Since the first publication describing the identification of prostate-specific antigen （PSA） in the 1960s, much progress has been made. The PSA test changed from being initially a monitoring tool to being also used ...Since the first publication describing the identification of prostate-specific antigen （PSA） in the 1960s, much progress has been made. The PSA test changed from being initially a monitoring tool to being also used as a diagnostic tool. Over time, the test has been heavily debated due to its lack of sensitivity and specificity. However, up to now the PSA test is still the only biomarker for the detection and monitoring of prostate cancer. PSA-based screening for prostate cancer is associated with a high proportion of unnecessary testing and overdiagnosis with subsequent overtreatment. In the early years of screening for prostate cancer, high rates of uptake were very important. However, over time the opinion on PSA-based screening has shifted towards the notion of informed choice. Nowadays, it is thought to be unethical to screen men without them being aware of the pros and cons of PSA testing, as well as the fact that an informed choice is related to better patient outcomes. Now, as the results of three major screening studies have been presented and the downsides of screening are becoming better understood, informed choice is becoming more relevant.展开更多
To solve the problem of information fusion from multiple sources in innovation alliances, an information fusion model based on the Bayesian network is presented. The multi-source information fusion process of innovati...To solve the problem of information fusion from multiple sources in innovation alliances, an information fusion model based on the Bayesian network is presented. The multi-source information fusion process of innovation alliances was classified into three layers, namely, the information perception layer, the feature clustering layer,and the decision fusion layer. The agencies in the alliance were defined as sensors through which information is perceived and obtained, and the features were clustered. Finally, various types of information were fused by the innovation alliance based on the fusion algorithm to achieve complete and comprehensive information. The model was applied to a study on economic information prediction, where the accuracy of the fusion results was higher than that from a single source and the errors obtained were also smaller with the MPE less than 3%, which demonstrates the proposed fusion method is more effective and reasonable. This study provides a reasonable basis for decision-making of innovation alliances.展开更多
文摘Since the first publication describing the identification of prostate-specific antigen （PSA） in the 1960s, much progress has been made. The PSA test changed from being initially a monitoring tool to being also used as a diagnostic tool. Over time, the test has been heavily debated due to its lack of sensitivity and specificity. However, up to now the PSA test is still the only biomarker for the detection and monitoring of prostate cancer. PSA-based screening for prostate cancer is associated with a high proportion of unnecessary testing and overdiagnosis with subsequent overtreatment. In the early years of screening for prostate cancer, high rates of uptake were very important. However, over time the opinion on PSA-based screening has shifted towards the notion of informed choice. Nowadays, it is thought to be unethical to screen men without them being aware of the pros and cons of PSA testing, as well as the fact that an informed choice is related to better patient outcomes. Now, as the results of three major screening studies have been presented and the downsides of screening are becoming better understood, informed choice is becoming more relevant.
基金supported by the National Natural Science Foundation of China(Nos.71472053,71429001,and91646105)
文摘To solve the problem of information fusion from multiple sources in innovation alliances, an information fusion model based on the Bayesian network is presented. The multi-source information fusion process of innovation alliances was classified into three layers, namely, the information perception layer, the feature clustering layer,and the decision fusion layer. The agencies in the alliance were defined as sensors through which information is perceived and obtained, and the features were clustered. Finally, various types of information were fused by the innovation alliance based on the fusion algorithm to achieve complete and comprehensive information. The model was applied to a study on economic information prediction, where the accuracy of the fusion results was higher than that from a single source and the errors obtained were also smaller with the MPE less than 3%, which demonstrates the proposed fusion method is more effective and reasonable. This study provides a reasonable basis for decision-making of innovation alliances.
