Logit regression analysis is widely applied in scientific studies and laboratory experiments, where skewed observations on a data set are often encountered. A number of problems with this method, for example, oudiers ...Logit regression analysis is widely applied in scientific studies and laboratory experiments, where skewed observations on a data set are often encountered. A number of problems with this method, for example, oudiers and influential observations, can cause overdispersion when a model is fitted. In this study a systematic statistical approach, including the plotting of several indices is used to diagnose the lack-of-fit of a logistic regression model. The outliers and influential observations on data from laboratory experiments are then detected. Specifically we take account of the interaction of an internal sohtary wave （ISW） with an obstacle, i.e., an underwater ridge, and also analyze the effects of the ridge height, the lower layer water depth, and the potential energy on the amplitude-based transmission rate of the ISW. As concluded, the goodness-of-fit of the revised logit regression model is better than that of the model without this approach.展开更多
A method was proposed for the detection of outliers and influential observations in the framework of a mixed linear model, prior to the quantitative trait locus (QTL) mapping analysis. We investigated the impact of ou...A method was proposed for the detection of outliers and influential observations in the framework of a mixed linear model, prior to the quantitative trait locus (QTL) mapping analysis. We investigated the impact of outliers on QTL mapping for complex traits in a mouse BXD population, and observed that the dropping of outliers could provide the evidence of additional QTL and epistatic loci affecting the 1stBrain-OB and the 2ndBrain-OB in a cross of the abovementioned population. The results could also reveal a remarkable increase in estimating heritabilities of QTL in the absence of outliers. In addition, simulations were conducted to investigate the detection powers and false discovery rates (FDRs) of QTLs in the presence and absence of outliers. The results suggested that the presence of a small proportion of outliers could increase the FDR and hence decrease the detection power of QTLs. A drastic increase could be obtained in the estimates of standard errors for position, additive and additive× environment interaction effects of QTLs in the presence of outliers.展开更多
When a real-world data set is fitted to a specific type of models, it is often encountered that one or a set of observations have undue influence on the model fitting, which may lead to misleading conclusions. Therefo...When a real-world data set is fitted to a specific type of models, it is often encountered that one or a set of observations have undue influence on the model fitting, which may lead to misleading conclusions. Therefore, it is necessary for data analysts to identify these influential observations and assess their impact on various aspects of model fitting. In this paper, one type of modified Cook＇s distances is defined to gauge the influence of one or a set observations on the estimate of the constant coefficient part in partially varying- coefficient models, and the Cook＇s distances are expressed as functions of the corresponding residuals and leverages. Meanwhile, a bootstrap procedure is suggested to derive the reference values for the proposed Cook＇s distances. Some simulations are conducted, and a real-world data set is further analyzed to examine the performance of the proposed method. The experimental results are satisfactory.展开更多
基金Science Council of Taiwan Province under Grant Nos.NSC 96-2628-E-366-004-MY2 and 96-2628-E-132-001-MY2
文摘Logit regression analysis is widely applied in scientific studies and laboratory experiments, where skewed observations on a data set are often encountered. A number of problems with this method, for example, oudiers and influential observations, can cause overdispersion when a model is fitted. In this study a systematic statistical approach, including the plotting of several indices is used to diagnose the lack-of-fit of a logistic regression model. The outliers and influential observations on data from laboratory experiments are then detected. Specifically we take account of the interaction of an internal sohtary wave （ISW） with an obstacle, i.e., an underwater ridge, and also analyze the effects of the ridge height, the lower layer water depth, and the potential energy on the amplitude-based transmission rate of the ISW. As concluded, the goodness-of-fit of the revised logit regression model is better than that of the model without this approach.
基金supported by the National Basic Research Program (973) of China (No. 2004CB117306)the Hi-Tech Research and Devel-opment Program (863) of China (No. 2006AA10A102)
文摘A method was proposed for the detection of outliers and influential observations in the framework of a mixed linear model, prior to the quantitative trait locus (QTL) mapping analysis. We investigated the impact of outliers on QTL mapping for complex traits in a mouse BXD population, and observed that the dropping of outliers could provide the evidence of additional QTL and epistatic loci affecting the 1stBrain-OB and the 2ndBrain-OB in a cross of the abovementioned population. The results could also reveal a remarkable increase in estimating heritabilities of QTL in the absence of outliers. In addition, simulations were conducted to investigate the detection powers and false discovery rates (FDRs) of QTLs in the presence and absence of outliers. The results suggested that the presence of a small proportion of outliers could increase the FDR and hence decrease the detection power of QTLs. A drastic increase could be obtained in the estimates of standard errors for position, additive and additive× environment interaction effects of QTLs in the presence of outliers.
基金the National Natural Science Foundations of China(No.10531030,No.60675013)
文摘When a real-world data set is fitted to a specific type of models, it is often encountered that one or a set of observations have undue influence on the model fitting, which may lead to misleading conclusions. Therefore, it is necessary for data analysts to identify these influential observations and assess their impact on various aspects of model fitting. In this paper, one type of modified Cook＇s distances is defined to gauge the influence of one or a set observations on the estimate of the constant coefficient part in partially varying- coefficient models, and the Cook＇s distances are expressed as functions of the corresponding residuals and leverages. Meanwhile, a bootstrap procedure is suggested to derive the reference values for the proposed Cook＇s distances. Some simulations are conducted, and a real-world data set is further analyzed to examine the performance of the proposed method. The experimental results are satisfactory.
