X-ray computed tomography(CT)imaging plays an essential role in disease diagnosis due to its noninvasive,painless mode and superior penetration depth.However,the resolution of the soft tissue and minor lesions remains...X-ray computed tomography(CT)imaging plays an essential role in disease diagnosis due to its noninvasive,painless mode and superior penetration depth.However,the resolution of the soft tissue and minor lesions remains limited.And the disadvantages of conventional contrast agents,such as their inefficient targeting capability,poor biocompatibility,and short circulation times,are considered intractable in clinical use.To overcome these“Gordian knots,”nanoparticles(NPs)for CT imaging have been developed.The advantages of NPs are their exceptionally high sensitivity to X-ray,better imaging performance in vivos and even therapeutic effects.In particular,based on various designs,NP contrast agents composed of different materials integrate multiple imaging modalities,make up for the inadequacy of a single imaging type,and thus provide more accurate information for diagnosis.This review focuses on NPs for X-ray CT imaging and their multifunctional designs.Some perspectives of crucial problems and prospective challenges are also discussed.展开更多
Objective: The aim of the study was to analyze the CT morphology features of pulmonary sclerosing hemangiomas (PSHs) and improve the diagnosis ability of this disease.Methods: The 18 cases of pulmonary sclerosing hema...Objective: The aim of the study was to analyze the CT morphology features of pulmonary sclerosing hemangiomas (PSHs) and improve the diagnosis ability of this disease.Methods: The 18 cases of pulmonary sclerosing hemangioma (PSH) confirmed by operation and histopathology from August 2002 to May 2009 were collected,including 17 females and 2 males,aged from 19 to 60 years old,with an average age of 43 years.All the cases underwent plain CT scan,among them,16 cases received enhanced CT scan.Results: The 18 cases had isolated mass.Mean long-axis diameter of these lesions was (2.7 ± 1.3) cm (range,1.9–4.2 cm).Of all cases,5 cases (27.8%) were round in shape,9 cases (50%) were oval,4 cases (22.2%) were lobulated,and 14 cases (77.8%) were smooth margin.The air meniscus sign was in 2 cases (11.1%),and the halo sign in 3 cases (16.7%).Two cases (11.1%) contained small nodular calcification,the remaining 16 cases (70%) were homogeneous density,the CT density of the masses ranged from 24–47 HU,and the mean value was 35 HU.Sixteen cases received enhanced scan,the welt vessel sign was in 8 cases (44.4%),1 case showed less enhancement,5 cases showed marked homogeneous enhancement and 10 cases showed intense and patchy heterogeneous enhanced.The CT density of the enhancing masses ranged from 60–110 HU,the mean value was 35 HU,and the net enhancement value was 14–80 HU,the mean value was 55 HU.Conclusion: PSH should be considered in middle-aged female whose CT found that single round or oval pulmonary nodules,with smooth margin,or associated with the air meniscus sign,the halo sign,or the marked enhancement.展开更多
基金The authors gratefully acknowledge the financial support received from the National Natural Science Foundation of China(nos.21721003 and 21635007)and the K.C.Wong Education Foundation.
文摘X-ray computed tomography(CT)imaging plays an essential role in disease diagnosis due to its noninvasive,painless mode and superior penetration depth.However,the resolution of the soft tissue and minor lesions remains limited.And the disadvantages of conventional contrast agents,such as their inefficient targeting capability,poor biocompatibility,and short circulation times,are considered intractable in clinical use.To overcome these“Gordian knots,”nanoparticles(NPs)for CT imaging have been developed.The advantages of NPs are their exceptionally high sensitivity to X-ray,better imaging performance in vivos and even therapeutic effects.In particular,based on various designs,NP contrast agents composed of different materials integrate multiple imaging modalities,make up for the inadequacy of a single imaging type,and thus provide more accurate information for diagnosis.This review focuses on NPs for X-ray CT imaging and their multifunctional designs.Some perspectives of crucial problems and prospective challenges are also discussed.
文摘Objective: The aim of the study was to analyze the CT morphology features of pulmonary sclerosing hemangiomas (PSHs) and improve the diagnosis ability of this disease.Methods: The 18 cases of pulmonary sclerosing hemangioma (PSH) confirmed by operation and histopathology from August 2002 to May 2009 were collected,including 17 females and 2 males,aged from 19 to 60 years old,with an average age of 43 years.All the cases underwent plain CT scan,among them,16 cases received enhanced CT scan.Results: The 18 cases had isolated mass.Mean long-axis diameter of these lesions was (2.7 ± 1.3) cm (range,1.9–4.2 cm).Of all cases,5 cases (27.8%) were round in shape,9 cases (50%) were oval,4 cases (22.2%) were lobulated,and 14 cases (77.8%) were smooth margin.The air meniscus sign was in 2 cases (11.1%),and the halo sign in 3 cases (16.7%).Two cases (11.1%) contained small nodular calcification,the remaining 16 cases (70%) were homogeneous density,the CT density of the masses ranged from 24–47 HU,and the mean value was 35 HU.Sixteen cases received enhanced scan,the welt vessel sign was in 8 cases (44.4%),1 case showed less enhancement,5 cases showed marked homogeneous enhancement and 10 cases showed intense and patchy heterogeneous enhanced.The CT density of the enhancing masses ranged from 60–110 HU,the mean value was 35 HU,and the net enhancement value was 14–80 HU,the mean value was 55 HU.Conclusion: PSH should be considered in middle-aged female whose CT found that single round or oval pulmonary nodules,with smooth margin,or associated with the air meniscus sign,the halo sign,or the marked enhancement.
