Optimal Structural Parameters for a Plastic Centrifugal Pump Inducer

The aim of the study is to determine the optimal structural parameters for a plastic centrifugal pump inducer within the framework of an orthogonal experimental method.For this purpose,a numerical study of the related flow field is performed using CFX.The shaft power and the head of the pump are taken as the evaluation indicators.Accordingly,the examined variables are the thickness(S),the blade cascade degree(t),the blade rim angle(β1),the blade hub angle(β2)and the hub length(L).The impact of each structural parameter on each evaluation index is examined and special attention is paid to the following combinations:S2 mm,t 2,β1235°,β2360°and L 140 mm(corresponding to a maximum head of 98.15 m);S 5 mm,t 1.6,β1252°,β2350°and L 140 mm(corresponding to a minimum shaft power of 63.06 KW).Moreover,using least squares and fish swarm algorithms,the pump shaft power and head are further optimized,yielding the following optimal combination:S 5 mm,t 1.9,β1252°,β2360°and L 145 mm(corresponding to the maximum head of 91.90 m,and a minimum shaft power of 64.83 KW).

Pharmacologic inducers of the uric acid exporter ABCG2 as potential drugs for treatment of gouty arthritis

Uric acid is the end product of purine catabolism and its plasma levels are maintained below its maximum solubility in water(6–7 mg/dl).The plasma levels are tightly regulated as the balance between the rate of production and the rate of excretion,the latter occurring in urine(kidney),bile(liver)and feces(intestinal tract).Reabsorption in kidney is also an important component of this process.Both excretion and reabsorption are mediated by specific transporters.Disruption of the balance between production and excretion leads to hyperuricemia,which increases the risk of uric acid crystallization as monosodium urate with subsequent deposition of the crystals in joints causing gouty arthritis.Loss-of-function mutations in the transporters that mediate uric acid excretion are associated with gout.The ATP-Binding Cassette exporter ABCG2 is important in uric acid excretion at all three sites:kidney(urine),liver(bile),and intestine(feces).Mutations in this transporter cause gout and these mutations occur at significant prevalence in general population.However,mutations that are most prevalent result only in partial loss of transport function.Therefore,if the expression of these partially defective transporters could be induced,the increased number of the transporter molecules would compensate for the mutation-associated decrease in transport function and hence increase uric acid excretion.As such,pharmacologic agents with ability to induce the expression of ABCG2 represent potentially a novel class of drugs for treatment of gouty arthritis.

An Experiment on Cavitating Flow in Rocket Engine Inducer

An experiment for rocket engine inducer cavitating flow is conducted on a new experimental platform.The experiment platform,using water as working medium,can be used to investigate the steady and unsteady flows of cavitating and noncavitating turbopumps.The experimental platform is designed as a flexible and versatile apparatus for any kind of fluid dynamic phenomena relating to high performance liquid rocket engine turbopumps.Design details for the platform is introduced.Various extend of cavitation images and dynamic pressure impulse are obtained,which provides a reference for cavitating flow study in rocket engine inducer.

Screening of Epstein-Barr Virus Early Antigen Expression Inducers from Chinese Medicinal Herbs and Plants

Ether extrilcls of 1693 Chinesc medicinal herbs and plilnts from 268 families werestudied for the induction of Epstcin-Barr viral (EBV ) early antigcn (EA ) expression in theRaji cell line. Fifty-two from 18 families were found to have inducing activity. Twenty-fiveand seven of them were from Euphorbiaccae and Thymclaeaceae, respectively. Some ofthem, such as Croton tiglium, Euphorbia kansui, Daphnc genkwa, Wikstrocmia chamacdaphen, Wikstroemia indica, Prunus mandshurica Koehne and Achyranthes bidentata arecommonly used drugs. The significance of these herbs in the activation of EBV in vivo andtheir relation to the development of nasopharyngeal carcinoma were discussed.

Mammalian target of rapamycin complex 1 as an inducer of neurotrophic factors in dopaminergic neurons

The defining neuropathological feature of Parkinson＇s disease （PD） is the loss of nigrostriatal dopaminergic （DA） projections. This results in striatal dopamine levels and a biochemical reduction of movement disorders, such as a tremor at rest, rigidity of the limbs, bradykinesia, and postural instability （Kim et al., 2011; Kim et al., 2012; Burke and O＇Malley, 2013; Leem et al., 2014; Namet al., 2014）.

Expression of Endothelial Nitric Oxide Synthase Traffic Inducer in the Placenta of Pregnancy Induced Hypertension

The expression of endothelial nitric oxide synthase traffic inducer （NOSTRIN） in the placenta of the patients with pregnancy induced hypertension （PIH） was detected and its role in the pathogenesis of PIH was studied. The pathological changes in placental vessels were observed by HE staining. NO2-/NO3- , the stable metabolic end products of NO, was measured with nitrate reductase. The eNOS activity in placental tissues was assayed by spectrophotometry. Western blot analysis was applied to detect NOSTRIN expression. The incidence of thickening and fibronoid necrosis of placental vessels was significantly higher in women with PIH than in the normal group （P〈 0.01）. The levels of placental NO2-/NO3- in PIH patients （27. 53±7.48 μmol/mg） were significantly lower than in normal group （54. 27±9.53 μmol/mg, P〈0.01）. The activity of eNOS was significantly decreased in PIH group （12. 826±3.61 U/mg） as compared with that in normal group （21. 72±3.83 U/mg, P〈0.01）. Western blot analysis revealed that both groups expressed 58 kD NOSTRIN, but the protein level was significantly higher in women with PIH than in the normal group （P〈0.01）. A significant negative correlation existed between the expression of NOSTRIN protein and the activity of eNOS in placental tissue of women with PIH （r=-0.57, P〈0.01）. It was concluded that the level of NOSTRIN expression in placenta of women with PIH was increased, which may play an important role in the pathogenesis of PIH.

Combined therapeutic effects of cytotoxic agent and differentiation-inducer on human gastric carcinoma cell line SGC-7901

Objective:To study the combined therapeutic effects of cytotoxic agent and differentiation-inducer on human gas tric carcinoma celll line SGC-7901 in vitro. Methods: The combined therapeutic effects of all-trans retinoic acid (ATRA), interferon a (IFNa)and fluorouracil (5-Fu) on gastric carcinoma cell line ax 7901 were observed when one of the 3, the combination of any 2 of the 3 and combination of all the 3 were administered respectively. The morphological and functional changes of gastric carcinoma cells were studied with MTT assay, flow cytometry, image analysis and determination of CEA content in the culture medium of the cells. Results: The cytostatic rate was increased as shown by the decrease of the rate of colony formation of the cells on culture disc when one agent, the combination of 2 agents and the combination of the 3 were administered progressively. The cells were relatively accumulated in the phase of G0/G1 and synthesis of DNA in he cells was inhibited.The malignant phenotype of the cells disappeared gradually while the characteristics of matUre cells were in creased. Meanwhile, CEA Level in the culture medium was decreased progressively. Apoptosis of the cells was oborved and a large amount of apoptotic apoptotic were found. Conclusion: The administration of the 3 agents in combination result in signif icant inhibition on proliferation, inducing of differention and promotion of apoptosis of gastric caxcinoma cells. The combina tion of cytotoxic agent and differention-inducer exerts significant inhibition on gastric carcinoma cells in vitro.

Changes in Human Umbilical Vein Endothelial Cells Induced by Endothelial Nitric Oxide Synthase Traffic Inducer

This study investigated the changes in human umbilical vein endothelial cells （HUVECs） induced by overexpression of endothelial nitric oxide synthase traffic inducer （NOSTRIN） and its role in cellular injury. Recombinant NOSTRIN-expressing and empty vectors were transfected into cultured HUVECs, and factor Ⅷ-related antigen was examined by using immunohistochemical analysis. Growth curves were generated for both transfected and untransfected cells and these indicated that the prolifera- tive ability of cells overexpressing NOSTRIN was significantly decreased. The expression of NOSTRIN and eNOS proteins was detected by using Western blot analysis, endothelial NOS （eNOS） activity was assayed by using spectrophotometry, and NO2-/NO3- levels were measured usin~ nitrate reductase. Immunohistochemical analysis demonstrated that all groups expressed NOSTRIN in the plasma mem- brane and cytoplasm, and Western blot analysis confirmed that NOSTR1N levels were significantly higher in cells transfected with the NOSTR1N plasmid （P〈0.01）. The activity of eNOS and the levels of NO2-/NO3 were significantly decreased in NOSTRIN overexpressing cells as compared with empty vector and untransfected cells （P〈0.01 and P〈0.01, respectively）. Morphological and ultrastructural changes were observed under light and electron microscopy, and it was found that NOS- TRIN-overexpressing cells were elongated with deformities of the karyotheca, injury to the plasma membrane, increased lipids in the cytoplasm, and shortened microvilli. This study showed that overex- pression of NOSTRIN had a significant effect on eNOS activity in HUVECs and resulted in significant cellular damage.

Brain edema and tumor necrosis factor-like weak inducer of apoptosis in rats with cerebral ischemia

BACKGROUND： Recent studies have demonstrated that tumor necrosis factor-like weak inducer of apoptosis （TWEAK） participates in brain edema. However, it is unclear whether blood-brain barrier （BBB） disruption is associated with TWEAK during the process of brain edema OBJECTIVE： To investigate the effects of TWEAK on BBB permeability in brain edema. DESIGN, TIME AND SETTING： An immunohistochemical observation, randomized, controlled animal experiment was performed at the Laboratory of Neurosurgical Anatomy, Xiangya Medical College, Central South University ＆ Central Laboratory, Third Xiangya Hospital, Central South University between January 2006 and December 2007. MATERIALS： A total of 48 adult Wistar rats were randomly divided into three groups： normal control （n = 8）, sham-operated （n = 8）, and ischemia/reperfusion （n = 32）. Rats from the ischemia/reperfusion group were randomly assigned to four subgroups according to different time points, i.e., 2 hours of ischemia followed by 6 hours （n = 8）, 12 hours （n = 8）, 1 day （n = 8）, or 12 days （n = 8） of reperfusion. METHODS： Focal cerebral ischemia/reperfusion injury was induced by middle cerebral artery occlusion （MCAO） using the suture method in rats from the ischemia/reperfusion group. Thread was introduced at a depth of 17-19 mm. Rats in the sham-operated group were subjected to experimental procedures similar to the ischemia/reperfusion group; however, the introducing depth of thread was 10 mm. The normal control group was not given any intervention. MAIN OUTCOME MEASURES： TWEAK expression was examined by immunohistochemistry; brain water content on the ischemic side was calculated as the ratio of dry to wet tissue weight; BBB permeability was measured by Evans blue extravasation. RESULTS： A total of eight rats died prior to and after surgery and an additional eight rats were randomly entered into the study. Thus 48 rats were included in the final analysis. In the ischemia/reperfusion group, TWEAK-positive cells were present in the ischemic penumbra surrounding the lamellar necrotic region in the fight cerebral hemisphere at 6 hours reperfusion and increased thereafter; by 2 days reperfusion they had reached a peak level, which was significantly higher than the sham-operated and normal control groups （P 〈 0.05）. At 6 hours reperfusion, both brain water content and Evans blue extravasation showed the same tendency for change as TWEAK expression. Pearson correlation analysis results revealed that the degree of TWEAK expression was positively correlated with brain water content （r = 0.892, P 〈 0.05）. CONCLUSION： The present results confirmed that TWEAK was involved in BBB disruption and participated in brain edema following cerebral ischemia.

Hypersensitivity of vascular alpha-adrenoceptor responsiveness: a possible inducer of pain in neuropathic states

Dear editor,Dr. Peter Drummond＇s article noted that peripheral nerve and tissue injury in neuropathic pain syndromes releases cytokines which in turn lead to an increase in alphal-adrenoceptor upreg- ulation, resulting in a heightened sensitivity to noradrenaline. In these circumstances, noradrenaline acting on upregulated alpha1 a-adrenoceptors increases the release of cytokine interleukin-6. Hence, nociceptive afferent neurons exposed to injury induced cytokines become more hypersensitive to noradrenaline, which in turn promotes the release of more inflammatory cytokines. Dr. Drummond noted that this mechanism may contribute to the pain of post-herpetic neuralgia or complex regional pain syn- drome （Drummond, 2014）.

Correlation of extracellular matrix metalloproteinase inducer expression with inflammatory response and MMPs/TIMPs in patients with myocardial infarction

Objective:To study the correlation of extracellular matrix metalloproteinase inducer (EMMPRIN) expression with inflammatory response and matrix metalloproteinases (MMPs) /TIMPs in patients with myocardial infarction.Methods: The patients who were diagnosed with acute myocardial infarction and the patients who were diagnosed with stable angina pectoris in the Second People's Hospital of Juancheng County between March 2014 and December 2017 were selected as the AMI group and SAP group respectively, and the healthy volunteers who received physical examination during the same period were selected as the control group. Peripheral blood was collected to detect the expression of EMMPRIN, and serum was collected to determine the contents of inflammatory cytokines and MMPs/TIMPs. Results: Peripheral blood EMMPRIN expression as well as serum ICAM1, VCAM1, IL-1β, IL-17, MMP2, MMP8 and MMP9 contents of AMI group and SAP group were significantly higher than those of control group whereas TGF-β1, sFGL-2, TIMP1 and TIMP2 contents were significantly lower than those of control group and the changes of above indexes in AMI group were more significant than those in SAP group. Serum ICAM1, VCAM1, IL-1β, IL-17, MMP2, MMP8 and MMP9 contents of AMI group of patients with high EMMPRIN expression were significantly higher than those of patients with low EMMPRIN expression whereas TGF-β1, sFGL-2, TIMP1 and TIMP2 contents were significantly lower than those of patients with low EMMPRIN expression.Conclusion:The high EMMPRIN expression in peripheral blood of patients with myocardial infarction can aggravate the inflammatory response and destroy the balance of MMPs/TIMPs.

Mitochondria-targeted nano-AIEgens as a powerful inducer for evoking immunogenic cell death

AIEgens can serve as an effective platform for the construction of photosensitizer-based immunogenic cell death(ICD)inducers.To date,several mitochondria or endoplasmic reticulum(ER)-targeted aggregationinduced emission(AIE)molecules have been developed and have evoked massive ICD in cells.However,due to the complex physicochemical environment in cells,these small AIE molecules cannot maintain a stable aggregate state,which not only affects the fluorescence intensity of the photosensitizer but also decreases the generation of reactive oxygen species(ROS),and thus reducing the effect of the photosensitizer to elicit ICD.AIEgen-based nanomicelles,which maintain a stable micellar structure,can prevent defects of AIE molecules in photodynamic therapy(PDT)applications.Therefore,in this study,a mitochondria-targeted AIE nanophotosensitizer was synthesized and used as a highly potent ICD inducer for vaccine preparation and tumor prevention.

Experimental study on effects of air injection on cavitation pressure pulsation and vibration in a centrifugal pump with inducer

Cavitation commonly induces performance deterioration and system vibration in many engineering applications.This paper aims to investigate the effects of air injection on cavitation evolution,pressure pulsation and vibration in a centrifugal pump with inducer.In this paper,the high-speed camera is used to capture the gas flow pattern and cavitation evolution process in the inducer.The impacts of air injection on the inlet pressure pulsation and vibration are also investigated.The results show that the cavitation development in the inducer undergoes four patterns:incipient cavitation,sheet cavitation,cloud cavitation and super cavitation.During the development of cavitation,the main frequency of the pressure pulsation shifts to lower frequencies,and the amplitude of the vibration increases.In addition,air injection promotes the incipient cavitation but delays the cavitation development.A small amount of air can effectively decrease amplitudes of pressure pulsation and vibration.But as the air content increases,the fluctuations and amplitudes of pressure pulsation and vibration increase.

Current and Potential Roles of Ferroptosis in Bladder Cancer

Ferroptosis,a type of regulated cell death driven by iron-dependent lipid peroxidation,is mainly initiated by extramitochondrial lipid peroxidation due to the accumulation of iron-dependent reactive oxygen species.Ferroptosis is a prevalent and primitive form of cell death.Numerous cellular metabolic processes regulate ferroptosis,including redox homeostasis,iron regulation,mitochondrial activity,amino acid metabolism,lipid metabolism,and various disease-related signaling pathways.Ferroptosis plays a pivotal role in cancer therapy,particularly in the eradication of aggressive malignancies resistant to conventional treatments.Multiple studies have explored the connection between ferroptosis and bladder cancer,focusing on its incidence and treatment outcomes.Several biomolecules and tumor-associated signaling pathways,such as p53,heat shock protein 1,nuclear receptor coactivator 4,RAS-RAF-MEK,phosphatidylinositol 3-kinase-AKT-mammalian target of rapamycin,and the Hippo-tafazzin signaling system,exert a moderating influence on ferroptosis in bladder cancer.Ferroptosis inducers,including erastin,artemisinin,conjugated polymer nanoparticles,and quinazolinyl-arylurea derivatives,hold promise for enhancing the effectiveness of conventional anticancer medications in bladder cancer treatment.Combining conventional therapeutic drugs and treatment methods related to ferroptosis offers a promising approach for the treatment of bladder cancer.In this review,we analyze the research on ferroptosis to augment the efficacy of bladder cancer treatment.

Photobiomodulation:a novel approach to promote trans-differentiation of adipose-derived stem cells into neuronal-like cells

Photobiomodulation,originally used red and near-infrared lasers,can alter cellular metabolism.It has been demonstrated that the visible spectrum at 451-540 nm does not necessarily increase cell proliferation,near-infrared light promotes adipose stem cell proliferation and affects adipose stem cell migration,which is necessary for the cells homing to the site of injury.In this in vitro study,we explored the potential of adipose-derived stem cells to differentiate into neurons for future translational regenerative treatments in neurodegenerative disorders and brain injuries.We investigated the effects of various biological and chemical inducers on trans-differentiation and evaluated the impact of photobiomodulation using 825 nm near-infrared and 525 nm green laser light at 5 J/cm2.As adipose-derived stem cells can be used in autologous grafting and photobiomodulation has been shown to have biostimulatory effects.Our findings reveal that adipose-derived stem cells can indeed trans-differentiate into neuronal cells when exposed to inducers,with pre-induced cells exhibiting higher rates of proliferation and trans-differentiation compared with the control group.Interestingly,green laser light stimulation led to notable morphological changes indicative of enhanced trans-differentiation,while near-infrared photobiomodulation notably increased the expression of neuronal markers.Through biochemical analysis and enzyme-linked immunosorbent assays,we observed marked improvements in viability,proliferation,membrane permeability,and mitochondrial membrane potential,as well as increased protein levels of neuron-specific enolase and ciliary neurotrophic factor.Overall,our results demonstrate the efficacy of photobiomodulation in enhancing the trans-differentiation ability of adipose-derived stem cells,offering promising prospects for their use in regenerative medicine for neurodegenerative disorders and brain injuries.

NUMERICAL INVESTIGATION OF PERFORMANCE OF AN AXIAL-FLOW PUMP WITH INDUCER

The interaction of flow through the inducer and impeller of an axial-flow pump equipped with an inducer has significant effect on its performance. This article presents a recent numerical investigation on this topic. The studied pump has an inducer with 3 blades mounted on a conical hub and a 6-blade impeller. The blade angle of the impeller is adjustable to generate different relative circumferential angles between the inducer blade trailing edge and the impeller blade leading edge. A computational fluid dynamics code was used to investigate the flow characteristics and performance of the axial-flow pump. For turbulence closure, the RNG k-ε model was applied with an unstructured grid system. The rotor-stator interaction was treated with a Multiple Reference Frame （MRF） strategy. Computations were performed in different cases： 7 different relative circumferential angles （ Δθ ） between the inducer blade trailing edge and the impeller blade leading edge, and 3 different axial gaps （G） between the inducer and the impeller. The variation of the hydraulic loss in the rotator was obtained by changing Δθ . The numerical results show that the pressure generated is minimum in the case of （ G = 3%D）, which indicates that the interference between inducer and impeller is strong if the axial gap is small. The pump performances were predicted and compared to the experimental measurements. Recommendations for future modifications and improvements to the pump design were also given.

NUMERICAL ANALYSIS OF THE INFLUENCE OF THE TIP CLEARANCE FLOWS ON THE UNSTEADY CAVITATING FLOWS IN A THREE- D IMENSIONAL INDUCER

To clarify the influences of the tip clearance flows on the unsteady cavitating flow, the three-dimensional unsteady cavitating flows through both the two-dimensional cascades and the three-dimensional inducer with and without tip clearance are performed numerically. The governing equations for the compressible fluid flow with the DES turbulence model are employed with the assumption of the isentropic process of liquid phase. The evolution of cavities is represented as the source/sink of vapor phase. The basic equations in the curve linear coordinate are solved by the finite difference method. As the results of the three-dimensional cavitating flows through the two-dimensional cascades, the tip clearance flows from the pressure side to the suction side of the blade produces the tip vortex cavitation, which affects the sheet cavitation on the leading edge of the next blade and enhances the blockage effect near the casing than the flows without tip clearance. On the other hand, in the case of the three-dimensional inducer, the large backflow cavitation is observed around the inlet of the inducer, where the cavities are developed on the casing by the tip clearance flows. The large pressure gradient between the non-cavitating pressure side and the cavitating suction side enhances the tip clearance flows. The calculation considering the tip clearance reproduces the developed cavitation region similar to that of experimental visualizations. Additionally, the backflow cavitation rotates with the speed slower than the rotation speed of the inducer. Then, the rotation of backflow cavitation causes the periodic fluctuation of the outlet pressure greater than that of the inlet pressure.

Long non-coding RNA H19 regulates neurogenesis of induced neural stem cells in a mouse model of closed head injury

Stem cell-based therapies have been proposed as a potential treatment for neural regeneration following closed head injury.We previously reported that induced neural stem cells exert beneficial effects on neural regeneration via cell replacement.However,the neural regeneration efficiency of induced neural stem cells remains limited.In this study,we explored differentially expressed genes and long non-coding RNAs to clarify the mechanism underlying the neurogenesis of induced neural stem cells.We found that H19 was the most downregulated neurogenesis-associated lnc RNA in induced neural stem cells compared with induced pluripotent stem cells.Additionally,we demonstrated that H19 levels in induced neural stem cells were markedly lower than those in induced pluripotent stem cells and were substantially higher than those in induced neural stem cell-derived neurons.We predicted the target genes of H19 and discovered that H19 directly interacts with mi R-325-3p,which directly interacts with Ctbp2 in induced pluripotent stem cells and induced neural stem cells.Silencing H19 or Ctbp2 impaired induced neural stem cell proliferation,and mi R-325-3p suppression restored the effect of H19 inhibition but not the effect of Ctbp2 inhibition.Furthermore,H19 silencing substantially promoted the neural differentiation of induced neural stem cells and did not induce apoptosis of induced neural stem cells.Notably,silencing H19 in induced neural stem cell grafts markedly accelerated the neurological recovery of closed head injury mice.Our results reveal that H19 regulates the neurogenesis of induced neural stem cells.H19 inhibition may promote the neural differentiation of induced neural stem cells,which is closely associated with neurological recovery following closed head injury.

Cavitation performance of high-speed centrifugal pump with annular jet and inducer at different temperatures and void fractions

The cavitation is very common in a centrifugal pump,especially when the speed is very high,and it seriously influences the centrifugal pump performance.In this investigation,the RNG k-ε turbulence model and the cavitation model with consideration of the mass transferring are first used to simulate the cavitation performance of the high-speed centrifugal pump without taking any measure for improving the pump cavitation performance.The calculation results reveal that a number of bubbles appear in the centrifugal pump flow channel,and the head as well as the flow rate of the high-speed centrifugal pump are far from its design condition.The cavitation performance can be improved effectively by arranging a variable pitch inducer and adopting an annular nozzle scheme.The flow field analysis of the pump is conducted to obtain the suitable working temperature distribution at different void fractions.On one hand,with the same void fraction,the head of the centrifugal pump drops slowly with the increase of temperature.However,when the temperature exceeds 90°C,the head of the pump drops rapidly.On the other hand,at the constant temperature,the higher the void fraction,the worse the cavitation performance.This research conducted under different temperatures and void fractions provides some guidance for designing an effective high-speed centrifugal pump.

Experimental investigation of thermal effect on cavitation characteristics in a liquid rocket engine turbopump inducer

The objective of this paper is to investigate the effect of water temperature on cavitation characteristics in a turbopump inducer,a series of experiments at different temperatures have been conducted in a newly developed visualization test facility.It is found that higher temperature shows little influence on the non-cavitation performance and breakdown characteristic in the investigated range.The relationship between cavitation development and pressure fluctuation has been discussed in detail.Higher temperature displays a remarkable stabilization effect on the cavitation excited pressure.In particular,the inception cavitation numbers of both the super-synchronous rotating cavitation and synchronous rotating cavitation are decreased at higher temperatures,and the corresponding frequencies are not affected,while the amplitudes are distinctly reduced,and the occurrence range of synchronous rotating cavitation is significantly narrowed.A generalized RayleighPlesset equation has been employed to account for the thermal effect on the bubble development,which may provide a deep insight in understanding the experimental results.Thermal effect is found to act as a remarkable dissipation mechanism to suppress the bubble growth,smooth the collapse.In particular,the excited pressure during collapse is smaller at higher temperatures,which may lead to the stabilization effect of high temperature in this study.