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Novel Hybrid X GBoost Model to Forecast Soil Shear Strength Based on Some Soil Index Tests 被引量:1
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作者 Ehsan Momeni Biao He +1 位作者 Yasin Abdi Danial Jahed Armaghani 《Computer Modeling in Engineering & Sciences》 SCIE EI 2023年第9期2527-2550,共24页
When building geotechnical constructions like retaining walls and dams is of interest,one of the most important factors to consider is the soil’s shear strength parameters.This study makes an effort to propose a nove... When building geotechnical constructions like retaining walls and dams is of interest,one of the most important factors to consider is the soil’s shear strength parameters.This study makes an effort to propose a novel predictive model of shear strength.The study implements an extreme gradient boosting(XGBoost)technique coupled with a powerful optimization algorithm,the salp swarm algorithm(SSA),to predict the shear strength of various soils.To do this,a database consisting of 152 sets of data is prepared where the shear strength(τ)of the soil is considered as the model output and some soil index tests(e.g.,dry unit weight,water content,and plasticity index)are set as model inputs.Themodel is designed and tuned using both effective parameters of XGBoost and SSA,and themost accuratemodel is introduced in this study.Thepredictionperformanceof theSSA-XGBoostmodel is assessedbased on the coefficient of determination(R2)and variance account for(VAF).Overall,the obtained values of R^(2) and VAF(0.977 and 0.849)and(97.714%and 84.936%)for training and testing sets,respectively,confirm the workability of the developed model in forecasting the soil shear strength.To investigate the model generalization,the prediction performance of the model is tested for another 30 sets of data(validation data).The validation results(e.g.,R^(2) of 0.805)suggest the workability of the proposed model.Overall,findings suggest that when the shear strength of the soil cannot be determined directly,the proposed hybrid XGBoost-SSA model can be utilized to assess this parameter. 展开更多
关键词 Predictive model salp swarm algorithm soil index tests soil shear strength XGBoost
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A Review of Index Case Testing Induced Intimate Partner Violence and Electronic Management of Information in HIV Care
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作者 Tihnje Abena Mbah Ajeh Rogers +1 位作者 Nguetti Joseph Honoré Honoré Luc Einstein Ngend 《E-Health Telecommunication Systems and Networks》 2023年第4期61-77,共17页
Intimate Partner Violence (IPV) is a form of Gender Base Violence (GBV) where an intimate partner perpetrates violence. In the HIV care continua which has the aim of achieving epidemic control based on the goals defin... Intimate Partner Violence (IPV) is a form of Gender Base Violence (GBV) where an intimate partner perpetrates violence. In the HIV care continua which has the aim of achieving epidemic control based on the goals defined by UNAIDS, 95% of people living with HIV (PLHIV) have to know their HIV status, 95% initiated ARV treatment and 95% are virally suppressed in order to achieve epidemic control. One of the evidence-based strategies used for achieving an optimal number of PLHIV who know their HIV status is the Index Case Testing Strategy (ICT). While the ICT strategy helps the achievement of epidemic control, its implementation increases the incidence of IPV among either serodiscordant or concordant couples. Tackling information about IPV is very sensitive. A review of the literature on the management of HIV patient information has shown that shifting from paper-based management of HIV patient information to computerized Electronic Medical Records (EMR) systems, using software such as OPEN MRS has significantly improved the management of HIV patient information with high-level confidentiality of patient information. The reviews showed that the EMR systems put in place to manage HIV patient information need to integrate the stages used for the management of IPV among PLHIV. 展开更多
关键词 Intimate Partner Violence index Case testing Electronic HIV Patient Information
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Establishment and Test of a Lightning Potential Prediction Index
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作者 Ou Jianfang Qi Haixia Wang Haitao 《Meteorological and Environmental Research》 CAS 2019年第5期51-54,58,共5页
The mesoscale forecasting model WRF is used to simulate two strong convective weather processes accompanied by lightning in Qinghai Province,and the simulated lightning potential index (LPI) and the observed lightning... The mesoscale forecasting model WRF is used to simulate two strong convective weather processes accompanied by lightning in Qinghai Province,and the simulated lightning potential index (LPI) and the observed lightning are compared.Finally,the application of LPI in another lightening case is examined.The results show that the simulated LPI corresponds well to the observed lightning in time.In terms of spatial distribution,the simulated LPI tends to be consistent with the observed lightning density,but there are some minor differences in the locations.Therefore,the LPI can be used to forecast lightning density. 展开更多
关键词 WRF model LIGHTNING FORECAST index Analysis test
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Simulation Analysis on Navigation Indexes of Wanzhou Yangtze River Highway Bridge after the Anti-Collision Device Construction by Ship Model Test
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作者 Kui Yu Chao Tao +1 位作者 Xuequan Chu Xiqin Ma 《Engineering(科研)》 2016年第11期806-814,共9页
After the anti-collision facility construction of Wanzhou Yangtze River Highway Bridge, the conditions of navigation in bridge area are complex. In order to study the navigation conditions of the reach and layout opti... After the anti-collision facility construction of Wanzhou Yangtze River Highway Bridge, the conditions of navigation in bridge area are complex. In order to study the navigation conditions of the reach and layout optimization measures, ensuring the safety of the ship navigation test has been carried out on the ship model navigation in the bridge area. According to the requirements of the maximum safety limit of the ship model test, the paper puts forward the best route, the control method and the difficulty of navigation through the analysis of the test results, and finally gives the recommendations and suggestions. 展开更多
关键词 Wanzhou Yangtze River Highway Bridge Anti-Collision Facility Ship Model test Navigation indexes
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How to Write and Assess M/C Tests Paper Based on the Theory of Item Analysis
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作者 赵梓岑 《科技信息》 2012年第35期I0256-I0256,I0325,共2页
M/C test is always an essential means of testing for language teachers.However,we have every reason to doubt whether a randomly designed M/C test could effectively reflect the testees' language standard.In most la... M/C test is always an essential means of testing for language teachers.However,we have every reason to doubt whether a randomly designed M/C test could effectively reflect the testees' language standard.In most language testing,before the actual writing of a test paper,we should first analyze the items to see whether they're good or qualified enough to be put into the test paper or to be included in the item bank for further use because it is only through item analysis that we can make the test paper more scientific.Based on this theory,there 're some principles we should follow when writing or assessing M/C tests. 展开更多
关键词 英文摘要 编辑工作 学术论文 教学研究
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EV-TEST评价体系中性能指标的确定分析 被引量:2
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作者 陈光 张妍懿 +2 位作者 郝冬 王晓兵 王仁广 《汽车工程师》 2017年第11期14-17,共4页
为了综合评价纯电动汽车的综合性能,中国汽车技术研究中心推出了EV-TEST电动汽车测试评价规程。EV-TEST评价规程根据实际调研结果,从中选择续驶、电耗、充电、安全及动力5个一级性能指标进行综合评价,每个一级性能指标下又细分了二级指... 为了综合评价纯电动汽车的综合性能,中国汽车技术研究中心推出了EV-TEST电动汽车测试评价规程。EV-TEST评价规程根据实际调研结果,从中选择续驶、电耗、充电、安全及动力5个一级性能指标进行综合评价,每个一级性能指标下又细分了二级指标。该文对评价体系中的5个一级性能指标和14个二级指标的确定进行了具体分析,给出采用这些具体指标的原因和依据。通过分析有助于加深对EV-TEST评价体系的理解和应用,促进电动汽车性能提升。 展开更多
关键词 电动车 则试 生能指标 综合评价
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Simulated Sample Behaviour of a Dissimilarity Index When Sampling from Populations Differing by a Location Parameter Only
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作者 Fabio Manca Claudia Marin 《Applied Mathematics》 2014年第15期2199-2208,共10页
In this paper the authors study empirically the power of the test based on the index of dissimilarity to compare two samples drawn from two populations differing only in the location parameter. We call such a test as ... In this paper the authors study empirically the power of the test based on the index of dissimilarity to compare two samples drawn from two populations differing only in the location parameter. We call such a test as test of homogeneity. In practice the power of such a bidirectional test will be studied referring to the absolute value of the shiftδand to the same probability models considered by Fried and Dehling. 展开更多
关键词 DISSIMILARITY index test of HOMOGENEITY Empirical Distribution Simulation Studies
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Dimensional analysis of the impact toughness test for synthetic diamond grits
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作者 杨慧 麦绿波 +4 位作者 卢灿华 仝毅 王志涛 张凤岭 黄风雷 《Journal of Beijing Institute of Technology》 EI CAS 2016年第1期1-6,共6页
The method,in which a few carats of diamond grits are placed inside a capsule together with a steel ball,shaken for a number of times,and the unbroken ratio of the grits is then used to evaluate the quality of the dia... The method,in which a few carats of diamond grits are placed inside a capsule together with a steel ball,shaken for a number of times,and the unbroken ratio of the grits is then used to evaluate the quality of the diamond,has been well established for many years.However,the unbroken percentage,in an equivalent view,represents the impact toughness of the grits and cannot reflect the value of the crushing energy.Most of the previous empirical formulas obtained from experiments by scholars cannot be applied to practical tests.In this paper,a dimensional analysis was applied to investigate the impact toughness experiment,and the dimensionless relationship has been built among those variables such as the toughness index,the impact time,the impact frequency and the crushing energy per unit area.According to the results of a large number of experiments with synthetic diamond grits of mesh size 45/50,the percentage of the broken grits H is proportional to the impact time T^(1.14) when the impact frequency is 2400 r/min,and the impact frequency f^(2.576) when the number of impacts is 2000. 展开更多
关键词 synthetic diamond toughness index dimensional analysis impact toughness test
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不同鸡马立克病疫苗的免疫保护效果比较 被引量:1
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作者 杨慧明 蒲兴 +2 位作者 党海斌 孙璐 张国中 《中国畜牧兽医》 CAS CSCD 北大核心 2024年第3期1267-1276,共10页
【目的】对国内外共7个批次/品种(A~D,F~H)的CVI988或CVI988+HVT商品疫苗进行免疫保护分析,以期了解不同马立克病(MD)疫苗的保护效果,为该病的防控提供参考。【方法】将140只1日龄SPF鸡随机分为9组,G01~G09组,其中G01~G07组(15只/组)分... 【目的】对国内外共7个批次/品种(A~D,F~H)的CVI988或CVI988+HVT商品疫苗进行免疫保护分析,以期了解不同马立克病(MD)疫苗的保护效果,为该病的防控提供参考。【方法】将140只1日龄SPF鸡随机分为9组,G01~G09组,其中G01~G07组(15只/组)分别按推荐剂量免疫A~D及F~H马立克病疫苗,G08(攻毒对照组,15只)和G09(空白对照组,20只)组不免疫,7日龄时G01~G08组分别经腹腔注射马立克病病毒(MDV)超强毒Md5株(1000 PFU/只),所有鸡隔离饲养120 d。通过检测疫苗毒蚀斑数、疫苗毒复制情况、攻毒后体重差异、临床表现和病理变化综合评估各疫苗的保护力。【结果】7个批次疫苗的病毒蚀斑数均符合国家标准(2000 PFU/羽份),疫苗F的病毒蚀斑数最高(6467 PFU/羽份)。以1羽份剂量免疫1日龄SPF鸡后,疫苗F的复制速率相对较快。用Md5株攻毒后,攻毒对照组鸡体重减轻,且有93.3%(14/15)的鸡死亡,100%(15/15)剖检出现MD典型病变;G01~G07各免疫组鸡体重与空白对照组鸡相比,均无显著差异(P>0.05),死亡比例分别为0/14、3/15、5/15、0/14、0/13、0/15和1/15,剖检出现MD典型病理变化的比例为5/14、8/15、7/15、5/14、3/13、3/15和5/15,攻毒保护试验结果显示,7个批次的马立克病疫苗对鸡均具有一定保护力,保护指数为45.7%~73.3%。【结论】不同厂家生产的鸡马立克病疫苗对MDV超强毒Md5株的攻击具有相似的保护效果,二价苗的保护力(73.3%)高于单价疫苗。 展开更多
关键词 马立克病 商品化疫苗 攻毒保护试验 保护指数
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类风湿关节炎中医证候客观化研究
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作者 姬森国 吴頔 +2 位作者 张徐明 刘芳 刘炬 《光明中医》 2024年第11期2109-2112,共4页
目的探究类风湿关节炎(RA)相关指标与中医证型之间的关系。方法选取RA患者300例,根据中医辨证分型的不同将其分为湿热痹阻证、寒湿痹阻证、肾气虚寒证、肝肾阴虚证和瘀血痹阻证5个证型,每个证型60例。分析各个证型患者的临床表现、免疫... 目的探究类风湿关节炎(RA)相关指标与中医证型之间的关系。方法选取RA患者300例,根据中医辨证分型的不同将其分为湿热痹阻证、寒湿痹阻证、肾气虚寒证、肝肾阴虚证和瘀血痹阻证5个证型,每个证型60例。分析各个证型患者的临床表现、免疫学指标、检验学指标与各个证型之间的联系。结果中医证候在关节肿胀、关节疼痛、关节畸形3种临床表现方面,差异有统计学意义(P<0.05);各证型RA患者的类风湿因子(RF)、抗环瓜氨酸多肽(CCP)抗体、红细胞沉降率(ESR)、C反应蛋白(CRP)、血小板计数(PLT)、D-二聚体(DD)等指标之间比较,差异无统计学意义(P>0.05)。结论类风湿关节炎严重程度与各指标无明显相关性;各指标与中医证候无明显相关性。中医治疗各个证型的RA患者主要原则是活血化瘀,并贯穿于整个治疗过程。 展开更多
关键词 痹证 类风湿关节炎 中医证候 免疫学指标 检验学指标
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烟用框架纸应用现状与性能指标分析
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作者 陈宸 杨芳 +7 位作者 李青常 叶长文 濮厚庆 张玮韬 谭明杰 牛佳佳 李栋 葛畅 《中国造纸》 CAS 北大核心 2024年第5期109-115,共7页
烟用框架纸是重要的卷烟包装材料,具有保护卷烟等作用。本文首先介绍了烟用框架纸产品的技术发展和应用情况;然后重点分析了烟用框架纸的主要性能指标,并对行业代表性样品开展了性能指标普查测试研究,评价了烟用框架纸产品的整体质量水... 烟用框架纸是重要的卷烟包装材料,具有保护卷烟等作用。本文首先介绍了烟用框架纸产品的技术发展和应用情况;然后重点分析了烟用框架纸的主要性能指标,并对行业代表性样品开展了性能指标普查测试研究,评价了烟用框架纸产品的整体质量水平;最后展望了烟用框架纸产品的发展方向。 展开更多
关键词 烟用框架纸 产品现状 性能指标 普查测试 发展方向
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Contamination and Ecological Risk Assessment of Heavy Metal in the Sediment of Turag River, Bangladesh: An Index Analysis Approach 被引量:5
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作者 Zoynab Banu Md. Shariful Alam Chowdhury +1 位作者 Md. Delwar Hossain Ken’ichi Nakagami 《Journal of Water Resource and Protection》 2013年第2期239-248,共10页
Encroachment, disposal of untreated domestic and industrial wastewater and dumping of solid wastes have degraded the overall quality of the river Turag, which is located in Dhaka—the Capital City of Bangladesh. The p... Encroachment, disposal of untreated domestic and industrial wastewater and dumping of solid wastes have degraded the overall quality of the river Turag, which is located in Dhaka—the Capital City of Bangladesh. The present study investigated the extent of pollution of sediments of this river and analyzed the regional variability for the concentrations of Cr, Pb, Zn, Cu and Cd—all of concern because of their potential toxicity, using atomic absorption spectrophotometer. As per US EPA sediment quality guideline, metal concentrations ranged between Cd: 0.00 - 0.80, Cr: 32.00 - 75.50, Cu: 46.30 - 60.00, Pb: 28.30 - 36.40, and Zn: 94.60 - 190.10 mg/kg in the Turag river sediments. Cr, Cu, Zn belongs to moderately to highly polluted, Pb and Cd belongs to not polluted for Turag river. The heavy metals contamination in the sediments were also evaluated by applying Index of geo-accumulation (Igeo), contamination factor (Cf), pollution load index (PLI) etc. Toxicity characteristics leaching procedure (TCLP) test (US EPA 1311) for sediment samples have been performed also for metals (Pb, Cd, Cr, Cu and Zn) to determine the readily toxicity level of heavy metals. Sieve analysis of sediment performed in this study to determine the physical characteristic of sediment samples. The metal concentrations are well below the regulated level as per US EPA. This index can be complemented with the contamination index, which allows more site-specific and accurate information on contaminant levels. If the aim of work on contamination evaluation is to assess the overall contamination of a study area, the indices are highly appropriate. 展开更多
关键词 Heavy Metal TCLP test SEDIMENT Geo-Accumulation index Ecological Risk index CONTAMINATION Factor Turag RIVER etc.
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The Empirical Analysis of the Relationship between our Country Steel Price Index and the International Iron ore Freight Rate
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作者 陈佳娜 朱意秋 《海外英语》 2012年第9X期286-288,共3页
The use of econometric methods to analyze the relationship between our country steel price index and the international iron ore freight rate,time series stationarity test,cointegration test,Granger test of causality a... The use of econometric methods to analyze the relationship between our country steel price index and the international iron ore freight rate,time series stationarity test,cointegration test,Granger test of causality and model parameter estimation tools use,find that there is Granger causality between our country steel price index and the international iron ore freight rate,China' s steel price fluctuations to some extent affect the international iron ore freight. 展开更多
关键词 China factors STEEL PRICE index iron ORE FREIGHT r
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6种植物油料油脂的品质及氧化稳定性研究
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作者 王亚萍 姚小华 +4 位作者 曹永庆 常君 任华东 张成才 王开良 《中国油脂》 CAS CSCD 北大核心 2024年第9期50-58,65,共10页
为拓宽我国植物油料的开发利用途径,测定了薄壳山核桃、油茶、香榧、核桃、花生、油菜等6种植物种子的含油率及其油脂的总酚、生育酚含量和脂肪酸组成,并采用加速氧化试验对其油脂的氧化稳定性进行评价,探究了各项品质指标与氧化稳定性... 为拓宽我国植物油料的开发利用途径,测定了薄壳山核桃、油茶、香榧、核桃、花生、油菜等6种植物种子的含油率及其油脂的总酚、生育酚含量和脂肪酸组成,并采用加速氧化试验对其油脂的氧化稳定性进行评价,探究了各项品质指标与氧化稳定性指标的相关性。结果表明:薄壳山核桃仁的含油率最高(73.07%),且其油脂的总酚含量最高(12.6 mg/kg),香榧籽油的生育酚总量最高(114.90 mg/100 g);6种植物油中有5种共同脂肪酸,分别为棕榈酸、硬脂酸、油酸、亚油酸和花生烯酸;6种植物油中,薄壳山核桃油的氧化稳定性最强,其酸值、过氧化值、共轭二烯值、共轭三烯值、羰基值的变化幅度均较小,氧化诱导时间(OSI值)处于最高水平,核桃油的变化幅度较大;加速氧化过程中6种植物油的油酸、亚油酸、不饱和脂肪酸、饱和脂肪酸含量均无明显变化;油脂的OSI值与油酸、生育酚、总酚含量呈显著正相关,与亚油酸、亚麻酸含量呈显著负相关。综上,薄壳山核桃含油率高,薄壳山核桃油含有较高的总酚含量和较好的氧化稳定性,是一种优质的食用油,可作为营养保健油开发利用。 展开更多
关键词 木本植物油 品质指标 加速氧化试验 氧化稳定性 相关性分析
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Information content method for evaluating diagnostic tests and its comparison of power with other methods 被引量:1
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作者 陈平雁 王斌会 莫一心 《Journal of Medical Colleges of PLA(China)》 CAS 1996年第2期106-113,共8页
This paper derives the variance of the information content and develops its statistical inference method. We describe the relations between information content and sensitivity, specificity, efficiency, prevalence rate... This paper derives the variance of the information content and develops its statistical inference method. We describe the relations between information content and sensitivity, specificity, efficiency, prevalence rate. If sensitivity, specificity and efficiency are fixed, the closer to 0. 5 the prevalence rate is, the more the information content. If prevalence rate and efficiency are fixed, the closer to each other the sensitivity and specificity are, the more the information content. We compare the power of information content method, efficiecy test, Youden's index test and kappa coefficient method. The information content method has higher power than the other methods in most conditions. It is especially sensitive to the difference between two sensitivities. It comes to conclusion that the information content method has more virtues than the other methods mentioned in this paper. 展开更多
关键词 DIAGNOSTIC test INFORMATION CONTENT POWER KAPPA COEFFICIENT Youden’s index
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Body mass index is not associated with sperm-zona pellucida binding ability in subfertile males 被引量:4
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作者 Nathalie Sermondade Charlotte Dupont +5 位作者 Celine Faure Marouane Boubaya Isabelle Cedrin-Durnerin Pascale Chavatte-Palmer Christophe Sifer Rachel Levy 《Asian Journal of Andrology》 SCIE CAS CSCD 2013年第5期626-629,共4页
Lifestyle factors, such as weight and nutritional status may affect male fertility, including sperm fertilization ability. The objective of this retrospective study was to evaluate the association between body mass in... Lifestyle factors, such as weight and nutritional status may affect male fertility, including sperm fertilization ability. The objective of this retrospective study was to evaluate the association between body mass index (BMI) and sperm-zona pellucida binding ability assessed according to the zona binding (ZB) test, which has been described to be a relevant diagnostic tool for the prediction of in vitro fertilization (IVF) ability. Three hundred and six male patients from couples diagnosed with primary idiopathic or mild male factor infertility were included. Correlations between BMI and semen parameters according to ZB test indices were assessed, together with frequencies of positive and negative tests across the BMI categories. In this selected population, BMI was not related to conventional semen parameters or sperm quality assessed according to the ability of spermatozoa to bind to the zona pellucida. The previously described poor outcomes of IVF procedures in cases of male obesity could be due to other sperm defects, such as alterations of sperm capacitation or acrosome reaction. The link between male BMI and biological outcomes during IVF procedures, such as fertilization rates, should be further evaluated. 展开更多
关键词 body mass index (BMI) fertilization ability OBESITY semen quality zona binding test
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Effects of Moisture Content and Plasticity Index on Duncan-Chang Model Parameters of Hydraulic Fill Soft Soil
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作者 Erzhong Chen Meng Yan +2 位作者 Jihui Ding Cen Gao Yu Gan 《World Journal of Engineering and Technology》 2019年第3期408-417,共10页
In order to explore the effects of moisture content and plasticity index on Duncan-Chang model parameters?K,n,?C?and?Rf,?we selected 8 groups of soft soil with water content of 69.1%?-?94.3% and plasticity index of 32... In order to explore the effects of moisture content and plasticity index on Duncan-Chang model parameters?K,n,?C?and?Rf,?we selected 8 groups of soft soil with water content of 69.1%?-?94.3% and plasticity index of 32.2?-?54.1 for triaxial unconsolidated undrained shear test. The results show that?Cuu,?K?and?n?values all showed a downward trend, and?Rf?variation was not obvious with the increase of moisture content. The variation rule of each parameter is not obvious with the increase of plasticity index. When moisture content is constant,?Cuu?and?n?values do not change much,?K?increases with the increase of plasticity index within the range of 70%?-?80% moisture content, and does not change much with the increase of plasticity index when moisture content is greater than 80%,?Rf?has no obvious rule.?When the plasticity index is constant,?Cuu,?Kand?n?decrease with the increase of moisture content,?Rf?has no obvious rule. The maximum value of?Cuu?is 20.18?kPa, the minimum is 3.72?kPa, and the maximum to minimum ratio is 5.42. The maximum value of?K?is 0.517, the minimum is 0.022, and the maximum to minimum ratio is 23.5. The maximum value of?n?is 1.198, the minimum is 0.150, and the maximum to minimum ratio is 7.99. The maximum value of?Rf?is 0.872, the minimum is 0.679, and the maximum to minimum ratio is 1.28. 展开更多
关键词 MOISTURE CONTENT PLASTICITY index DUNCAN-CHANG Model Unconsolidated UNDRAINED test
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Assessment of cerebrovascular reserve impairment using the breath-holding index in patients with leukoaraiosis 被引量:5
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作者 Ying Bian Jin-Chun Wang +6 位作者 Feng Sun Zi-Yi Sun Yu-Jiao Lin Yang Liu Bin Zhao Li Liu Xiao-Guang Luo 《Neural Regeneration Research》 SCIE CAS CSCD 2019年第8期1412-1418,共7页
Many studies have demonstrated that leukoaraiosis is associated with impaired cerebrovascular reserve function. However, the definitive hemodynamic changes that occur in leukoaraiosis are not clear, and there are many... Many studies have demonstrated that leukoaraiosis is associated with impaired cerebrovascular reserve function. However, the definitive hemodynamic changes that occur in leukoaraiosis are not clear, and there are many controversies. This study aimed to investigate hemodynamic changes in symptomatic leukoaraiosis using transcranial Doppler ultrasonography and the breath-holding test in a Chinese Han population, from northern China. A total of 203 patients who were diagnosed with ischemic stroke or clinical chronic progressive ischemic symptoms were enrolled in this study, including 97 males and 106 females, with an age range of 43-93 years. The severity of leukoaraiosis was evaluated according to the Fazekas grading scale, and patients were divided into four groups accordingly. Grade 0 was no leukoaraiosis, and grades I, II, and III were mild, moderate, and severe leukoaraiosis, respectively, with 44, 79, 44, and 36 cases in each group. Transcranial Doppler ultrasonography and the breath-holding test were performed. The mean blood flow velocity of the bilateral middle cerebral artery was measured and the breath-holding index was calculated. The breath holding index was correlated with leukoaraiosis severity and cognitive impairment. Patients with a low breath holding index presented poor performance in the Montreal Cognitive Assessment (MoCA) and executive function tests. That is, the lower the breath holding index, the lower the scores for the MoCA and the higher for the trail-making test Parts A and B. These results indicate that the breath-holding index is a useful parameter for the evaluation of cerebrovascular reserve impairment in patients with leukoaraiosis. In addition, the breath-holding index can reflect cognitive dysfunction, providing a new insight into the pathophysiology of leukoaraiosis. This study was approved by the Ethics Committee of the Fifth Peoples Hospital of Shenyang, China (approval No. 20160301) and registered in the Chinese Clinical Trial Registry (registration number: ChiCTR1800014421). 展开更多
关键词 nerve REGENERATION CEREBRAL small vascular disease white matter HYPERINTENSITIES CEREBRAL hemodynamics CEREBRAL hypoperfusion middle CEREBRAL artery blood flow velocity breath-holding test breath-holding index cognitive function neural REGENERATION
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静脉注射头孢菌素类药物患者过敏反应发生率及其影响因素的多中心临床研究
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作者 阳平 戴单单 +7 位作者 李晴宇 詹海潮 李旭梅 芦小燕 何敏 陈娜 姜赛平 卢晓阳 《浙江大学学报(医学版)》 CAS CSCD 北大核心 2024年第5期615-622,共8页
目的:分析头孢菌素类药物过敏反应的发生率及其影响因素。方法:横断面调研2021年4月1日至6月30日浙江省29家医疗机构所有接受静脉注射头孢菌素类药物的患者,统计头孢菌素类药物过敏反应的发生率,采用泊松回归模型分析头孢菌素类药物诱... 目的:分析头孢菌素类药物过敏反应的发生率及其影响因素。方法:横断面调研2021年4月1日至6月30日浙江省29家医疗机构所有接受静脉注射头孢菌素类药物的患者,统计头孢菌素类药物过敏反应的发生率,采用泊松回归模型分析头孢菌素类药物诱导过敏反应发生的相关影响因素。结果:研究共纳入56155例患者,头孢菌素类药物过敏反应总发生率为1.67‰,过敏反应发生率最高的是头孢唑肟(4.27‰),其次是头孢曲松(3.49‰)和头孢噻肟(2.40‰)。与皮试阴性组比较,非皮试组患者过敏反应发生率无明显增加(分别为1.75‰与1.63‰,RR=1.07,95%CI:0.70~1.63,P>0.05)。泊松回归分析结果显示,体重指数低于18.5 kg/m^(2)(RR=2.43,95%CI:1.23~4.82,P<0.05)、其他β-内酰胺类药物过敏史(RR=33.88,95%CI:1.47~781.12,P<0.05)会增加头孢菌素类药物过敏反应的发生率,且与头孢呋辛比较,头孢曲松(RR=3.08,95%CI:1.70~5.59,P<0.01)、头孢他啶(RR=1.89,95%CI:1.03~3.47,P<0.05)和头孢唑肟(RR=3.74,95%CI:1.64~8.50,P<0.01)过敏反应发生的风险增加。结论:头孢菌素类药物过敏反应与低体重指数和β-内酰胺类药物过敏史有关,头孢菌素类药物的常规皮试筛查并不能减少过敏反应发生。 展开更多
关键词 头孢菌素 皮试 过敏反应 体重指数 Β-内酰胺类药物
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大鼠脓毒症肺损伤与中性粒细胞载脂蛋白的相关性研究
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作者 郑军 祝木建 +3 位作者 李江东 余涵聪 施明栋 李林 《中国感染控制杂志》 CAS CSCD 北大核心 2024年第11期1344-1349,共6页
目的探究大鼠脓毒症肺损伤与中性粒细胞载脂蛋白(HNL)的相关性。方法45只大鼠按照随机方法分为对照组、sham组及模型组,模型组建立脓毒症肺损伤大鼠模型,sham组开腹后仅游离盲肠后关腹,不进行结扎和穿刺,对照组为健康大鼠。使用试剂盒... 目的探究大鼠脓毒症肺损伤与中性粒细胞载脂蛋白(HNL)的相关性。方法45只大鼠按照随机方法分为对照组、sham组及模型组,模型组建立脓毒症肺损伤大鼠模型,sham组开腹后仅游离盲肠后关腹,不进行结扎和穿刺,对照组为健康大鼠。使用试剂盒检测各组大鼠血清白细胞介素(IL)-6、IL-1β、肿瘤坏死因子-α(TNF-α)及HNL;血气分析仪检测氧合指数;计算肺组织湿/干比;HE染色观察肺组织病理形态,计算肺损伤评分。结果对照组及sham组12、24、36 h的IL-6、IL-1β、TNF-α、HNL水平、氧合指数、肺组织湿/干比、肺损伤评分比较,差异均无统计学意义(均P>0.05);与sham组相比,模型组12、24、36 h的IL-6、IL-1β、TNF-α、HNL水平、氧合指数、肺组织湿/干比、肺损伤评分均升高,差异均有统计学意义(均P<0.05)。对照组大鼠12、24、36 h肺组织结构正常,且未见水肿,sham组大鼠12、24、36 h肺组织仅有少量炎症细胞,模型组大鼠12、24、36 h肺组织结构严重破坏,肺泡萎陷,炎症细胞严重浸润,但随着时间延长病理改善。脓毒症肺损伤大鼠中,HNL与IL-6、IL-1β、TNF-α、肺部湿/干比、肺损伤评分呈现正相关性(均P<0.05),与氧合指数呈现负相关性(P<0.05)。结论脓毒症肺损伤大鼠中HNL显著升高,炎症反应严重,肺组织湿/干比、肺损伤加重,氧合指数降低,且HNL水平与IL-6、IL-1β、TNF-α水平、肺组织湿/干比、肺损伤呈正相关性,与氧合指数呈负相关性。 展开更多
关键词 脓毒症 肺损伤 中性粒细胞载脂蛋白 炎症因子 氧合指数 病理形态 动物试验 大鼠
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