础上,通过调研国内高校实验室教学模式,构建高校危化品实验室安全教育培训体系。结果表明:行为安全24Model普遍适用于事故原因分析,利用该模型研究高校危化品实验室事故发生原因,并从个人层面和组织层面提出改进建议,能够完善高校危化品实验室安全管理水平,提高学生安全风险意识,进而从根本上防范危化品实验室事故的发生。