The Support Systems and Coping Strategies of Infertile Women Attending the Out-Patient Consultation Unit of CHRACERH Yaoundé, Cameroon: A Cross-Sectional Study

Background: Infertility is a complex disorder with significant psycho-social and economic consequences. It globally affects 10% - 15% of couples. In Cameroon, little is known about what women do to overcome the psychosocial aspects of the disease. Objectives: This study aimed to identify the support systems and coping strategies of infertile women attending the outpatient consultation unit of the Gynaecological Endoscopic Surgery and Reproductive Teaching Hospital (CHRACERH), Yaoundé, Cameroon. Methods: A hospital-based cross-sectional study was conducted from the 14th of March to the 6th of April 2023 at CHRACERH Yaoundé. A total of 190 participants were recruited using a convenience sampling method. Data regarding socio-demographic characteristics, support systems and coping strategies were collected using a pretested questionnaire. Descriptive and analytic statistics were conducted using SPSS version 25. Results: The mean age of participants was 39.52 ± 7.64 years. The majority 78.9% of participants were workers (public, private sector, or traders) and were Christians 95.8%. The most common source of psychological support was from family 76.8 and husbands 72.63%. Most of the participants 89.5% resorted to prayer and getting busy 48.4% as a coping strategy. There was no statistically significant relationship between coping strategies and psychological disorders p > 0.05. Conclusion: The main support system of participants was family, husband, and friends. Prayer, getting busy and adoption were the most common coping strategies. There is a need for the Ministry of Public Health and other stakeholders to put in place other support systems and coping strategies (FELICIA) used elsewhere and provide adequate health education and infection control to prevent infertility in Cameroon.

Clinical, Psychological and Socio-Economic Profile of Women Consulting for Couple Infertility in the Yaounde Gynaeco-Obstetric and Paediatric Hospital

Introduction: Infertility is defined as the inability to achieve a pregnancy after at least 12 months or more of regular unprotected sexual intercourse. Our main objective was to describe the clinical, psychological and socio-economic profile of women consulting for infertility in the Yaounde Gyneco-Obstetric and Pediatric Hospital. Methodology: This was a descriptive cross-sectional study with prospective data collection at the Yaounde Gyneco Obstetric and Pediatric Hospital over a period of 7 months from 1st December 2021 to 31st June 2022. Results: We included 171 patients. The mean age was 32.3 ± 5.5 years. The mean duration of infertility was 4.0 ± 3.7 years. Primary and secondary Infertility made up 31.6% and 68.4% of cases respectively. Past medical history was significant for Abortions (50%), Chlamydia and Mycoplasma infections (43.8%), chronic pelvic pain (49.7%) and endouterine manipulations (33.3%) of cases. Majority of our patients were stressed (76.6%). The most represented stress score was severe stress (66.1%). 51% of our patients were mentally depressed and 35.6% were anxious. Majority of them (74.9%) had low socio-economic status. Conclusion: Couple infertility is most often secondary. It triggers the onset of psychological problems like stress, mental depression and anxiety. Most of our patients had a low socio-economic status.

Psychiatric Aspects of Egyptian Women with Unexplained Infertility

Background: The diagnosis of unexplained infertility may be very frustrating for infertile couples and they show higher depression levels when compared to fertile couples. Aim: To assess the psychiatric aspects of Egyptian women with unexplained infertility. Methods: 220 infertile women were included in this study (110 with unexplained infertility and 110 with explained infertility). The psychiatric aspect of these women was evaluated using the translated and validated Hamilton Anxiety Rating Scale and the Beck Depression Inventory-II. Findings: The number of women with mild depression was significantly higher in the unexplained infertility group (47/110 (42.7%)) versus (22/110 (20%)) in the explained infertility group (P = 0.007). The number of women with moderate anxiety was significantly higher in the unexplained infertility group (26/110 (23.6%)) versus (8/110 (7.3%)) in the explained infertility group (P = 0.003). Conclusion: The current study concluded that mild depression and moderate anxiety were significantly higher in the unexplained infertility group. It is crucial to identify infertility women who are in need of psychological support and counseling during infertility treatment, because the psychological disturbance of the infertile women may affect the outcome of infertility treatment.

Types of Infertility and Its Risk Factors among Infertile Women: A Prospective Study in Dhaka City

Background: Infertility is a global health issue, and it is a multidimensional problem with social, economic, and cultural influences. Objectives: The study aimed to determine types of infertility and their contributing factors among the respondent infertile women. Methods: This prospective cross-sectional study was conducted among infertile women visiting Sir Salimullah Medical College and Hospital, Dhaka. From January to December 2020, 111 infertile women were included and evaluated for infertility types and their contributing factors. Data were collected by face-to-face interviewing, and data were analyzed statistically. Results: Primary infertility was found among 90 (81%) and secondary infertility among 21 (18.9%). Among the direct risk factors of female infertility, ovulation failure was the majority of the cases, 74 (35.1%), and its mainly observed in primarily infertile women 58 (33.9%). These observations were statistically significant. Conclusions: Infertility should be treated as a public health problem, government and non-government organizations should develop a basic policy to create effective fertility centers.

Management of Women Infertility in Tropical Africa: The Experience of the Gynecology Department of University and Hospital Center of Treichville (Abidjan-Cote d’Ivoire)

Objectives: This study aimed to clarify the etiology of women infertility and describe their management in our service with limited technical equipment. Methodology: We conducted a retrospective and descriptive study on 175 women treated for infertility and followed in the gynecology services of the university Hospital center of Treichville from 1st January 2012 to 31st December 2014. Results: During the study, we recorded 12072 consultations in gynecology including 1582 (13.1%) cases of infertility, but only 175 cases were selected for this study. The patients had an average age of 31.3 years and an average socio-economic level in general (78.9%). The etiologies were found in 79.4% of patients, dominated by classical abnormalities: uterine (fibroids: 41.8%), hormonal, tubo peritoneal (5%). We also found some unusual pathologies related to cultural practices (female genital mutilation, caustic stenosis of the vagina). The surgery was performed in several patients, including myomectomy by laparotomy (46.6%), laparoscopy, hysteroscopy and vaginal surgeries. As to drug treatment, they were various combinations, and the ovarian stimulation practices (62.3%) and induction of ovulation (47.2%) were common. The result of this support has been marked by the occurrence of 74 pregnancies (42.3%), with the birth of healthy children in the majority of cases (95.9%). Conclusion: The management of infertile women was frequent and yielded encouraging results despite our limited technical equipment.

Prevalence of Polycystic Ovary Syndrome in Nigerian Women with Infertility: A Prospective Study of the Three Assessment Criteria

Background: Polycystic ovarian syndrome (PCOS) is a frequent diagnosis in oligomenorrheic and infertile Nigerian women. However, to date there is a paucity of data on the prevalence of PCOS in Nigerian women. The objective of this study was to investigate the prevalence of PCOS in a cross-section of women attending Infertility Clinics in Benin City, Nigeria using the three assessment criteria namely: the 1990 National Institutes of Health (NIH), the 2003 Rotterdam and 2006 Androgen Excess Society (AES) criteria. Method: Four hundred and twenty-one consecutive infertile premenopausal women aged 18 - 45 years were recruited and evaluated with a proforma that elicited information about their maternal and reproductive health history. Blood samples were analyzed for hormone levels using standard immunoassay procedures, while trans-vaginal ultrasound scan was carried out to determine the presence of ultrasonic features of PCOS. The control group comprised of eumenorrheics (n = 180). Results: An estimated prevalence of biochemical hyperandrogenism (BHA) was as high as 20.9% (88 women), while 3.6% (15 women) presented with clinical hyperandrogenism (CHA). Also the prevalence of polycystic ovaries (PCO) was 13.8%. The prevalence of PCOS based on NIH, Rotterdam and AES criteria was 16.9% (71 women), 27.6% (116 women) and 20.7% (87 women) respectively. However, women with PCOS were significantly younger and had higher total testosterone levels (p = 0.001) when compared to controls. Conclusion: The prevalence of PCOS is as high in the population under study as in other prevalence studies. The hormonal investigations were clinically useful in assessing the prevalence rates. However, the recruitment criteria, together with the regional and racial factors may have contributed to the estimates obtained, and the high incidence of biochemical hyperandrogenism in this region.

Effect of Yangjing Zhongyu Decoction (养精种玉汤) on MatrixMetalloproteinase-9 Expression in Endometrium and SexHormone Regulation in Women with Cryptogenic Infertility

Objective: To investigate the effect of Yangjing Zhongyu decoction (YZD, 养精种玉汤) on metalloproteinase-9 (MMP-9) and its inhibitor-1 (TIMP-1) expression and sex hormone regulation in mid-luteal phase endometrium of women with cryptogenic infertility. Methods: Twenty-two infertile women were treated with YZD for 30 days successively. During the mid-luteal phase, in situ hybridization and reverse transcription-polymerase chain reaction method was used to detect MMP-9 and TIMP-1 mRNA, and radioimmunoassay was used to determine levels of serum estradiol (E2) and progesterone (P) synchronously. Results: After treatment, the mid-luteal serum E2 and P level were 451. 501 ± 226. 342 pmol/L and 46. 502 ± 19. 948 nmol/L respectively, significantly higher than that before treatment (304.656 ± 135.853 pmol/L and 33. 782 ± 15. 459 nmol/L respectively) , the difference was significant ( P < 0. 01). Staining of MMP-9 mRNA positive granules in cytoplasm and nuclei of adeno-epithelial cell in mid-luteal phase endometrium deepened significantly, but the change in mesenchym was insignificant. The MMP-9 mRNA expression after treatment was 0.617 ± 0.186 (grey level), significantly higher than the level before treatment (0.490 ± 0. 370), comparison between them showed significant difference ( P < 0. 05 ) . Change of TIMP-1 mRNA expression in adeno-epithelial and mesenchym before and after treatment was insignificant (0. 588 ± 0. 191 vs 0. 621 ± 0. 146,P>0. 05). Correlation analysis showed that the quantitative difference of P level before and after treatment was positively correlated with the difference of MMP-9 mRNA before and after treatment (r=0. 682, P< 0.01). Conclusion: YZD could soothen Gan(肝) and nourish Shen(肾) , raise the level of mid-luteal phase serum P, and further promote MMP-9 gene expression in endometrium to benefit the degradation of extracellular matrix of endometrium, and facilitate for blastocyst implantation.Original article on CJITWM (Chin) 2004 ;24 (4): 294

重复辅助生殖助孕女性希望水平关联因素分析

目的:观察重复辅助生殖助孕女性的希望水平并探究其相关影响因素。方法:选择2022年5月-2023年6月于本院重复接受辅助生殖技术的不孕症患者为调查对象,采用Herth希望指数量表(HHI)调查患者希望水平,以中文版事件相关反刍性沉思问卷(C-ERRI)评估反刍性沉思,简易医学应对方式问卷(SCSQ)评估应对方式,领悟社会支持量表(PSSS)评估社会支持情况,一般资料调查表收集患者临床资料分析可能影响因素,Pearson相关系数模型分析C-ERRI目的性反刍性沉思及侵入性反刍性沉思、PSSS、SCSQ消极应对及积极应对评分与HHI评分的关系,多元线性回归模型分析重复辅助生殖助孕女性希望水平的影响因素。结果:发放调查问卷235份,有效回收219份,有效回收率为93.2%;重复辅助生殖助孕女性HHI评分为32.49±4.86分,其中高水平20例(9.1%)、中水平188例(85.8%)、低水平11例(5.0%)。Pearson相关分析显示,SCSQ消极应对评分与HHI评分呈负相关,C-ERRI目的性反刍性沉思评分、PSSS评分、SCSQ积极应对评分与HHI评分呈正相关(均P<0.05);多元线性回归分析显示,年龄大、不孕年限长、治疗周期长、目的性反刍性沉思不足、社会支持不佳、消极应对方式为重复辅助生殖助孕女性希望水平主要影响因素(均P<0.05)。结论:本次调查的重复辅助生殖助孕女性希望水平处于中等水平,年龄、不孕年限、治疗周期、目的性反刍性沉思、社会支持、应对方式等均是其影响因素,临床可据此采取相关应对措施。

二至天癸方改善高龄女性体外受精-胚胎移植结局的Meta分析

目的系统性评价二至天癸方改善高龄女性体外受精-胚胎移植(IVF-ET)结局的有效性和安全性,为高龄女性IVF-ET的临床用药提供循证医学依据。方法检索中国知网、万方、维普、PubMed、Web of Science、Cochrane Library数据库中有关二至天癸方改善高龄女性IVF-ET结局的随机对照试验,检索时间为建库至2022年5月1日。采用RevMan 5.3软件对纳入文献研究进行Meta分析。结果最终纳入符合标准的文献共9篇,共677例患者。Meta分析结果显示,二至天癸方显著改善了行IVF-ET高龄女性的临床妊娠率、优质胚胎率、获卵数,且显著减少了促性腺激素(Gn)使用剂量(P<0.05)。试验组的2PN受精率虽优于对照组,但差异无统计学意义(P=0.06)。结论二至天癸方在改善高龄女性IVF-ET结局方面效果良好,是高龄女性IVF-ET临床用药中较有前景的中药方剂。

门成福教授治疗不明原因高龄女性不孕症经验总结

不明原因高龄女性不孕症是目前妇科生殖领域研究的重难点,临证时发现“肝郁”是其核心病机,主要涉及肝、脾、肾三脏。文中系统总结了门成福教授在不明原因高龄女性不孕症诊疗方面的学术思想及治疗经验。门成福教授运用中医整体思维审证求因,采用疏、健、调分期辨证治疗,形成具有独具特色的中药人工周期,组方严谨,攻补兼施,配合心理疏导,取得了事半功倍的效果。

高龄不孕女性心理困顿感、生育生活质量及与夫妻支持应对关系分析

目的:调查分析高龄不孕妇女心理困顿感、生育生活质量及与夫妻支持应对的关系。方法:采用便利抽样法,选取2023年1-12月在本院生殖中心就诊的高龄不孕症女性212例,采用调查表进行一般资料调查,困顿感量表(ES)、生育生存质量量表(Ferti-QOL)、夫妻支持应对量表(DCI)评价不孕女性心理困顿感、生育生活质量和夫妻支持应对水平。结果:高龄不孕妇女ES评分33.65±5.61分,Ferti-QOL评分70.97±12.61分,DCI评分107.95±12.04分。相关性分析显示,ES评分与Ferti-QOL评分、DCI评分呈负相关性,Ferti-QOL评分与DCI评分呈正相关性(均P<0.05)。logistic多元回归分析显示,年龄高、未生育、不孕年限长、家庭年收入低均是影响高龄不孕妇女心理困顿感的独立危险因素,而中等及以上Ferti-QOL评分和DCI评分是保护性因素(均P<0.05)。结论:本次调查的高龄不孕症女性心理困顿感处于中等水平,其生育生活质量、夫妻支持应对有待提高,提高生育生活质量、夫妻支持应对水平有利于减轻心理困顿感。

Intrafollicular Soluble RAGE Benefits Embryo Development and Predicts Clinical Pregnancy in Infertile Patients of Advanced Maternal Age Undergoing In Vitro Fertilization

Soluble receptor for advanced glycation end products（s RAGE） can decoy the toxic AGEs and is considered to be a protective factor.This study aimed to evaluate the correlation between intrafollicular s RAGE levels and clinical outcomes in infertile women of young or advanced maternal age（AMA） undergoing in vitro fertilization（IVF）.A total of 62 young women and 62 AMA women who would undergo IVF were included in this prospective study.The intrafollicular s RAGE concentration was measured to determine its association with the number of retrieved oocytes,fertilized oocytes,high-quality embryos or achievement of clinical pregnancy in young and AMA women,respectively.Besides,correlations between sR AGE and age or follicle-stimulating hormone（FSH） were examined.We found that the intrafollicular s RAGE levels were higher in young patients than those in AMA patients,suggesting that the s RAGE levels were inversely correlated with age.In young patients,sR AGE showed no correlation with the number of retrieved oocytes,fertilized oocytes,high-quality embryos or achievement of clinical pregnancy.But it was found that AMA patients with more retrieved oocytes,fertilized oocytes and high-quality embryos demonstrated higher sR AGE levels,which were a prognostic factor for getting clinical pregnancy independent of age or FSH level.In conclusion,the s RAGE levels decrease with age.Elevated intrafollicular s RAGE levels indicate good follicular growth,fertilization and embryonic development,and successful clinical pregnancy in AMA women,while in young women,the role of s RAGE may not be so predominant.

女性不孕中的个体体验、社会境遇与医学干预分析

对17名不孕女性进行了半结构式访谈,并用解释现象学中Colaizzi分析方法对资料进行了分析。结果表明,不孕女性忍受着医学技术介入导致的生理痛苦,以期望治愈“残缺化”的身体,并遭遇内疚、缺憾感等负面心理体验以及家庭关系的失序与重塑。不孕事件与中国传统文化中“传宗接代”“母职”建构等相关联,不仅使女性形成低价值感的身份认同,还会遭遇社会污名,而污名管理中的集体沉默策略又影响了女性的社会生活质量。专业人员可以通过个人叙事表达生命关怀,通过社会政策和组织给予支持。

女性不孕症患者亲密伴侣暴力发生现状及影响因素研究

目的 了解女性不孕症患者亲密伴侣暴力(intimate partner violence,IPV)的发生情况,探讨女性不孕症患者IPV发生的影响因素。方法 对广东省妇幼保健院生殖中心就诊的女性不孕症患者进行问卷调查,包括社会人口学特征,临床资料,社会支持,生育压力及IPV。结果 本次回收343份有效问卷,120例(35.0%)发生过亲密伴侣暴力,其中心理暴力发生率最高111例(32.4%),其次为身体暴力31例(9.0%),伤害暴力22例(6.4%),性暴力发生率最低12例(3.5%)。通过回归分析结果显示配偶抽烟(P=0.004,OR=2.005)以及生育压力(P=0.013,OR=1.043)是女性不孕症患者IPV发生的危险因素,配偶年龄(P=0.022,OR=0.948)及社会支持(P <0.001,OR=0.940)是女性不孕症患者IPV发生的保护因素。结论 女性不孕症患者IPV发生率为35.0%,且受配偶抽烟、生育压力、配偶年龄等因素的影响。

不孕症女性患者良好婚姻调适过程的叙事研究

良好的婚姻调适对不孕症女性患者的压力、不孕症治疗及婚姻生活有积极作用。为深入探索不孕症女性良好的婚姻调适过程,采用质性研究方法,通过目的抽样法对13例不孕症女性患者进行半结构式访谈,运用情境分析法分析资料。以不孕症女性的视角,诠释其良好的婚姻调适是以个体化婚姻背景为基础,女性与配偶在互动中激发的情感为主要驱动力,夫妻在认知、行为、态度层面动态趋同的过程。在不孕症女性患者的护理过程中,应给予专业的知识指导和心理支持,帮助不孕症女性患者通过有效婚姻调适改善婚姻质量,进而降低不孕症带来的压力。

基于列线图建立女性不孕预测模型

目的探讨女性不孕症的危险因素,构建不孕女性个体化风险预测模型。方法选取2018年5月至2021年10月重庆医科大学附属妇女儿童医院及陆军军医大学西南医院收治的自愿参与本研究的辅助生殖助孕人群为观察组,选取同期在重庆医科大学附属妇女儿童医院产科建档的已自然妊娠<12周的孕妇为对照组,最终纳入观察组4276例,对照组3240例。采用问卷填写方式收集数据,采用Logistic回归分析数据并建立列线图预测模型,通过Bootstrap法对模型内部进行验证,采用一致性指数(C-index)及校准曲线评价列线图模型性能。结果年龄、孕前体质量指数、初潮年龄、毒物接触史、烟草摄入、节食、代餐饮食、毒品摄入、近2年痛经、初次性生活年龄、文化程度、家庭人均月收入、近2年月经量均是女性不孕症的影响因素(P<0.05)。建立的预测不孕风险列线图模型具有较好的预测效能[C-index为0.812(95%CI:0.802~0.822),校正后C-index为0.810(95%CI:0.800~0.819)]。结论列线图预测女性不孕症效果良好,提供了预测女性不孕风险可视化工具,具有一定的临床价值。

不孕症女性生育压力与病耻感、归因方式调查及相关性分析

目的:探究不孕症女性生育压力与病耻感、归因方式的相关性。方法:以本院2021年3月-2022年12月就诊的120例不孕症女性为研究对象,通过一般资料问卷、生育相关压力量表(FPI)、羞耻感量表(ISS)、归因方式问卷(ASQ)调查,Pearson相关性分析FPI与ISS、ASQ评分的关系。结果:120例不孕症女性中,FPI总分154.62±23.45分、ISS总分69.44±20.13分,ASQ中正性事件得分120.00±20.75分,负性事件得分105.24±20.28分。不同学历、人均月收入、独生女与否、有无生育史、家庭类型、婚龄、不孕时间及原因不孕症女性FPI总分有差异(P<0.05)。除了拒绝无子女的生活方式性压力外,生育压力其他维度得分、ISS总分均与ISS总分和各维度得分正相关;FPI总分与正性事件得分、宿命感维度得分均负相关,与负性事件得分、普遍维度得分均正相关(P<0.05)。逐步回归分析显示,学历、独生女、生育史、家庭类型、ISS总分、ASQ中正性事件与负性事件是不孕症女性生育压力总分的影响因素(P<0.05)。结论:不孕症女性生育压力较高,与病耻感、归因方式密切相关。

不孕女性夫妻支持应对与心理困扰间的关系:亲密关系的中介效应

目的探讨不孕女性夫妻支持应对、亲密关系对心理困扰的影响,并明确3者之间的关系模型。方法采用便利抽样法,选取2021年8月至2022年2月在温州医科大学附属第二医院生殖中心就诊的不孕女性患者262例作为研究对象。采用一般资料调查表、夫妻支持应对量表、Locke-Wallace婚姻调适量表、凯斯勒心理困扰量表对其进行问卷调查。结果不孕女性的夫妻支持应对对心理困扰具有负向影响(r=-0.540,P<0.01),且夫妻支持应对可通过亲密关系的中介作用影响心理困扰,中介效应占48.47%。结论亲密关系是不孕女性夫妻支持应对与心理困扰间的中介变量,提示研究人员应重视亲密关系的重要作用,在提高夫妻积极应对水平的基础上,关注亲密关系的变化,促进有效沟通,以降低患者的心理困扰水平。

肥胖对助孕前不孕女性心脏功能和结构的影响

目的评估肥胖对助孕前不孕女性心脏功能和结构的影响,为加强临床无症状肥胖患者心脏异常情况的及早识别与干预,为预防妊娠合并心脏病提供参考。方法回顾性分析2016年1月至2018年12月宁夏医科大学总医院生殖医学中心拟行辅助生殖技术(ART)助孕的495例女性患者的临床、生化指标及超声心动图资料。以体质量指数(BMI)将患者分为BMI正常组(n=238)和BMI异常组(n=257),再将BMI异常者分为超重组(n=111)、Ⅰ度肥胖组(n=121)、Ⅱ度肥胖组(n=25),比较BMI正常组与异常组及不同程度肥胖的患者间临床代谢指标、血压与心率、心脏结构参数和功能参数间的差异。结果所有患者助孕前未出现心脏病相关临床症状;BMI异常组基础卵泡刺激素(bFSH)/基础黄体生成素(bLH)和多囊卵巢综合征(PCOS)发生率均高于BMI正常组(P均<0.05)。BMI异常组收缩压、舒张压、空腹血糖、尿酸、天冬氨酸转移酶、丙氨酸转移酶、甘油三酯、总胆固醇、低密度脂蛋白与BMI正常组相比升高,高密度脂蛋白降低(P均<0.05),且肥胖程度越重,改变越明显。BMI异常组与正常组相比左室舒张末期内径(LVEDd)、左室收缩末期内径(LVESd)、主动脉根部内径(AO)均增宽,室间隔厚度(IVST)和左室后壁厚度(LVPWT)增厚,左室质量(LVM)、左室质量指数(LVMI)增加,每搏量(SV)和舒张晚期峰值(A)升高,舒张早期峰值(E)下降,E/A值降低(P均<0.05),并随肥胖程度的加重存在加重趋势。结论肥胖对不孕女性心脏功能和结构及糖脂代谢产生不利影响,且肥胖程度越重,不利影响越大。

屈螺酮炔雌醇片联合坤灵丸对未育女性重复人工流产术后生殖健康的影响

目的探讨屈螺酮炔雌醇片联合坤灵丸对未育女性重复人工流产术后生殖健康的影响。方法选取2016年10月至2017年10月于惠州卫生职业技术学院附属医院行人工流产术的360例未育重复人工流产患者作为研究对象,按照随机数字表法分为优思明组、联合组与对照组,每组120例。优思明组采用屈螺酮炔雌醇片治疗,联合组采用屈螺酮炔雌醇片联合坤灵丸治疗,对照组不服用上述药物,比较3组术后阴道出血时间、阴道分泌物、月经复潮时间、月经恢复情况、子宫内膜厚度、宫颈宫腔粘连、宫内残留、盆腔炎性疾病、点滴出血等情况。结果3组月经复潮时间、月经规律情况比较差异有统计学意义(P<0.05);优思明组、联合组月经复潮时间均短于对照组,联合组月经复潮时间长于优思明组,且联合组月经规律情况优于优思明组、对照组,差异有统计学意义(P<0.05)。优思明组与对照组月经规律情况比较差异无统计学意义。优思明组、联合组阴道出血时间短于对照组,阴道分泌物增多、阴道炎比例均低于对照组,联合组阴道出血时间短于优思明组,差异有统计学意义(P<0.05)。优思明组、联合组术后15d子宫内膜厚度均厚于对照组,宫颈宫腔粘连、宫内残留、盆腔炎性疾病比例均低于对照组,联合组点滴状出血比例低于优思明组、对照组,差异有统计学意义(P<0.05)。结论屈螺酮炔雌醇片联合坤灵丸治疗未育女性重复人工流产术后效果显著,可有效缩短阴道流血事件,恢复患者月经周期,减少阴道分泌物,预防宫腔粘连、盆腔炎和痛经的发,减少未育女性非意愿妊娠发生和再次流产的危害,保留生育功能,值得临床推广应用。