With the modernization and internationalization of traditional Chinese medicine(TCM),the requirement for quality control has increased.The quality marker(Q-marker)is an important standard in this field and has been im...With the modernization and internationalization of traditional Chinese medicine(TCM),the requirement for quality control has increased.The quality marker(Q-marker)is an important standard in this field and has been implemented with remarkable success in recent years.However,the establishment of Qmarkers remains fragmented and the process lacks systematicity,resulting in inconsistent quality control and insufficient correlation with clinical efficacy and safety of TCM.This review introduces four multimodal integrated approaches that contribute to the discovery of more comprehensive and accurate Qmarkers,thus aiding in the establishment of new quality control patterns based on the characteristics and principles of TCM.These include the whole-process quality control strategy,chemical-activity-based screening method,efficacy,safety,and consistent combination strategy,and TCM theory-guided approach.Furthermore,methodologies and representative examples of these strategies are described,and important future directions and questions in this field are also proposed.展开更多
The integrated traditional Chinese and western medicine (ICWM) of obstetrics and gynecology (OBS/GYN) emerged eventually with more than 40 years’ hard struggle, and one of the most promising articles is the integrati...The integrated traditional Chinese and western medicine (ICWM) of obstetrics and gynecology (OBS/GYN) emerged eventually with more than 40 years’ hard struggle, and one of the most promising articles is the integration of the masterpieces of menstrual disorder and infertility in TCM and the virtual explosion of new knowledge and methods in展开更多
Traditional Chinese medicine(TCM)and Western medicine are two medical systems formed in different cultural backgrounds.The differences between them are that TCM focuses on the study of the invisible state while Wester...Traditional Chinese medicine(TCM)and Western medicine are two medical systems formed in different cultural backgrounds.The differences between them are that TCM focuses on the study of the invisible state while Western medicine focuses more on the study of the visible state of the human body;TCM pays attention to systematicity and integrity,while Western medicine pays attention to local evidence;TCM attaches importance to dialectical thinking,while Western medicine attaches importance to materialistic thinking.For the development of TCM.it is necessary to take the initiative to learm from and absorb all the advanced scientific and technological achievements in the world today.To innovate TCM,it is necessary to need to adhere to(1)the integration of"research on TCM with the thought of TCM"and"research on TCM based on the thought of Western medicine";(2)the integration of scientization of TCM and scientization for TCM;(3)the integration of mobilization therapy and allopathic therapy;(4)the integration of treating patients and treating diseases;(5)the integration of preventive treatment and existent disease treatment;(6)the integration of individuality and commonality;and(7)the integration of the macro and the micro.展开更多
分析了当前地理信息服务与其元数据不对称导致多源地理信息服务难于无缝集成的现状,提出根据OGC(Open Geospatial Consortium)网络地图服务(Web Map Service,WMS)动态生成自身元数据的方法,并基于OGCCSW(Catalogue Service for the Web)...分析了当前地理信息服务与其元数据不对称导致多源地理信息服务难于无缝集成的现状,提出根据OGC(Open Geospatial Consortium)网络地图服务(Web Map Service,WMS)动态生成自身元数据的方法,并基于OGCCSW(Catalogue Service for the Web)、WMS规范和ISO19139元数据标准开发了MS2 MD中间件。提出用于监测地理信息服务质量的方法,实现了对多源、分布式CSW与WMS的准实时动态监测;同时,设计了多源分布式CSW和WMS地理信息服务的集成体系结构,并将上述方法应用于全球综合地球观测系统(Global Earth Observation Systemof Systems,GEOSS)的空气质量与健康项目中,解决了WMS与其自身元数据信息不对称以及地理信息服务质量的准实时监测问题,实现了多源分布式CSW和WMS地理信息服务的无缝集成与互操作。展开更多
BACKGROUND： The core symptoms of attention deficit, impulsiveness, hyperactivity of attention deficit hyperactivity disorders （ADHD） can concurrently present in spontaneous hypertensive rats. Neuropathological, bio...BACKGROUND： The core symptoms of attention deficit, impulsiveness, hyperactivity of attention deficit hyperactivity disorders （ADHD） can concurrently present in spontaneous hypertensive rats. Neuropathological, biochemical and pharmacological studies also support it. Spontaneous hypertensive rats are one kind of best ADHD animal models, which has been accepted at present. Yizhining elixation can reinforce kidney and calm liver, strengthen spleen and nourish heart, benefit intelligence and focus attention, but its therapeutic effect on treatment of ADHD needs to be further investigated. OBJECTIVE： To observe the effect of Yizhining elixation on the persistent active attention deficit and impulsiveness of rats with spontaneous hypertension. DESIGN： Observational and controlled analysis. SETTING： Department of Pediatrics, the First Affiliated Hospital of Guangzhou University of Chinese Medicine. MATERIALS： Thirty-six male rats with spontaneous hypertension, of clean grade, were involved in this experiment. The involved rats were provided by Shanghai SLAC Laboratory Animal Co., Ltd., and they did not undergo any experiments; Yizhining elixation was composed by Guiban, Shenglonggu, Yuanzhi, Shichangpu, Yejiaoteng, Shudi, Dangshen, Yunling, Fuxiaomai, Wueizi. etc. Crude drug, provided by Outpatient Dispensary, Affiliated Hospital of Guangzhou University of Chinese Medicine, was prepared into water elixation, which contained crude drug of 1.154 g/mL. METHODS： This experiment was carried out in the Department of Pediatrics, First Affiliated Hospital of Guangzhou University of Chinese Medicine between March and July 2005. The involved rats were randomized into 3 groups： Yizhining high dose group, Yizhining low dose group and blank control group, with 12 rats in each. Changes in sustained attention and impulsiveness of rats were detected before and after administration of Yizhining elixation by ＂5-choice serial response time task＂ method. Following above-mentioned training and detection, rats in each group were daily drenched with Yizhining elixation once for 14 days successively. Rats in the Yizhining High-dose and low-dose groups we, e drenched with 12.6 mL/kg and 6.3 mL/kg Yizhining elixation （diluted to 25 mL/kg） respectively, and those in the blank control group were drenched with 12.5 mL/kg normal saline. On the 14^th day after administration, the ratios of correct and immature response of rats were re-detected for 3 days successively by formal detection method for later analysis. The sustained attention of rats was evaluated with ratio of correct response： Ratio of correct response=[times of correct response/（times of correct response ＋ times of incorrect response）]; impulsiveness was evaluated with the ratio of immature response： ratio of immature response=[times of immature response/ （times of correct response＋times of incorrect response＋times of omission＋times of immature response） ]. MAIN OUTCOME MEASURES： The effects of different doses of Yizhining elixation on the sustained attention （ratio of correct response） and impulsiveness （ratio of immature response） of spontaneous hypertensive rats. RESULTS： Thirty-six spontaneous hypertensive rats were involved in the final analysis. The ratio of correct response of rats in the Yizhining high dose and low dose groups after administration was （98.9±2.30）% and （96.6±4.00） %, respectively, which was significantly higher than that before administration [ （80.4±11.5 ） %, （839±8.90） %, P 〈 0.01] and that in the blank control group[ （83.3±6.30） %, P 〈 0.01]. The ratio of immature response of rats in the Yizhining high dose and low dose groups after adminisWafion was （5.04 ±1.04 ） %, （7.23 ± 1.22 ） %, respectively, which was lower than that before administration [ （9.85 ±2.50） %, （9.40±1.73 ） %, P 〈 0.05] and that in the blank control group [ （ 9.42 ±1.64） %, P 〈 0.01 ]. CONCLUSION： Yizhining elixation can improve the sustained attention and impulsiveness of spontaneous hypertensive rats.展开更多
Background: Obsessive-compulsive, anxiety disorder, and depression are the most common negative emotions. The incidence rate is high and spread across all age groups. With the rapid development of the world economy an...Background: Obsessive-compulsive, anxiety disorder, and depression are the most common negative emotions. The incidence rate is high and spread across all age groups. With the rapid development of the world economy and the increasing competition in social life, the incidence rate has also increased rapidly, more and more young suffer from these three kinds of mental illnesses. Many studies have been carried out to investigate the pathogenesis and therapeutic method. It is necessary to summarize the progress for references to further research and treatment. Method: Based on a series of literature, the studies on the pathogenesis and therapeutic method of the three kinds of illnesses are summarized and analyzed. The points and results either of West medicine (WM) or traditional Chinese medicine (TCM) are collected and compared to find the best tendency of study and the best therapeutic method. Results: Obsessive-compulsive disorder, anxiety disorder and depression are common in recent years and severely affect people’s lives. In view of WM. These three kinds of illnesses are all related to the changes or damage of part of brain and nervous system. While TCM thinks that they are due to Qi stagnation or deficiency of heart Yin. Many methods of treatment have been presented and used clinically, but the effect is limited. Conclusion: The most promising and effective methods are those combining WM and TCM.展开更多
EDITORIAL Severe Acute Respiratory Syndrome(SARS)is a new intractable disease worldwide,itsonset is acute,its infectivity and mortality is high,the knowledge about its etiology and pathogenesis is in-sufficient,the ex...EDITORIAL Severe Acute Respiratory Syndrome(SARS)is a new intractable disease worldwide,itsonset is acute,its infectivity and mortality is high,the knowledge about its etiology and pathogenesis is in-sufficient,the experience on SARS treatment awaits accumulation.Following pilot experiences of applyingICWM in fighting SARS is most valuable with scientific significance.展开更多
The gradually ex—panding number of peo—pie suffering from hy—pertension and the trendof lowering of their ageindicate that one shouldpay more attention tothe illness and tOstrengthen preventionand treatment of it i...The gradually ex—panding number of peo—pie suffering from hy—pertension and the trendof lowering of their ageindicate that one shouldpay more attention tothe illness and tOstrengthen preventionand treatment of it inorder tO elevate clinicaltherapeutic effect,so as展开更多
Member of Political Bureau of Central Committee of CPC, Vice Premier of State Council concurrently Minister of Health, General Command of National Protecting and Treating Severe Acute Respiratory Syndrome ( SARS) Head...Member of Political Bureau of Central Committee of CPC, Vice Premier of State Council concurrently Minister of Health, General Command of National Protecting and Treating Severe Acute Respiratory Syndrome ( SARS) Headquarters Vice premier WU Yi cordially met the well-known TCM specialists, and held a symposium with them. Sixteen specialists including WANG Yong-yan, CHEN Ke-ji, LI Fu-ren, JIAO Shu-de, HE Pu-ren, LIU展开更多
Objective: To investigate the suitable time of treating virulent and side effects of chemotherapy for malignant tumor by acupoint injection of Astragalus Root injection. Methods: Sixty three patients with malignant tu...Objective: To investigate the suitable time of treating virulent and side effects of chemotherapy for malignant tumor by acupoint injection of Astragalus Root injection. Methods: Sixty three patients with malignant tumor were divided into three groups: prevention treatment (PT) group (n=23 cases),post chemotherapy treatment (PCT) group( n=22 cases), Western medicine (WM) group ( n=18 cases). The patients in PT, PCT and WM groups were treated respectively from the fifth day on before chemotherapy and from the first day on after chemotherapy, 18 days in all. The patients in WM group were administered Batilol and Leucogen from the first day on after chemotherapy. Changes of leukocytes and immunoglobulin before and after treatment were observed. Results: 1) Acupoint injection of Astragalus Root injectio could increase the number of leukocytes and immunoglobulin content and its effect was better than that of Western medicine (P<0.05); 2) The effect of PT group was better than that of PCT group in preventing and treating virulent and side effects of chemotherapy (P<0.05). Conclusion: It should be stressed on prevention of malignant tumor by using acupoint injection of Astragalus Root for relieving virulent and side effects of chemotherapy.展开更多
Interview Time:15:00 pm,October 13th,2018Location:Shennongjia Forest Area,Hubei Prof.Zou:Hello.Professor Shen,thank you very much for accepting the interview of World Journal of Integrated traditional and western Medi...Interview Time:15:00 pm,October 13th,2018Location:Shennongjia Forest Area,Hubei Prof.Zou:Hello.Professor Shen,thank you very much for accepting the interview of World Journal of Integrated traditional and western Medicine(English version).展开更多
基金supported by the National Natural Science Foundation of China(Grant No.:81973701)Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(Grant No.:ZYYCXTD-D-202002)Westlake Laboratory(Westlake Laboratory of Life Sciences and Biomedicine).
文摘With the modernization and internationalization of traditional Chinese medicine(TCM),the requirement for quality control has increased.The quality marker(Q-marker)is an important standard in this field and has been implemented with remarkable success in recent years.However,the establishment of Qmarkers remains fragmented and the process lacks systematicity,resulting in inconsistent quality control and insufficient correlation with clinical efficacy and safety of TCM.This review introduces four multimodal integrated approaches that contribute to the discovery of more comprehensive and accurate Qmarkers,thus aiding in the establishment of new quality control patterns based on the characteristics and principles of TCM.These include the whole-process quality control strategy,chemical-activity-based screening method,efficacy,safety,and consistent combination strategy,and TCM theory-guided approach.Furthermore,methodologies and representative examples of these strategies are described,and important future directions and questions in this field are also proposed.
文摘The integrated traditional Chinese and western medicine (ICWM) of obstetrics and gynecology (OBS/GYN) emerged eventually with more than 40 years’ hard struggle, and one of the most promising articles is the integration of the masterpieces of menstrual disorder and infertility in TCM and the virtual explosion of new knowledge and methods in
基金supported by the National TCM Clinical Research Base Construction Project(Chinese medicine science and technology letter[2018]No.131)National Key R&D Project(2018YFC1704100,2018YFC1704102)and the Hebei Provincial Science and Technology Program(21377724d,21377740d)。
文摘Traditional Chinese medicine(TCM)and Western medicine are two medical systems formed in different cultural backgrounds.The differences between them are that TCM focuses on the study of the invisible state while Western medicine focuses more on the study of the visible state of the human body;TCM pays attention to systematicity and integrity,while Western medicine pays attention to local evidence;TCM attaches importance to dialectical thinking,while Western medicine attaches importance to materialistic thinking.For the development of TCM.it is necessary to take the initiative to learm from and absorb all the advanced scientific and technological achievements in the world today.To innovate TCM,it is necessary to need to adhere to(1)the integration of"research on TCM with the thought of TCM"and"research on TCM based on the thought of Western medicine";(2)the integration of scientization of TCM and scientization for TCM;(3)the integration of mobilization therapy and allopathic therapy;(4)the integration of treating patients and treating diseases;(5)the integration of preventive treatment and existent disease treatment;(6)the integration of individuality and commonality;and(7)the integration of the macro and the micro.
文摘分析了当前地理信息服务与其元数据不对称导致多源地理信息服务难于无缝集成的现状,提出根据OGC(Open Geospatial Consortium)网络地图服务(Web Map Service,WMS)动态生成自身元数据的方法,并基于OGCCSW(Catalogue Service for the Web)、WMS规范和ISO19139元数据标准开发了MS2 MD中间件。提出用于监测地理信息服务质量的方法,实现了对多源、分布式CSW与WMS的准实时动态监测;同时,设计了多源分布式CSW和WMS地理信息服务的集成体系结构,并将上述方法应用于全球综合地球观测系统(Global Earth Observation Systemof Systems,GEOSS)的空气质量与健康项目中,解决了WMS与其自身元数据信息不对称以及地理信息服务质量的准实时监测问题,实现了多源分布式CSW和WMS地理信息服务的无缝集成与互操作。
基金Scientific Research Innovation of Guangzhou University of Chinese Medicine, No.K004052
文摘BACKGROUND： The core symptoms of attention deficit, impulsiveness, hyperactivity of attention deficit hyperactivity disorders （ADHD） can concurrently present in spontaneous hypertensive rats. Neuropathological, biochemical and pharmacological studies also support it. Spontaneous hypertensive rats are one kind of best ADHD animal models, which has been accepted at present. Yizhining elixation can reinforce kidney and calm liver, strengthen spleen and nourish heart, benefit intelligence and focus attention, but its therapeutic effect on treatment of ADHD needs to be further investigated. OBJECTIVE： To observe the effect of Yizhining elixation on the persistent active attention deficit and impulsiveness of rats with spontaneous hypertension. DESIGN： Observational and controlled analysis. SETTING： Department of Pediatrics, the First Affiliated Hospital of Guangzhou University of Chinese Medicine. MATERIALS： Thirty-six male rats with spontaneous hypertension, of clean grade, were involved in this experiment. The involved rats were provided by Shanghai SLAC Laboratory Animal Co., Ltd., and they did not undergo any experiments; Yizhining elixation was composed by Guiban, Shenglonggu, Yuanzhi, Shichangpu, Yejiaoteng, Shudi, Dangshen, Yunling, Fuxiaomai, Wueizi. etc. Crude drug, provided by Outpatient Dispensary, Affiliated Hospital of Guangzhou University of Chinese Medicine, was prepared into water elixation, which contained crude drug of 1.154 g/mL. METHODS： This experiment was carried out in the Department of Pediatrics, First Affiliated Hospital of Guangzhou University of Chinese Medicine between March and July 2005. The involved rats were randomized into 3 groups： Yizhining high dose group, Yizhining low dose group and blank control group, with 12 rats in each. Changes in sustained attention and impulsiveness of rats were detected before and after administration of Yizhining elixation by ＂5-choice serial response time task＂ method. Following above-mentioned training and detection, rats in each group were daily drenched with Yizhining elixation once for 14 days successively. Rats in the Yizhining High-dose and low-dose groups we, e drenched with 12.6 mL/kg and 6.3 mL/kg Yizhining elixation （diluted to 25 mL/kg） respectively, and those in the blank control group were drenched with 12.5 mL/kg normal saline. On the 14^th day after administration, the ratios of correct and immature response of rats were re-detected for 3 days successively by formal detection method for later analysis. The sustained attention of rats was evaluated with ratio of correct response： Ratio of correct response=[times of correct response/（times of correct response ＋ times of incorrect response）]; impulsiveness was evaluated with the ratio of immature response： ratio of immature response=[times of immature response/ （times of correct response＋times of incorrect response＋times of omission＋times of immature response） ]. MAIN OUTCOME MEASURES： The effects of different doses of Yizhining elixation on the sustained attention （ratio of correct response） and impulsiveness （ratio of immature response） of spontaneous hypertensive rats. RESULTS： Thirty-six spontaneous hypertensive rats were involved in the final analysis. The ratio of correct response of rats in the Yizhining high dose and low dose groups after administration was （98.9±2.30）% and （96.6±4.00） %, respectively, which was significantly higher than that before administration [ （80.4±11.5 ） %, （839±8.90） %, P 〈 0.01] and that in the blank control group[ （83.3±6.30） %, P 〈 0.01]. The ratio of immature response of rats in the Yizhining high dose and low dose groups after adminisWafion was （5.04 ±1.04 ） %, （7.23 ± 1.22 ） %, respectively, which was lower than that before administration [ （9.85 ±2.50） %, （9.40±1.73 ） %, P 〈 0.05] and that in the blank control group [ （ 9.42 ±1.64） %, P 〈 0.01 ]. CONCLUSION： Yizhining elixation can improve the sustained attention and impulsiveness of spontaneous hypertensive rats.
文摘Background: Obsessive-compulsive, anxiety disorder, and depression are the most common negative emotions. The incidence rate is high and spread across all age groups. With the rapid development of the world economy and the increasing competition in social life, the incidence rate has also increased rapidly, more and more young suffer from these three kinds of mental illnesses. Many studies have been carried out to investigate the pathogenesis and therapeutic method. It is necessary to summarize the progress for references to further research and treatment. Method: Based on a series of literature, the studies on the pathogenesis and therapeutic method of the three kinds of illnesses are summarized and analyzed. The points and results either of West medicine (WM) or traditional Chinese medicine (TCM) are collected and compared to find the best tendency of study and the best therapeutic method. Results: Obsessive-compulsive disorder, anxiety disorder and depression are common in recent years and severely affect people’s lives. In view of WM. These three kinds of illnesses are all related to the changes or damage of part of brain and nervous system. While TCM thinks that they are due to Qi stagnation or deficiency of heart Yin. Many methods of treatment have been presented and used clinically, but the effect is limited. Conclusion: The most promising and effective methods are those combining WM and TCM.
文摘EDITORIAL Severe Acute Respiratory Syndrome(SARS)is a new intractable disease worldwide,itsonset is acute,its infectivity and mortality is high,the knowledge about its etiology and pathogenesis is in-sufficient,the experience on SARS treatment awaits accumulation.Following pilot experiences of applyingICWM in fighting SARS is most valuable with scientific significance.
文摘The gradually ex—panding number of peo—pie suffering from hy—pertension and the trendof lowering of their ageindicate that one shouldpay more attention tothe illness and tOstrengthen preventionand treatment of it inorder tO elevate clinicaltherapeutic effect,so as
文摘Member of Political Bureau of Central Committee of CPC, Vice Premier of State Council concurrently Minister of Health, General Command of National Protecting and Treating Severe Acute Respiratory Syndrome ( SARS) Headquarters Vice premier WU Yi cordially met the well-known TCM specialists, and held a symposium with them. Sixteen specialists including WANG Yong-yan, CHEN Ke-ji, LI Fu-ren, JIAO Shu-de, HE Pu-ren, LIU
文摘Objective: To investigate the suitable time of treating virulent and side effects of chemotherapy for malignant tumor by acupoint injection of Astragalus Root injection. Methods: Sixty three patients with malignant tumor were divided into three groups: prevention treatment (PT) group (n=23 cases),post chemotherapy treatment (PCT) group( n=22 cases), Western medicine (WM) group ( n=18 cases). The patients in PT, PCT and WM groups were treated respectively from the fifth day on before chemotherapy and from the first day on after chemotherapy, 18 days in all. The patients in WM group were administered Batilol and Leucogen from the first day on after chemotherapy. Changes of leukocytes and immunoglobulin before and after treatment were observed. Results: 1) Acupoint injection of Astragalus Root injectio could increase the number of leukocytes and immunoglobulin content and its effect was better than that of Western medicine (P<0.05); 2) The effect of PT group was better than that of PCT group in preventing and treating virulent and side effects of chemotherapy (P<0.05). Conclusion: It should be stressed on prevention of malignant tumor by using acupoint injection of Astragalus Root for relieving virulent and side effects of chemotherapy.
文摘Interview Time:15:00 pm,October 13th,2018Location:Shennongjia Forest Area,Hubei Prof.Zou:Hello.Professor Shen,thank you very much for accepting the interview of World Journal of Integrated traditional and western Medicine(English version).
