This article reviews and discusses the definition, classification, performance, properties of the bioce-ramics which began to be researched on and developed in seventies and has been applied to the medical clinic sinc...This article reviews and discusses the definition, classification, performance, properties of the bioce-ramics which began to be researched on and developed in seventies and has been applied to the medical clinic since then, and the present situation of research on and development of the biological requirement put forward to bioce-ramic performance by the biont and comes to that the bioce-ramics is the most promising biological material in the modern medical clinic application.展开更多
目的:比较两种材料在犬前牙区拔牙位点的引导新骨形成作用。方法:选取6只12月龄雄性Beagle犬,将其随机分为A、B、C三组,微创拔除实验犬下颌双侧第一侧切牙,A组犬填入羟基磷灰石生物陶瓷(天博),B组填入骨诱导活性材料(osteoinduction act...目的:比较两种材料在犬前牙区拔牙位点的引导新骨形成作用。方法:选取6只12月龄雄性Beagle犬,将其随机分为A、B、C三组,微创拔除实验犬下颌双侧第一侧切牙,A组犬填入羟基磷灰石生物陶瓷(天博),B组填入骨诱导活性材料(osteoinduction active material,OAM),C组空置(对照)。三组实验犬在1个月末各处死1只,在3个月末各处死1只。取实验样本,进行标本测量,利用CBCT分析进行骨形成密度的评估。结果:所有位点骨量均有不同程度的吸收。OAM组与天博组牙槽嵴宽度平均骨量吸收程度低于对照组(P<0.05),OAM组平均骨量吸收程度低于天博组(P<0.05);牙槽嵴高度丧失OAM与天博均低于对照组(P<0.05),但OAM与天博间差异无统计学意义(P>0.05);CT值比较结果可见愈合后期OAM吸收快于天博(P<0.05)。结论:OAM具有良好的位点保存效果。展开更多
This work is focused on developing zinc-doped hydroxyapatite-zeolite(Zn HA-Zeo)and polycaprolactone(PCL)composite coatings on magnesium(Mg)substrate to improve the corrosion resistance and antimicrobial properties.Dip...This work is focused on developing zinc-doped hydroxyapatite-zeolite(Zn HA-Zeo)and polycaprolactone(PCL)composite coatings on magnesium(Mg)substrate to improve the corrosion resistance and antimicrobial properties.Dip-coating technique was used to coat Zn HA-Zeo/PCL on the Mg substrate at room temperature.The samples were subjected to field emission scanning electron microscopy(FESEM),X-ray diffraction(XRD),Fourier transform infrared(FTIR),energy dispersive X-ray spectroscopy(EDX)and antimicrobial potential.Results demonstrated that composite coatings consist of HA,scholzite,zeolite,and PCL phases.EDX spectra indicated the presence of calcium(Ca),silicon(Si),aluminum(Al),zinc(Zn),phosphorus(P)and oxygen(O).The composite surface appeared in spherical-like microstructure on coating with thickness ranging 226-260μm.Zinc-doped HA-Zeo composite coating had a high corrosion resistance and provided sufficient protection to the Mg surface against galvanic corrosion.Doped Zn HA-Zeo coating samples exhibited superior disc inhibition by confirming antimicrobial activity against the E.coli as compared to HA-Zeo sample.Altogether these results showed that the Zn HA-Zeo coatings not only improved the corrosion resistance,but also enhanced the antimicrobial property and hence they can be used as suitable candidates for implant applications.展开更多
Development of novel biomaterials for bone regeneration is based on the sufficient bone-bonding ability,bioactivity and biocompatibility.In this study,novel flexible poly(butylene succinate)/polydimethysiloxane-modifi...Development of novel biomaterials for bone regeneration is based on the sufficient bone-bonding ability,bioactivity and biocompatibility.In this study,novel flexible poly(butylene succinate)/polydimethysiloxane-modified bioactive glass/nano-hydroxyapatite(PBSu/PDMS-BG/nHA)hybrid bioceramic with various nHA concentration on the in vitro bone-like hydroxyapatite(HA)formation,biomineralization activity and osteoblast cell biocompatibility were investigated.The rapid precipitation of HA on the hybrid bioceramic surfaces was found after being immersed in simulated body fluid(SBF)for seven days.Results show that the amount of HA deposition increased with the increase of nHA concentration.The optimized PBSu/PDMS-BG/nHA hybrid bioceramic exhibited good flexibility,high biomineralization activity and good osteoblast cell biocompatibility.展开更多
文摘This article reviews and discusses the definition, classification, performance, properties of the bioce-ramics which began to be researched on and developed in seventies and has been applied to the medical clinic since then, and the present situation of research on and development of the biological requirement put forward to bioce-ramic performance by the biont and comes to that the bioce-ramics is the most promising biological material in the modern medical clinic application.
文摘目的:比较两种材料在犬前牙区拔牙位点的引导新骨形成作用。方法:选取6只12月龄雄性Beagle犬,将其随机分为A、B、C三组,微创拔除实验犬下颌双侧第一侧切牙,A组犬填入羟基磷灰石生物陶瓷(天博),B组填入骨诱导活性材料(osteoinduction active material,OAM),C组空置(对照)。三组实验犬在1个月末各处死1只,在3个月末各处死1只。取实验样本,进行标本测量,利用CBCT分析进行骨形成密度的评估。结果:所有位点骨量均有不同程度的吸收。OAM组与天博组牙槽嵴宽度平均骨量吸收程度低于对照组(P<0.05),OAM组平均骨量吸收程度低于天博组(P<0.05);牙槽嵴高度丧失OAM与天博均低于对照组(P<0.05),但OAM与天博间差异无统计学意义(P>0.05);CT值比较结果可见愈合后期OAM吸收快于天博(P<0.05)。结论:OAM具有良好的位点保存效果。
基金supported by University of Engineering and Technology,Lahore,faculty under research project#ORIC/102-ASRB/1288 and UTM,FRGS grant#R.J130000.7845.4F768.
文摘This work is focused on developing zinc-doped hydroxyapatite-zeolite(Zn HA-Zeo)and polycaprolactone(PCL)composite coatings on magnesium(Mg)substrate to improve the corrosion resistance and antimicrobial properties.Dip-coating technique was used to coat Zn HA-Zeo/PCL on the Mg substrate at room temperature.The samples were subjected to field emission scanning electron microscopy(FESEM),X-ray diffraction(XRD),Fourier transform infrared(FTIR),energy dispersive X-ray spectroscopy(EDX)and antimicrobial potential.Results demonstrated that composite coatings consist of HA,scholzite,zeolite,and PCL phases.EDX spectra indicated the presence of calcium(Ca),silicon(Si),aluminum(Al),zinc(Zn),phosphorus(P)and oxygen(O).The composite surface appeared in spherical-like microstructure on coating with thickness ranging 226-260μm.Zinc-doped HA-Zeo composite coating had a high corrosion resistance and provided sufficient protection to the Mg surface against galvanic corrosion.Doped Zn HA-Zeo coating samples exhibited superior disc inhibition by confirming antimicrobial activity against the E.coli as compared to HA-Zeo sample.Altogether these results showed that the Zn HA-Zeo coatings not only improved the corrosion resistance,but also enhanced the antimicrobial property and hence they can be used as suitable candidates for implant applications.
基金National Natural Science Foundation of China(51962013 and 51762023)Natural Science Foundation of Jiangxi Province(20192ACB20018 and 20181BAB206008)Key R&D Program of Jiangxi Province(20192ACB80007 and 20201BBE51011)。
基金This work was supported by the Natural Science Basic Research Plan in Shaanxi Province of China(Program No.2019JM-520)by the Special Natural Science Foundation of Science and Technology Bureau of Xi’an City(2017CGWL23,2017CGWL26,2017CGWL27,2017CGWL28)The SEM work was done at International Center for Dielectric Research,Xi’an Jiaotong University.
文摘Development of novel biomaterials for bone regeneration is based on the sufficient bone-bonding ability,bioactivity and biocompatibility.In this study,novel flexible poly(butylene succinate)/polydimethysiloxane-modified bioactive glass/nano-hydroxyapatite(PBSu/PDMS-BG/nHA)hybrid bioceramic with various nHA concentration on the in vitro bone-like hydroxyapatite(HA)formation,biomineralization activity and osteoblast cell biocompatibility were investigated.The rapid precipitation of HA on the hybrid bioceramic surfaces was found after being immersed in simulated body fluid(SBF)for seven days.Results show that the amount of HA deposition increased with the increase of nHA concentration.The optimized PBSu/PDMS-BG/nHA hybrid bioceramic exhibited good flexibility,high biomineralization activity and good osteoblast cell biocompatibility.
