Analyzed the main problems which were found in current conditions and prob- lems of informationization in coal enterprises.It clarified how to achieve informationization in coal mine and put forward a general configur...Analyzed the main problems which were found in current conditions and prob- lems of informationization in coal enterprises.It clarified how to achieve informationization in coal mine and put forward a general configuration of informationization construction in which informationization in coal enterprises was divided into two parts: informationization of safety production and informationization of management.Planned a platform of inte- grated management of informationization in coal enterprises.Ultimately,it has brought forward that an overall integrated digital mine is the way to achieve the goal of informa- tionization in coal enterprises,which can promote the application of automation,digitaliza- tion,networking,informaitionization to intellectualization.At the same time,the competi- tiveness of enterprises can be improved entirely,and new type of coal industry can be supported by information technology.展开更多
This paper explains the basic concepts of " Internet + " and big data,analyzes the main problems in the application of big data technology in agricultural informationization of Shandong Province,summarizes c...This paper explains the basic concepts of " Internet + " and big data,analyzes the main problems in the application of big data technology in agricultural informationization of Shandong Province,summarizes corresponding solutions from the aspects of government guidance,financial input,open sharing of agricultural big data,big data storage and processing,data mining,etc.,and prospects the application trend of big data technology in agricultural informationization to achieve the connotative development of agriculture in Shandong Province.展开更多
The informationization of accounting information systems has brought many improvements to those systems. This paper highlights some of those significant advances in the informationization of accounting information sys...The informationization of accounting information systems has brought many improvements to those systems. This paper highlights some of those significant advances in the informationization of accounting information systems in China. As China has become a major industrial power in the international economy, further improvements for these information systems are critical to the continued successes of China. To additionally improve these systems, China can draw upon the systems from other world economic leaders. With its fully developed capital markets, the United States offers development experience for the external reporting components of a fully integrated information system. This paper discusses a typical integrated information system in the United States and addresses the regulatory milestones that were instrumental in the development of those external components of accounting information systems. Recommendations are presented for improving informationization of systems in China based on U.S. systems' responses to those milestones.展开更多
In China, household registration system has the problems of unreasonable standard setting and relevant supporting measures failure to keep pace with the development trend. From analysis of current problems and situati...In China, household registration system has the problems of unreasonable standard setting and relevant supporting measures failure to keep pace with the development trend. From analysis of current problems and situations, it is believed that household registration system should undertake reform and take a new road by means of informationization. Strengthening informationization management in land, population, education and labor market can better perform urban and rural integration.展开更多
The purpose of rural informationization is to provide effective information for farmers,increase production efficiency and income level of farmers in agricultural production.In recent years,under the guidance of No.1 ...The purpose of rural informationization is to provide effective information for farmers,increase production efficiency and income level of farmers in agricultural production.In recent years,under the guidance of No.1 document of central government,China's rural informationization has obtained considerable development.However,due to influence of terrain,mountain areas are still backward in informationization development.Combining actual conditions of Pingshan County of Hebei Province,the authors visited local farmers and made detailed survey on basic conditions of farmers,and analyzed factors obstructing agricultural informationization development in mountain areas,to provide theoretical reference for promoting informationization development in mountain areas and increasing income of local farmers.展开更多
Agricultural informationization is the objective demand for transforming the traditional agriculture and promoting the development of agricultural modernization. Using the statistical data of the gross agricultural ou...Agricultural informationization is the objective demand for transforming the traditional agriculture and promoting the development of agricultural modernization. Using the statistical data of the gross agricultural output value of Hubei Province in 2005-2014,based on the C-D production function,it calculated the average contribution rate(2. 48%) of agricultural informationization to the growth of agricultural economy in Hubei Province,indicating that agricultural informationization can promote growth of agricultural economy. This is basically consistent with previous findings. In addition,investment in agricultural informationization and broadband access rate also influenced the growth of agricultural economy in Hubei Province. Therefore,government should further improve the infrastructure of agricultural informationization,strengthen training of farmers’ information skills,establish auxiliary mechanism for achievement feedback of information-based agricultural production,increase the contribution rate of informationization to agricultural operation and management,promote the contribution of informationization to the growth of agricultural economy,so as to increase agricultural income of farmers.展开更多
Based on the current situation of rural educational informationization, my study found that the boost of rural elementary and secondary school’s educational informationization needed the cooperation of higher normal ...Based on the current situation of rural educational informationization, my study found that the boost of rural elementary and secondary school’s educational informationization needed the cooperation of higher normal universities and local education administrative department. The construction of “IT education community” is the key to step off the predicament. The practice application and effect in Gaoping City further proved that the cooperation project broke the bottleneck of rural elementary and secondary school’s educational informationization.展开更多
With the constant development of China's economy,rural financial management information gradually plays a major role in China's economic development. This paper mainly studied related management information of...With the constant development of China's economy,rural financial management information gradually plays a major role in China's economic development. This paper mainly studied related management information of accounting information system and main characteristics of rural management. On the basis of analysis,it came up with pertinent recommendations,including improving software for financial informationization,improving the quality of rural financial personnel,strengthening government support for rural financial management informationization,and enhancing popularization of accounting computerized software.展开更多
The enterprise informationization (El) project has already become modernization level and synthesis power of the enterprise. However, information project risk. In order to reduce the El project risk, it is necessary...The enterprise informationization (El) project has already become modernization level and synthesis power of the enterprise. However, information project risk. In order to reduce the El project risk, it is necessary to adopt reasonable incentive and constraint effectively and to structure perfect market environment. an urgent work to raise the asymmetry increases the EI investment mode, to carry on incentive and constraint effectively and to structure perfect market environment.展开更多
Enterprise Informationization (El) is encountering a large variety of non-systematic risks in demanding and planning, designing and selecting, implementing and controlling, managerial and cultural aspects,due to whi...Enterprise Informationization (El) is encountering a large variety of non-systematic risks in demanding and planning, designing and selecting, implementing and controlling, managerial and cultural aspects,due to which the investment in IT normally cannot simultaneously create the expected commercial values. Through analyzing the factors influencing non-systematic risks of EI, the paper established a risk evaluating index system and accordingly proposed a set of appropriate risk evaluating methodology, with which enterprise can well control informationization risks.展开更多
With the advent of 5G era,it has become an inevitable trend to drive educational modernization with educational informationization.The modern-day education uses science and technology as well as culture in cultivating...With the advent of 5G era,it has become an inevitable trend to drive educational modernization with educational informationization.The modern-day education uses science and technology as well as culture in cultivating independent learning as the ultimate goal.However,there are many drawbacks in the system and practical aspects of higher vocational education in which one of it is that the independent learning has been neglected in the learning process.This article analyzed the issues in the autonomous learning of the English language among higher vocational college students and discussed strategies to improve their autonomous learning ability based on informationization to promote bidirectional interaction between teachers and students,cultivate students'consciousness of lifelong learning,improve teachers5 technical skills,and perfect the development of a connotative system in higher vocational colleges.展开更多
随着隔震技术的推广应用以及建筑业信息化水平的持续提升,在隔震工程中对隔震层建筑信息模型(building information modeling, BIM)建模的需求逐渐增长,然而针对性的研究工作相对较少。为此,围绕隔震支座BIM模型的高效建模方法和应用模...随着隔震技术的推广应用以及建筑业信息化水平的持续提升,在隔震工程中对隔震层建筑信息模型(building information modeling, BIM)建模的需求逐渐增长,然而针对性的研究工作相对较少。为此,围绕隔震支座BIM模型的高效建模方法和应用模块开展了研究。首先,综合隔震支座应用情况和力学特性,可将其分为橡胶隔震支座、滑移摩擦隔震支座和其他类型隔震支座,据此提出了隔震支座BIM快速建模模块基本架构;随后,基于Revit和Visual Studio平台开发了三类隔震支座BIM模型的快速建模功能,并实现了连接节点参数化建模和支座批量/手动布置的操作功能;最后,开展了某化工公司的库房隔震加固项目的隔震层BIM模型建模实践,结果表明:利用快速建模模块可将隔震层BIM建模操作从7个步骤降低至2个步骤,且使用过程中对隔震支座构造细节的认知要求相对较低。同时,建成后的BIM模型与实际工程在建筑信息的多个方面具有较好的一致性。相关研究可为建筑和桥梁隔震工程的BIM建模提供参考和借鉴。展开更多
BACKGROUND Acute liver failure(ALF)has a high mortality with widespread hepatocyte death involving ferroptosis and pyroptosis.The silent information regulator sirtuin 1(SIRT1)-mediated deacetylation affects multiple b...BACKGROUND Acute liver failure(ALF)has a high mortality with widespread hepatocyte death involving ferroptosis and pyroptosis.The silent information regulator sirtuin 1(SIRT1)-mediated deacetylation affects multiple biological processes,including cellular senescence,apoptosis,sugar and lipid metabolism,oxidative stress,and inflammation.AIM To investigate the association between ferroptosis and pyroptosis and the upstream regulatory mechanisms.METHODS This study included 30 patients with ALF and 30 healthy individuals who underwent serum alanine aminotransferase(ALT)and aspartate aminotransferase(AST)testing.C57BL/6 mice were also intraperitoneally pretreated with SIRT1,p53,or glutathione peroxidase 4(GPX4)inducers and inhibitors and injected with lipopolysaccharide(LPS)/D-galactosamine(D-GalN)to induce ALF.Gasdermin D(GSDMD)^(-/-)mice were used as an experimental group.Histological changes in liver tissue were monitored by hematoxylin and eosin staining.ALT,AST,glutathione,reactive oxygen species,and iron levels were measured using commercial kits.Ferroptosis-and pyroptosis-related protein and mRNA expression was detected by western blot and quantitative real-time polymerase chain reaction.SIRT1,p53,and GSDMD were assessed by immunofluorescence analysis.RESULTS Serum AST and ALT levels were elevated in patients with ALF.SIRT1,solute carrier family 7a member 11(SLC7A11),and GPX4 protein expression was decreased and acetylated p5,p53,GSDMD,and acyl-CoA synthetase long-chain family member 4(ACSL4)protein levels were elevated in human ALF liver tissue.In the p53 and ferroptosis inhibitor-treated and GSDMD^(-/-)groups,serum interleukin(IL)-1β,tumour necrosis factor alpha,IL-6,IL-2 and C-C motif ligand 2 levels were decreased and hepatic impairment was mitigated.In mice with GSDMD knockout,p53 was reduced,GPX4 was increased,and ferroptotic events(depletion of SLC7A11,elevation of ACSL4,and iron accumulation)were detected.In vitro,knockdown of p53 and overexpression of GPX4 reduced AST and ALT levels,the cytostatic rate,and GSDMD expression,restoring SLC7A11 depletion.Moreover,SIRT1 agonist and overexpression of SIRT1 alleviated acute liver injury and decreased iron deposition compared with results in the model group,accompanied by reduced p53,GSDMD,and ACSL4,and increased SLC7A11 and GPX4.Inactivation of SIRT1 exacerbated ferroptotic and pyroptotic cell death and aggravated liver injury in LPS/D-GalNinduced in vitro and in vivo models.CONCLUSION SIRT1 activation attenuates LPS/D-GalN-induced ferroptosis and pyroptosis by inhibiting the p53/GPX4/GSDMD signaling pathway in ALF.展开更多
Energy limitation of traditional Wireless Sensor Networks(WSNs)greatly confines the network lifetime due to generating and processing massive sensing data with a limited battery.The energy harvesting WSN is a novel ne...Energy limitation of traditional Wireless Sensor Networks(WSNs)greatly confines the network lifetime due to generating and processing massive sensing data with a limited battery.The energy harvesting WSN is a novel network architecture to address the limitation of traditional WSN.However,existing coverage and deployment schemes neglect the environmental correlation of sensor nodes and external energy with respect to physical space.Comprehensively considering the spatial correlation of the environment and the uneven distribution of energy in energy harvesting WSN,we investigate how to deploy a collection of sensor nodes to save the deployment cost while ensuring the target perpetual coverage.The Confident Information Coverage(CIC)model is adopted to formulate the CIC Minimum Deployment Cost Target Perpetual Coverage(CICMTP)problem to minimize the deployed sensor nodes.As the CICMTP is NP-hard,we devise two approximation algorithms named Local Greedy Threshold Algorithm based on CIC(LGTA-CIC)and Overall Greedy Search Algorithm based on CIC(OGSA-CIC).The LGTA-CIC has a low time complexity and the OGSA-CIC has a better approximation rate.Extensive simulation results demonstrate that the OGSA-CIC is able to achieve lower deployment cost and the performance of the proposed algorithms outperforms GRNP,TPNP and EENP algorithms.展开更多
BACKGROUND As one of the fatal diseases with high incidence,lung cancer has seriously endangered public health and safety.Elderly patients usually have poor self-care and are more likely to show a series of psychologi...BACKGROUND As one of the fatal diseases with high incidence,lung cancer has seriously endangered public health and safety.Elderly patients usually have poor self-care and are more likely to show a series of psychological problems.AIM To investigate the effectiveness of the initial check,information exchange,final accuracy check,reaction(IIFAR)information care model on the mental health status of elderly patients with lung cancer.METHODS This study is a single-centre study.We randomly recruited 60 elderly patients with lung cancer who attended our hospital from January 2021 to January 2022.These elderly patients with lung cancer were randomly divided into two groups,with the control group taking the conventional propaganda and education and the observation group taking the IIFAR information care model based on the conventional care protocol.The differences in psychological distress,anxiety and depression,life quality,fatigue,and the locus of control in psychology were compared between these two groups,and the causes of psychological distress were analyzed.RESULTS After the intervention,Distress Thermometer,Hospital Anxiety and Depression Scale(HADS)for anxiety and the HADS for depression,Revised Piper’s Fatigue Scale,and Chance Health Locus of Control scores were lower in the observation group compared to the pre-intervention period in the same group and were significantly lower in the observation group compared to those of the control group(P<0.05).After the intervention,Quality of Life Questionnaire Core 30(QLQ-C30),Internal Health Locus of Control,and Powerful Others Health Locus of Control scores were significantly higher in the observation and the control groups compared to the pre-intervention period in their same group,and QLQ-C30 scores were significantly higher in the observation group compared to those of the control group(P<0.05).CONCLUSION The IIFAR information care model can help elderly patients with lung cancer by reducing their anxiety and depression,psychological distress,and fatigue,improving their tendencies on the locus of control in psychology,and enhancing their life qualities.展开更多
In this editorial we comment on the article published in a recent issue of the World Journal of Gastroenterology.Acute liver failure(ALF)is a critical condition characterized by rapid hepatocellular injury and organ d...In this editorial we comment on the article published in a recent issue of the World Journal of Gastroenterology.Acute liver failure(ALF)is a critical condition characterized by rapid hepatocellular injury and organ dysfunction,and it often necessitates liver transplant to ensure patient survival.Recent research has eluci-dated the involvement of distinct cell death pathways,namely ferroptosis and pyroptosis,in the pathogenesis of ALF.Ferroptosis is driven by iron-dependent lipid peroxidation,whereas pyroptosis is an inflammatory form of cell death;both pathways contribute to hepatocyte death and exacerbate tissue damage.This comprehensive review explores the interplay between ferroptosis and pyroptosis in ALF,highlighting the role of key regulators such as silent information regulator sirtuin 1.Insights from clinical and preclinical studies provide valuable perspectives on the dysregulation of cell death pathways in ALF and the therapeutic potential of targeting these pathways.Collaboration across multiple disciplines is essential for translating the experimental insights into effective treatments for this life-threatening condition.展开更多
The subversive nature of information war lies not only in the information itself, but also in the circulation and application of information. It has always been a challenge to quantitatively analyze the function and e...The subversive nature of information war lies not only in the information itself, but also in the circulation and application of information. It has always been a challenge to quantitatively analyze the function and effect of information flow through command, control, communications, computer, kill, intelligence,surveillance, reconnaissance (C4KISR) system. In this work, we propose a framework of force of information influence and the methods for calculating the force of information influence between C4KISR nodes of sensing, intelligence processing,decision making and fire attack. Specifically, the basic concept of force of information influence between nodes in C4KISR system is formally proposed and its mathematical definition is provided. Then, based on the information entropy theory, the model of force of information influence between C4KISR system nodes is constructed. Finally, the simulation experiments have been performed under an air defense and attack scenario. The experimental results show that, with the proposed force of information influence framework, we can effectively evaluate the contribution of information circulation through different C4KISR system nodes to the corresponding tasks. Our framework of force of information influence can also serve as an effective tool for the design and dynamic reconfiguration of C4KISR system architecture.展开更多
Positional information encoded in spatial concentration patterns is crucial for the development of multicellular organisms.However,it is still unclear how such information is affected by the physically dissipative dif...Positional information encoded in spatial concentration patterns is crucial for the development of multicellular organisms.However,it is still unclear how such information is affected by the physically dissipative diffusion process.Here we study one-dimensional patterning systems with analytical derivation and numerical simulations.We find that the diffusion constant of the patterning molecules exhibits a nonmonotonic effect on the readout of the positional information from the concentration patterns.Specifically,there exists an optimal diffusion constant that maximizes the positional information.Moreover,we find that the energy dissipation due to the physical diffusion imposes a fundamental upper limit on the positional information.展开更多
For unachievable tracking problems, where the system output cannot precisely track a given reference, achieving the best possible approximation for the reference trajectory becomes the objective. This study aims to in...For unachievable tracking problems, where the system output cannot precisely track a given reference, achieving the best possible approximation for the reference trajectory becomes the objective. This study aims to investigate solutions using the Ptype learning control scheme. Initially, we demonstrate the necessity of gradient information for achieving the best approximation.Subsequently, we propose an input-output-driven learning gain design to handle the imprecise gradients of a class of uncertain systems. However, it is discovered that the desired performance may not be attainable when faced with incomplete information.To address this issue, an extended iterative learning control scheme is introduced. In this scheme, the tracking errors are modified through output data sampling, which incorporates lowmemory footprints and offers flexibility in learning gain design.The input sequence is shown to converge towards the desired input, resulting in an output that is closest to the given reference in the least square sense. Numerical simulations are provided to validate the theoretical findings.展开更多
基金the Hi-Tech and Research Development Program of China(2005AA133070)the Electronics Information Industry Development Fund Tender Project(XDJ2-0514-27)
文摘Analyzed the main problems which were found in current conditions and prob- lems of informationization in coal enterprises.It clarified how to achieve informationization in coal mine and put forward a general configuration of informationization construction in which informationization in coal enterprises was divided into two parts: informationization of safety production and informationization of management.Planned a platform of inte- grated management of informationization in coal enterprises.Ultimately,it has brought forward that an overall integrated digital mine is the way to achieve the goal of informa- tionization in coal enterprises,which can promote the application of automation,digitaliza- tion,networking,informaitionization to intellectualization.At the same time,the competi- tiveness of enterprises can be improved entirely,and new type of coal industry can be supported by information technology.
基金Supported by Science Research Foundation of Binzhou University(BZXYG1712,BZXYG1714)Teaching and Research Project(BZXYSYXM201606,BZXYWTXM201621)Soft Science Research Project of Shandong Province(2018RKB01136)
文摘This paper explains the basic concepts of " Internet + " and big data,analyzes the main problems in the application of big data technology in agricultural informationization of Shandong Province,summarizes corresponding solutions from the aspects of government guidance,financial input,open sharing of agricultural big data,big data storage and processing,data mining,etc.,and prospects the application trend of big data technology in agricultural informationization to achieve the connotative development of agriculture in Shandong Province.
文摘The informationization of accounting information systems has brought many improvements to those systems. This paper highlights some of those significant advances in the informationization of accounting information systems in China. As China has become a major industrial power in the international economy, further improvements for these information systems are critical to the continued successes of China. To additionally improve these systems, China can draw upon the systems from other world economic leaders. With its fully developed capital markets, the United States offers development experience for the external reporting components of a fully integrated information system. This paper discusses a typical integrated information system in the United States and addresses the regulatory milestones that were instrumental in the development of those external components of accounting information systems. Recommendations are presented for improving informationization of systems in China based on U.S. systems' responses to those milestones.
基金Supported by Key Project of National Soft Science Research Plan (Grant No.:2011GXS1D003 )Key Project of Soft Science Research Plan of Chongqing Municipality (Grant No.:cstc2011cx-rkxB00008)
文摘In China, household registration system has the problems of unreasonable standard setting and relevant supporting measures failure to keep pace with the development trend. From analysis of current problems and situations, it is believed that household registration system should undertake reform and take a new road by means of informationization. Strengthening informationization management in land, population, education and labor market can better perform urban and rural integration.
文摘The purpose of rural informationization is to provide effective information for farmers,increase production efficiency and income level of farmers in agricultural production.In recent years,under the guidance of No.1 document of central government,China's rural informationization has obtained considerable development.However,due to influence of terrain,mountain areas are still backward in informationization development.Combining actual conditions of Pingshan County of Hebei Province,the authors visited local farmers and made detailed survey on basic conditions of farmers,and analyzed factors obstructing agricultural informationization development in mountain areas,to provide theoretical reference for promoting informationization development in mountain areas and increasing income of local farmers.
基金Supported by Soft Science Project of Wuhan City in Hubei Province(201604-0306010178)
文摘Agricultural informationization is the objective demand for transforming the traditional agriculture and promoting the development of agricultural modernization. Using the statistical data of the gross agricultural output value of Hubei Province in 2005-2014,based on the C-D production function,it calculated the average contribution rate(2. 48%) of agricultural informationization to the growth of agricultural economy in Hubei Province,indicating that agricultural informationization can promote growth of agricultural economy. This is basically consistent with previous findings. In addition,investment in agricultural informationization and broadband access rate also influenced the growth of agricultural economy in Hubei Province. Therefore,government should further improve the infrastructure of agricultural informationization,strengthen training of farmers’ information skills,establish auxiliary mechanism for achievement feedback of information-based agricultural production,increase the contribution rate of informationization to agricultural operation and management,promote the contribution of informationization to the growth of agricultural economy,so as to increase agricultural income of farmers.
文摘Based on the current situation of rural educational informationization, my study found that the boost of rural elementary and secondary school’s educational informationization needed the cooperation of higher normal universities and local education administrative department. The construction of “IT education community” is the key to step off the predicament. The practice application and effect in Gaoping City further proved that the cooperation project broke the bottleneck of rural elementary and secondary school’s educational informationization.
基金Supported by Student Innovation Project of University of Science and Technology Liaoning in 2016
文摘With the constant development of China's economy,rural financial management information gradually plays a major role in China's economic development. This paper mainly studied related management information of accounting information system and main characteristics of rural management. On the basis of analysis,it came up with pertinent recommendations,including improving software for financial informationization,improving the quality of rural financial personnel,strengthening government support for rural financial management informationization,and enhancing popularization of accounting computerized software.
文摘The enterprise informationization (El) project has already become modernization level and synthesis power of the enterprise. However, information project risk. In order to reduce the El project risk, it is necessary to adopt reasonable incentive and constraint effectively and to structure perfect market environment. an urgent work to raise the asymmetry increases the EI investment mode, to carry on incentive and constraint effectively and to structure perfect market environment.
基金Supported by National Natural Science Foundation of China (NSFC) (70302006)
文摘Enterprise Informationization (El) is encountering a large variety of non-systematic risks in demanding and planning, designing and selecting, implementing and controlling, managerial and cultural aspects,due to which the investment in IT normally cannot simultaneously create the expected commercial values. Through analyzing the factors influencing non-systematic risks of EI, the paper established a risk evaluating index system and accordingly proposed a set of appropriate risk evaluating methodology, with which enterprise can well control informationization risks.
基金Supported by Guangdong University Innovation Young Talents Project,''Research on the Cultivation of English Autonomous Learning Ability in Higher Vocational Colleges Based on SPOC55(Project number:2020WQNCX240)Achievements of the visiting period of Guangdong University of Foreign Studies.
文摘With the advent of 5G era,it has become an inevitable trend to drive educational modernization with educational informationization.The modern-day education uses science and technology as well as culture in cultivating independent learning as the ultimate goal.However,there are many drawbacks in the system and practical aspects of higher vocational education in which one of it is that the independent learning has been neglected in the learning process.This article analyzed the issues in the autonomous learning of the English language among higher vocational college students and discussed strategies to improve their autonomous learning ability based on informationization to promote bidirectional interaction between teachers and students,cultivate students'consciousness of lifelong learning,improve teachers5 technical skills,and perfect the development of a connotative system in higher vocational colleges.
文摘随着隔震技术的推广应用以及建筑业信息化水平的持续提升,在隔震工程中对隔震层建筑信息模型(building information modeling, BIM)建模的需求逐渐增长,然而针对性的研究工作相对较少。为此,围绕隔震支座BIM模型的高效建模方法和应用模块开展了研究。首先,综合隔震支座应用情况和力学特性,可将其分为橡胶隔震支座、滑移摩擦隔震支座和其他类型隔震支座,据此提出了隔震支座BIM快速建模模块基本架构;随后,基于Revit和Visual Studio平台开发了三类隔震支座BIM模型的快速建模功能,并实现了连接节点参数化建模和支座批量/手动布置的操作功能;最后,开展了某化工公司的库房隔震加固项目的隔震层BIM模型建模实践,结果表明:利用快速建模模块可将隔震层BIM建模操作从7个步骤降低至2个步骤,且使用过程中对隔震支座构造细节的认知要求相对较低。同时,建成后的BIM模型与实际工程在建筑信息的多个方面具有较好的一致性。相关研究可为建筑和桥梁隔震工程的BIM建模提供参考和借鉴。
基金Supported by National Natural Science Foundation of China,No.82060123Doctoral Start-up Fund of Affiliated Hospital of Guizhou Medical University,No.gysybsky-2021-28+1 种基金Fund Project of Guizhou Provincial Science and Technology Department,No.[2020]1Y299Guizhou Provincial Health Commission,No.gzwjk2019-1-082。
文摘BACKGROUND Acute liver failure(ALF)has a high mortality with widespread hepatocyte death involving ferroptosis and pyroptosis.The silent information regulator sirtuin 1(SIRT1)-mediated deacetylation affects multiple biological processes,including cellular senescence,apoptosis,sugar and lipid metabolism,oxidative stress,and inflammation.AIM To investigate the association between ferroptosis and pyroptosis and the upstream regulatory mechanisms.METHODS This study included 30 patients with ALF and 30 healthy individuals who underwent serum alanine aminotransferase(ALT)and aspartate aminotransferase(AST)testing.C57BL/6 mice were also intraperitoneally pretreated with SIRT1,p53,or glutathione peroxidase 4(GPX4)inducers and inhibitors and injected with lipopolysaccharide(LPS)/D-galactosamine(D-GalN)to induce ALF.Gasdermin D(GSDMD)^(-/-)mice were used as an experimental group.Histological changes in liver tissue were monitored by hematoxylin and eosin staining.ALT,AST,glutathione,reactive oxygen species,and iron levels were measured using commercial kits.Ferroptosis-and pyroptosis-related protein and mRNA expression was detected by western blot and quantitative real-time polymerase chain reaction.SIRT1,p53,and GSDMD were assessed by immunofluorescence analysis.RESULTS Serum AST and ALT levels were elevated in patients with ALF.SIRT1,solute carrier family 7a member 11(SLC7A11),and GPX4 protein expression was decreased and acetylated p5,p53,GSDMD,and acyl-CoA synthetase long-chain family member 4(ACSL4)protein levels were elevated in human ALF liver tissue.In the p53 and ferroptosis inhibitor-treated and GSDMD^(-/-)groups,serum interleukin(IL)-1β,tumour necrosis factor alpha,IL-6,IL-2 and C-C motif ligand 2 levels were decreased and hepatic impairment was mitigated.In mice with GSDMD knockout,p53 was reduced,GPX4 was increased,and ferroptotic events(depletion of SLC7A11,elevation of ACSL4,and iron accumulation)were detected.In vitro,knockdown of p53 and overexpression of GPX4 reduced AST and ALT levels,the cytostatic rate,and GSDMD expression,restoring SLC7A11 depletion.Moreover,SIRT1 agonist and overexpression of SIRT1 alleviated acute liver injury and decreased iron deposition compared with results in the model group,accompanied by reduced p53,GSDMD,and ACSL4,and increased SLC7A11 and GPX4.Inactivation of SIRT1 exacerbated ferroptotic and pyroptotic cell death and aggravated liver injury in LPS/D-GalNinduced in vitro and in vivo models.CONCLUSION SIRT1 activation attenuates LPS/D-GalN-induced ferroptosis and pyroptosis by inhibiting the p53/GPX4/GSDMD signaling pathway in ALF.
基金supported by National Natural Science Foundation of China(Grant No.61871209,No.62272182 and No.61901210)Shenzhen Science and Technology Program under Grant JCYJ20220530161004009+2 种基金Natural Science Foundation of Hubei Province(Grant No.2022CF011)Wuhan Business University Doctoral Fundamental Research Funds(Grant No.2021KB005)in part by Artificial Intelligence and Intelligent Transportation Joint Technical Center of HUST and Hubei Chutian Intelligent Transportation Co.,LTD under project Intelligent Tunnel Integrated Monitoring and Management System.
文摘Energy limitation of traditional Wireless Sensor Networks(WSNs)greatly confines the network lifetime due to generating and processing massive sensing data with a limited battery.The energy harvesting WSN is a novel network architecture to address the limitation of traditional WSN.However,existing coverage and deployment schemes neglect the environmental correlation of sensor nodes and external energy with respect to physical space.Comprehensively considering the spatial correlation of the environment and the uneven distribution of energy in energy harvesting WSN,we investigate how to deploy a collection of sensor nodes to save the deployment cost while ensuring the target perpetual coverage.The Confident Information Coverage(CIC)model is adopted to formulate the CIC Minimum Deployment Cost Target Perpetual Coverage(CICMTP)problem to minimize the deployed sensor nodes.As the CICMTP is NP-hard,we devise two approximation algorithms named Local Greedy Threshold Algorithm based on CIC(LGTA-CIC)and Overall Greedy Search Algorithm based on CIC(OGSA-CIC).The LGTA-CIC has a low time complexity and the OGSA-CIC has a better approximation rate.Extensive simulation results demonstrate that the OGSA-CIC is able to achieve lower deployment cost and the performance of the proposed algorithms outperforms GRNP,TPNP and EENP algorithms.
文摘BACKGROUND As one of the fatal diseases with high incidence,lung cancer has seriously endangered public health and safety.Elderly patients usually have poor self-care and are more likely to show a series of psychological problems.AIM To investigate the effectiveness of the initial check,information exchange,final accuracy check,reaction(IIFAR)information care model on the mental health status of elderly patients with lung cancer.METHODS This study is a single-centre study.We randomly recruited 60 elderly patients with lung cancer who attended our hospital from January 2021 to January 2022.These elderly patients with lung cancer were randomly divided into two groups,with the control group taking the conventional propaganda and education and the observation group taking the IIFAR information care model based on the conventional care protocol.The differences in psychological distress,anxiety and depression,life quality,fatigue,and the locus of control in psychology were compared between these two groups,and the causes of psychological distress were analyzed.RESULTS After the intervention,Distress Thermometer,Hospital Anxiety and Depression Scale(HADS)for anxiety and the HADS for depression,Revised Piper’s Fatigue Scale,and Chance Health Locus of Control scores were lower in the observation group compared to the pre-intervention period in the same group and were significantly lower in the observation group compared to those of the control group(P<0.05).After the intervention,Quality of Life Questionnaire Core 30(QLQ-C30),Internal Health Locus of Control,and Powerful Others Health Locus of Control scores were significantly higher in the observation and the control groups compared to the pre-intervention period in their same group,and QLQ-C30 scores were significantly higher in the observation group compared to those of the control group(P<0.05).CONCLUSION The IIFAR information care model can help elderly patients with lung cancer by reducing their anxiety and depression,psychological distress,and fatigue,improving their tendencies on the locus of control in psychology,and enhancing their life qualities.
基金Supported by China Medical University,No.CMU111-MF-10.
文摘In this editorial we comment on the article published in a recent issue of the World Journal of Gastroenterology.Acute liver failure(ALF)is a critical condition characterized by rapid hepatocellular injury and organ dysfunction,and it often necessitates liver transplant to ensure patient survival.Recent research has eluci-dated the involvement of distinct cell death pathways,namely ferroptosis and pyroptosis,in the pathogenesis of ALF.Ferroptosis is driven by iron-dependent lipid peroxidation,whereas pyroptosis is an inflammatory form of cell death;both pathways contribute to hepatocyte death and exacerbate tissue damage.This comprehensive review explores the interplay between ferroptosis and pyroptosis in ALF,highlighting the role of key regulators such as silent information regulator sirtuin 1.Insights from clinical and preclinical studies provide valuable perspectives on the dysregulation of cell death pathways in ALF and the therapeutic potential of targeting these pathways.Collaboration across multiple disciplines is essential for translating the experimental insights into effective treatments for this life-threatening condition.
基金supported by the Natural Science Foundation Research Plan of Shanxi Province (2023JCQN0728)。
文摘The subversive nature of information war lies not only in the information itself, but also in the circulation and application of information. It has always been a challenge to quantitatively analyze the function and effect of information flow through command, control, communications, computer, kill, intelligence,surveillance, reconnaissance (C4KISR) system. In this work, we propose a framework of force of information influence and the methods for calculating the force of information influence between C4KISR nodes of sensing, intelligence processing,decision making and fire attack. Specifically, the basic concept of force of information influence between nodes in C4KISR system is formally proposed and its mathematical definition is provided. Then, based on the information entropy theory, the model of force of information influence between C4KISR system nodes is constructed. Finally, the simulation experiments have been performed under an air defense and attack scenario. The experimental results show that, with the proposed force of information influence framework, we can effectively evaluate the contribution of information circulation through different C4KISR system nodes to the corresponding tasks. Our framework of force of information influence can also serve as an effective tool for the design and dynamic reconfiguration of C4KISR system architecture.
基金Project supported by the National Natural Science Foundation of China (Grant Nos.32271293 and 11875076)。
文摘Positional information encoded in spatial concentration patterns is crucial for the development of multicellular organisms.However,it is still unclear how such information is affected by the physically dissipative diffusion process.Here we study one-dimensional patterning systems with analytical derivation and numerical simulations.We find that the diffusion constant of the patterning molecules exhibits a nonmonotonic effect on the readout of the positional information from the concentration patterns.Specifically,there exists an optimal diffusion constant that maximizes the positional information.Moreover,we find that the energy dissipation due to the physical diffusion imposes a fundamental upper limit on the positional information.
基金supported by the National Natural Science Foundation of China (62173333, 12271522)Beijing Natural Science Foundation (Z210002)the Research Fund of Renmin University of China (2021030187)。
文摘For unachievable tracking problems, where the system output cannot precisely track a given reference, achieving the best possible approximation for the reference trajectory becomes the objective. This study aims to investigate solutions using the Ptype learning control scheme. Initially, we demonstrate the necessity of gradient information for achieving the best approximation.Subsequently, we propose an input-output-driven learning gain design to handle the imprecise gradients of a class of uncertain systems. However, it is discovered that the desired performance may not be attainable when faced with incomplete information.To address this issue, an extended iterative learning control scheme is introduced. In this scheme, the tracking errors are modified through output data sampling, which incorporates lowmemory footprints and offers flexibility in learning gain design.The input sequence is shown to converge towards the desired input, resulting in an output that is closest to the given reference in the least square sense. Numerical simulations are provided to validate the theoretical findings.