Abnormal Basal Ganglia Functional Connectivity in Idiopathic Generalized Epilepsy

The basal ganglia have been implicated in a modulation role in idiopathic generalized epilepsy （IGE） by an invasive electrophysioigic means. This paper investigates the basal ganglia functional connectivity by using the region-wise functional connection analysis in resting-state functional magnetic resonance imaging （fMRI） in IGE. The increased functional connectivity within basal ganglia, and between the basal ganglia and the thalamus, and decreased functional connectivity between basal ganglia and motor cortex are found in IGE compared with the controls. These findings not only implicate dysfunctional integration in the motor loop in IGE and the enhanced interaction in the modulated loop, but also suggest that the basal ganglia modulate the generalized epileptic discharges with the influence over thalamus in the corticothalamus network.

特发性全面性癫痫动态功能连接的应用及进展

特发性全面性癫痫(idiopathic generalized epilepsy,IGE)是一组和遗传因素密切相关的癫痫综合征,主要临床表现为癫痫的全面性发作,在脑电图(electroencephalogram,EEG)上表现为全面性或双侧对称性异常放电,而常规MRI检查为阴性。随着MRI新方法的逐步运用,如今在IGE发生发展机制研究上取得了一定进展,但尚未完全阐明。近年来,动态功能连接(dynamic functional connectivity,DFC)作为一种新的脑网络分析方法,逐渐被应用到神经科学研究中,用于分析认知功能障碍与动态信息传递及整合方面的关联性,为人们进一步了解IGE的发生发展机制提供了有价值的新见解。在此,本文对近些年来有关IGE的DFC研究应用及进展进行综述,希望为IGE的研究提供一定的参考。

特发性全面性癫痫多模态fMRI的研究进展

特发性全面性癫痫(IGE)是癫痫疾病中一组常见类型的统称,包括全身强直阵挛发作、青少年肌阵挛性癫痫、儿童失神癫痫及青少年失神性癫痫等公认亚型。多模态功能磁共振成像技术可以检测IGE患者脑结构及功能的改变,对于研究IGE的病因、对发作类型进行分类及判断认知功能改变等有重要的作用和意义。