The patient with irregular menstruation went to our Department(Gynecological Department,the Third Affiliated Hospital,Sun Yat-sen University,Guangzhou,China) with the complaint of no pregnancy at the age of 26 in 2007...The patient with irregular menstruation went to our Department(Gynecological Department,the Third Affiliated Hospital,Sun Yat-sen University,Guangzhou,China) with the complaint of no pregnancy at the age of 26 in 2007,and oral contraceptive pills were given when simple type of endometrial hyperplasia was pathologically diagnosed,and then ovulation induction was performed.But after nearly two years from the beginning of infertility treatment,endometrial stromal sarcoma was diagnosed and radical treatment was performed for the young patient.And the relative relationship between endometrial stromal sarcoma and infertility is worth discussing.展开更多
This paper entitled, Theological Moral Appraisal of the Challenges of Infertility Treatments on Christian Families in Africa seeks to explore the effects of infertility treatments on Christian families in Africa. It a...This paper entitled, Theological Moral Appraisal of the Challenges of Infertility Treatments on Christian Families in Africa seeks to explore the effects of infertility treatments on Christian families in Africa. It also attempts to give appraisal of the activities of birth science and issues surrounding it and proffer some ways forward for its better use to enhance the dignity of humans and safeguard our families. This is because many Christian families in Africa have deviated from the commands of the creator in an attempt to find solution to the problem of infertility that has engulfed many families, with the assistant of the modem reproductive technology. Many Christian families in Africa have broken down, the sacramental nature and the dignity of Christian marriage and family have been relegated to the background; and many legal, moral and social problems from these techniques abound. In this situation, some people are calling on the Church to condemn outfight the use of the modem reproductive technology. But this will not solve the problem of infertility which is staring us calling for solution. Some scholars have pointed out that the advent of reproductive technology has come to stay, and that it has already given smiles to many faces and families. This paper employs descriptive, analytical and social methods. The paper argues that Science should not be devoid of Religion. There must be a link between Science and Religion as the creator intended. This will enable the activities in birth science to be in line with the mind of the creator. When this is done as it should, our families and society are spared and the dignity human person respected. Science and Religion are not at war, instead they are meant to serve humans. They are complementary and should always be in partnership to serve humanity.展开更多
In recent years, social research surrounding the consequences of infertility has increasingly focused on the male perspective;however, a gap exists in the understanding of men’s experiences of male infertility treatm...In recent years, social research surrounding the consequences of infertility has increasingly focused on the male perspective;however, a gap exists in the understanding of men’s experiences of male infertility treatment. This review aims to synthesize theexisting evidence concerning the psychological, social, and sexual burden of male infertility treatment on men, as well as patientneeds during clinical care. A systematic search identified 12 studies that are diverse in design, setting, and methods. Psychologicalevaluations have found that urological surgery may have a lasting impact on infertility-specific stress, and treatment failure canlead to feelings of depression, grief, and inadequacy. Men tended to have an avoidant coping mechanism throughout fertilitytreatment, and their self-esteem, relationship quality, and sexual functions can be tied to outcomes of treatment. Partner bonds canbe strengthened by mutual support and enhanced communication;couple separation, however, has been noted as a predominantreason for discontinuing male infertility treatment and may be associated with difficult circumstances surrounding severe maleinfertility. Surgical treatments can affect the sexual functioning of infertile men;however, the impact of testicular sperm extractionoutcomes appears to be psychologically driven whereas the improvements after microsurgical varicocelectomy are only evident inhypogonadal men. Clinically, there is a need for better inclusion, communication, education, and resource provision, to addressreported issues of marginalization and uncertainty in men. Routine psychosocial screening in cases of severe male infertility andfollow-up in cases of surgical treatment failure are likely beneficial.展开更多
Human immature oocytes can be matured in vitro following culture. In vitro maturation(IVM) refers to maturation in culture of immature oocytes at different stages that may or may not have been exposed to short courses...Human immature oocytes can be matured in vitro following culture. In vitro maturation(IVM) refers to maturation in culture of immature oocytes at different stages that may or may not have been exposed to short courses of gonadotropins. The source of immature oocytes is an important feature for the subsequent embryonic development and pregnancy, as well healthy live births. IVM is an efficient treatment that has already achieved significant outcomes in terms of acceptable pregnancies and implantation rates and resulted in the births of several thousands of healthy babies. As the development of IVM treatment continues, an attractive possibility for improving the already successful outcome is to combine a natural cycle in vitro fertilization(IVF) treatment with an immature oocyte retrieval followed by IVM of those immature oocytes.If the treatment processes can be simplified with immature oocyte retrieval, different types of infertile women may be able to take advantage of these treatments. Although IVM treatment is still considered experimental by the society, it is time to reconsider the IVM technological evolution. Mild stimulation IVF combined with IVM treatment represents a viable alternative to the standard treatment, and as data accumulate over time, it may prove to be an optimal first-line treatment approach.展开更多
There is currently no universally accepted unified diagnostic standard for infertility treatment and maternity protection related to polycystic ovary syndrome (PCOS) worldwide,and the treatment options vary greatly.To...There is currently no universally accepted unified diagnostic standard for infertility treatment and maternity protection related to polycystic ovary syndrome (PCOS) worldwide,and the treatment options vary greatly.To improve the understanding of PCOS-related infertility among Chinese obstetricians and gynecologists at all levels for better patient diagnosis and management,we have referred to the international expert recommendations and literature and taken into account the Chinese clinical practice to develop the "Consensus on infertility management and fertility preservation related to PCOS."展开更多
Both fatty acids (FAs) and calcium ions play important roles in contraceptive cyclesvia several systems. Polyunsaturated FAs (PUFAs) act as precursors for prostaglandin production and can alter the expression of numer...Both fatty acids (FAs) and calcium ions play important roles in contraceptive cyclesvia several systems. Polyunsaturated FAs (PUFAs) act as precursors for prostaglandin production and can alter the expression of numerous crucial catalysts that are involved in prostaglandin and steroid digestion. Lipids are essential components of cell membranes. A diet rich in PUFAs enhances sperm motility and viability. It also improves testis development and spermatogenesis in several domesticated animal species. Increased PUFA content in spermatozoa increases plasma membrane fluidity, which is important for fertilization. However, the major drawback of high dietary PUFA intake is that it increases the levels of reactive oxygen species in the body. An increase in reactive oxygen species levels markedly affects fertility. Calcium is an important component that acts as an intra-cellular secondary messenger and plays an important role in some of the physiological processes that occur in male gametes. Some of these processes include spermatogenesis, sperm motility, capacitation, acrosome response, and fusion of gametes. These processes are associated with calcium influx through ion protein channels. Dietary fat intake is associated with increased intestinal calcium absorption. In this review, we discuss the impact of lipids, particularly PUFAs and monounsaturated FAs, and calcium ions on male reproduction, along with their effects on each other.展开更多
文摘The patient with irregular menstruation went to our Department(Gynecological Department,the Third Affiliated Hospital,Sun Yat-sen University,Guangzhou,China) with the complaint of no pregnancy at the age of 26 in 2007,and oral contraceptive pills were given when simple type of endometrial hyperplasia was pathologically diagnosed,and then ovulation induction was performed.But after nearly two years from the beginning of infertility treatment,endometrial stromal sarcoma was diagnosed and radical treatment was performed for the young patient.And the relative relationship between endometrial stromal sarcoma and infertility is worth discussing.
文摘This paper entitled, Theological Moral Appraisal of the Challenges of Infertility Treatments on Christian Families in Africa seeks to explore the effects of infertility treatments on Christian families in Africa. It also attempts to give appraisal of the activities of birth science and issues surrounding it and proffer some ways forward for its better use to enhance the dignity of humans and safeguard our families. This is because many Christian families in Africa have deviated from the commands of the creator in an attempt to find solution to the problem of infertility that has engulfed many families, with the assistant of the modem reproductive technology. Many Christian families in Africa have broken down, the sacramental nature and the dignity of Christian marriage and family have been relegated to the background; and many legal, moral and social problems from these techniques abound. In this situation, some people are calling on the Church to condemn outfight the use of the modem reproductive technology. But this will not solve the problem of infertility which is staring us calling for solution. Some scholars have pointed out that the advent of reproductive technology has come to stay, and that it has already given smiles to many faces and families. This paper employs descriptive, analytical and social methods. The paper argues that Science should not be devoid of Religion. There must be a link between Science and Religion as the creator intended. This will enable the activities in birth science to be in line with the mind of the creator. When this is done as it should, our families and society are spared and the dignity human person respected. Science and Religion are not at war, instead they are meant to serve humans. They are complementary and should always be in partnership to serve humanity.
文摘In recent years, social research surrounding the consequences of infertility has increasingly focused on the male perspective;however, a gap exists in the understanding of men’s experiences of male infertility treatment. This review aims to synthesize theexisting evidence concerning the psychological, social, and sexual burden of male infertility treatment on men, as well as patientneeds during clinical care. A systematic search identified 12 studies that are diverse in design, setting, and methods. Psychologicalevaluations have found that urological surgery may have a lasting impact on infertility-specific stress, and treatment failure canlead to feelings of depression, grief, and inadequacy. Men tended to have an avoidant coping mechanism throughout fertilitytreatment, and their self-esteem, relationship quality, and sexual functions can be tied to outcomes of treatment. Partner bonds canbe strengthened by mutual support and enhanced communication;couple separation, however, has been noted as a predominantreason for discontinuing male infertility treatment and may be associated with difficult circumstances surrounding severe maleinfertility. Surgical treatments can affect the sexual functioning of infertile men;however, the impact of testicular sperm extractionoutcomes appears to be psychologically driven whereas the improvements after microsurgical varicocelectomy are only evident inhypogonadal men. Clinically, there is a need for better inclusion, communication, education, and resource provision, to addressreported issues of marginalization and uncertainty in men. Routine psychosocial screening in cases of severe male infertility andfollow-up in cases of surgical treatment failure are likely beneficial.
文摘Human immature oocytes can be matured in vitro following culture. In vitro maturation(IVM) refers to maturation in culture of immature oocytes at different stages that may or may not have been exposed to short courses of gonadotropins. The source of immature oocytes is an important feature for the subsequent embryonic development and pregnancy, as well healthy live births. IVM is an efficient treatment that has already achieved significant outcomes in terms of acceptable pregnancies and implantation rates and resulted in the births of several thousands of healthy babies. As the development of IVM treatment continues, an attractive possibility for improving the already successful outcome is to combine a natural cycle in vitro fertilization(IVF) treatment with an immature oocyte retrieval followed by IVM of those immature oocytes.If the treatment processes can be simplified with immature oocyte retrieval, different types of infertile women may be able to take advantage of these treatments. Although IVM treatment is still considered experimental by the society, it is time to reconsider the IVM technological evolution. Mild stimulation IVF combined with IVM treatment represents a viable alternative to the standard treatment, and as data accumulate over time, it may prove to be an optimal first-line treatment approach.
文摘There is currently no universally accepted unified diagnostic standard for infertility treatment and maternity protection related to polycystic ovary syndrome (PCOS) worldwide,and the treatment options vary greatly.To improve the understanding of PCOS-related infertility among Chinese obstetricians and gynecologists at all levels for better patient diagnosis and management,we have referred to the international expert recommendations and literature and taken into account the Chinese clinical practice to develop the "Consensus on infertility management and fertility preservation related to PCOS."
基金The first author Taniya Naz is funded by University Grants Commission Junior Research Fellowship(UGC-RF)and the lab expenses including second author's fellowship(JRF)is funded by the Science and Engineering Research Board-Start up Research Grant(SERB-SRG)(Grant No.:SRG/2019/000501)of Department of Science and Technology,New Delhi,India.
文摘Both fatty acids (FAs) and calcium ions play important roles in contraceptive cyclesvia several systems. Polyunsaturated FAs (PUFAs) act as precursors for prostaglandin production and can alter the expression of numerous crucial catalysts that are involved in prostaglandin and steroid digestion. Lipids are essential components of cell membranes. A diet rich in PUFAs enhances sperm motility and viability. It also improves testis development and spermatogenesis in several domesticated animal species. Increased PUFA content in spermatozoa increases plasma membrane fluidity, which is important for fertilization. However, the major drawback of high dietary PUFA intake is that it increases the levels of reactive oxygen species in the body. An increase in reactive oxygen species levels markedly affects fertility. Calcium is an important component that acts as an intra-cellular secondary messenger and plays an important role in some of the physiological processes that occur in male gametes. Some of these processes include spermatogenesis, sperm motility, capacitation, acrosome response, and fusion of gametes. These processes are associated with calcium influx through ion protein channels. Dietary fat intake is associated with increased intestinal calcium absorption. In this review, we discuss the impact of lipids, particularly PUFAs and monounsaturated FAs, and calcium ions on male reproduction, along with their effects on each other.