Analysis on medication rule of traditional Chinese medicine treating chemotherapy-induced diarrhea based on traditional Chinese medicine(TCM) inheritance computing platform system

Objective:To dig deeper into the traditional Chinese medicine treatment rules of chemotherapy-induced diarrhea with traditional Chinese medicine(TCM)inheritance computing platform system.Methods:Taking“traditional Chinese medicine”,“chemotherapy”and“diarrhea”as the theme words,comprehensive search of the database of CNKI,Wanfang and VIP from its inception to November 2020 was conduct-ed.The formulas of external treatment of traditional Chinese medicine for chemotherapy-induced diarrhea were included and the association rule,clustering and factor analysis were carried out.Results:A total of 145 papers,57 prescriptions meeting the inclusion criteria were collected,among which high-frequency drugs including Baizhu(Atractylodis macrocephalae rhizoma),Fuling(Poria),Dangshen(Codonopsisradix),Huanglian(Coptidis rhizoma),Zhigancao(Glycyrrhizae radix et rhizoma praeparata cum melle)were the most commonly used.The confidence level was set as 0.7 and the support level was set as 10,12 core compatibility groups were obtained,and 6 categories were cluster analyzed.Conclusion:The principle of external treatment of chemotherapy-induced diarrhea is mainly“restore deficiency and benefiting qi”,“benefiting water infiltration and dampness”,“clearing heat”and“inducing astringency”.Prescription combination and new prescription combination based on traditional Chinese medicine(TCM)inheritance computing platform system can be used as reference for clinicians and applied in primary hospitals.

Analysis of professor Wang Yongyan's experience in treating hemorrhagic diseases based on traditional Chinese medicine inheritance support system

Based on the data analysis platform provided by TCMISS(V2.5),this paper analyzes the rule of prescribing drugs used by Professor Yongyan Wang for the treatment of apoplexy and deepens the understanding of his academic research on syndrome differentiation and treatment.Professor Wang’s medical records were summarized and sorted into the"Chinese Medicine inheritance Assistance system".Through the functions of"frequency statistics","drug use mode","rule analysis"and so on,the characteristics of professor Yongyan Wang's prescription for treating apoplexy were statistically analyzed.It is helpful to understand and inherit Professor Wang's academic thoughts by analyzing the data of professor Wang's medical records of apoplexy.

Rule of prescribing traditional Chinese medicine in the treatment of pneumoconiosis basedon association rules and k-means clustering algorithm

Objective:To analyze the rule of prescribing traditional Chinese medicine for treating pneumoconiosis,so as to provide reference for differential diagnosis and treatment of pneumoconiosis as well as for the development of new drugs for treatingthe disease.Methods:We searched China National Knowledge Infrastructure,Wanfang Database and VIP Chinese PublicationDatabase to retrieve relevant literatures which were then screened according to the enrollment criteria to establish a prescriptiondatabase of traditional Chinese medicine for the treatment of pneumoconiosis.The inheritance calculation platform of traditionalChinese medicine was used to analyze the prescribing rule of traditional Chinese medicine in the treatment of pneumoconiosisbased on association rules,k-means clustering algorithm and regression model analysis.Results:A total of 131 related literature were preliminarily selected,from which 97 prescriptions of traditional Chinese medicine with a total of 195 herbs were included.The most frequently prescribed herbs included Radix astragali,Platycodon grandiflorum,Pinellia ternata,licorice,Codonopsispilosula,Salvia miltiorrhiza,bitter almond etc.A total of 14 association rules,13 high-frequency herb pairs were found and 5groups of formulas were revealed by cluster analysis.Conclusion:The prescriptions for the treatment of pneumoconiosis are mainly composed of herbs for tonifying deficiency,resolving phlegm,relieving cough and asthma,activating blood circulation and removingblood stasis,which are supplemented with herbs for clearing heat,relieving appearance,regulating qi,promoting waterand permeating dampness,etc.,The prescribing rules reflect the basic pathological characteristics of lung deficiency and collateral arthralgia in pneumoconiosis,which provides some ideas for the clinical differentiation and treatment of pneumoconiosis in traditionalChinese medicine.It also provides reference for the research and development of new treatment methods.

Compatibility rule of traditional Chinese medicine for treatment of cardiac neurosis based on data mining

Objective:To analyze the prescription and medication rule of traditional Chinese medicine(TCM)in treating cardiac neurosis by using the software of"Traditional Chinese Medicine Inheritance Assistant Platform(V2.5)".Methods:China Journal Full-Text Database,Wanfang database,Weipu Chinese Periodical Service Platform and Chinese biomedical literature database were retrieved according to the inclusion and exclusion criteria.Literatures on the treatment of cardiac neurosis with TCM prescriptions were screened out and data mining was carried out using the TCM inheritance assistant platform.Use frequency,commonly used dose,the frequency of properties,flavors and meridian distribution were counted.Association rules and entropy clustering analysis for complex system were used to extract core drug combinations and unsupervised entropy hierarchical clustering was used to predict potential new prescriptions.Results:Through literature retrieval and screening,210 types of prescriptions were finally selected,and 181 types of Chinese herbs were extracted,with cumulative frequency of 2410 times.Among them,there were 46 traditional Chinese medicines that were used more than 15 times.According to the efficacy and indication,they were classified into qi-regulating drugs,tranquilizers,qi-tonifying drugs,heat-clearing drugs,blood-tonifying drugs,etc.According to properties,flavors,and meridian distribution,warm and sweet drugs were the most commonly used,mostly distributing to the heart meridian,followed by liver and spleen meridians.Association rules showed that combination of radix paeoniae and paeonia-bupleurum was the most used;faructus aurantii and bupleurum had the strongest correlation,up to 90%.The network diagram indicated that bupleurum,angelica sinensis,radix paeoniae radix,and poria cocos were the core of the association network.Based on complex system entropy clustering,24 core drug combinations were obtained.The unsupervised entropy hierarchical clustering algorithm was used to extract 12 core drug combinations,and 6 potential new formulae were obtained by further clustering.Conclusion:Regulating qi and blood,addressing both symptoms and causes,and using purgation and tonification at the same time is the principle of the treatment of cardiac neuropathy with TCM.The treatment mainly starts from the heart,liver and spleen,and therapies include soothing the liver and regulating qi,clearing heat and resolving phlegm,tranquilizing and calming the nerves,and prompting blood circulation and diuresis.

Professor Zhang Yu-zhen's medication rule in treating metrorrhagia and bleeding based on data mining

Objective:To explore the medication rules of Professor Zhang Yuzhen in treating the bleeding period of metrorrhagia and metrostaxisthe,and to explore the treatment of the disease.Methods:Collected 520 prescriptions of Professor Zhang Yuzhen in the treatment of patients with the bleeding period of metrorrhagia and metrostaxis,and analyzed the regularity of medication by using"TCM inheritance assist platform(V2.5)".Results:According to the analysis,the top 30 most frequently used herbs for treating the bleeding period of metrorrhagia and metrostaxisthe were Codonopsis pilosula,Trogopterus dung,Cattail pollen,Motherwort,Cornus,Ophiopogon japonicas,Schisandra,Tortoiseshell,Panax notoginseng,Radix Paeoniae Alba,etc.Core combination 35 In the group,the core prescription has 1 hemostasis,followed by 2 hemostasis,and evolves to get 3 new prescriptions.Conclusion:Professor Zhang Yuzhen's medication for the treatment of metrorrhagia and metrostaxisthe is mostly Gan Wen's product.The treatment is based on the three organs of the liver,spleen,and kidney,and the disease is treated with"tonifying the kidney and benefiting qi,reducing blood stasis and stopping bleeding".

Mining the rules of acupoint selection and manipulation scheme of massage in reducing or substituting drug treatment of simple obesity based on association rules and entropy cluster analysis

Based on the data mining of clinical literature,we analyzed the characteristics of Acupoint Selection and manipulation in the clinical treatment of“simple obesity”,in order to optimize the compatibility of clinical acupoints,simplify the manipulation,and summarize the core prescription of Massage in the treatment of simple obesity.Methods:First we search and screen the clinical literature of Chinese Massage therapy for“simple obesity”by scholars at home and abroad.Then we analyze the Acupoint Selection and manipulation rules of Chinese Massage therapy for“simple obesity”by using data mining technology and traditional Chinese Medicine Inheritance assistant system.Finally we obtain the optimal new prescription based on complex system entropy clustering and unsupervised entropy hierarchical clustering analysis.Results:Fifty-seven prescriptions meeting the inclusion criteria were selected,including TIANSHU(ST25)(36),ZHONGWAN(RN12)(32),GUANYUAN(RN4)(30),ZUSANLI(ST36)(27),QIHAI(RN6)(23),“Stomach Meridians”(10),“Spleen Meridians”(8),Renmai(7),Abdomen(36),Umbilicus(8),Pressing(33),Holding(27),Pressing(26),and get 4 core Prescriptions like ST25-RN12-Renmai-Stomach Meridians-Abdominal Rub-Rubbing-Pushing thumb-Rubbing-Palm Pushing-Thumb Point Acupuncture-Palm Vibration and 4 new prescription of Massage manipulation for the treatment of simple obesity.Conclusion:The results of clinical diagnosis and treatment data are mined and analyzed by traditional Chinese medicine inheritance assistant system.The acupoint compatibility,manipulation rules and core prescriptions obtained can provide statistical basis and references for clinical Massage manipulation in the treatment of simple obesity.

Administration Rule of Hyperlipidemic Acute Pancreatitis Based on Data Mining

Objective:To excavate the medical pattern of hyperlipidemic acute pancreatitis based on Chinese Medicine Inheritance Assistant Platform software,hope to offer ideas for the treatment of the disease.Methods:Inpatient cases admitted to the Department of Gastroenterology of Shenzhen Hospital of Traditional Chinese Medicine for HLAP from September 2013 to June 2020 were collected,information on evidence patterns and formulations was extracted,an Excel database was established and professional terms were standardized,and data mining methods such as association rules and entropy clustering of complex systems were used to analyze medical patterns.Results:The main symbols of HLAP include abdominal pain,abdominal distinction,vomiting,fever,etc.The common used drags include Immature Orange Fruit,Baical Skullcap Root,Rhubarb and Chinese Thorowax Root,etc.The main drug pairs based on association rule analysis are"Baical Skullcap Root,Immature Orange Fruit","Rhubarb,Immature Orange Fruit","Baical Skullcap Root,Rhubarb,Immature Orange Fruit",etc,and 14 drug core combinations and 7 new formulations were extracted.Conclusion:The main synthesis of HLAP are solid-heat knots in the internal organs and dam-heat in the liver and gallbladder,and the formula is based on Da-chai-hu Decoction,the clinical treatment is based on attacking stagnation,activating blood circulation and removing dampness,which can offer reference for the clinical treatment of the disease.

Medication patterns of ancient Chinese medicinal prescriptions fordiabetic retinopathy

Objective:To mine the medication patterns of ancient prescriptions for diabetic retinopathy(DR)from databases of traditional Chinese medicine(TCM)ancient books,and provide evidence for clinical practice and scientific research of TCM treatment for DR.Methods:The traditional library retrieval and modern data retrieval technology were combined to collect the ancient prescriptions in these databases,including the library ofHunan University ofChinese Medicine,Chinese Medical Dictionary,Duxiu,and Chaoxing Digital Library.And the TCM inheritance auxiliary platform(V3.0)was used for data mining,mainly including drug frequency analysis,medicinal property and meridian tropism analysis,efficacy analysis,correlation analysis,complex network analysis,and cluster analysis.Results:A total of 271 ancient prescriptions for the treatment of DR were collected,involving 296 drugs.The total medication frequency was 2,727.Most of them were cold and sweet drugs.The meridians primarily targeted were the liver,kidney,and spleen.The main effects of drugs were supplementing deficiency,clearing heat,releasing the exterior,inducing urination to drain dampness,pacifying liver and extinguishing wind,and circulating blood and transforming stasis.Saposhnikovia divaricata was the most frequently Chinese herbal medicine for DR in TCM ancient books.Saposhnikovia divaricata and ligusticum wallichi,saposhnikovia divaricata and notopterygium root,angelica sinensis and ligusticum wallichii were common herbal pairs.Saposhnikovia divaricata,ginseng,plantain seed,angelica sinensis,prepared rehmannia root and cassia seed constituted the core formula with the highest frequency.Conclusion:The core prescriptions for treating DR are mainly crafted from Dihuang pill,Ruiren powder,Siwu decoction,and Zhujing pill.Saposhnikovia divaricata is an important meridian-guiding medicine to open Xuanfu for DR.In clinical practice,the prescriptions should be modified according to the evolution of pathogenesis.