Evidence for benefits of anti-oxidative power of polyphenols in cardiovascular diseases has been established. In the present study, effect of polyphenol rich green tea on selected metabolic biomarkers among Asian Indi...Evidence for benefits of anti-oxidative power of polyphenols in cardiovascular diseases has been established. In the present study, effect of polyphenol rich green tea on selected metabolic biomarkers among Asian Indian women with metabolic syndrome in normal free living condition has been recorded. Thirty three Asian Indian women (>30 y) confirmed as having metabolic syndrome, were enrolled for the present study based on written informed consent. Subjects were asked to consume three cups of green tea daily for a period of four months. Regular telephonic contact and periodic visit to supply the tea were made to ensure compliance with the intervention and maintenance of lifestyle and dietary pattern, as followed before the experimental period. Parameters analyzed at baseline have been used as control data to eliminate individual variation. Double-blind analysis of selected metabolic markers was done at baseline, 2 months and 4 months of the intervention period. At four months, a significant reduction from baseline was observed in weight (2%), waist circumference (4.5%), blood sugar (4%), glycosylated hemoglobin (4%), total cholesterol (11%) and LDL cholesterol (13%) (p < 0.01). The effect of green tea consumption on BMI, fasting insulin, HDL cholesterol, triglyceride, VLDL, C-reactive protein and homocysteine levels was either inconsistent or non significant. The present study showed that green tea consumption by free living subjects with metabolic syndrome resulted in significant improvements in some of the cardiovascular risk factors including visceral fat, blood sugar and cholesterol level.展开更多
杨君是一位女大学生。她在给我们发来的此文时表示了她的“不平”:印度女同胞们似乎“太软弱,太不可理解”!同时,她也承认,这也许应该从性文化,或婚姻文化的视角去观察,去理解。杨君非常幽默地写道,希望此文不要成了男同胞们wife-beatin...杨君是一位女大学生。她在给我们发来的此文时表示了她的“不平”:印度女同胞们似乎“太软弱,太不可理解”!同时,她也承认,这也许应该从性文化,或婚姻文化的视角去观察,去理解。杨君非常幽默地写道,希望此文不要成了男同胞们wife-beating的一个藉口:你看,人家印度妇女! 印度妇女中有相当一部分竟然认为以下五点理由为wife-beating之可接受理由: 1/neglecting the house or children 2/going out without informing their husbands 3/showing disrespect to in-laws 4/suspicion of infidelity 5/inadequate dowry(嫁妆)6/improper cooking 读者朋友,你感到吃惊吗?】展开更多
With the increase in longevity and demographic shift, menopause is emerging as one of the major health issues affecting middle aged women in developing countries. In this study our aim was to define & develop usef...With the increase in longevity and demographic shift, menopause is emerging as one of the major health issues affecting middle aged women in developing countries. In this study our aim was to define & develop useful predictive indicators to assess menopausal health status in women with diverse socio-economic & cultural backgrounds. The model was developed using the data drawn from known published works as well as our own epidemiological & clinical case records. A linear equation was derived and expected results were obtained and analysed. The outcome was measured in terms of menopausal health & wellbeing index. Wide cultural diversity, unequal socio-economic status and gender inequality are some of the sensitive multi factorial determinants that influence the menopausal health. Education and availability of optimal quality health care facilities positively influenced level of awareness and improved the health seeking behavior & health literacy. The menopausal health & wellbeing index can be used as a predictive tool to develop interventional management modalities to improve quality of life.展开更多
CHEK2 (Checkpoint kinase homolog 2) encodes a protein involved in pathways that arrest the cell cycle in response to genomic stress such as DNA damage or replication blocks. Carriers of some of the CHEK2 mutations are...CHEK2 (Checkpoint kinase homolog 2) encodes a protein involved in pathways that arrest the cell cycle in response to genomic stress such as DNA damage or replication blocks. Carriers of some of the CHEK2 mutations are at an increased risk of breast cancer. A mutation in the kinase domain of the CHEK2 gene resulting in the R406H substitution has been reported. However, it is currently unknown whether the substitution alters the function of CHEK2 in vitro. We evaluated the effect of the R406H substitution on the normal function of CHEK2 using a yeast complementation assay. The yeast cells lacking Rad53, the yeast homologue of human CHEK2 were transformed with the wild type as well as plasmids carrying mutations resulting in the R406H, 1100delC, and S428F variants. Yeast cells carrying the R406H variant grew at a rate similar to those carrying the wild type CHEK2, whereas the yeast carrying the S428F and 1100delC mutants grew at a slower rate. These results suggest that, unlike the well-known pathogenic alleles such as 1100delC and S428F, the R406H substitution does not abrogate the function of CHEK2. Therefore, this variant is probably not important in development of breast cancer in women.展开更多
文摘Evidence for benefits of anti-oxidative power of polyphenols in cardiovascular diseases has been established. In the present study, effect of polyphenol rich green tea on selected metabolic biomarkers among Asian Indian women with metabolic syndrome in normal free living condition has been recorded. Thirty three Asian Indian women (>30 y) confirmed as having metabolic syndrome, were enrolled for the present study based on written informed consent. Subjects were asked to consume three cups of green tea daily for a period of four months. Regular telephonic contact and periodic visit to supply the tea were made to ensure compliance with the intervention and maintenance of lifestyle and dietary pattern, as followed before the experimental period. Parameters analyzed at baseline have been used as control data to eliminate individual variation. Double-blind analysis of selected metabolic markers was done at baseline, 2 months and 4 months of the intervention period. At four months, a significant reduction from baseline was observed in weight (2%), waist circumference (4.5%), blood sugar (4%), glycosylated hemoglobin (4%), total cholesterol (11%) and LDL cholesterol (13%) (p < 0.01). The effect of green tea consumption on BMI, fasting insulin, HDL cholesterol, triglyceride, VLDL, C-reactive protein and homocysteine levels was either inconsistent or non significant. The present study showed that green tea consumption by free living subjects with metabolic syndrome resulted in significant improvements in some of the cardiovascular risk factors including visceral fat, blood sugar and cholesterol level.
文摘杨君是一位女大学生。她在给我们发来的此文时表示了她的“不平”:印度女同胞们似乎“太软弱,太不可理解”!同时,她也承认,这也许应该从性文化,或婚姻文化的视角去观察,去理解。杨君非常幽默地写道,希望此文不要成了男同胞们wife-beating的一个藉口:你看,人家印度妇女! 印度妇女中有相当一部分竟然认为以下五点理由为wife-beating之可接受理由: 1/neglecting the house or children 2/going out without informing their husbands 3/showing disrespect to in-laws 4/suspicion of infidelity 5/inadequate dowry(嫁妆)6/improper cooking 读者朋友,你感到吃惊吗?】
文摘With the increase in longevity and demographic shift, menopause is emerging as one of the major health issues affecting middle aged women in developing countries. In this study our aim was to define & develop useful predictive indicators to assess menopausal health status in women with diverse socio-economic & cultural backgrounds. The model was developed using the data drawn from known published works as well as our own epidemiological & clinical case records. A linear equation was derived and expected results were obtained and analysed. The outcome was measured in terms of menopausal health & wellbeing index. Wide cultural diversity, unequal socio-economic status and gender inequality are some of the sensitive multi factorial determinants that influence the menopausal health. Education and availability of optimal quality health care facilities positively influenced level of awareness and improved the health seeking behavior & health literacy. The menopausal health & wellbeing index can be used as a predictive tool to develop interventional management modalities to improve quality of life.
文摘CHEK2 (Checkpoint kinase homolog 2) encodes a protein involved in pathways that arrest the cell cycle in response to genomic stress such as DNA damage or replication blocks. Carriers of some of the CHEK2 mutations are at an increased risk of breast cancer. A mutation in the kinase domain of the CHEK2 gene resulting in the R406H substitution has been reported. However, it is currently unknown whether the substitution alters the function of CHEK2 in vitro. We evaluated the effect of the R406H substitution on the normal function of CHEK2 using a yeast complementation assay. The yeast cells lacking Rad53, the yeast homologue of human CHEK2 were transformed with the wild type as well as plasmids carrying mutations resulting in the R406H, 1100delC, and S428F variants. Yeast cells carrying the R406H variant grew at a rate similar to those carrying the wild type CHEK2, whereas the yeast carrying the S428F and 1100delC mutants grew at a slower rate. These results suggest that, unlike the well-known pathogenic alleles such as 1100delC and S428F, the R406H substitution does not abrogate the function of CHEK2. Therefore, this variant is probably not important in development of breast cancer in women.
