Objective To identify technical risks in the process of innovative drug development,and to provide reference for technical risk management so as to reduce the uncertainties and improve the efficiency of research and d...Objective To identify technical risks in the process of innovative drug development,and to provide reference for technical risk management so as to reduce the uncertainties and improve the efficiency of research and development.Methods The initial risk index was investigated by literature research.Then,the Likert scale was used to design a questionnaire,and the experts’opinion was used to analyze the risk factors affecting the different stages of the development of innovative drugs in China.Results and Conclusion Based on the analysis of questionnaire,31 risk indicators of five key stages in the development of innovative drugs from drug discovery to marketing authorization were established.The key risk indicators constructed in this study can provide reference for technology-related risk management in the process of innovative drug development.展开更多
In the 21st century,which is known as the age of information,the integration of electronic technology and e-commerce has become an irreversible trend in the field of business.This trend not only promotes the innovativ...In the 21st century,which is known as the age of information,the integration of electronic technology and e-commerce has become an irreversible trend in the field of business.This trend not only promotes the innovative development of e-commerce,but also brings unprecedented opportunities and challenges for enterprises.With the continuous development and popularization of Internet technology,more and more people choose to carry out shopping,payment and other consumption activities through e-commerce platforms,which also provides merchants with a broader market space and more sales channels.At the same time,e-commerce also brings more convenience and choice to consumers,making it easier for consumers to obtain the goods and services they need.However,the development of e-commerce has also brought some new challenges,such as how to ensure the quality of goods,how to protect consumer privacy and so on.Therefore,enterprises and government departments need to strengthen the supervision and management of e-commerce to ensure its healthy and orderly development.In general,the integration of electronic technology and e-commerce has become an important trend in today’s business field,which brings both opportunities and challenges to enterprises.展开更多
Enterprises must develop and implement effective strategic measures to achieve sustainable development.This entails evaluating corporate performance,understanding the impact of sustainable development strategies on co...Enterprises must develop and implement effective strategic measures to achieve sustainable development.This entails evaluating corporate performance,understanding the impact of sustainable development strategies on corporate performance,and implementing such strategies.The article proposes eight critical countermeasures to foster harmony and sustainable development among humanity,nature,the economy,and society:innovation-driven initiatives,green development practices,social responsibility initiatives,talent cultivation programs,collaborative cooperation efforts,sound financial management,brand-building endeavors,and effective information management.展开更多
In recent years,China’s property rights trading market has been extremely competitive,but there are also new contradictions and challenges.This paper aims to analyze the external and internal competitive market of th...In recent years,China’s property rights trading market has been extremely competitive,but there are also new contradictions and challenges.This paper aims to analyze the external and internal competitive market of the property rights market through Porter’s five forces competition model,then find out the problems and defects in the development,thereby promoting the better development and progress of China’s property rights trading market.展开更多
In recent years,Henan sticks to the points of General Secretary Xi Jinping,makes full use of its rich resources and relations,makes efforts to deepen friendship with people around the world,promotes relations with for...In recent years,Henan sticks to the points of General Secretary Xi Jinping,makes full use of its rich resources and relations,makes efforts to deepen friendship with people around the world,promotes relations with foreign countries,pushes展开更多
The marine ecological cultural heritage demonstrates tiie long-standing wisdom of human marine ecological culture. Its effective protection and inheritance is a continuation of the traditional marine ecological lifest...The marine ecological cultural heritage demonstrates tiie long-standing wisdom of human marine ecological culture. Its effective protection and inheritance is a continuation of the traditional marine ecological lifestyle, and is also an important impetus to the current construction of marine ecological civilization in China. The paf ticipation and interaction of cultural origins should be pfomoted, system protection management systems should be continuously improved, policies, reguktions and supporting mechanisms should be improved, and scientific evaluation mechanisms should be established, gradually realizing innovative development.展开更多
On July 6,2016,China Textile Innovation Conference Shishi Forum was held in Shishi,Fujian,with the theme of'exploring innovative gene for textile products',focusing on the discussion of how to enhance the qual...On July 6,2016,China Textile Innovation Conference Shishi Forum was held in Shishi,Fujian,with the theme of'exploring innovative gene for textile products',focusing on the discussion of how to enhance the quality and efficiency of supply,how to activate and release effective demand;how to explore innovative gene for textile products from the nature of the product on the foundation of'ingenuity spirit',so as to boost reconstruction and展开更多
This paper introduces the current status of standardization work in marine field of natural resources,and summarizes the important role that standardization has played in promoting the progress of marine science and t...This paper introduces the current status of standardization work in marine field of natural resources,and summarizes the important role that standardization has played in promoting the progress of marine science and technology,assisting the development of marine economy and industry,and improving the level of marine service management.It points out that marine standards are an important technical support for the development of marine economy and society.After analyzing the new situation of marine standardization work,it provides the suggestions on applying a coordinated and unified standard management thinking,promoting the collaborative output of technology and standards,and using standardization to assist the innovative development of natural resource marine industry.展开更多
The development of diversified foods such as melons under the big food concept can reduce the pressure on staple food grain.Xinjiang has the advantages of building a new development pattern of dual circulation of dive...The development of diversified foods such as melons under the big food concept can reduce the pressure on staple food grain.Xinjiang has the advantages of building a new development pattern of dual circulation of diversified food industry and establishing a national diversified food safety and high-quality assurance center.The construction of an agricultural power needs the strategic support of an intellectual property power.This paper introduced and studied Xinjiang s melon industry and its agricultural intellectual property resources,analyzed the six main problems,including many idle land resources have not been developed into melon fields and the role of melons in diversified food supply systems not well played.Finally,it proposed to vigorously develop diversified food industries such as melons in Xinjiang and establish an eight-point strategy such as national diversified food safety and high-quality assurance center.展开更多
With the rapid development of the market economy, complex changes have occurred in the market environment, and the competition among enterprises has become extremely fierce. The transformation of the structure of the ...With the rapid development of the market economy, complex changes have occurred in the market environment, and the competition among enterprises has become extremely fierce. The transformation of the structure of the market economy has prompted enterprises to seek for new developments and innovations. Under the background of the new economy, enterprises must begin from the perspective of internal management and internal strategic development to ensure quality enterprise operation mechanism innovation. This would help direct enterprise operation and development as well as demonstrate the value of enterprise internal management. In this way, enterprises will be able to array their overall competitiveness. This paper comprises a detailed analysis of the connotation and innovation of enterprise operation mechanism under the economic transformation, with the purpose of investigating the innovation strategy of enterprise operation mechanism under the economic transformation.展开更多
This paper attempts to identify major natural hazards and disaster incidents damage and losses in Nepal.Using participatory and geographical diversity approach and for collecting information,multi-criteria decision ma...This paper attempts to identify major natural hazards and disaster incidents damage and losses in Nepal.Using participatory and geographical diversity approach and for collecting information,multi-criteria decision making methods and analytical hierarchic process to identify the hazard prone area with type and intensity and location-specific innovative practices and their legitimization for integrating local knowledge and skills into mainstream development policy,science and technology through educational assessment to incorporate local knowledge as live science for disaster management,climate change adaptation and sustainable livelihood improvement.Findings of the study reveal that their variety of natural hazards,such as landslides,flood/inundation,droughts,soil erosion,earthquakes,thunderstorm/lightening and fire are exacerbated by environmental degradation processes.There are location specific local practices for resource conservation,utilization and disaster management for the well-being of communities before,during and after disasters.Such practices passed on from one generation to the next without being integrated into mainstream development strategies,disaster policy and science.Knowledge of ecology and local skills and materials for hazard prevention and mitigation have the important role to mitigate the hazards and ensure the sustainability for community life style.Moreover,this study proposed an action-oriented model i.e.political-ecological framework of the environmental resource conservation,disaster management and climate change adaptation practices in mostly vulnerable locations of Nepal.Moreover,measures are suggested to enhance the community capacity for managing their livelihood resources and are hindrance to policy making and scientific advancement at the community level with proper integration of local knowledge with science and mainstream development policy.展开更多
The platform of distributed design and resource sharing is important for medium-sized and small companies in developing products to improve competitiveness. As a background of creative product design, a knowledge mode...The platform of distributed design and resource sharing is important for medium-sized and small companies in developing products to improve competitiveness. As a background of creative product design, a knowledge model based on product collaborative innovation development of products (CIDP) is proposed. Characteristics of CIDP are analyzed, and the framework and key technologies of the CIDP-platform based knowledge studied. Through integration of existing system and interface designs, a development platform has been built to support the PCID within knowledge-based engineering (KBE). An example is presented, indicating that the prototype system is maneuverable and practical.展开更多
This year marks the 90th anniversary of the found- ing of the Communist Party of China （CPC）. As Party General Secretary Hu Jintao said, for the past 90 years, under the leadership of the CPC, the Chinese people hav...This year marks the 90th anniversary of the found- ing of the Communist Party of China （CPC）. As Party General Secretary Hu Jintao said, for the past 90 years, under the leadership of the CPC, the Chinese people have accomplished the three missions of New Democratic Revolution, the Socialist Revolution and reform and opening-up. During the process, the Party and the people have opened a new path of socialism with Chinese characteristics, formed the theory of socialism with Chinese characteristics, as well as established a system of socialism with Chinese characteristics.展开更多
Since China’s Reform and Opening-up,the innovation and development of refractories for ironmaking industry in Sinosteel Luonai were narrated,including silica materials,Al_(2)O_(3)-SiO_(2) refractories and non-oxide c...Since China’s Reform and Opening-up,the innovation and development of refractories for ironmaking industry in Sinosteel Luonai were narrated,including silica materials,Al_(2)O_(3)-SiO_(2) refractories and non-oxide composites;and the development direction of refractories for ironmaking industry was prospected.展开更多
This paper proposes that the business model of mobile Internet services is shifting from a walled garden to an open one. The service development model relies more on open Application Programme Interface (API); and the...This paper proposes that the business model of mobile Internet services is shifting from a walled garden to an open one. The service development model relies more on open Application Programme Interface (API); and the online application software store is becoming an important platform for service delivery. The terminal platform has been the commanding point of the layout and competition of the mobile Inernet in the world. Based on the smart terminal, the competition for platform system from the hardware platform to the operation system, the middleware and the applications platform have been in shape globally. The competition in the terminal platform of mobile Internet is moving from close to open, from uni-controlled by one company to open and cooperated by the whole industry. China should forge a terminal platform system and the ecosystem for the mobile Internet industry, and seek to achieve an overall breakthrough in the whole value chain of the industry based on the huge mobile user market and the productivity of the terminal. The breakthrough should start from the application software, stepping from the top to the bottom platform, to extend the industry chain.展开更多
China’s first supercomputer capable of 100 million calculations per second was the YH-1,which was independently developed by the Institute of Computer Science at the National University of Defense Technology(NUDT)bet...China’s first supercomputer capable of 100 million calculations per second was the YH-1,which was independently developed by the Institute of Computer Science at the National University of Defense Technology(NUDT)between 1978 and 1983.YH-1 played an important role in China’s national defense construction and national economic development.It made China one of the few countries in the world to successfully develop a supercomputer.Based on original archive documents,interviews with relevant personnel,and an analysis of the technological parameters of the supercomputers YH-1 in China and Cray-1 in the United States,this paper reviews in detail the historic process of the development of YH-1,analyzing its innovation and summarizing the experience and lessons learned from it.This analysis is significant for current military-civilian integration,and the commercialization of university research findings in China.展开更多
Effects on sustainable development of climate change have been going further nowadays.National Five Year Development Plan in China should have specific policies on how to take climate change impacts into account throu...Effects on sustainable development of climate change have been going further nowadays.National Five Year Development Plan in China should have specific policies on how to take climate change impacts into account through the environmental planning.Key fields distribute in three levels of natural bearing capacity,production system and human settlements,and include seven aspects:ecosystems,water resources,disasters and risks,low-carbon economy,vulnerable departments,urbanization,and coastland.展开更多
文摘Objective To identify technical risks in the process of innovative drug development,and to provide reference for technical risk management so as to reduce the uncertainties and improve the efficiency of research and development.Methods The initial risk index was investigated by literature research.Then,the Likert scale was used to design a questionnaire,and the experts’opinion was used to analyze the risk factors affecting the different stages of the development of innovative drugs in China.Results and Conclusion Based on the analysis of questionnaire,31 risk indicators of five key stages in the development of innovative drugs from drug discovery to marketing authorization were established.The key risk indicators constructed in this study can provide reference for technology-related risk management in the process of innovative drug development.
文摘In the 21st century,which is known as the age of information,the integration of electronic technology and e-commerce has become an irreversible trend in the field of business.This trend not only promotes the innovative development of e-commerce,but also brings unprecedented opportunities and challenges for enterprises.With the continuous development and popularization of Internet technology,more and more people choose to carry out shopping,payment and other consumption activities through e-commerce platforms,which also provides merchants with a broader market space and more sales channels.At the same time,e-commerce also brings more convenience and choice to consumers,making it easier for consumers to obtain the goods and services they need.However,the development of e-commerce has also brought some new challenges,such as how to ensure the quality of goods,how to protect consumer privacy and so on.Therefore,enterprises and government departments need to strengthen the supervision and management of e-commerce to ensure its healthy and orderly development.In general,the integration of electronic technology and e-commerce has become an important trend in today’s business field,which brings both opportunities and challenges to enterprises.
文摘Enterprises must develop and implement effective strategic measures to achieve sustainable development.This entails evaluating corporate performance,understanding the impact of sustainable development strategies on corporate performance,and implementing such strategies.The article proposes eight critical countermeasures to foster harmony and sustainable development among humanity,nature,the economy,and society:innovation-driven initiatives,green development practices,social responsibility initiatives,talent cultivation programs,collaborative cooperation efforts,sound financial management,brand-building endeavors,and effective information management.
文摘In recent years,China’s property rights trading market has been extremely competitive,but there are also new contradictions and challenges.This paper aims to analyze the external and internal competitive market of the property rights market through Porter’s five forces competition model,then find out the problems and defects in the development,thereby promoting the better development and progress of China’s property rights trading market.
文摘In recent years,Henan sticks to the points of General Secretary Xi Jinping,makes full use of its rich resources and relations,makes efforts to deepen friendship with people around the world,promotes relations with foreign countries,pushes
基金Sponsored by Post-Doctoral Applied Research Project of Qingdao(861605040100)
文摘The marine ecological cultural heritage demonstrates tiie long-standing wisdom of human marine ecological culture. Its effective protection and inheritance is a continuation of the traditional marine ecological lifestyle, and is also an important impetus to the current construction of marine ecological civilization in China. The paf ticipation and interaction of cultural origins should be pfomoted, system protection management systems should be continuously improved, policies, reguktions and supporting mechanisms should be improved, and scientific evaluation mechanisms should be established, gradually realizing innovative development.
文摘On July 6,2016,China Textile Innovation Conference Shishi Forum was held in Shishi,Fujian,with the theme of'exploring innovative gene for textile products',focusing on the discussion of how to enhance the quality and efficiency of supply,how to activate and release effective demand;how to explore innovative gene for textile products from the nature of the product on the foundation of'ingenuity spirit',so as to boost reconstruction and
基金This study is supported by the Innovation Fund of the National Marine Standards and Metrology Center,titled“Research on the operation mechanism of national standards verification points in the marine field of natural resources”(Project No.22-03-04-05A).
文摘This paper introduces the current status of standardization work in marine field of natural resources,and summarizes the important role that standardization has played in promoting the progress of marine science and technology,assisting the development of marine economy and industry,and improving the level of marine service management.It points out that marine standards are an important technical support for the development of marine economy and society.After analyzing the new situation of marine standardization work,it provides the suggestions on applying a coordinated and unified standard management thinking,promoting the collaborative output of technology and standards,and using standardization to assist the innovative development of natural resource marine industry.
基金Supported by Youth Project of National Social Science Fund of China(22CMZ015)。
文摘The development of diversified foods such as melons under the big food concept can reduce the pressure on staple food grain.Xinjiang has the advantages of building a new development pattern of dual circulation of diversified food industry and establishing a national diversified food safety and high-quality assurance center.The construction of an agricultural power needs the strategic support of an intellectual property power.This paper introduced and studied Xinjiang s melon industry and its agricultural intellectual property resources,analyzed the six main problems,including many idle land resources have not been developed into melon fields and the role of melons in diversified food supply systems not well played.Finally,it proposed to vigorously develop diversified food industries such as melons in Xinjiang and establish an eight-point strategy such as national diversified food safety and high-quality assurance center.
文摘With the rapid development of the market economy, complex changes have occurred in the market environment, and the competition among enterprises has become extremely fierce. The transformation of the structure of the market economy has prompted enterprises to seek for new developments and innovations. Under the background of the new economy, enterprises must begin from the perspective of internal management and internal strategic development to ensure quality enterprise operation mechanism innovation. This would help direct enterprise operation and development as well as demonstrate the value of enterprise internal management. In this way, enterprises will be able to array their overall competitiveness. This paper comprises a detailed analysis of the connotation and innovation of enterprise operation mechanism under the economic transformation, with the purpose of investigating the innovation strategy of enterprise operation mechanism under the economic transformation.
文摘This paper attempts to identify major natural hazards and disaster incidents damage and losses in Nepal.Using participatory and geographical diversity approach and for collecting information,multi-criteria decision making methods and analytical hierarchic process to identify the hazard prone area with type and intensity and location-specific innovative practices and their legitimization for integrating local knowledge and skills into mainstream development policy,science and technology through educational assessment to incorporate local knowledge as live science for disaster management,climate change adaptation and sustainable livelihood improvement.Findings of the study reveal that their variety of natural hazards,such as landslides,flood/inundation,droughts,soil erosion,earthquakes,thunderstorm/lightening and fire are exacerbated by environmental degradation processes.There are location specific local practices for resource conservation,utilization and disaster management for the well-being of communities before,during and after disasters.Such practices passed on from one generation to the next without being integrated into mainstream development strategies,disaster policy and science.Knowledge of ecology and local skills and materials for hazard prevention and mitigation have the important role to mitigate the hazards and ensure the sustainability for community life style.Moreover,this study proposed an action-oriented model i.e.political-ecological framework of the environmental resource conservation,disaster management and climate change adaptation practices in mostly vulnerable locations of Nepal.Moreover,measures are suggested to enhance the community capacity for managing their livelihood resources and are hindrance to policy making and scientific advancement at the community level with proper integration of local knowledge with science and mainstream development policy.
文摘The platform of distributed design and resource sharing is important for medium-sized and small companies in developing products to improve competitiveness. As a background of creative product design, a knowledge model based on product collaborative innovation development of products (CIDP) is proposed. Characteristics of CIDP are analyzed, and the framework and key technologies of the CIDP-platform based knowledge studied. Through integration of existing system and interface designs, a development platform has been built to support the PCID within knowledge-based engineering (KBE). An example is presented, indicating that the prototype system is maneuverable and practical.
文摘This year marks the 90th anniversary of the found- ing of the Communist Party of China （CPC）. As Party General Secretary Hu Jintao said, for the past 90 years, under the leadership of the CPC, the Chinese people have accomplished the three missions of New Democratic Revolution, the Socialist Revolution and reform and opening-up. During the process, the Party and the people have opened a new path of socialism with Chinese characteristics, formed the theory of socialism with Chinese characteristics, as well as established a system of socialism with Chinese characteristics.
文摘Since China’s Reform and Opening-up,the innovation and development of refractories for ironmaking industry in Sinosteel Luonai were narrated,including silica materials,Al_(2)O_(3)-SiO_(2) refractories and non-oxide composites;and the development direction of refractories for ironmaking industry was prospected.
文摘This paper proposes that the business model of mobile Internet services is shifting from a walled garden to an open one. The service development model relies more on open Application Programme Interface (API); and the online application software store is becoming an important platform for service delivery. The terminal platform has been the commanding point of the layout and competition of the mobile Inernet in the world. Based on the smart terminal, the competition for platform system from the hardware platform to the operation system, the middleware and the applications platform have been in shape globally. The competition in the terminal platform of mobile Internet is moving from close to open, from uni-controlled by one company to open and cooperated by the whole industry. China should forge a terminal platform system and the ecosystem for the mobile Internet industry, and seek to achieve an overall breakthrough in the whole value chain of the industry based on the huge mobile user market and the productivity of the terminal. The breakthrough should start from the application software, stepping from the top to the bottom platform, to extend the industry chain.
文摘China’s first supercomputer capable of 100 million calculations per second was the YH-1,which was independently developed by the Institute of Computer Science at the National University of Defense Technology(NUDT)between 1978 and 1983.YH-1 played an important role in China’s national defense construction and national economic development.It made China one of the few countries in the world to successfully develop a supercomputer.Based on original archive documents,interviews with relevant personnel,and an analysis of the technological parameters of the supercomputers YH-1 in China and Cray-1 in the United States,this paper reviews in detail the historic process of the development of YH-1,analyzing its innovation and summarizing the experience and lessons learned from it.This analysis is significant for current military-civilian integration,and the commercialization of university research findings in China.
基金Natural Science Foundation of China (Grant No.40976021,40901081,41101141)
文摘Effects on sustainable development of climate change have been going further nowadays.National Five Year Development Plan in China should have specific policies on how to take climate change impacts into account through the environmental planning.Key fields distribute in three levels of natural bearing capacity,production system and human settlements,and include seven aspects:ecosystems,water resources,disasters and risks,low-carbon economy,vulnerable departments,urbanization,and coastland.
