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Advancement in utilization of magnetic resonance imaging and biomarkers in the understanding of schizophrenia
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作者 Aidan K Tirpack Danyaal G Buttar Mandeep Kaur 《World Journal of Clinical Cases》 SCIE 2025年第1期11-15,共5页
Historically,psychiatric diagnoses have been made based on patient’s reported symptoms applying the criteria from diagnostic and statistical manual of mental disorders.The utilization of neuroimaging or biomarkers to... Historically,psychiatric diagnoses have been made based on patient’s reported symptoms applying the criteria from diagnostic and statistical manual of mental disorders.The utilization of neuroimaging or biomarkers to make the diagnosis and manage psychiatric disorders remains a distant goal.There have been several studies that examine brain imaging in psychiatric disorders,but more work is needed to elucidate the complexities of the human brain.In this editorial,we examine two articles by Xu et al and Stoyanov et al,that show developments in the direction of using neuroimaging to examine the brains of people with schizo-phrenia and depression.Xu et al used magnetic resonance imaging to examine the brain structure of patients with schizophrenia,in addition to examining neurotransmitter levels as biomarkers.Stoyanov et al used functional magnetic resonance imaging to look at modulation of different neural circuits by diagnostic-specific scales in patients with schizophrenia and depression.These two studies provide crucial evidence in advancing our understanding of the brain in prevalent psychiatric disorders. 展开更多
关键词 schizophrenia magnetic resonance imaging Biomarkers NEUROTRANSMITTERS Psychiatric disorders
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Functional magnetic resonance imaging study of group independent components underpinning item responses to paranoid-depressive scale
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作者 Drozdstoy Stoyanov Rositsa Paunova +3 位作者 Julian Dichev Sevdalina Kandilarova Vladimir Khorev Semen Kurkin 《World Journal of Clinical Cases》 SCIE 2023年第36期8458-8474,共17页
BACKGROUND Our study expand upon a large body of evidence in the field of neuropsychiatric imaging with cognitive,affective and behavioral tasks,adapted for the functional magnetic resonance imaging(MRI)(fMRI)experime... BACKGROUND Our study expand upon a large body of evidence in the field of neuropsychiatric imaging with cognitive,affective and behavioral tasks,adapted for the functional magnetic resonance imaging(MRI)(fMRI)experimental environment.There is sufficient evidence that common networks underpin activations in task-based fMRI across different mental disorders.AIM To investigate whether there exist specific neural circuits which underpin differ-ential item responses to depressive,paranoid and neutral items(DN)in patients respectively with schizophrenia(SCZ)and major depressive disorder(MDD).METHODS 60 patients were recruited with SCZ and MDD.All patients have been scanned on 3T magnetic resonance tomography platform with functional MRI paradigm,comprised of block design,including blocks with items from diagnostic paranoid(DP),depression specific(DS)and DN from general interest scale.We performed a two-sample t-test between the two groups-SCZ patients and depressive patients.Our purpose was to observe different brain networks which were activated during a specific condition of the task,respectively DS,DP,DN.RESULTS Several significant results are demonstrated in the comparison between SCZ and depressive groups while performing this task.We identified one component that is task-related and independent of condition(shared between all three conditions),composed by regions within the temporal(right superior and middle temporal gyri),frontal(left middle and inferior frontal gyri)and limbic/salience system(right anterior insula).Another com-ponent is related to both diagnostic specific conditions(DS and DP)e.g.It is shared between DEP and SCZ,and includes frontal motor/language and parietal areas.One specific component is modulated preferentially by to the DP condition,and is related mainly to prefrontal regions,whereas other two components are significantly modulated with the DS condition and include clusters within the default mode network such as posterior cingulate and precuneus,several occipital areas,including lingual and fusiform gyrus,as well as parahippocampal gyrus.Finally,component 12 appeared to be unique for the neutral condition.In addition,there have been determined circuits across components,which are either common,or distinct in the preferential processing of the sub-scales of the task.CONCLUSION This study has delivers further evidence in support of the model of trans-disciplinary cross-validation in psychiatry. 展开更多
关键词 Paranoid-depressive scale Functional magnetic resonance imaging Cross-validation Group independent component analysis schizophrenia Depression
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Multimodal morphometry and functional magnetic resonance imaging in schizophrenia and auditory hallucinations 被引量:3
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作者 Gracián García-Martí Eduardo Jesús Aguilar +2 位作者 Luis Martí-Bonmatí M José Escartí Julio Sanjuán 《World Journal of Radiology》 CAS 2012年第4期159-166,共8页
AIM: To validate a multimodal [structural and functional magnetic resonance (MR)] approach as coincidence brain clusters are hypothesized to correlate with clinical severity of auditory hallucinations. METHODS: Twenty... AIM: To validate a multimodal [structural and functional magnetic resonance (MR)] approach as coincidence brain clusters are hypothesized to correlate with clinical severity of auditory hallucinations. METHODS: Twenty-two patients meeting Diagnostic and Statistical Manual of Mental Disorders (fourth edition, DSM-IV) criteria for schizophrenia and experiencing persistent hallucinations together with 28 healthy controls were evaluated with structural and functional MR imaging with an auditory paradigm designed to replicate those emotions related to the patients’ hallucinatory experiences. Coincidence maps were obtained by combining structural maps of gray matter reduction with emotional functional increased activation. Abnormal areas were correlated with the brief psychiatric rating scale (BPRS) and the psychotic symptom rating scale (PSYRATS) scales. RESULTS: The coincidence analysis showed areas with coexistence gray matter reductions and emotional activation in bilateral middle temporal and superior temporal gyri. Significant negative correlations between BPRS and PSYRATS scales were observed. BPRS scores were negatively correlated in the middle temporal gyrus (right) (t = 6.86, P = 0.001), while negative PSYRATS correlation affected regions in both the superior temporal gyrus (left) (t = 7.85, P = 0.001) and middle temporal gyrus (left) (t = 4.97, P = 0.002). CONCLUSION: Our data identify left superior and middle temporal gyri as relevant areas for the understanding of auditory hallucinations in schizophrenia. The use of multimodal approaches, sharing structural and functional information, may demonstrate areas specifically linked to the severity of auditory hallucinations. 展开更多
关键词 FUNCTIONAL MORPHOMETRY magnetic resonance schizophrenia Auditory hallucinations MULTIMODAL COINCIDENCE
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Proton magnetic resonance spectroscopy of the anterior cingulate gyrus and caudate nucleus in schizophrenia patients versus healthy controls
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作者 Lutfi Incesu Meral Baydin +4 位作者 Kerim Aslan Baris Diren Huseyin Sahin Omer Boke Senol Dane 《Neural Regeneration Research》 SCIE CAS CSCD 2011年第6期467-473,共7页
Proton magnetic resonance spectroscopy (^1 H-MRS) permits the assessment of cerebral neurometabolites, such as N-acetylaspartate, choline, and creatine, in vivo and has been used to study schizophrenia. The present ... Proton magnetic resonance spectroscopy (^1 H-MRS) permits the assessment of cerebral neurometabolites, such as N-acetylaspartate, choline, and creatine, in vivo and has been used to study schizophrenia. The present study used ^1H-MRS to compare the spectroscopy change of N-acetylaspartate, creatine, and choline metabolite levels in the anterior cingulate and caudate nucleus of both schizophrenia patients and healthy controls, as well as between the left and right cerebral hemispheres in the schizophrenia patients. Results showed that N-acetylaspartate and creatine metabolite levels in the left anterior cingulate gyrus were significantly lower in the schizophrenia patients than in the healthy controls, indicating hypometabolism. In addition, choline concentration in the left caudate nucleus of schizophrenia patients was significantly lower than in the right caudate nucleus, indicating that it is necessary to study the cerebral lateralization of ^1H-MRS in schizophrenia patients. 展开更多
关键词 schizophrenia magnetic resonance spectroscopy anterior cingulate gyrus caudate nucleus neurocognitive test
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Identification of male schizophrenia patients using brain morphology based on machine learning algorithms
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作者 Tao Yu Wen-Zhi Pei +2 位作者 Chun-Yuan Xu Chen-Chen Deng Xu-Lai Zhang 《World Journal of Psychiatry》 SCIE 2024年第6期804-811,共8页
BACKGROUND Schizophrenia is a severe psychiatric disease,and its prevalence is higher.However,diagnosis of early-stage schizophrenia is still considered a challenging task.AIM To employ brain morphological features an... BACKGROUND Schizophrenia is a severe psychiatric disease,and its prevalence is higher.However,diagnosis of early-stage schizophrenia is still considered a challenging task.AIM To employ brain morphological features and machine learning method to differentiate male individuals with schizophrenia from healthy controls.METHODS The least absolute shrinkage and selection operator and t tests were applied to select important features from structural magnetic resonance images as input features for classification.Four commonly used machine learning algorithms,the general linear model,random forest(RF),k-nearest neighbors,and support vector machine algorithms,were used to develop the classification models.The performance of the classification models was evaluated according to the area under the receiver operating characteristic curve(AUC).RESULTS A total of 8 important features with significant differences between groups were considered as input features for the establishment of classification models based on the four machine learning algorithms.Compared to other machine learning algorithms,RF yielded better performance in the discrimination of male schizophrenic individuals from healthy controls,with an AUC of 0.886.CONCLUSION Our research suggests that brain morphological features can be used to improve the early diagnosis of schizophrenia in male patients. 展开更多
关键词 schizophrenia Machine learning CLASSIFICATION Structure magnetic resonance imaging
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Affected cortico-striatal-cerebellar network inschizophrenia with catatonia revealed by magneticresonance imaging:indications for electroconvulsive therapy and repetitive transcranial magnetic stimulation
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作者 Xiao-Fan Liu Shu-Wan Zhao +9 位作者 Zachary Kratochvil Jia-Cheng Jiang Di Cui Lu Wang Jing-Wen Fan Yue-Wen Gu Hong Yin Jin-Jin Cui Xiao Chang Long-Biao Cui 《Psychoradiology》 2023年第1期28-32,共5页
Catatonia is a psychomotor syndrome that can occur in a broad spectrum of brain disorders,including schizophrenia.Current findings suggest that the neurobiological process underlying catatonia symptoms in schizophreni... Catatonia is a psychomotor syndrome that can occur in a broad spectrum of brain disorders,including schizophrenia.Current findings suggest that the neurobiological process underlying catatonia symptoms in schizophrenia is poorly understood.However,emerging neuroimaging studies in catatonia patients have indicated that a disruption in anatomical connectivity of the cortico-striatal-cerebellar system is part of the neurobiology of catatonia,which could serve as a target of neurostimulation such as electroconvulsive therapy and repetitive transcranial magnetic stimulation. 展开更多
关键词 CATATONIA schizophrenia magnetic resonance imaging NEUROSTIMULATION
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首发与复发急性期精神分裂症患者静息态低频振幅与分数低频振幅分析
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作者 黄欢 王惠玲 +1 位作者 荣蓓 陈诚 《临床精神医学杂志》 CAS 2024年第2期99-103,共5页
目的:分析首发和复发急性期精神分裂症患者静息态低频振幅与分数低频振幅改变情况。方法:纳入2014年6月至2020年05月在武汉大学人民医院精神卫生中心60例首发、60例复发急性期精神分裂症患者及60名健康对照者进行静息态功能磁共振扫描,... 目的:分析首发和复发急性期精神分裂症患者静息态低频振幅与分数低频振幅改变情况。方法:纳入2014年6月至2020年05月在武汉大学人民医院精神卫生中心60例首发、60例复发急性期精神分裂症患者及60名健康对照者进行静息态功能磁共振扫描,采用基于体素水平的低频振幅(ALFF)及分数低频振幅(fALFF)指标分析3组间局部脑功能活动情况。结果:协方差分析显示三组间ALFF值存在显著差异的脑区位于双侧纹状体(左侧F=23.06,P<0.001;右侧F=19.31,P<0.001),而fALFF值存在显著差异的脑区位于双侧纹状体(左侧F=19.71,P<0.001;右侧F=13.53,P<0.001)和前额叶内侧皮质(F=5.46,P<0.001);事后检验显示与对照组相比,首发组和复发组双侧纹状体ALFF及fALFF值均显著升高、内侧前额叶皮质fALFF值降低;复发组内侧前额叶皮质fALFF值降低较首发组更为明显。结论:首发和复发急性期精神分裂症患者均存在双侧纹状体、内侧前额叶皮质的局部功能活动异常,而复发精神分裂症患者内侧前额叶皮质局部脑功能损害更显著。 展开更多
关键词 精神分裂症 静息态功能磁共振成像 低频振幅 分数低频振幅
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Abnormal Degree Centrality of Bilateral Putamen and Left Superior Frontal Gyrus in Schizophrenia with Auditory Hallucinations: A Resting-state Functional Magnetic Resonance Imaging Study 被引量:6
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作者 Cheng Chen Hui-Ling Wang +6 位作者 Shi-Hao Wu Huan Huang Ji-Lin Zou Jun Chen Tian-Zi Jiang Yuan Zhou Gao-Hua Wang 《Chinese Medical Journal》 SCIE CAS CSCD 2015年第23期3178-3184,共7页
Background: Dysconnectivity hypothesis of schizophrenia has been increasingly emphasized. Recent researches showed that this dysconnectivity might be related to occurrence of auditory hallucination (AH). However, t... Background: Dysconnectivity hypothesis of schizophrenia has been increasingly emphasized. Recent researches showed that this dysconnectivity might be related to occurrence of auditory hallucination (AH). However, there is still no consistent conclusion. This study aimed to explore intrinsic dysconnectivity pattern of whole-brain functional networks at voxel level in schizophrenic with AH. Methods: Auditory hallucinated patients group (n = 42 APG), no hallucinated patients group (n = 42 NPG) and normal controls (n = 84 NCs) were analyzed by resting-state functional magnetic resonance imaging. The functional connectivity metrics index (degree centrality [DC]) across the entire brain networks was calculated and evaluated among three groups. Results: DC decreased in the bilateral putamen and increased in the left superior frontal gyrus in all the patients. However, in APG. the changes of DC were more obvious compared with NPG. Symptomology scores were negatively correlated with the DC of bilateral putamen in all patients. AH score of APG positively correlated with the DC in left superior frontal gyrus but negatively correlated with the DC in bilateral putamen. Conclusion: Our findings corroborated that schizophrenia was characterized by functional dysconnectivity, and the abnormal DC in bilateral putamen and left superior frontal gyrus might be crucial in the occurrence of AH. 展开更多
关键词 Auditory Hallucinations Degree Centrality Functional magnetic resonance Imaging RESTING-STATE schizophrenia
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首发精神分裂症患者视觉情绪识别与静息态脑局部一致性的相关性研究 被引量:1
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作者 覃旭骢 王惠玲 +2 位作者 黄欢 郑帆帆 刘莹 《神经损伤与功能重建》 2024年第4期192-195,216,共5页
目的:探究首发精神分裂症患者视觉情绪识别能力特点与静息态大脑局部一致性(ReHo)改变及其相关性。方法:FES患者和健康对照者分别纳入FES组和HC组,各32例;2组均进行视觉情绪识别任务,采集静息态功能磁共振数据,对数据进行预处理并计算个... 目的:探究首发精神分裂症患者视觉情绪识别能力特点与静息态大脑局部一致性(ReHo)改变及其相关性。方法:FES患者和健康对照者分别纳入FES组和HC组,各32例;2组均进行视觉情绪识别任务,采集静息态功能磁共振数据,对数据进行预处理并计算个体ReHo值。比较2组的视觉情绪识别得分及全脑ReHo值的差异,并提取组间差异脑区的ReHo值与视觉情绪识别得分进行相关性分析。结果:与HC组相比,FES组的正性情绪识别得分、非正性情绪识别得分及情绪识别总得分均更低(P<0.05)。与HC组相比,FES组右侧中央后回、中央前回、额内侧回、中央旁小叶ReHo降低,双侧海马旁回、左侧壳核ReHo升高(Alphasim多重比较校正,P<0.05)。FES组非正性情绪识别得分与左侧壳核ReHo值之间存在显著负相关(r=-0.471,P=0.031)。结论:FES患者存在情绪识别障碍及多个脑区ReHo改变,其中左侧壳核ReHo值的升高与精神分裂症患者对非正性情绪的识别困难有关。 展开更多
关键词 精神分裂症 静息态功能磁共振成像 局部一致性 情绪识别
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精神分裂症住院患者磁共振检查流程规范
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作者 河南省医师协会精神科医师分会 吕路线 +2 位作者 李文强 李晓静 刘须振 《新乡医学院学报》 CAS 2024年第10期901-903,共3页
精神分裂症是一种重性精神疾病,对公众健康产生重大影响。精神分裂症的临床表现在某些情况下与脑器质性疾病相似,因此,其临床诊断和治疗面临巨大挑战。磁共振已被广泛用于评估精神分裂症患者的大脑结构和功能,以排查潜在的脑器质性病变... 精神分裂症是一种重性精神疾病,对公众健康产生重大影响。精神分裂症的临床表现在某些情况下与脑器质性疾病相似,因此,其临床诊断和治疗面临巨大挑战。磁共振已被广泛用于评估精神分裂症患者的大脑结构和功能,以排查潜在的脑器质性病变或研究脑结构和功能特征。精神分裂症住院患者存在严重思维和行为紊乱,目前迫切需要建立针对这一特殊群体的磁共振检查流程规范。本文依据国内外从事精神分裂症磁共振检查的经验和数据,制定了精神分裂症患者磁共振检查整体流程,以促进该检查流程的规范应用。 展开更多
关键词 精神分裂症 磁共振 流程规范
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额顶网络功能改变与精神分裂症认知损害的相关性
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作者 顾悦文 刘晓帆 +5 位作者 范靖雯 姜金波 李小飒 李娟娟 印弘 崔龙彪 《放射学实践》 CSCD 北大核心 2024年第8期1007-1013,共7页
目的:基于fMRI探讨精神分裂症患者额顶网络中背外侧前额叶(DLPFC)和顶下小叶(IPL)功能改变与认知损害的相关性。方法:于2015年-2020年前瞻性招募在本院就诊的151例精神分裂症患者及年龄、性别、民族和利手相匹配的60例健康对照者。采集... 目的:基于fMRI探讨精神分裂症患者额顶网络中背外侧前额叶(DLPFC)和顶下小叶(IPL)功能改变与认知损害的相关性。方法:于2015年-2020年前瞻性招募在本院就诊的151例精神分裂症患者及年龄、性别、民族和利手相匹配的60例健康对照者。采集每个受试者的静息态fMRI图像和高分辨率T_(1)WI图像,在MATLAB软件中将双侧DLPFC、IPL作为种子点进行局部一致性(Reho)分析。同期由临床医师采用中国修订韦氏成人智力量表(WAIS-RC)评估每例受试者的认知功能,包括数字广度顺背、倒背粗分和数字符号得分。根据认知功能评分将患者分为认知正常组(患者得分低于健康对照组平均得分的0.5个标准差以下即为认知正常)及认知损害组(患者得分低于健康对照组得分的1个标准差以上即为认知损害)。采用Pearson或Spearman相关性分析方法对认知功能评分与ReHo值进行分析。此外,将双侧DLPFC、IPL作为种子点进行有效功能连接分析,并采用曼-惠特尼U检验进行组间比较。结果:对照组的数字顺背粗分与右侧DLPFC的ReHo值呈正相关性(r=0.446,校正后P=0.0012);在左侧IPL的相关性分析中,对照组和认知正常组的数字倒背粗分与ReHo值均呈正相关(r=0.374,校正后P=0.0117;r=0.548,校正后P=0.0372),而认知损害组认知评分与fMRI指标之间均无显著相关性(P>0.05)。有效连接分析结果显示从右侧到左侧DLPFC的有效连接在对照组与认知损害组之间的差异有统计学意义(P<0.05)。结论:DLPFC和IPL的功能改变在精神分裂症患者认知障碍的发病机制中起着重要作用,提示可以将DLPFC和IPL作为无创性神经刺激治疗精神分裂症认知障碍的靶点进行研究,从而有助于探索优化目前的临床治疗策略。 展开更多
关键词 精神分裂症 磁共振成像 认知功能障碍 脑功能网络
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深度学习在磁共振影像脑疾病诊断中的应用 被引量:1
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作者 朱健椿 魏嘉昕 +3 位作者 毛浚彬 刘坤 何鸿宇 刘锦 《工程科学学报》 EI CSCD 北大核心 2024年第2期306-316,共11页
由于脑疾病的发生会对社会产生严重危害,所以脑疾病诊断研究的重要性日益显著.中国“脑计划”列入“十三五”规划与国务院《“健康中国2023”规划纲要》的印发表明国家对脑疾病诊疗问题的高度重视.由于磁共振影像的高分辨率及非入侵性... 由于脑疾病的发生会对社会产生严重危害,所以脑疾病诊断研究的重要性日益显著.中国“脑计划”列入“十三五”规划与国务院《“健康中国2023”规划纲要》的印发表明国家对脑疾病诊疗问题的高度重视.由于磁共振影像的高分辨率及非入侵性等优势使其成为脑疾病研究与临床检查的主要技术手段,为脑疾病诊断提供丰富的数据基础.深度学习由于其可拓展性与灵活性在各个领域得到广泛应用,展现出巨大的发展潜力.本文针对深度学习在典型脑疾病诊断中的应用进行综述,结构组织如下:首先对深度学习在自闭症、精神分裂症、阿尔兹海默症三种典型脑疾病诊断上的应用进行了阐述;然后对用于三种脑疾病研究的数据集和已有的开源工具进行了汇总;最后对深度学习在磁共振影像脑疾病诊断应用中的局限性及未来发展方向进行总结与展望. 展开更多
关键词 磁共振影像 深度学习 脑疾病 自闭症 精神分裂症 阿尔兹海默症
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基于图论的精神分裂症患者静息态功能脑网络分析
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作者 任秀芳 罗捷 《中国医学物理学杂志》 CSCD 2024年第7期821-827,共7页
目的:运用静息态功能磁共振探讨精神分裂症患者的脑网络及其拓扑属性。方法:收集the Center of Biomedical Research Excellence提供的35名精神分裂症患者资料作为患者组以及35名健康被试者资料作为对照组,计算两组的局部一致性,并进行... 目的:运用静息态功能磁共振探讨精神分裂症患者的脑网络及其拓扑属性。方法:收集the Center of Biomedical Research Excellence提供的35名精神分裂症患者资料作为患者组以及35名健康被试者资料作为对照组,计算两组的局部一致性,并进行统计学分析。然后使用Dosenbach's 160 atlas检查全脑功能网络,提取全脑网络的两个子网络:默认模式网络和躯体运动网络,构成一个新网络,计算全脑网络及新网络的拓扑属性。结果:精神分裂症患者大脑的默认模式网络与躯体运动网络之间及默认模式网络内部的功能连接存在显著减弱(P<0.05,FDR校正),全脑网络聚集系数有所下降,默认模式网络与躯体运动网络构成的网络的全局和局部效率降低(P<0.05)。结论:精神分裂症患者默认模式网络与躯体运动网络之间及默认模式网络内部功能连接存在显著异常,默认模式网络与躯体运动网络之间拓扑属性的显著改变可能成为关键因素。此外,该结论可运用于默认模式网络与躯体运动网络对应的脑神经元随机微分方程组的定性分析,从而对精神分裂症的物理治疗有所帮助。 展开更多
关键词 精神分裂症 静息态功能磁共振 脑网络 图论
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静息态功能磁共振成像在青少年精神分裂症中的应用进展
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作者 王露 刘芮杉 +2 位作者 廖娟 李宏伟 卓丽华 《磁共振成像》 CAS CSCD 北大核心 2024年第5期168-174,180,共8页
青少年精神分裂症(adolescent-onset schizophrenia,AOS)属于早发性精神分裂症的范畴,是指发病年龄在13~18岁之间的精神分裂症,与成人发病的精神分裂症相比,其症状更不典型,程度更严重,对抗精神病药物的治疗反应更差,并且其病因及发病... 青少年精神分裂症(adolescent-onset schizophrenia,AOS)属于早发性精神分裂症的范畴,是指发病年龄在13~18岁之间的精神分裂症,与成人发病的精神分裂症相比,其症状更不典型,程度更严重,对抗精神病药物的治疗反应更差,并且其病因及发病机制至今尚不明确。静息态功能MRI(resting-state functional MRI,rs-fMRI)是一种操作便捷、无创客观且受试者易于配合的MRI技术,它能够从局部和整体反映脑神经元的自发性活动情况,为AOS神经病理学机制研究提供了强有力的手段。本文从功能分离分析和功能整合分析两方面展开,围绕rs-fMRI在AOS研究中应用的最新进展进行综述,探讨了当前研究的不足之处,并对未来进一步研究的方向进行了展望,旨在为进一步探索精神分裂症的病理生理学机制提供一定线索和依据。 展开更多
关键词 精神分裂症 青少年 磁共振成像 静息态功能磁共振成像
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发掘精神分裂症大脑连接变异的集成聚类动态功能连接分析方法
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作者 方嵩柯 杜宇慧 《中国生物医学工程学报》 CAS CSCD 北大核心 2024年第3期257-266,共10页
近年来,基于功能磁共振成像的动态功能连接在研究精神疾病方面表现出巨大的潜力。传统的基于聚类的动态功能连接分析方法(如K-means)受到类别个数、初始值和噪声的影响可能导致不可靠的功能连接状态(FCSs)。本研究提出了一种新的集成聚... 近年来,基于功能磁共振成像的动态功能连接在研究精神疾病方面表现出巨大的潜力。传统的基于聚类的动态功能连接分析方法(如K-means)受到类别个数、初始值和噪声的影响可能导致不可靠的功能连接状态(FCSs)。本研究提出了一种新的集成聚类动态功能连接分析方法。首先,利用多个不同的类别个数(k值)进行K-means产生多样性的簇;然后,基于Jaccard系数和随机游走挖掘不同簇之间的相似性以构造反应簇间关系的加权图;最终,对加权图进行社区检测获得可靠的元簇,并通过投票的方式将每个功能连接窗口分组到不同的元簇中,计算其质心作为功能连接状态。基于105名健康对照(HC)和70名精神分裂症(SZ)患者的fMRI数据,全方位比较所提出的方法和常用的基于K-means的方法进行动态功能网络分析的效果。相较于K-means方法,所提出方法在FCS 2上的平均类间相似性由83.2%降低至81.1%,在FCS 3上的平均类间相似性由76.8%降低至73.5%,聚类评估指标Davies Bouldin指数由6.74降低至6.44,Silhouette Coefficient指数由0.018提高至0.031。显示HC和SZ组的组间差异更集中于FCS 2,而K-means方法的组间差异分散在FCS 2、FCS 3和FCS 4。所提出方法可以自动获得FCSs数目,并具有更好的聚类质量和更可靠的功能连接状态,还发现了比K-means更有意义的组间差异,支持了该方法在探索精神疾病生物标志物方面的应用潜力。 展开更多
关键词 功能磁共振成像 动态功能连接 集成聚类 K-MEANS聚类 精神分裂症
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不同诊断类型的言语性幻听症状间影像遗传学差异研究
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作者 黄子夜 张素兮 +3 位作者 叶鑫武 金晓庄 蔡子耀 陈策 《现代实用医学》 2024年第6期710-713,共4页
目的探讨不同诊断类型的言语性幻听(AVHs)症状在COMT基因型和影像学中的差异情况。方法前瞻性选取2021年1月至2024年1月在温州市第七人民医院接受治疗的精神分裂症合并AVHs患者58例(精神分裂症组),单纯抑郁障碍合并AVHs患者42例(抑郁障... 目的探讨不同诊断类型的言语性幻听(AVHs)症状在COMT基因型和影像学中的差异情况。方法前瞻性选取2021年1月至2024年1月在温州市第七人民医院接受治疗的精神分裂症合并AVHs患者58例(精神分裂症组),单纯抑郁障碍合并AVHs患者42例(抑郁障碍组),另选同期在本院体检健康者50例作为对照组,记录3组研究对象的临床资料、COMT基因型和磁共振检测数据。结果3组COMT val158met基因型分布符合哈迪温伯格平衡(P>0.05)。3组val158met等位基因型频率和等位基因差异均无统计学意义(均P>0.05)。与对照组相比,精神分裂症组患者在左顶下小叶、右缘上回、左楔前叶及右内侧额上回的分数低频振幅(fALFF)值升高,在左辅助运动区、右中央后回及右舌回的fALFF值降低(均P<0.05)。与对照组相比,抑郁障碍组患者在右内侧额上回的fALFF值升高,在左辅助运动区、右中央后回、右舌回的fALFF值降低(均P<0.05)。精神分裂症组和抑郁障碍组患者不同脑区的fALFF值差异无统计学意义(均P>0.05)。结论精神分裂症合并AVHs患者楔前叶与顶下小叶神经活动加强,这可能是此类患者与单纯抑郁障碍合并AVHs患者导致AVHs症状的差异神经影像学基础。 展开更多
关键词 精神分裂症 单纯抑郁障碍 言语性幻听 COMT基因 核磁共振
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Hippocampal and thalamic neuronal metabolism in a putative rat model of schizophrenia° 被引量:2
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作者 Guolin Ma Tianbin Song +6 位作者 Min Chen Yuan Fu Yong Xu Ensen Ma Wu Wang Jiang Du Mingxiong Huang 《Neural Regeneration Research》 SCIE CAS CSCD 2013年第26期2415-2423,共9页
The transcription factor early growth response protein 3 (EGR3) is involved in schizophrenia. We developed a putative rat model of schizophrenia by transfecting lentiviral particles carrying the Egr3 gene into bilat... The transcription factor early growth response protein 3 (EGR3) is involved in schizophrenia. We developed a putative rat model of schizophrenia by transfecting lentiviral particles carrying the Egr3 gene into bilateral hippocampal dentate gyrus. We assessed spatial working memory using the Morris water maze test, and neuronal metabolite levels in bilateral hippocampus and thalamus were determined by 3.0 T proton magnetic resonance spectroscopy. Choline content was significantly greater in the hippocampus after transfection, while N-acetylaspartate and the ratio of N-acetylaspartate to creatine/phosphocreatine in the thalamus were lower than in controls. This study is the first to report evaluation of brain metabolites using 3,0 T proton magnetic resonance spectroscopy in rats transfected with Egr3, and reveals metabolic abnormalities in the hippocampus and thalamus in this putative model of schizophrenia. 展开更多
关键词 neural regeneration NEUROIMAGING schizophrenia proton magnetic resonance spectroscopy early growth response protein 3 hippocampus THALAMUS gene NEUROREGENERATION
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Abnormal Local Activity and Functional Dysconnectivity in Patients with Schizophrenia Having Auditory Verbal Hallucinations 被引量:4
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作者 Cheng CHEN Gao-hua WANG +3 位作者 Shi-hao WU Ji-lin ZOU Yuan ZHOU Hui-ling WANG 《Current Medical Science》 SCIE CAS 2020年第5期979-984,共6页
Auditory verbal hallucination(AVH)is emphasized as a pathological hallmark of schizophrenia.Neuroimaging studies provide evidence linking AVH to overlapping functional abnormalities in distributed networks.However,no ... Auditory verbal hallucination(AVH)is emphasized as a pathological hallmark of schizophrenia.Neuroimaging studies provide evidence linking AVH to overlapping functional abnormalities in distributed networks.However,no clear conclusion has still been reached.This study aimed to further explore the brain activity of patients with schizophrenia having AVH from both local activity(LA)and functional connectivity(FC)insights,while excluding confounding factors from other positive symptoms.A total of 42 patients with AVH(AVH patients group,APG),26 without AVH(non-AVH patients group,NPG),and 82 normal controls(NC)underwent resting-state functional magnetic resonance imaging(fMRI).LA measures,including regional homogeneity(ReHo)and fractional amplitude of low-frequency fluctuations(fALFF),and FC measures were evaluated to understand the neuroimaging mechanism of AVH.APG showed increased ReHo and fALFF in the bilateral putamen(Put)compared with NPG and NC.FC analysis(using bilateral putamen as seeds)revealed that all patients showed abnormal FC of multiple resting state network regions,including the anterior and post cingulate cortex,middle frontal gyrus,inferior parietal gyrus,and left angular gyrus.Interestingly,APG showed significantly decreased FC of insula extending to the superior temporal gyrus and inferior frontal gyrus compared with NPG and NC.The present findings suggested a significant correlation of abnormal LA and dysfunctional putamen-auditory cortical connectivity with the neuropathological mechanism of AVH,providing evidence for the functional disconnection hypothesis of schizophrenia. 展开更多
关键词 auditory verbal hallucination functional connectivity local activity resting-state functional magnetic resonance imaging schizophrenia
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Brain activation regions in schizophrenia patients performing the game piece memory task 被引量:1
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作者 Daxing WU Huifang Yin +3 位作者 Lirong Yan Changlian Tan Dewen Hu Shuqiao Yao 《Neural Regeneration Research》 SCIE CAS CSCD 2009年第2期98-105,共8页
BACKGROUND: Go, a traditional Chinese chess-like game, requires many unknown functions of the brain including attention, imaging, problem solving and processing of spatial working memory. To date, it remains uncertai... BACKGROUND: Go, a traditional Chinese chess-like game, requires many unknown functions of the brain including attention, imaging, problem solving and processing of spatial working memory. To date, it remains uncertain whether the intellectual activities required to play Go are related to the frontal lobe. OBJECTIVE: To investigate various patterns of brain region activity while schizophrenic patients and normal subjects engaged in memorizing piece placement in the Chinese game of Go. Spatial working memory was measured in order to validate whether the prefrontal lobe participates in this memory process. DESIGN, TIME AND SETTING: Non-randomized, concurrent control trial was performed at Second Xiangya Hospital of Central South University, between May and December 2004. PARTICIPANTS: A total of nine Chinese schizophrenic patients with no brain or bodily diseases and not undergoing electroshock treatment, who were in accordance with the DSM-Ⅳ criteria for schizophrenia, as well as thirteen healthy staffs and students with matched age, sex, and education were included. Patients and control subjects had no neurological disorders or mental retardation. In addition, all participants were right-handed. METHODS: The cognitive task for functional magnetic resonance imaging was a block design experiment. Both groups were asked to remember the placement of pieces in the Chinese game of Go on a computer screen. A brain activation map was analyzed in SPM99. MAIN OUTCOME MEASURES: Brain responses were compared with regard to activation region size, volume, and asymmetry indices. RESULTS: Compared with the control group, the reaction time was significantly delayed in schizophrenics performing the working memory task (P 〈 0.05). When performing the tasks, normal subjects showed significant activation of the bilateral dorsolateral prefrontal lobe with left dominance; the asymmetry indices were: frontal lobe, +0.32; temporal lobe, 0.58; parietal lobe, 0.41 ; and occipital lobe, 0.34. On the other hand, schizophrenics showed right dominance and had a broader activation region of the prefrontal lobe (asymmetry indices: frontal lobe, 0.10; temporal lobe, +0.38; parietal lobe, +0.24; and occipital lobe, 0.00). When comparing the normal group subtracted with the schizophrenic group, no significant lateralization was found in the frontal lobes but significant activation was found in the left anterior central gyrus, left middle frontal gyrus and in both sides of the cingulate gyrus. Comparing the schizophrenic group subtracted with the normal group, there was significant right lateralization of the frontal lobe and abnormally activated regions on both sides of the anterior central gyrus, middle frontal gyrus, left inferior frontal gyrus, right medial frontal gyrus and the right insular lobe. CONCLUSION: Different brain activation regions are involved in memorizing the placement of pieces in Chinese Go between schizophrenia and healthy subjects. Schizophrenics showed right dominance and border activation range, indicating that the prefrontal cortex plays an important role in memory information processing and resource allocation when remembering piece placement in the game of Go. 展开更多
关键词 schizophrenia prefrontal cortex Chinese game of Go spatial working memory functional magnetic resonance imaging
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Olfactory function in psychotic disorders: Insights from neuroimaging studies 被引量:1
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作者 Kimberley P Good Randii Lynn Sullivan 《World Journal of Psychiatry》 SCIE 2015年第2期210-221,共12页
Olfactory deficits on measures of identification, familiarity,and memory are consistently noted in patients with psychotic disorders relative to age-matched controls. Olfactory intensity ratings, however, appear to re... Olfactory deficits on measures of identification, familiarity,and memory are consistently noted in patients with psychotic disorders relative to age-matched controls. Olfactory intensity ratings, however, appear to remain intact while the data on hedonics and detection threshold are inconsistent. Despite the behavioral abnormalities noted, no specific regional brain hypoactivity has been identified in psychosis patients, for any of the olfactory domains. However, an intriguing finding emerged from this review in that the amygdala and pirifom cortices were not noted to be abnormal in hedonic processing(nor was the amygdala identified abnormal in any study) in psychotic disorders. This finding is in contrast to the literature in healthy individuals, in that this brain region is strongly implicated in olfactory processing(particularly for unpleasant odorants). Secondary olfactory cortex(orbitofrontal cortices, thalamus, and insula) was abnormally activated in the studies examined, particularly for hedonic processing. Further research, using consistent methodology, is required for better understanding the neurobiology of olfactory deficits. The authors suggest taking age and sex differences into consideration and further contrasting olfactory subgroups(impaired vs intact) to better our understanding of the heterogeneity of psychotic disorders. 展开更多
关键词 OLFACTION schizophrenia NEUROIMAGING Functional magnetic resonance imaging POSITRON EMISSION TOMOGRAPHY Single photon EMISSION computed TOMOGRAPHY
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