Objective To determine the prevalence and determinants of folic acid(FA)supplementation in Chinese couples planning for pregnancy and in women during early pregnancy.Methods This was a cross-sectional study based on t...Objective To determine the prevalence and determinants of folic acid(FA)supplementation in Chinese couples planning for pregnancy and in women during early pregnancy.Methods This was a cross-sectional study based on the Shanghai PreConception Cohort(SPCC)study.Data on FA supplementation and socio-demographic features were collected using questionnaires.Couples visiting clinics for pre-pregnancy examination and pregnant women at<14 gestational weeks were recruited in Shanghai,China,between March 2016 and September 2018.Results Among the pregnancy planners,42.4%(4,710/11,099)women and 17.1%(1,377/8,045)men used FA supplements,while 93.4%(14,585/15,615)of the pregnant women used FA supplements.FA supplement use was higher in female pregnancy planners who were older(RR:1.13,95%CI:1.08–1.18),had higher education(RR:1.71,95%CI:1.53–1.92),and were residing in urban districts(RR:1.06,95%CI:1.01–1.11)of FA supplementation;female pregnancy planners with alcohol consumption(RR:0.95,95%CI:0.90–0.99)had lower odds of FA supplementation.In early pregnancy,women with higher educational level(RR:1.04,95%CI:1.03–1.06),who underwent pre-pregnancy examination(RR:1.02,95%CI:1.01–1.03)had higher odds of using an FA supplement;older aged(RR:0.99,95%CI:0.98–0.99),and multigravida(RR:0.97,95%CI:0.96–0.98)had lower odds of FA supplementation.Conclusion Although the majority of pregnant women took FA supplements,more than half of the women planning for pregnancy did not.Urgent strategies are needed to improve pre-conception FA supplementation.展开更多
目的了解陕西省千阳县围孕期妇女叶酸增补情况及叶酸增补的影响因素，为有效开展增补叶酸的工作提供依据。方法采用定量和定性研究结合的方法，对千阳县近3年分娩的948名妇女进行问卷调查；对就诊于县级医院的孕产妇和2岁以内儿童的母...目的了解陕西省千阳县围孕期妇女叶酸增补情况及叶酸增补的影响因素，为有效开展增补叶酸的工作提供依据。方法采用定量和定性研究结合的方法，对千阳县近3年分娩的948名妇女进行问卷调查；对就诊于县级医院的孕产妇和2岁以内儿童的母亲进行了个人访谈。结果①农村妇女孕期的叶酸增补率为38．2％，8．5％的妇女从孕前3个月开始增补叶酸；②多元Logistics回归结果显示，妇女教育水平高中及以上vs小学及以下（OR=2．11，P=0．004）、产检次数≥5次 vs 〈5次（OR=1．51，P=0．011）、早孕期进行首次产检vs中晚孕期进行首次产检（OR=1．62，P=0．020）等因素与叶酸增补有关；③不增补叶酸的原因包括“没有人宣传过要吃叶酸”占62％、“认为叶酸是药，害怕有副作用”占47％、“觉得不需要吃叶酸”占2l％等。结论千阳县妇女的叶酸增补率较低，产前检查利用与叶酸增补有关。建议充分结合产前检查及婚前检查服务，多部门合作提高人群叶酸增补率。展开更多
目的:本文旨在系统评价孕前和孕早期补充叶酸对双胎妊娠的作用。方法:系统收集1966-2012年来自PubMed/Medline、EMBASE、OVID、Cochrane Central Register of Clinical Trials、Google Scholarism、CNKI、维普、万方数据库关于孕前和孕...目的:本文旨在系统评价孕前和孕早期补充叶酸对双胎妊娠的作用。方法:系统收集1966-2012年来自PubMed/Medline、EMBASE、OVID、Cochrane Central Register of Clinical Trials、Google Scholarism、CNKI、维普、万方数据库关于孕前和孕早期补充叶酸的相关文献,并根据预先制定的纳入与排除标准筛选文献,严格评价纳入文献质量,提取数据,RevMan 5.2.1软件进行Meta分析。结果:纳入3篇随机对照试验,Meta分析结果示孕前和孕早期补充叶酸与未补充相比双胎妊娠率(RR=1.40,95%CI=0.93～2.11),双卵双生率(RR=1.27,95%CI=0.61～2.67)与单卵双生率(RR=0.91,95%CI=0.68～1.21)的差异均无统计学意义。结论:孕前和孕早期补充叶酸与未补充相比,没有提高双胎妊娠率。展开更多
基金Supported by a grant from the National Key Research and Development Program[2016YFC1000506]the Shanghai Public Health Three-year Action Plan[2015-82]+1 种基金the National Natural Science Foundation[81370198,81570283]CAMS Innovation Fund for Medical Sciences[2019-I2M-5-001].
文摘Objective To determine the prevalence and determinants of folic acid(FA)supplementation in Chinese couples planning for pregnancy and in women during early pregnancy.Methods This was a cross-sectional study based on the Shanghai PreConception Cohort(SPCC)study.Data on FA supplementation and socio-demographic features were collected using questionnaires.Couples visiting clinics for pre-pregnancy examination and pregnant women at<14 gestational weeks were recruited in Shanghai,China,between March 2016 and September 2018.Results Among the pregnancy planners,42.4%(4,710/11,099)women and 17.1%(1,377/8,045)men used FA supplements,while 93.4%(14,585/15,615)of the pregnant women used FA supplements.FA supplement use was higher in female pregnancy planners who were older(RR:1.13,95%CI:1.08–1.18),had higher education(RR:1.71,95%CI:1.53–1.92),and were residing in urban districts(RR:1.06,95%CI:1.01–1.11)of FA supplementation;female pregnancy planners with alcohol consumption(RR:0.95,95%CI:0.90–0.99)had lower odds of FA supplementation.In early pregnancy,women with higher educational level(RR:1.04,95%CI:1.03–1.06),who underwent pre-pregnancy examination(RR:1.02,95%CI:1.01–1.03)had higher odds of using an FA supplement;older aged(RR:0.99,95%CI:0.98–0.99),and multigravida(RR:0.97,95%CI:0.96–0.98)had lower odds of FA supplementation.Conclusion Although the majority of pregnant women took FA supplements,more than half of the women planning for pregnancy did not.Urgent strategies are needed to improve pre-conception FA supplementation.
文摘目的了解陕西省千阳县围孕期妇女叶酸增补情况及叶酸增补的影响因素，为有效开展增补叶酸的工作提供依据。方法采用定量和定性研究结合的方法，对千阳县近3年分娩的948名妇女进行问卷调查；对就诊于县级医院的孕产妇和2岁以内儿童的母亲进行了个人访谈。结果①农村妇女孕期的叶酸增补率为38．2％，8．5％的妇女从孕前3个月开始增补叶酸；②多元Logistics回归结果显示，妇女教育水平高中及以上vs小学及以下（OR=2．11，P=0．004）、产检次数≥5次 vs 〈5次（OR=1．51，P=0．011）、早孕期进行首次产检vs中晚孕期进行首次产检（OR=1．62，P=0．020）等因素与叶酸增补有关；③不增补叶酸的原因包括“没有人宣传过要吃叶酸”占62％、“认为叶酸是药，害怕有副作用”占47％、“觉得不需要吃叶酸”占2l％等。结论千阳县妇女的叶酸增补率较低，产前检查利用与叶酸增补有关。建议充分结合产前检查及婚前检查服务，多部门合作提高人群叶酸增补率。
文摘目的:本文旨在系统评价孕前和孕早期补充叶酸对双胎妊娠的作用。方法:系统收集1966-2012年来自PubMed/Medline、EMBASE、OVID、Cochrane Central Register of Clinical Trials、Google Scholarism、CNKI、维普、万方数据库关于孕前和孕早期补充叶酸的相关文献,并根据预先制定的纳入与排除标准筛选文献,严格评价纳入文献质量,提取数据,RevMan 5.2.1软件进行Meta分析。结果:纳入3篇随机对照试验,Meta分析结果示孕前和孕早期补充叶酸与未补充相比双胎妊娠率(RR=1.40,95%CI=0.93～2.11),双卵双生率(RR=1.27,95%CI=0.61～2.67)与单卵双生率(RR=0.91,95%CI=0.68～1.21)的差异均无统计学意义。结论:孕前和孕早期补充叶酸与未补充相比,没有提高双胎妊娠率。
