The global incidence of infectious diseases has increased in recent years,posing a significant threat to human health.Hospitals typically serve as frontline institutions for detecting infectious diseases.However,accur...The global incidence of infectious diseases has increased in recent years,posing a significant threat to human health.Hospitals typically serve as frontline institutions for detecting infectious diseases.However,accurately identifying warning signals of infectious diseases in a timely manner,especially emerging infectious diseases,can be challenging.Consequently,there is a pressing need to integrate treatment and disease prevention data to conduct comprehensive analyses aimed at preventing and controlling infectious diseases within hospitals.This paper examines the role of medical data in the early identification of infectious diseases,explores early warning technologies for infectious disease recognition,and assesses monitoring and early warning mechanisms for infectious diseases.We propose that hospitals adopt novel multidimensional early warning technologies to mine and analyze medical data from various systems,in compliance with national strategies to integrate clinical treatment and disease prevention.Furthermore,hospitals should establish institution-specific,clinical-based early warning models for infectious diseases to actively monitor early signals and enhance preparedness for infectious disease prevention and control.展开更多
The plague of the late Ming Dynasty(15511644 C.E.)was long lasting,affected a wide range of the population,and had serious consequences.The purpose of this study is to review the medical system in place at the time an...The plague of the late Ming Dynasty(15511644 C.E.)was long lasting,affected a wide range of the population,and had serious consequences.The purpose of this study is to review the medical system in place at the time and the measures instituted to prevent and control the plague during the late Ming Dynasty.Information on the history of the Ming Dynasty(13681644 C.E.),local chronicles,and related research literature were consulted and analyzed in terms of duration,geographical area,and other dimensions of the epidemic.Because of the abnormal climate,wide range of natural disasters,and the impact of war,the epidemic spread over a wide area during the late Ming Dynasty.The government’s epidemic prevention measures were affected by war and other factors,resulting in poor control of the outbreak.However,in terms of the medical system in place during the Ming Dynasty,some of the thinking and methods of prevention and control of the plague were historical and progressive.Some outstanding physicians such as Wu Youke(15821652 C.E.)appeared during this period.His theory of plague prevention and control had a profound influence on the formation and development of pestilence deterrence in later generations.In the late Ming Dynasty,rich experiences and measures of prevention and control were accumulated in the struggle against the plague.These methods and experiences also have a significant,positive guiding influence on the prevention and control of plague in the present day.展开更多
Validating a method of analysis goes through different steps, which aims at testing the normality of measurements distribution, estimating the uncertainty of the components of a measurement （i.e., accuracy and correc...Validating a method of analysis goes through different steps, which aims at testing the normality of measurements distribution, estimating the uncertainty of the components of a measurement （i.e., accuracy and correctness）, and finally, define the control tests of non degradation of the method performances. This paper outlines the steps for validating a biological method of analysis. It involves the construction of an experimental design, a statistical model, and the preparation of an interne laboratory reference material （pilot vaccine）. The latter is used to study the impact of deviation and variation factors, in order to, optimize the analytical method, to evaluate the bias （random error）, and to calculate the uncertainty of measurement, and make the control charts. This method is applied in the titration of live viral vaccines of Gumboro disease on chicken＇s embryos fibroblasts. The experimental results show that potential influence factors related to the titration method had no significant influence on the obtained results. Taking into account these results, an operating mode has been elaborated. The finalized method proved to be faithful to standard deviation of repeatability and reproducibility of 0.21 and 0.22, respectively, with a confidence level of 95%. The calculated uncertainty of measurement is equal to 0.2, which represents the average error level of a titer. A homogeneous stock of interne laboratory reference vaccine （MRIL）, with an average titer of 5.9 log DIT 50, was produced and the control chart set in away to provide the laboratory with an important tool of control and monitoring of the viral titers evolution in time, as well as, the mastery of the validated titration method performances.展开更多
文摘The global incidence of infectious diseases has increased in recent years,posing a significant threat to human health.Hospitals typically serve as frontline institutions for detecting infectious diseases.However,accurately identifying warning signals of infectious diseases in a timely manner,especially emerging infectious diseases,can be challenging.Consequently,there is a pressing need to integrate treatment and disease prevention data to conduct comprehensive analyses aimed at preventing and controlling infectious diseases within hospitals.This paper examines the role of medical data in the early identification of infectious diseases,explores early warning technologies for infectious disease recognition,and assesses monitoring and early warning mechanisms for infectious diseases.We propose that hospitals adopt novel multidimensional early warning technologies to mine and analyze medical data from various systems,in compliance with national strategies to integrate clinical treatment and disease prevention.Furthermore,hospitals should establish institution-specific,clinical-based early warning models for infectious diseases to actively monitor early signals and enhance preparedness for infectious disease prevention and control.
基金2017 Liaoning Province Traditional Chinese Medicine Clinics(Specialized)Branch Capacity Building Project2018 Liaoning Doctoral Start-up Foundation(20180540043).
文摘The plague of the late Ming Dynasty(15511644 C.E.)was long lasting,affected a wide range of the population,and had serious consequences.The purpose of this study is to review the medical system in place at the time and the measures instituted to prevent and control the plague during the late Ming Dynasty.Information on the history of the Ming Dynasty(13681644 C.E.),local chronicles,and related research literature were consulted and analyzed in terms of duration,geographical area,and other dimensions of the epidemic.Because of the abnormal climate,wide range of natural disasters,and the impact of war,the epidemic spread over a wide area during the late Ming Dynasty.The government’s epidemic prevention measures were affected by war and other factors,resulting in poor control of the outbreak.However,in terms of the medical system in place during the Ming Dynasty,some of the thinking and methods of prevention and control of the plague were historical and progressive.Some outstanding physicians such as Wu Youke(15821652 C.E.)appeared during this period.His theory of plague prevention and control had a profound influence on the formation and development of pestilence deterrence in later generations.In the late Ming Dynasty,rich experiences and measures of prevention and control were accumulated in the struggle against the plague.These methods and experiences also have a significant,positive guiding influence on the prevention and control of plague in the present day.
文摘Validating a method of analysis goes through different steps, which aims at testing the normality of measurements distribution, estimating the uncertainty of the components of a measurement （i.e., accuracy and correctness）, and finally, define the control tests of non degradation of the method performances. This paper outlines the steps for validating a biological method of analysis. It involves the construction of an experimental design, a statistical model, and the preparation of an interne laboratory reference material （pilot vaccine）. The latter is used to study the impact of deviation and variation factors, in order to, optimize the analytical method, to evaluate the bias （random error）, and to calculate the uncertainty of measurement, and make the control charts. This method is applied in the titration of live viral vaccines of Gumboro disease on chicken＇s embryos fibroblasts. The experimental results show that potential influence factors related to the titration method had no significant influence on the obtained results. Taking into account these results, an operating mode has been elaborated. The finalized method proved to be faithful to standard deviation of repeatability and reproducibility of 0.21 and 0.22, respectively, with a confidence level of 95%. The calculated uncertainty of measurement is equal to 0.2, which represents the average error level of a titer. A homogeneous stock of interne laboratory reference vaccine （MRIL）, with an average titer of 5.9 log DIT 50, was produced and the control chart set in away to provide the laboratory with an important tool of control and monitoring of the viral titers evolution in time, as well as, the mastery of the validated titration method performances.
