BACKGROUND Paradoxically,patients with T4N0M0(stage II,no lymph node metastasis)colon cancer have a worse prognosis than those with T2N1-2M0(stage III).However,no previous report has addressed this issue.AIM To screen...BACKGROUND Paradoxically,patients with T4N0M0(stage II,no lymph node metastasis)colon cancer have a worse prognosis than those with T2N1-2M0(stage III).However,no previous report has addressed this issue.AIM To screen prognostic risk factors for T4N0M0 colon cancer and construct a prognostic nomogram model for these patients.METHODS Two hundred patients with T4N0M0 colon cancer were treated at Tianjin Medical University General Hospital between January 2017 and December 2021,of which 112 patients were assigned to the training cohort,and the remaining 88 patients were assigned to the validation cohort.Differences between the training and validation groups were analyzed.The training cohort was subjected to multi-variate analysis to select prognostic risk factors for T4N0M0 colon cancer,followed by the construction of a nomogram model.RESULTS The 3-year overall survival(OS)rates were 86.2%and 74.4%for the training and validation cohorts,respectively.Enterostomy(P=0.000),T stage(P=0.001),right hemicolon(P=0.025),irregular review(P=0.040),and carbohydrate antigen 199(CA199)(P=0.011)were independent risk factors of OS in patients with T4N0M0 colon cancer.A nomogram model with good concordance and accuracy was constructed.CONCLUSION Enterostomy,T stage,right hemicolon,irregular review,and CA199 were independent risk factors for OS in patients with T4N0M0 colon cancer.The nomogram model exhibited good agreement and accuracy.展开更多
Mn-rich LiFe_(1-x)Mn_(x)PO_(4)(x>0.5),which combines the high operation voltage of LiMnPO_(4)with excellent rate performa nce of LiFePO4,is hindered by its sluggish kinetic properties.Herein,thermodynamic equilibri...Mn-rich LiFe_(1-x)Mn_(x)PO_(4)(x>0.5),which combines the high operation voltage of LiMnPO_(4)with excellent rate performa nce of LiFePO4,is hindered by its sluggish kinetic properties.Herein,thermodynamic equilibrium analysis of Mn^(2+)-Fe^(2+)-Mg^(2+)-C_(2)O_(4)^(2-)-H_(2)O system is used to guide the design and preparation of insitu Mg-doped(Fe_(0.4)Mn_(0.6))_(1-x)Mg_(x)C_(2)O_(4)intermediate,which is then employed as an innovative precursor to synthesize high-performance Mg-doped LiFe_(0.4)Mn_(0.6)PO_(4).It indicates that the metal ions with a high precipitation efficiency and the stoichiometric precursors with uniform element distribution can be achieved under the optimized thermodynamic conditions.Meanwhile,accelerated Li+diffusivity and reduced charge transfer resistance originating from Mg doping are verified by various kinetic characterizations.Benefiting from the contributions of inherited homogeneous element distribution,small particle size,uniform carbon layer coating,enhanced Li+migration ability and structural stability induced by Mg doping,the Li(Fe_(0.4)Mn_(0.6))_(0.97)Mg_(0.03)PO_(4)/C exhibits splendid electrochemical performance.展开更多
本文利用普林斯顿大学全球大气强迫场资料，驱动公用陆面过程模式（Community Land Model version 4．0，CLM4．O）模拟了中国区域1961-2010年土壤湿度的时空变化。将模拟结果与观测结果、美国国家环境预报中心再分析数据（Naional Cent...本文利用普林斯顿大学全球大气强迫场资料，驱动公用陆面过程模式（Community Land Model version 4．0，CLM4．O）模拟了中国区域1961-2010年土壤湿度的时空变化。将模拟结果与观测结果、美国国家环境预报中心再分析数据（Naional Centers for Environmental Prediction Reanalysis，NCEP）和高级微波扫描辐射计（Advanced Microwave Scanning Radiometer-EOS，AMSR-E）反演的土壤湿度进行了对比分析，结果表明CLM4．0模拟结果可以反映出中国区域观测土壤湿度的空间分布和时空变化特征，但东北、江淮和河套三个地区模拟值相对于观测值在各层次均系统性偏大。模拟与NCEP再分析土壤湿度的空间分布基本一致，与AMSR-E的反演值在35°N以北的分布也基本一致；从1961-2010年土壤湿度模拟结果分析得出，各层土壤湿度空间分布从西北向东南增加。低值区主要分布在新疆、青海、甘肃和内蒙古西部地区。东北平原、江淮地区和长江流域为高值区。土壤湿度数值总体上从浅层向深层增加。不同深度土壤湿度变化趋势基本相同。除新疆西部和东北部分地区外，土壤湿度在35°N以北以减少趋势为主，30°N以南的长江流域、华南及西南地区以增加为主。在全球气候变暖的背景下，CLM4．0模拟的夏季土壤湿度在不同程度上响应了降水的变化。中国典型干旱区和半干旱区土壤湿度减小，湿润区增加。其中湿润区土壤湿度对降水的响应最为显著，其次是半干旱区和干旱区。展开更多
基金Supported by Health Science and Technology Project of Tianjin Health Commission,No.ZC20190Tianjin Key Medical Discipline(Specialty)Construction Project,No.TJYXZDXK-005ATianjin Medical University Clinical Research Fund,No.22ZYYLCCG04.
文摘BACKGROUND Paradoxically,patients with T4N0M0(stage II,no lymph node metastasis)colon cancer have a worse prognosis than those with T2N1-2M0(stage III).However,no previous report has addressed this issue.AIM To screen prognostic risk factors for T4N0M0 colon cancer and construct a prognostic nomogram model for these patients.METHODS Two hundred patients with T4N0M0 colon cancer were treated at Tianjin Medical University General Hospital between January 2017 and December 2021,of which 112 patients were assigned to the training cohort,and the remaining 88 patients were assigned to the validation cohort.Differences between the training and validation groups were analyzed.The training cohort was subjected to multi-variate analysis to select prognostic risk factors for T4N0M0 colon cancer,followed by the construction of a nomogram model.RESULTS The 3-year overall survival(OS)rates were 86.2%and 74.4%for the training and validation cohorts,respectively.Enterostomy(P=0.000),T stage(P=0.001),right hemicolon(P=0.025),irregular review(P=0.040),and carbohydrate antigen 199(CA199)(P=0.011)were independent risk factors of OS in patients with T4N0M0 colon cancer.A nomogram model with good concordance and accuracy was constructed.CONCLUSION Enterostomy,T stage,right hemicolon,irregular review,and CA199 were independent risk factors for OS in patients with T4N0M0 colon cancer.The nomogram model exhibited good agreement and accuracy.
基金financially supported by the National Natural Science Foundation of China(No.51904250)the China Postdoctoral Science Foundation(No.2021M692254)+2 种基金the Sichuan Science and Technology Program(No.2022YFG0098)the Fundamental Research Funds for the Central Universities(Nos.2021CDSN-02,2022SCU12002,2022CDZG-17,2022CDSN-08,2022CDZG-9)the Hohhot Science and Technology Program(No.2023-Jie Bang Gua Shuai-Gao-3)。
文摘Mn-rich LiFe_(1-x)Mn_(x)PO_(4)(x>0.5),which combines the high operation voltage of LiMnPO_(4)with excellent rate performa nce of LiFePO4,is hindered by its sluggish kinetic properties.Herein,thermodynamic equilibrium analysis of Mn^(2+)-Fe^(2+)-Mg^(2+)-C_(2)O_(4)^(2-)-H_(2)O system is used to guide the design and preparation of insitu Mg-doped(Fe_(0.4)Mn_(0.6))_(1-x)Mg_(x)C_(2)O_(4)intermediate,which is then employed as an innovative precursor to synthesize high-performance Mg-doped LiFe_(0.4)Mn_(0.6)PO_(4).It indicates that the metal ions with a high precipitation efficiency and the stoichiometric precursors with uniform element distribution can be achieved under the optimized thermodynamic conditions.Meanwhile,accelerated Li+diffusivity and reduced charge transfer resistance originating from Mg doping are verified by various kinetic characterizations.Benefiting from the contributions of inherited homogeneous element distribution,small particle size,uniform carbon layer coating,enhanced Li+migration ability and structural stability induced by Mg doping,the Li(Fe_(0.4)Mn_(0.6))_(0.97)Mg_(0.03)PO_(4)/C exhibits splendid electrochemical performance.
文摘本文利用普林斯顿大学全球大气强迫场资料，驱动公用陆面过程模式（Community Land Model version 4．0，CLM4．O）模拟了中国区域1961-2010年土壤湿度的时空变化。将模拟结果与观测结果、美国国家环境预报中心再分析数据（Naional Centers for Environmental Prediction Reanalysis，NCEP）和高级微波扫描辐射计（Advanced Microwave Scanning Radiometer-EOS，AMSR-E）反演的土壤湿度进行了对比分析，结果表明CLM4．0模拟结果可以反映出中国区域观测土壤湿度的空间分布和时空变化特征，但东北、江淮和河套三个地区模拟值相对于观测值在各层次均系统性偏大。模拟与NCEP再分析土壤湿度的空间分布基本一致，与AMSR-E的反演值在35°N以北的分布也基本一致；从1961-2010年土壤湿度模拟结果分析得出，各层土壤湿度空间分布从西北向东南增加。低值区主要分布在新疆、青海、甘肃和内蒙古西部地区。东北平原、江淮地区和长江流域为高值区。土壤湿度数值总体上从浅层向深层增加。不同深度土壤湿度变化趋势基本相同。除新疆西部和东北部分地区外，土壤湿度在35°N以北以减少趋势为主，30°N以南的长江流域、华南及西南地区以增加为主。在全球气候变暖的背景下，CLM4．0模拟的夏季土壤湿度在不同程度上响应了降水的变化。中国典型干旱区和半干旱区土壤湿度减小，湿润区增加。其中湿润区土壤湿度对降水的响应最为显著，其次是半干旱区和干旱区。
