Transformations of phosphatidylinositol phosphates in the outer and inner nuclear membrane are linked to synthesis and restitution of cellular membranes

The ultimate goal in phosphoinositides cellular metabolism is to decipher their global functional organization and coordination of the com- partmentalized signaling processes. In this report we present evidence linking nuclear phos- phoinositides cycle with endoplasmic reticulum synthesis and function. The rapid transformation of [3H]inositol-labeled phosphoinositides in the intact nuclei (IN) was captured in chase studies for 0-5 min, followed by examination of phosphatidylinositides in the inner nuclear me- mbrane (INM), the outer nuclear membrane (ONM) and endoplasmic reticulum (ER). We revealed that synthesis of phosphatidylinositol phosphates (PIPs) occurs in ONM and the de- phosphorylation takes place in the INM. The rapid transformation of the radiolabeled PIPs in ONM reverberated in their appearance and successive transformation in INM, and in the 5min chased nuclei was tracked to ONM as the re- emerging radiolabeled phosphatidylinositol (PI). These chase-uncovered changes in ONM and INM PIPs profiles allow us to conclude that the observed conversions in the nuclear membrane continuum are induced by the lateral movement of the membrane and its transit from the cytosolic to nuclear and back to cytosolic environment. The suggested membrane synthesisinduced movement provides the means to transport the membrane- and the membrane lipid ligand-associated cytosolic proteins to the intranuclear spaces and renewal of INM. Export of the nuclear components interacting with the modified INM, by exiting from nuclear to cytosolic site, endows ER with a steady influx of the membrane that is conditioned to generate vesicles according to the nucleus delivered templates.

Lipophilic extractives of the inner and outer barks from six different Pinus species grown in Indonesia

The chemical compositions of the dichloromethane extracts of inner and outer barks from six Pinus species（P.elliotii,P.oocarpa,P.caribeae,P.merkusii,P.montezumae,and P.insularis） grown in Indonesia were investigated by GC and GC–MS.Generally,the amounts of extractive contents were higher in the inner bark than in the outer bark except for P.merksuii.Fatty acids,monoterpenes,sesquiterpenes,resin acids,triterpenoids,and steroids were detected and quantified.Inner and outer barks differed not only in content of these compounds but also in their composition.Fatty acids and alcohols were the major classes of lipophilic compounds in the outer bark of P.caribeae, P.insularis,and P.montezumae.Steroids and triterpenoids were the dominant compounds identified in the inner bark of P.elliotii,P.insularis,and P.merkusii.Resin acids were the most abundant group in the inner bark of P.oocarpa whereas monoterpenes and sesquiterpenes were recorded in minor quantities in both bark layers of all species.

Viscous Inner and Outer Pressure Forming Method of Thin-walled Tube and Its Application

Aiming at overcoming the difficulties in integral forming of thin-walled tubes with complex shapes, a novel forming method by inner and outer pressure through viscous was proposed. In this method, by dividing large deformation of the part into inner and outer pressure forming deformations, the limit deformation of tube part can be increased by several times. Meanwhile, the principle of viscous inner and outer pressure forming was provided, and key problems during the forming process such as reduction of the wall-thickness and instability wrinkling were analyzed. Thereby, the complex curved surface super-alloy GH3044 thin-walled tube with varying diameter ratio of 1.35（the ratio between the maximum and minimum diameters of the part） can be integrally formed by this method. The experimental surface of the formed part is superior in quality and the wall-thickness distribution is uniform. The results show that the viscous inner and outer pressure forming can provide a new approach for integral forming of thin-walled tubes with complex shapes.

Influence of Inner/Outer Stator Pole Ratio and Relative Position on Electromagnetic Performance of Partitioned Stator Switched Flux Permanent Magnet Machines

Based on the 6-pole outer stator(armature winding-stator),the influence of inner(permanent magnet-stator)/outer stator pole ratio n(n=NIS/NOS),stator relative positions and rotor pole number combinations on electromagnetic performance of partitioned stator switched flux permanent magnet(PM)machines(PS-SFPMMs)is investigated in this paper.Since the armature windings and PMs are located in two separated stators and PMs are stationary,PS-SFPMMs have high fault tolerance capabilities.To maximize the torque performance,the PM of inner stator pole should be aligned with outer stator pole when n is odd while the iron rib of inner stator pole should be aligned with outer stator pole when n is even.No matter what n is selected,the rotor pole number NR can be any integers except the phase number and its multiples.The analysis results indicate that the optimal NR is closed to(NIS+NOS)/2 and it is odd when n is odd while it is even when n is even.Meanwhile,symmetrical phase back-EMF waveform will be obtained when the ratio of Min(NOS,NIS)to the greatest common divisor of Min(NOS,NIS)and NR is even.Based on the optimal rotor pole numbers for 6-pole outer stator with different n and corresponding optimal relative position together with same rated copper loss,the average torque is improved by 18.4%,25.1%and 25.7%respectively in PS-SFPMMs with n equal to 2,3 and 4 when compared with PS-SFPMM with n equal to 1.The analyses are validated by experiment results of the prototype machine.

Inner and outer pressure forming of nickel based super-alloy thin-walled part with variable diameter sections

A novel forming method of nickel based super-alloy thin-walled part with variable diameter sections was proposed by using inner and outer pressure with the visco-elasto-plastic pressure-carrying medium at room temperature,and the principle of the method was provided.Experiments and FE simulations were carried out to analyze the deformation characteristics for the part with larger variable diameter ratio(35%).The results show that visco-elasto-plastic pressure-carrying medium can meet the requirements of the room-temperature deformation condition for nickel based super-alloy sheet.The inner and outer pressure forming with the visco-elasto-plastic pressure-carrying medium can meet the requirements of dimensional accuracy for the thin-walled part with variable diameter sections.The thinning of wall-thickness is less than 4%.This method provides a new approach for near-net shape forming of nickel based super-alloy thin-walled parts with variable diameter sections.

Synchronization investigation of the network group constituted by the nearest neighbor networks under inner and outer synchronous couplings

A new synchronization technique of inner and outer couplings is proposed in this work to investigate the synchro- nization of network group. Some Haken-Lorenz lasers with chaos behaviors are taken as the nodes to construct a few nearest neighbor complex networks and those sub-networks are also connected to form a network group. The effective node controllers are designed based on Lyapunov function and the complete synchronization among the sub-networks is realized perfectly under inner and outer couplings. The work is of potential applications in the cooperation output of lasers and the communication network.

Forward masking in distinguishing inner and outer hair cell damage

Forward Masking Temporal audiotory resolution is the ability of the auditory system to resolve auditory signals in the time domain. Forward masking is a means of studying temporal resolution where one tone, the probe, is masked by a preceding tone, the masker. Forward masking is

Performance evaluations on inner vs. outer decomposition first parallel join algorithms for two nested loop joins

Two popular traditional join algorithms and their parallel versions are introduced. When designing join algorithms in serial computing environment, decomposing inner relation is considered as the right direction to save disk I/Os. However, two different decomposition algorithms are compared, such as inner vs. outer decomposition first algorithms for tuple-based and block-based nested loop joins, showing that the proposed approach is 20% better than general approach. Also lemmas are proved, when we have to use the outer decomposition first parallel join algorithms.

内圣外王的期盼:中国古代君德论及其特征

中国古代君德论起源于殷周,发展于两汉,兴盛于唐,繁荣于两宋,变革于明末清初,一脉相承而内容不断丰富。君德的内容包含了君主的德性、器识、才智、能力等诸多因素,主要体现在君主个人修养以及施政过程中如何处理君臣关系、君民关系等方面。完善君德的方式主要有经筵讲读、皇储教育、家训教化、大臣谏诤、史书褒贬。古代君德论特征鲜明,君主地位的尊崇、历史的教训与现实的需要是君德论的起点,儒家“修齐治平”“内圣外王”理论是君德论的思想基础,读经观史,以经为则、以史为鉴是完善君德的重要手段,“致君尧舜”是君德修养的重点。古人已经形成了一套围绕君主而展开的关于君德修养的理论体系。同时也要看到,古人讨论君德,既存在“师道”与“君道”之间无法调和的矛盾,也没有进行制度层面的反思,反映的只是一种泛道德化的政治伦理观。

圆柱滚子轴承滚子对数修形优化研究

为了提高轴承的疲劳寿命,采用Romax Designer工程分析软件,在充分考虑径向游隙和内外圈相对倾斜量(影响轴承寿命的主要因素)对修形效果影响的基础上,对某大兆瓦风电机组齿轮箱输出轴轴承进行了对数修形优化分析。首先,对国际标准ISO/TS 16281寿命计算方法进行了简要分析;然后,对不同径向游隙情况下对数修形的效果进行了分析;最后,对不同内外圈相对倾斜量情况下对数修形的效果进行了分析。研究结果表明:以轴承最大接触应力最小为优化目标和以国际标准ISO/TS 16281寿命最长为优化目标的轴承对数修形,其最佳修形量不同,相应的ISO/TS 16281寿命有很大不同;在该轴承的具体条件下,以ISO/TS 16281寿命最长为优化目标的最佳修形凸度量对应的ISO/TS 16281寿命比以最大接触应力最小为优化目标的最佳修形凸度量对应的ISO/TS 16281寿命长2.39%~10.63%;以ISO/TS 16281寿命最长为优化目标的最佳修形凸度量对应的ISO/TS 16281寿命比未修形的ISO/TS 16281寿命长111.47%~1054.88%,建议以ISO/TS 16281寿命最长为优化目标对轴承进行修形优化设计。该研究结果可为滚子类轴承的优化设计提供参考。

概率区间值犹豫模糊集多属性群决策模型及其应用

目的:研究概率区间值犹豫模糊集及应用。方法:将概率区间值犹豫模糊数,用区间值隶属度的中位数、区间值隶属度的清晰度以及概率构成的三维点坐标进行刻画,在此基础上提出了概率区间值犹豫模糊元的相关运算。根据概率区间值犹豫模糊元的相关运算采用熵值法计算属性权重。最后基于TOPSIS思想给出了一个新的贴近度公式,并利用新的贴近度公式对方案排序。结果:建立的概率区间值犹豫模糊集多属性群决策模型可以有效排序方案。结论:将概率区间值犹豫模糊集采用区间值隶属度的中位数、区间值隶属度的清晰度以及概率来表示不仅可行,而且可以用来解决多属性群决策问题。

内外圈相对倾斜对圆柱滚子轴承寿命的影响

采用Romax Designer工程分析软件对某大兆瓦风电机组齿轮箱进行整体建模,应用经典滚动轴承理论和“切片法”基本思想,对齿轮箱输出轴圆柱滚子轴承在不同内外圈相对倾斜情况下的接触应力、修形效果和轴承寿命进行大量分析计算;重点对轴承ISO/TS 16281寿命进行分析,分析内外圈相对倾斜量对ISO/TS 16281寿命的影响以及对未修形和对数修形最佳修形凸度量时两种情况下寿命的影响;还将ISO 281寿命和ISO/TS 16281寿命进行对比。研究结果表明,无论轴承是否修形,内外圈相对倾斜对轴承ISO/TS 16281寿命影响非常大,倾斜量越大,ISO/TS 16281寿命越短,对应的最佳修形凸度量越大,相应修形效果越好,ISO/TS 16281:2008额定寿命提高得越大;在内外圈相对倾斜量相同的情况下,ISO/TS 16281寿命与ISO281寿命相差非常大。研究结果可为圆柱滚子轴承优化设计提供参考。

内/外隔热复合结构炸药装药快速烤燃热防护效应

为了研究快速烤燃(火烧)条件下炸药装药内/外隔热复合结构(内隔热材料/外阻燃材料)的热防护效应,对多种内/外隔热复合结构的炸药装药进行多点测温快速烤燃试验,得到火焰场和炸药装药各测点的温度-时间曲线及装药点火响应时间。开展内/外隔热复合结构炸药装药快速烤燃数值模拟,获得内/外隔热复合结构对装药快速烤燃点火响应时间的影响规律。研究结果表明:在快速烤燃过程中,外阻燃材料由于火烧变性存在导热增强及隔热减弱效应,在数值模拟中需考虑该效应;无论使用单独的隔热/阻燃材料还是使用内/外隔热复合结构,炸药装药的点火响应时间均随着材料涂覆厚度增加而延后,其中内/外隔热复合结构具有更好的热防护能力;点火位置均发生在装药端面棱角处,装药点火后反应烈度不受内/外隔热复合结构影响,反应等级均为爆燃;对于一定热防护性能范围内的隔热阻燃材料,壳体外表面涂层材料是耐高温纳米隔热材料、壳体内表面涂层材料是高效隔热防护材料时复合结构的隔热效果最好,并且当需求的隔热效果给定时,可考虑优先增加壳体外表面涂层的涂覆厚度,实现以最小涂覆厚度的内/外隔热复合结构满足所需的隔热效果。研究成果可为提升弹药热安全性设计提供参考。

磁信号检测高温合金内外壁缺陷分类研究

为区分高温合金内外壁缺陷,采用高精度弱磁传感器对高温合金人工槽型缺陷进行检测。从有缺陷的一面检测为正面(即外壁缺陷),从另一面检测为反面(相当于内壁缺陷),发现单侧表面缺陷检测信号出现极性相反的情况,无法通过极性相反这一特征区分内外壁缺陷。针对这一现象,基于支持向量机中的分类功能,对采集到的弱磁信号进行特征提取获得面积、幅值和占宽3种特征量建立分类数据库,进行内外壁缺陷分类识别,并采用不同的核函数建立分类模型进行比较,最终发现径向基核函数分类模型正确率最高,为84.37%,且经过样本库外的试件验证后正确率仍有81.25%。结果表明该算法能够有效地对高温合金缺陷信号进行分析和辨识,具有一定的实用价值。

非钢制关节轴承制造材料研究进展

随着对关节轴承性能要求的不断提高,寻找新材料替代钢材制备高性能的关节轴承已经成为一个重要研究方向。对非钢制关节轴承内外圈材料及其处理工艺、衬垫和涂层材料进行了详细介绍,针对非钢制关节轴承内外圈材料存在铝合金加工难,钛合金成本高和自润滑层存在摩擦磨损性能较低的问题,提出具有优异摩擦性能,力学性能好、耐腐蚀、易加工的内外圈材料和制备工序简单、低摩擦、高寿命的自润滑层材料是未来非钢制关节轴承材料的发展方向。

超强台风“舒力基”(2021)的尺度可预报性

台风尺度表征了台风低层风场特定风速半径大小,是台风灾害影响范围的重要度量.针对超强台风“舒力基”(2021),对其尺度可预报性进行初步探讨.结果表明,模式可以模拟出台风发展初期台风尺度(内核尺度RMW、外围尺度R17)的演变趋势.基于集合预报的模拟试验,具体分析了内核尺度RMW、外围尺度R17演变及其误差增长特征.台风预报总体误差主要出现在对流层下层850 h Pa,距离台风中心50~150 km.从初始环境场看,初始相对湿度是影响台风尺度误差增长的重要因子,初始高湿环境有利于台风发展阶段的台风尺度高离散度,从而限制了台风尺度的可预报性.在一定程度上,外围风圈半径的可预报性要高于内核风圈半径.

基于微波原理的高精度液位传感器

本文提出并演示了一种基于微波谐振原理的带有电阻消能结构的高精度液位传感器,在0~50 mm的量程范围内,分辨率可达微米级。微波谐振原理传感器第一反射点是传感器自带的固定点,第二反射点为液面,即为可变点,两反射点之间形成谐振腔结构。当液面的高度发生变化时,第二反射点发生移动,会导致两个反射点之间的距离发生变化,因此改变谐振腔长,通过测量谐振腔长的大小即可确定液位的变化量。同时,所加入的电阻在提高量程范围的基础上,还大幅提升了频谱质量和测量精度。实验结果表明,该液位传感器在0~50 mm的量程范围内具有1μm数量级的分辨率和-1.927 2 mm/mm(谐振波长变化/液位)的灵敏度。该新型微波液位传感器具有机械鲁棒性强、易于制造、成本低和高分辨率等优点,有望应用于水利水电的量水堰监测等领域。

无人驾驶农机装备的模糊PI-LQR转向控制算法

无人驾驶农机装备转向系统处于小流量、小角度控制时会出现非线性和时滞,这会导致转向控制超调或者控制时滞,进而导致无法快速准确地跟踪到路径预瞄点。针对这个问题,本文提出了一种模糊比例积分-线性二次型调节器(PI-LQR)数据融合的内外环控制算法。该算法以模糊PI控制为内环,基于转角误差和转角误差变化率,通过模糊逻辑运算自适应调节PI参数,进行转向角度的闭环控制。以LQR控制为外环,基于农机装备XY-横摆角控制,融合内环的转角误差,进一步提升无人驾驶农机装备转向的精准控制。Carsim和Matlab/Simulink联合仿真表明:通过100 m长的双移线路径下,最大横向误差为0.18 m,最大横向摆角误差为0.067 rad。实车测试表明:通过100 m长的双移线路径下,最大横向误差0.26 m,相较于PID纯跟踪控制算法,最大横向误差减少了0.19 m。

基于形态学方法与边缘检测的原竹几何特征识别

为提高原竹初加工过程的自动化、智能化水平,针对竹节位置与原竹内外径的快速精准识别需求,提出了一种基于形态学方法与边缘检测的原竹几何特征识别方法。首先,通过对原竹图像进行预处理,去除背景干扰,获得原竹竹节及竹径截面前景信息。其次,基于边缘检测原理计算原竹竹节图片的梯度数值以判断竹节是否存在,并通过形态学方法确定竹节位置;采用Canny算法获得竹径截面图片的内外径轮廓,基于椭圆截面的最小二乘拟合得到内外径尺寸并分级。最后,进行了原竹竹节与内外径识别试验。结果表明:竹节识别速度为0.2 s/次,准确率为95.5%,内外径识别速度为0.2 s/次,准确率为98%,验证了该方法的有效性。

“内国”与“外土”:周代铜器铭文所见的两个疆域概念

周代铜器录卣铭中的“内国”及戎生钟铭中的“外土”构成了一对在内涵上密切相关的疆域概念。这两个概念有特定内涵,“内国”意为“内域”,在铭文中指以郑洛地区为中心的中原腹地,这一地区自夏代至两周一直是早期王朝的核心疆域。“外土”为周王朝领土的外层区域,其地存在着大量的土著族群。不过作为周王朝能够有效管辖的区域,该区仍属周王朝之疆域。“内国”与“外土”作为一对疆域概念,反映了周王朝疆域形态及疆域治理均具有多层次性的特征。“内国”是王朝疆域的内层,由王廷所任命的内服职官加以治理。“外土”则是王朝疆域的外层,周王朝于此广设侯、伯贵族以治理土著族群并威慑在其之外的敌对势力。至于“外土”之外的区域,亦可能受到周人的军事打击,但周王朝已无法对其进行有效控制,其地已非周之疆域。