In this paper,we mainly study the propagation properties of a nonlocal dispersal predator-prey system in a shifting environment.It is known that Choi et al.[J Differ Equ,2021,302:807-853]studied the persistence or ext...In this paper,we mainly study the propagation properties of a nonlocal dispersal predator-prey system in a shifting environment.It is known that Choi et al.[J Differ Equ,2021,302:807-853]studied the persistence or extinction of the prey and of the predator separately in various moving frames.In particular,they achieved a complete picture in the local diffusion case.However,the question of the persistence of the prey and of the predator in some intermediate moving frames in the nonlocal diffusion case was left open in Choi et al.'s paper.By using some a prior estimates,the Arzelà-Ascoli theorem and a diagonal extraction process,we can extend and improve the main results of Choi et al.to achieve a complete picture in the nonlocal diffusion case.展开更多
This study investigates the relationship between the persistence and the zonal scale of atmospheric dipolar modes(DMs). Results from the daily data of ERA5 and the long-term output of an idealized atmospheric model sh...This study investigates the relationship between the persistence and the zonal scale of atmospheric dipolar modes(DMs). Results from the daily data of ERA5 and the long-term output of an idealized atmospheric model show that the atmospheric DMs with a broader(narrower) zonal scale dipolar structure possess a longer(shorter) persistence. A detailed vorticity budget analysis indicates that the persistence of a hemispheric-scale DM(1/1 DM) and a regional or sectoral DM(1/8 DM) in the model both largely rely on the persistence of the nonlinear eddy forcing. Linear terms can indirectly reduce the persistence of the anomalous nonlinear eddy forcing in a 1/8 DM by modifying the baroclinicity via the arousal of anomalous vertical motions. Therefore, the atmospheric DMs with a broader(narrower) zonal scale possess a longer(shorter) persistence because the effects of the linear terms are less(more) pronounced when the atmospheric DMs have better(worse) zonal symmetry. Further analyses show that the positive eddy feedback effect is weak or even absent in a 1/8DM and the high-frequency eddy forcing acts more like a concomitant phenomenon rather than a leading driving factor for a 1/8 DM. Thus, the hemispheric-scale DM and the regional or sectoral DMs are different, not only in their persistence but also in their dynamics.展开更多
Fecal coliform bacteria such as Escherichia coli (E. coli) are one of the main sources of groundwater pollution. An assessment of the transport and Persistence of E. coli in poultry litter amended Decatur silty Clay s...Fecal coliform bacteria such as Escherichia coli (E. coli) are one of the main sources of groundwater pollution. An assessment of the transport and Persistence of E. coli in poultry litter amended Decatur silty Clay soil and Hartsells Sandy soil was conducted using soil columns and simulated groundwater leaching. Enumeration of initial E. coli was determined to range from 2.851 × 10<sup>3</sup> to 3.044 × 10<sup>3</sup> CFU per gram of soil. These results have been used in a batch study to determine the persistence rate of E. coli in Decatur silty Clay soil and Hartsells Sandy soil. Results prove that E. coli survival growth rate increases for clay soil later than and at a higher rate than sandy soil. The column study has determined that E. coli was transported at a rate of 3.7 × 10<sup>6</sup><sup> </sup>CFU for Decatur silty loam and 6.3 × 10<sup>6</sup><sup> </sup>CFU for Hartsells sandy per gram of soil. Further, linear regression analysis predictions show higher porosity and soil moisture content affect transport, and Hartsells sandy soil has higher transport of E. coli due to its higher porosity and lower volumetric water content.展开更多
We investigate the characteristics and mechanisms of persistent wet–cold events(PWCEs)with different types of coldair paths.Results show that the cumulative single-station frequency of the PWCEs in the western part o...We investigate the characteristics and mechanisms of persistent wet–cold events(PWCEs)with different types of coldair paths.Results show that the cumulative single-station frequency of the PWCEs in the western part of South China is higher than that in the eastern part.The pattern of single-station frequency of the PWCEs are“Yangtze River(YR)uniform”and“east–west inverse”.The YR uniform pattern is the dominant mode,so we focus on this pattern.The cold-air paths for PWCEs of the YR uniform pattern are divided into three types—namely,the west,northwest and north types—among which the west type accounts for the largest proportion.The differences in atmospheric circulation of the PWCEs under the three types of paths are obvious.The thermal inversion layer in the lower troposphere is favorable for precipitation during the PWCEs.The positive water vapor budget for the three types of PWCEs mainly appears at the southern boundary.展开更多
●AIM:To introduce the macular hole(MH)hydromassage technique as a potentially beneficial approach for the treatment of large or persistent MH.●METHODS:This retrospective observational case series comprised 16 consec...●AIM:To introduce the macular hole(MH)hydromassage technique as a potentially beneficial approach for the treatment of large or persistent MH.●METHODS:This retrospective observational case series comprised 16 consecutive patients(17 eyes)diagnosed with MH.Inclusion criteria involved a hole aperture diameter larger than 600μm or the presence of an unclosed MH larger than 600μm following the previous vitrectomy.Standard MH repair procedures were administered in all cases,involving the manipulation and aspiration of the hole margin through the application of water flow with a soft-tip flute needle.A comprehensive assessment was conducted for each case before and after surgery,and optical coherence tomography(OCT)images were captured at every follow-up point.●RESULTS:The mean preoperative aperture diameter was 747±156μm(range 611-1180μm),with a mean base diameter of 1390±435μm(range 578-2220μm).Following surgery,all cases achieved complete anatomical closure of MH,with 13 cases(76.5%)exhibiting type 1 closure and 4 cases(23.5%)demonstrating type 2 closure.No significant differences were observed in the preoperative OCT variables between the two closure types.Eyes with type 1 closure showed a significantly improved visual acuity(0.70±0.10,range 0.50-0.80)compared to those with type 2 closure(0.90±0.12,range 0.80-1.00,P=0.014).●CONCLUSION:The MH hydromassage technique demonstrates promising results,achieving acceptable closure rates in cases of large or persistent MH.This technique may serve as an effective adjunctive maneuver during challenging MH surgery.展开更多
BACKGROUND Intraoperative persistent hypotension(IPH)during pancreaticoduodenectomy(PD)is linked to adverse postoperative outcomes,yet its risk factors remain unclear.AIM To clarify the risk factors associated with IP...BACKGROUND Intraoperative persistent hypotension(IPH)during pancreaticoduodenectomy(PD)is linked to adverse postoperative outcomes,yet its risk factors remain unclear.AIM To clarify the risk factors associated with IPH during PD,ensuring patient safety in the perioperative period.METHODS A retrospective analysis of patient records from January 2018 to December 2022 at the First Affiliated Hospital of Nanjing Medical University identified factors associated with IPH in PD.These factors included age,gender,body mass index,American Society of Anesthesiologists classification,comorbidities,medication history,operation duration,fluid balance,blood loss,urine output,and blood gas parameters.IPH was defined as sustained mean arterial pressure<65 mmHg,requiring prolonged deoxyepinephrine infusion for>30 min despite additional deoxyepinephrine and fluid treatments.RESULTS Among 1596 PD patients,661(41.42%)experienced IPH.Multivariate logistic regression identified key risk factors:increased age[odds ratio(OR):1.20 per decade,95%confidence interval(CI):1.08-1.33](P<0.001),longer surgery duration(OR:1.15 per additional hour,95%CI:1.05-1.26)(P<0.01),and greater blood loss(OR:1.18 per 250-mL increment,95%CI:1.06-1.32)(P<0.01).A novel finding was the association of arterial blood Ca^(2+)<1.05 mmol/L with IPH(OR:2.03,95%CI:1.65-2.50)(P<0.001).CONCLUSION IPH during PD is independently associated with older age,prolonged surgery,increased blood loss,and lower plasma Ca^(2+).展开更多
BACKGROUND The neutrophil-to-lymphocyte ratio(NLR)and platelet-to-lymphocyte ratio(PLR)are novel inflammatory indicators that can be used to predict the severity and prognosis of various diseases.We categorize acute p...BACKGROUND The neutrophil-to-lymphocyte ratio(NLR)and platelet-to-lymphocyte ratio(PLR)are novel inflammatory indicators that can be used to predict the severity and prognosis of various diseases.We categorize acute pancreatitis by etiology into acute biliary pancreatitis(ABP)and hypertriglyceridemia-induced acute pancreatitis(HTGP).AIM To investigate the clinical significance of NLR and PLR in assessing persistent organ failure(POF)in HTGP and ABP.METHODS A total of 1450 patients diagnosed with acute pancreatitis(AP)for the first time at Shanxi Bethune Hospital between January 2012 and January 2023 were enrolled.The patients were categorized into two groups according to the etiology of AP:ABP in 530 patients and HTGP in 241 patients.We collected and compared the clinical data of the patients,including NLR,PLR,and AP prognostic scoring systems,within 48 h of hospital admission.RESULTS The NLR(9.1 vs 6.9,P<0.001)and PLR(203.1 vs 160.5,P<0.001)were significantly higher in the ABP group than in the HTGP group.In the HTGP group,both NLR and PLR were significantly increased in patients with severe AP and those with a SOFA score≥3.Likewise,in the ABP group,NLR and PLR were significantly elevated in patients with severe AP,modified computed tomography severity index score≥4,Japanese Severity Score≥3,and modified Marshall score≥2.Moreover,NLR and PLR showed predictive value for the development of POF in both the ABP and HTGP groups.CONCLUSION NLR and PLR vary between ABP and HTGP,are strongly associated with AP prognostic scoring systems,and have predictive potential for the occurrence of POF in both ABP and HTGP.展开更多
BACKGROUNDAlmost all cases of cervical cancer can be attributed to human papillomavirus(HPV) infection. The loop electrosurgical excision procedure (LEEP) is widelyused to treat HPV-mediated disease;thus, cervical can...BACKGROUNDAlmost all cases of cervical cancer can be attributed to human papillomavirus(HPV) infection. The loop electrosurgical excision procedure (LEEP) is widelyused to treat HPV-mediated disease;thus, cervical cancer is highly preventable.However, LEEP does not necessarily clear HPV rapidly and may affect theaccuracy of the results of ThinPrep cytology test (TCT) and cervical biopsy due tothe formation of cervical scars.CASE SUMMARYA 40-year-old woman underwent LEEP for cervical intraepithelial neoplasia grade1 approximately 10 years ago. Subsequent standard cervical cancer screeningsuggested persistent HPV-52 infection, but TCT results were negative. Cervicalbiopsy under colposcopy was performed thrice over a 10-year period, yieldingnegative pathology results. She developed abnormal vaginal bleeding after sexualactivity, persisting for approximately 1 year, and underwent hysteroscopy in ourhospital. Histopathologic evaluation confirmed adenocarcinoma in situ of theuterine cervix.CONCLUSIONPatients with long-term persistent, high-risk HPV infection and negative pathologyresults of cervical biopsy after LEEP are at risk of cervical cancer. Hysteroscopicresection of cervical canal tissue is recommended as a supplement tocervical biopsy because it helps define the lesion site and may yield a pathologicdiagnosis.展开更多
Chikungunya fever(CF)is caused by an arbovirus whose manifestations are extremely diverse,and it has evolved with significant severity in recent years.The clinical signs triggered by the Chikungunya virus are similar ...Chikungunya fever(CF)is caused by an arbovirus whose manifestations are extremely diverse,and it has evolved with significant severity in recent years.The clinical signs triggered by the Chikungunya virus are similar to those of other arboviruses.Generally,fever starts abruptly and reaches high levels,followed by severe polyarthralgia and myalgia,as well as an erythematous or petechial maculopapular rash,varying in severity and extent.Around 40%to 60%of affected individuals report persistent arthralgia,which can last from months to years.The symptoms of CF mainly represent the tissue tropism of the virus rather than the immunopathogenesis triggered by the host's immune system.The main mechanisms associated with arthralgia have been linked to an increase in T helper type 17 cells and a consequent increase in receptor activator of nuclear factor kappa-Βligand and bone resorption.This review suggests that persistent arthralgia results from the presence of viral antigens post-infection and the constant activation of signaling lymphocytic activation molecule family member 7 in synovial macrophages,leading to local infiltration of CD4+T cells,which sustains the inflammatory process in the joints through the secretion of pro-inflammatory cytokines.The term"long chikungunya"was used in this review to refer to persistent arthralgia since,due to its manifestation over long periods after the end of the viral infection,this clinical condition seems to be characterized more as a sequel than as a symptom,given that there is no active infection involved.展开更多
A three-species ratio-dependent predator-prey diffusion model with time delays is investigated. It is shown that the system is uniformly persistent under some appropriate conditions, and sufficient conditions axe obta...A three-species ratio-dependent predator-prey diffusion model with time delays is investigated. It is shown that the system is uniformly persistent under some appropriate conditions, and sufficient conditions axe obtained for the global stability of the positive equilibrium of the system.展开更多
A non-autonomous competing system is investigated in this paper,where the species x can diffuse between two patches of a heterogeneous environment with barriers between patches,but for species y,the diffusion does not...A non-autonomous competing system is investigated in this paper,where the species x can diffuse between two patches of a heterogeneous environment with barriers between patches,but for species y,the diffusion does not involve a barrier between patches,further it is assumed that all the parameters are time dependent.It is shown that the system can be made persistent under some appropriate conditions.Moreover,sufficient conditions that guarantee the existence of a unique positive periodic orbit which is globally asymptotic stable are derived.展开更多
In this article, the unique continuation and persistence properties of solutions of the 2-component Degasperis-Procesi equations are discussed. It is shown that strong solutions of the 2-component Degasperis-Procesi e...In this article, the unique continuation and persistence properties of solutions of the 2-component Degasperis-Procesi equations are discussed. It is shown that strong solutions of the 2-component Degasperis-Procesi equations, initially decaying exponentially together with its spacial derivative, must be identically equal to zero if they also decay exponentially at a later time.展开更多
This paper deals with the global dynamical behaviors of the positive solutions for a parabolic type ratio-dependent predator-prey system with a crowding term in the prey equation, where it is assumed that the coeffici...This paper deals with the global dynamical behaviors of the positive solutions for a parabolic type ratio-dependent predator-prey system with a crowding term in the prey equation, where it is assumed that the coefficient of the functional response is less than the coefficient of the intrinsic growth rates of the prey species. We demonstrated some special dynamical behaviors of the positive solutions of this system which the persistence of the coexistence of two species can be obtained when the crowding region in the prey equation only is designed suitably. Furthermore, we can obtain that under some conditions, the unique positive steady state solution of the system is globally asymptotically stable.展开更多
The predator-prey model for three species in which the right-hand sides are nonperiodic functions in time were considered, It's proved that the model is persistent under appropriate conditions.
The aims of this study was to investigate the persistence and the growth of culturable bacterial indicators (CBI) including total coliforms (TC) and faecal coliforms represented by Escherichia coli, enterococcus ...The aims of this study was to investigate the persistence and the growth of culturable bacterial indicators (CBI) including total coliforms (TC) and faecal coliforms represented by Escherichia coli, enterococcus (ENT), and aerobic mesophilic bacteria (AMB) in the surface sediments and the water column of Vidy Bay fLake Geneva, City of Lausanne, Switzerland). The study was carded out for 60 d using microcosms containing Sewage Treatment Plant (STP) effluent and nonsterile water without CBI, as well as contaminated and non-contaminated sediments. The effects of water temperature and of organic matter associated with sediments on the survival of CBI in the sediments and the water column were observed. The number of CBI colonies in the contaminated sediments of Vidy Bay and in the STP effluent was almost identical in the order of 10^5-10^7, 10^4-10^6, 10^5-10^5, and 10^4-10^7 CFU/100 g sediment or/100 mL water for TC, E. coli, ENT, and AMB respectively. A degradation of CBI was observed in the sediments where organic mater content was low and in the water column at a temperature of 10℃ after 5 d of experimentation. In addition, a growth of CBI was observed in the sediment which is rich in organic matter at 20℃. The results of this study indicate: (1) the higher concentrations of the CBI observed in different points in the water column of Vidy Bay may not be explained only by the recent contribution of the three potential sources of the Bay contamination including STP and the Chamberonne and Flon Rivers, but also by the persistence, removal from sediment and multiplication of CBI in the sediment and water column; (2) the sediment of Vidy Bay constitute a reservoir of CBI and can even support their growth; and (3) the CBI not only survive in sediments, but also can be remobilized and increased in the water column, therefore, it become a permanent microbiological pollution in Vidy Bay.展开更多
A stochastic logistic model with delays and impulsive perturbation is proposed and investigated. Sufficient conditions for extinction are established as well as nonpersistence in the mean, weak persistence and stochas...A stochastic logistic model with delays and impulsive perturbation is proposed and investigated. Sufficient conditions for extinction are established as well as nonpersistence in the mean, weak persistence and stochastic permanence. The threshold between weak persistence and extinction is obtained. Furthermore, the theoretical analysis results are also derivated with the help of numerical simulations.展开更多
The persistence barrier of sea surface temperature anomalies (SSTAs) in the North Pacific was investigated and compared with the ENSO spring persistence barrier. The results show that SSTAs in the central western No...The persistence barrier of sea surface temperature anomalies (SSTAs) in the North Pacific was investigated and compared with the ENSO spring persistence barrier. The results show that SSTAs in the central western North Pacific (CWNP) have a persistence barrier in summer: the persistence of SSTAs in the CWNP shows a significant decline in summer regardless of the starting month. Mechanisms of the summer persistence barrier in the CWNP are different from those of the spring persistence barrier of SSTAs in the central and eastern equatorial Pacific. The phase locking of SSTAs to the annual cycle does not explain the CWNP summer persistence barrier. Remote ENSO forcing has little linear influence on the CWNP summer persistence barrier, compared with local upper-ocean process and atmospheric forcing in the North Pacific. Starting in wintertime, SSTAs extend down to the deep winter mixed layer then become sequestered beneath the shallow summer mixed layer, which is decoupled from the surface layer. Thus, wintertime SSTAs do not persist through the following summer. Starting in summertime, persistence of summer SSTAs until autumn can be explained by the atmospheric forcing through a positive SSTAs-cloud/radiation feedback mechanism because the shallow summertime mixed layer is decoupled from the temperature anomalies at depth, then the following autumnwinter-spring, SSTAs persist. Thus, summer SSTAs in the CWNP have a long persistence, showing a significant decline in the following summer. In this way, SSTAs in the CWNP show a persistence barrier in summer regardless of the starting month.展开更多
Human oncogenic viruses are defined as necessary but not sufficient to initiate cancer. Experimental evidence suggests that the oncogenic potential of a virus is effective in cells that have already accumulated a numb...Human oncogenic viruses are defined as necessary but not sufficient to initiate cancer. Experimental evidence suggests that the oncogenic potential of a virus is effective in cells that have already accumulated a number of genetic mutations leading to cell cycle deregulation. Current models for viral driven oncogenesis cannot explain why tumor development in carriers of tumorigenic viruses is a very rare event, occurring decades after virus infection. Considering that viruses are mutagenic agents per se and human oncogenic viruses additionally establish latent and persistent infections, we attempt here to provide a general mechanism of tumor initiation both for RNA and DNA viruses, suggesting viruses could be both necessary and sufficient in triggering human tumorigenesis initiation. Upon reviewing emerging evidence on the ability of viruses to induce DNA damage while subverting the DNA damage response and inducing epigenetic disturbance in the infected cell, we hypothesize a general, albeit inefficient hit and rest mechanism by which viruses may produce a limited reservoir of cells harboring permanent damage that would be initiated when the vi-rus first hits the cell, before latency is established. Cells surviving virus generated damage would consequently become more sensitive to further damage mediated by the otherwise insufficient transforming activity of virus products expressed in latency, or upon episodic reactivations(viral persistence). Cells with a combination of genetic and epigenetic damage leading to a cancerous phenotype would emerge very rarely, as the probability of such an occurrence would be dependent on severity and frequency of consecutive hit and rest cycles due to viral reinfections and reactivations.展开更多
M 0.2Ca 0.8TiO 3∶Pr 3+(M=Mg 2+, Sr 2+, Ba 2+, Zn 2+) long persistence red phosphors were prepared by solid state reaction. The influence of the partially replacing Ca 2+ in CaTiO 3 with Mg 2+, Sr 2+, ...M 0.2Ca 0.8TiO 3∶Pr 3+(M=Mg 2+, Sr 2+, Ba 2+, Zn 2+) long persistence red phosphors were prepared by solid state reaction. The influence of the partially replacing Ca 2+ in CaTiO 3 with Mg 2+, Sr 2+, Ba 2+, Zn 2+ on the excitation spectra, the emission spectra and the long persistence properties were studied. The results suggest that certain quantity of Mg 2+, Sr 2+, Ba 2+, Zn 2+ which partially replace Ca 2+ can enhance the luminescent intensity and prolong the afterglow persistence of the samples. The intensity of Mg 0.2Ca 0.8TiO 3∶Pr 3+ is above all of the samples. Take Mg 0.2Ca 0.8TiO 3∶Pr 3+ as the basic sample, the influence of Pr 3+ concentrations (C(Pr 3+)) on the long afterglow properties were also studied. The results suggest that when the C(Pr 3+) is 0.10% (mol fraction) the intensity of the sample is the highest. The excitation spectra of all these samples show broad band spectra ranging from 300~500 nm peaking at about 342 nm. The emission spectra also exhibit a broad band peaking at 613 nm (CaTiO 3∶Pr 3+ is 612 nm). XRD research indicates that the crystalline phases change due to the replacement of divalent metal ions.The research on the thermoluminescence spectra of Mg 0.2Ca 0.8TiO 3∶Pr 3+ indicates that the peak is at 107.35 ℃ and the depth of the trap energy is about 0 852 eV.展开更多
基金supported by the National Natural Science Foundation of China(12171039,12271044)。
文摘In this paper,we mainly study the propagation properties of a nonlocal dispersal predator-prey system in a shifting environment.It is known that Choi et al.[J Differ Equ,2021,302:807-853]studied the persistence or extinction of the prey and of the predator separately in various moving frames.In particular,they achieved a complete picture in the local diffusion case.However,the question of the persistence of the prey and of the predator in some intermediate moving frames in the nonlocal diffusion case was left open in Choi et al.'s paper.By using some a prior estimates,the Arzelà-Ascoli theorem and a diagonal extraction process,we can extend and improve the main results of Choi et al.to achieve a complete picture in the nonlocal diffusion case.
基金supported by the National Key Research and Development Program of China (mechanism for disaster-causing Northeast cold vortex and key technologies for its forecast, Grant No.2023YFC3007700)。
文摘This study investigates the relationship between the persistence and the zonal scale of atmospheric dipolar modes(DMs). Results from the daily data of ERA5 and the long-term output of an idealized atmospheric model show that the atmospheric DMs with a broader(narrower) zonal scale dipolar structure possess a longer(shorter) persistence. A detailed vorticity budget analysis indicates that the persistence of a hemispheric-scale DM(1/1 DM) and a regional or sectoral DM(1/8 DM) in the model both largely rely on the persistence of the nonlinear eddy forcing. Linear terms can indirectly reduce the persistence of the anomalous nonlinear eddy forcing in a 1/8 DM by modifying the baroclinicity via the arousal of anomalous vertical motions. Therefore, the atmospheric DMs with a broader(narrower) zonal scale possess a longer(shorter) persistence because the effects of the linear terms are less(more) pronounced when the atmospheric DMs have better(worse) zonal symmetry. Further analyses show that the positive eddy feedback effect is weak or even absent in a 1/8DM and the high-frequency eddy forcing acts more like a concomitant phenomenon rather than a leading driving factor for a 1/8 DM. Thus, the hemispheric-scale DM and the regional or sectoral DMs are different, not only in their persistence but also in their dynamics.
文摘Fecal coliform bacteria such as Escherichia coli (E. coli) are one of the main sources of groundwater pollution. An assessment of the transport and Persistence of E. coli in poultry litter amended Decatur silty Clay soil and Hartsells Sandy soil was conducted using soil columns and simulated groundwater leaching. Enumeration of initial E. coli was determined to range from 2.851 × 10<sup>3</sup> to 3.044 × 10<sup>3</sup> CFU per gram of soil. These results have been used in a batch study to determine the persistence rate of E. coli in Decatur silty Clay soil and Hartsells Sandy soil. Results prove that E. coli survival growth rate increases for clay soil later than and at a higher rate than sandy soil. The column study has determined that E. coli was transported at a rate of 3.7 × 10<sup>6</sup><sup> </sup>CFU for Decatur silty loam and 6.3 × 10<sup>6</sup><sup> </sup>CFU for Hartsells sandy per gram of soil. Further, linear regression analysis predictions show higher porosity and soil moisture content affect transport, and Hartsells sandy soil has higher transport of E. coli due to its higher porosity and lower volumetric water content.
基金supported by the National Key Research and Development Program of China (Grant No. 2018YFC1505602)the National Natural Science Foundation of China (Grant No. 41705055)+2 种基金the Graduate Innovation Project of Jiangsu Province (Grant No. CXZZ11_0485)the Creative Teams of Jiangsu Qinglan Projectthe Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
文摘We investigate the characteristics and mechanisms of persistent wet–cold events(PWCEs)with different types of coldair paths.Results show that the cumulative single-station frequency of the PWCEs in the western part of South China is higher than that in the eastern part.The pattern of single-station frequency of the PWCEs are“Yangtze River(YR)uniform”and“east–west inverse”.The YR uniform pattern is the dominant mode,so we focus on this pattern.The cold-air paths for PWCEs of the YR uniform pattern are divided into three types—namely,the west,northwest and north types—among which the west type accounts for the largest proportion.The differences in atmospheric circulation of the PWCEs under the three types of paths are obvious.The thermal inversion layer in the lower troposphere is favorable for precipitation during the PWCEs.The positive water vapor budget for the three types of PWCEs mainly appears at the southern boundary.
基金Supported by National Natural Science Foundation of China(NSFC)fund(No.81970815).
文摘●AIM:To introduce the macular hole(MH)hydromassage technique as a potentially beneficial approach for the treatment of large or persistent MH.●METHODS:This retrospective observational case series comprised 16 consecutive patients(17 eyes)diagnosed with MH.Inclusion criteria involved a hole aperture diameter larger than 600μm or the presence of an unclosed MH larger than 600μm following the previous vitrectomy.Standard MH repair procedures were administered in all cases,involving the manipulation and aspiration of the hole margin through the application of water flow with a soft-tip flute needle.A comprehensive assessment was conducted for each case before and after surgery,and optical coherence tomography(OCT)images were captured at every follow-up point.●RESULTS:The mean preoperative aperture diameter was 747±156μm(range 611-1180μm),with a mean base diameter of 1390±435μm(range 578-2220μm).Following surgery,all cases achieved complete anatomical closure of MH,with 13 cases(76.5%)exhibiting type 1 closure and 4 cases(23.5%)demonstrating type 2 closure.No significant differences were observed in the preoperative OCT variables between the two closure types.Eyes with type 1 closure showed a significantly improved visual acuity(0.70±0.10,range 0.50-0.80)compared to those with type 2 closure(0.90±0.12,range 0.80-1.00,P=0.014).●CONCLUSION:The MH hydromassage technique demonstrates promising results,achieving acceptable closure rates in cases of large or persistent MH.This technique may serve as an effective adjunctive maneuver during challenging MH surgery.
文摘BACKGROUND Intraoperative persistent hypotension(IPH)during pancreaticoduodenectomy(PD)is linked to adverse postoperative outcomes,yet its risk factors remain unclear.AIM To clarify the risk factors associated with IPH during PD,ensuring patient safety in the perioperative period.METHODS A retrospective analysis of patient records from January 2018 to December 2022 at the First Affiliated Hospital of Nanjing Medical University identified factors associated with IPH in PD.These factors included age,gender,body mass index,American Society of Anesthesiologists classification,comorbidities,medication history,operation duration,fluid balance,blood loss,urine output,and blood gas parameters.IPH was defined as sustained mean arterial pressure<65 mmHg,requiring prolonged deoxyepinephrine infusion for>30 min despite additional deoxyepinephrine and fluid treatments.RESULTS Among 1596 PD patients,661(41.42%)experienced IPH.Multivariate logistic regression identified key risk factors:increased age[odds ratio(OR):1.20 per decade,95%confidence interval(CI):1.08-1.33](P<0.001),longer surgery duration(OR:1.15 per additional hour,95%CI:1.05-1.26)(P<0.01),and greater blood loss(OR:1.18 per 250-mL increment,95%CI:1.06-1.32)(P<0.01).A novel finding was the association of arterial blood Ca^(2+)<1.05 mmol/L with IPH(OR:2.03,95%CI:1.65-2.50)(P<0.001).CONCLUSION IPH during PD is independently associated with older age,prolonged surgery,increased blood loss,and lower plasma Ca^(2+).
基金Supported by Shanxi Province“136”Revitalization Medical Project Construction Funds,No.2019XY004.
文摘BACKGROUND The neutrophil-to-lymphocyte ratio(NLR)and platelet-to-lymphocyte ratio(PLR)are novel inflammatory indicators that can be used to predict the severity and prognosis of various diseases.We categorize acute pancreatitis by etiology into acute biliary pancreatitis(ABP)and hypertriglyceridemia-induced acute pancreatitis(HTGP).AIM To investigate the clinical significance of NLR and PLR in assessing persistent organ failure(POF)in HTGP and ABP.METHODS A total of 1450 patients diagnosed with acute pancreatitis(AP)for the first time at Shanxi Bethune Hospital between January 2012 and January 2023 were enrolled.The patients were categorized into two groups according to the etiology of AP:ABP in 530 patients and HTGP in 241 patients.We collected and compared the clinical data of the patients,including NLR,PLR,and AP prognostic scoring systems,within 48 h of hospital admission.RESULTS The NLR(9.1 vs 6.9,P<0.001)and PLR(203.1 vs 160.5,P<0.001)were significantly higher in the ABP group than in the HTGP group.In the HTGP group,both NLR and PLR were significantly increased in patients with severe AP and those with a SOFA score≥3.Likewise,in the ABP group,NLR and PLR were significantly elevated in patients with severe AP,modified computed tomography severity index score≥4,Japanese Severity Score≥3,and modified Marshall score≥2.Moreover,NLR and PLR showed predictive value for the development of POF in both the ABP and HTGP groups.CONCLUSION NLR and PLR vary between ABP and HTGP,are strongly associated with AP prognostic scoring systems,and have predictive potential for the occurrence of POF in both ABP and HTGP.
基金2024 Natural Science Joint Foundation of Zhejiang Province,No.LBY24H040007.
文摘BACKGROUNDAlmost all cases of cervical cancer can be attributed to human papillomavirus(HPV) infection. The loop electrosurgical excision procedure (LEEP) is widelyused to treat HPV-mediated disease;thus, cervical cancer is highly preventable.However, LEEP does not necessarily clear HPV rapidly and may affect theaccuracy of the results of ThinPrep cytology test (TCT) and cervical biopsy due tothe formation of cervical scars.CASE SUMMARYA 40-year-old woman underwent LEEP for cervical intraepithelial neoplasia grade1 approximately 10 years ago. Subsequent standard cervical cancer screeningsuggested persistent HPV-52 infection, but TCT results were negative. Cervicalbiopsy under colposcopy was performed thrice over a 10-year period, yieldingnegative pathology results. She developed abnormal vaginal bleeding after sexualactivity, persisting for approximately 1 year, and underwent hysteroscopy in ourhospital. Histopathologic evaluation confirmed adenocarcinoma in situ of theuterine cervix.CONCLUSIONPatients with long-term persistent, high-risk HPV infection and negative pathologyresults of cervical biopsy after LEEP are at risk of cervical cancer. Hysteroscopicresection of cervical canal tissue is recommended as a supplement tocervical biopsy because it helps define the lesion site and may yield a pathologicdiagnosis.
文摘Chikungunya fever(CF)is caused by an arbovirus whose manifestations are extremely diverse,and it has evolved with significant severity in recent years.The clinical signs triggered by the Chikungunya virus are similar to those of other arboviruses.Generally,fever starts abruptly and reaches high levels,followed by severe polyarthralgia and myalgia,as well as an erythematous or petechial maculopapular rash,varying in severity and extent.Around 40%to 60%of affected individuals report persistent arthralgia,which can last from months to years.The symptoms of CF mainly represent the tissue tropism of the virus rather than the immunopathogenesis triggered by the host's immune system.The main mechanisms associated with arthralgia have been linked to an increase in T helper type 17 cells and a consequent increase in receptor activator of nuclear factor kappa-Βligand and bone resorption.This review suggests that persistent arthralgia results from the presence of viral antigens post-infection and the constant activation of signaling lymphocytic activation molecule family member 7 in synovial macrophages,leading to local infiltration of CD4+T cells,which sustains the inflammatory process in the joints through the secretion of pro-inflammatory cytokines.The term"long chikungunya"was used in this review to refer to persistent arthralgia since,due to its manifestation over long periods after the end of the viral infection,this clinical condition seems to be characterized more as a sequel than as a symptom,given that there is no active infection involved.
文摘A three-species ratio-dependent predator-prey diffusion model with time delays is investigated. It is shown that the system is uniformly persistent under some appropriate conditions, and sufficient conditions axe obtained for the global stability of the positive equilibrium of the system.
基金the Start- up foundation of Fuzhou University ( 0 0 30 82 4 2 2 8),the Foundation ofDeveloping Science and Technical Developmentof Fuzhou University ( 2 0 0 3- QX- 2 1 ) and the Foundation ofScience and Technology of Fujian Province of PR China for Young
文摘A non-autonomous competing system is investigated in this paper,where the species x can diffuse between two patches of a heterogeneous environment with barriers between patches,but for species y,the diffusion does not involve a barrier between patches,further it is assumed that all the parameters are time dependent.It is shown that the system can be made persistent under some appropriate conditions.Moreover,sufficient conditions that guarantee the existence of a unique positive periodic orbit which is globally asymptotic stable are derived.
基金supported by NNSFC(11001219,10925104)the Scientific Research Program Funded by Shaanxi Provincial Education Department(2010JK860)
文摘In this article, the unique continuation and persistence properties of solutions of the 2-component Degasperis-Procesi equations are discussed. It is shown that strong solutions of the 2-component Degasperis-Procesi equations, initially decaying exponentially together with its spacial derivative, must be identically equal to zero if they also decay exponentially at a later time.
基金supported by the National Natural Science Foundation of China(11271120,11426099)the Project of Hunan Natural Science Foundation of China(13JJ3085)
文摘This paper deals with the global dynamical behaviors of the positive solutions for a parabolic type ratio-dependent predator-prey system with a crowding term in the prey equation, where it is assumed that the coefficient of the functional response is less than the coefficient of the intrinsic growth rates of the prey species. We demonstrated some special dynamical behaviors of the positive solutions of this system which the persistence of the coexistence of two species can be obtained when the crowding region in the prey equation only is designed suitably. Furthermore, we can obtain that under some conditions, the unique positive steady state solution of the system is globally asymptotically stable.
文摘The predator-prey model for three species in which the right-hand sides are nonperiodic functions in time were considered, It's proved that the model is persistent under appropriate conditions.
基金supported in part by Errst & Lucie Schmidheing foundation and by the Municipality of Lau- sanne, Switzerland.
文摘The aims of this study was to investigate the persistence and the growth of culturable bacterial indicators (CBI) including total coliforms (TC) and faecal coliforms represented by Escherichia coli, enterococcus (ENT), and aerobic mesophilic bacteria (AMB) in the surface sediments and the water column of Vidy Bay fLake Geneva, City of Lausanne, Switzerland). The study was carded out for 60 d using microcosms containing Sewage Treatment Plant (STP) effluent and nonsterile water without CBI, as well as contaminated and non-contaminated sediments. The effects of water temperature and of organic matter associated with sediments on the survival of CBI in the sediments and the water column were observed. The number of CBI colonies in the contaminated sediments of Vidy Bay and in the STP effluent was almost identical in the order of 10^5-10^7, 10^4-10^6, 10^5-10^5, and 10^4-10^7 CFU/100 g sediment or/100 mL water for TC, E. coli, ENT, and AMB respectively. A degradation of CBI was observed in the sediments where organic mater content was low and in the water column at a temperature of 10℃ after 5 d of experimentation. In addition, a growth of CBI was observed in the sediment which is rich in organic matter at 20℃. The results of this study indicate: (1) the higher concentrations of the CBI observed in different points in the water column of Vidy Bay may not be explained only by the recent contribution of the three potential sources of the Bay contamination including STP and the Chamberonne and Flon Rivers, but also by the persistence, removal from sediment and multiplication of CBI in the sediment and water column; (2) the sediment of Vidy Bay constitute a reservoir of CBI and can even support their growth; and (3) the CBI not only survive in sediments, but also can be remobilized and increased in the water column, therefore, it become a permanent microbiological pollution in Vidy Bay.
基金supported by the National Natural Science Foundation of China(11271101)the NNSF of Shandong Province(ZR2010AQ021)
文摘A stochastic logistic model with delays and impulsive perturbation is proposed and investigated. Sufficient conditions for extinction are established as well as nonpersistence in the mean, weak persistence and stochastic permanence. The threshold between weak persistence and extinction is obtained. Furthermore, the theoretical analysis results are also derivated with the help of numerical simulations.
基金supported by the 973 program(Grant No.2010CB950400)the Innovation Key Program(Grant No.KZCX2-YWQ11-02) of the Chinese Academy of Sciences+2 种基金the NSFC project(Grant Nos.41030961,41005042,and 41005049)the Fund of State Key Laboratory of Tropical Oceanography(South China Sea Institute of Oceanology,Chinese Academy of Sciences(LTO1101)the 973 program (Grant No.2012CB956000)
文摘The persistence barrier of sea surface temperature anomalies (SSTAs) in the North Pacific was investigated and compared with the ENSO spring persistence barrier. The results show that SSTAs in the central western North Pacific (CWNP) have a persistence barrier in summer: the persistence of SSTAs in the CWNP shows a significant decline in summer regardless of the starting month. Mechanisms of the summer persistence barrier in the CWNP are different from those of the spring persistence barrier of SSTAs in the central and eastern equatorial Pacific. The phase locking of SSTAs to the annual cycle does not explain the CWNP summer persistence barrier. Remote ENSO forcing has little linear influence on the CWNP summer persistence barrier, compared with local upper-ocean process and atmospheric forcing in the North Pacific. Starting in wintertime, SSTAs extend down to the deep winter mixed layer then become sequestered beneath the shallow summer mixed layer, which is decoupled from the surface layer. Thus, wintertime SSTAs do not persist through the following summer. Starting in summertime, persistence of summer SSTAs until autumn can be explained by the atmospheric forcing through a positive SSTAs-cloud/radiation feedback mechanism because the shallow summertime mixed layer is decoupled from the temperature anomalies at depth, then the following autumnwinter-spring, SSTAs persist. Thus, summer SSTAs in the CWNP have a long persistence, showing a significant decline in the following summer. In this way, SSTAs in the CWNP show a persistence barrier in summer regardless of the starting month.
文摘Human oncogenic viruses are defined as necessary but not sufficient to initiate cancer. Experimental evidence suggests that the oncogenic potential of a virus is effective in cells that have already accumulated a number of genetic mutations leading to cell cycle deregulation. Current models for viral driven oncogenesis cannot explain why tumor development in carriers of tumorigenic viruses is a very rare event, occurring decades after virus infection. Considering that viruses are mutagenic agents per se and human oncogenic viruses additionally establish latent and persistent infections, we attempt here to provide a general mechanism of tumor initiation both for RNA and DNA viruses, suggesting viruses could be both necessary and sufficient in triggering human tumorigenesis initiation. Upon reviewing emerging evidence on the ability of viruses to induce DNA damage while subverting the DNA damage response and inducing epigenetic disturbance in the infected cell, we hypothesize a general, albeit inefficient hit and rest mechanism by which viruses may produce a limited reservoir of cells harboring permanent damage that would be initiated when the vi-rus first hits the cell, before latency is established. Cells surviving virus generated damage would consequently become more sensitive to further damage mediated by the otherwise insufficient transforming activity of virus products expressed in latency, or upon episodic reactivations(viral persistence). Cells with a combination of genetic and epigenetic damage leading to a cancerous phenotype would emerge very rarely, as the probability of such an occurrence would be dependent on severity and frequency of consecutive hit and rest cycles due to viral reinfections and reactivations.
文摘M 0.2Ca 0.8TiO 3∶Pr 3+(M=Mg 2+, Sr 2+, Ba 2+, Zn 2+) long persistence red phosphors were prepared by solid state reaction. The influence of the partially replacing Ca 2+ in CaTiO 3 with Mg 2+, Sr 2+, Ba 2+, Zn 2+ on the excitation spectra, the emission spectra and the long persistence properties were studied. The results suggest that certain quantity of Mg 2+, Sr 2+, Ba 2+, Zn 2+ which partially replace Ca 2+ can enhance the luminescent intensity and prolong the afterglow persistence of the samples. The intensity of Mg 0.2Ca 0.8TiO 3∶Pr 3+ is above all of the samples. Take Mg 0.2Ca 0.8TiO 3∶Pr 3+ as the basic sample, the influence of Pr 3+ concentrations (C(Pr 3+)) on the long afterglow properties were also studied. The results suggest that when the C(Pr 3+) is 0.10% (mol fraction) the intensity of the sample is the highest. The excitation spectra of all these samples show broad band spectra ranging from 300~500 nm peaking at about 342 nm. The emission spectra also exhibit a broad band peaking at 613 nm (CaTiO 3∶Pr 3+ is 612 nm). XRD research indicates that the crystalline phases change due to the replacement of divalent metal ions.The research on the thermoluminescence spectra of Mg 0.2Ca 0.8TiO 3∶Pr 3+ indicates that the peak is at 107.35 ℃ and the depth of the trap energy is about 0 852 eV.