The evolution and integration of ports in global logistics chains has altered their traditional role while has initiated restructuring processes in many ports worldwide. While most of the research addresses this issue...The evolution and integration of ports in global logistics chains has altered their traditional role while has initiated restructuring processes in many ports worldwide. While most of the research addresses this issue by highlighting the need for re-positioning and redefining the role of the port within the supply chains, not much attention has been given to the structure, scope and reach as well as to the tools of regulation hat competent authorities could exploit in order to avert potential abusive actions of global powerful actors along the containerized transport chain, that would affect the competitive functioning of distinct segment or the integrity of supply chains. In this context, we propose the reconceptualization and reinforcement of the regulatory governance structures of ports on a national and international level as well as the extension of the scope of ports’ regulations along the supply chain to counterbalance the globalization, consolidation and integration of containerized transport actors.展开更多
Objective:A typical case of Xianling Gubao(XLGB)Tablets-induced liver injury was systematically studied in the clinic and the laboratory.Methods:A patient with herb-induced liver injury(HILI)and a history of taking XL...Objective:A typical case of Xianling Gubao(XLGB)Tablets-induced liver injury was systematically studied in the clinic and the laboratory.Methods:A patient with herb-induced liver injury(HILI)and a history of taking XLGB Tablets before disease onset was engaged as the study subject,and the case was diagnosed according to the updated Roussel Uclaf Causality Assessment Method(RUCAM)and the integrated evidence chain(iEC)method recommended by the Guidelines for Diagnosis and Treatment of Herb-induced Liver Injury(HILI Guidelines).Results:Clinical history,biochemical indexes and imaging tests were used to exclude the influence of fundamental diseases and confusing liver diseases such as viral,alcoholic and autoimmune liver diseases on the diagnosis.Based on an investigation of the patient’s medication history,she was suspected to have HILI caused by XLGB Tablets,as the patient was only taking an oral preparation of XLGB Tablets,and the influence of other drugs on the diagnosis was excluded.This patient with alanine aminotransferase(ALT)3 upper limit of normal(ULN)and a calculated R of 6 was diagnosed with possible acute drug-induced hepatocellular injury.The relationship was considered“highly probable”(score of 9)using the updated RUCAM of 2016.Moreover,the fingerprint similarity between the preparation taken by the patient and a commercially available preparation was 0.99,suggesting that the patient was consuming XLGB Tablets rather than another drug.LC-MS technology and the Agilent Fake TCM-Drugs database were used to investigate the drug,and no chemical additions were found.Examination of the drug for pesticide residues,heavy metals,aflatoxins and other exogenous substances indicated compliance with the content limits of the Chinese Pharmacopoeia.Conclusion:In summary,the final diagnosis of XLGB-induced liver injury reached the clinical diagnosis of HILI and was acute severe hepatocellular injury type by the updated RUCAM and iEC.Therefore,this study provides scientific evidence regarding the causality evaluation of compound preparations of traditional Chinese medicines-induced liver injury.展开更多
In order to satisfy the requirement of SI-traceable on-orbit absolute radiation calibration transfer with high accuracy for satellite remote sensors,a transfer chain consisting of a fiber coupling monochromator(FBM)...In order to satisfy the requirement of SI-traceable on-orbit absolute radiation calibration transfer with high accuracy for satellite remote sensors,a transfer chain consisting of a fiber coupling monochromator(FBM) and an integrating sphere transfer radiometer(ISTR) was designed in this paper.Depending on the Sun,this chain based on detectors provides precise spectral radiometric calibration and measurement to spectrometers in the reflective solar band(RSB) covering 300–2500 nm with a spectral bandwidth of 0.5–6 nm.It shortens the traditional chain based on lamp source and reduces the calibration uncertainty from 5% to 0.5% by using the cryogenic radiometer in space as a radiometric benchmark and trap detectors as secondary standard.This paper also gives a detailed uncertainty budget with reasonable distribution of each impact factor,including the weak spectral signal measurement with uncertainty of 0.28%.According to the peculiar design and comprehensive uncertainty analysis,it illustrates that the spectral radiance measurement uncertainty of the ISTR system can reach to 0.48%.The result satisfies the requirements of SI-traceable on-orbit calibration and has wider significance for expanding the application of the remote sensing data with high-quality.展开更多
A control problem of a chain of integrator system with measurement noise on feedback sensor is considered. We propose a gain-scaling controller for compensating measurement noise of feedback sensor. Because control sy...A control problem of a chain of integrator system with measurement noise on feedback sensor is considered. We propose a gain-scaling controller for compensating measurement noise of feedback sensor. Because control systems operate via feedback sensor's signal, the measurement noise in sensor' signal results in performance degradation or even system failure. Therefore, control systems often demand on compensating measurement noise. Our controller is equipped with a compensator and gain-scaling factor in order to reduce the effect of measurement noise on feedback sensor.展开更多
The food industry is evolving more towards new forms of organization much more complex and characterized by a greater degree of coordination, whether in the form of vertical integration of explicit or implicit contrac...The food industry is evolving more towards new forms of organization much more complex and characterized by a greater degree of coordination, whether in the form of vertical integration of explicit or implicit contracts between players of different levels of the industry. Therefore, the aim of this work is the search for mechanisms that can provide value to the production phase to better increase competitiveness of the sector. For the first time, in fact, discussion about food chains have as reference a recognized legal entity, which is the integrated projects of food chain as a result of actions of agricultural policy at community, national and regional levels. The methodology is related to two steps: the administration of questionnaires to the three companies participating in food chain partnerships that have proposed a draft of integrated design of food chain in response to the notice of the Apulia region for the submission of the integrated projects of the food chain; and a cluster analysis in the wine sector of the Italian regions. The results showed, thanks to Network Analysis, the importance for the chain development of relationships formed by market relations and cooperation relations (formal and informal) and the need for more actions for the enhancement of products by research and development activities.展开更多
We have talked about inclusiveness in many occasions in the SMEs taskforce working group.The starting point for our discussion is how to incorporate more people,more SMEs,morewomen and more young entrepreneurs into gl...We have talked about inclusiveness in many occasions in the SMEs taskforce working group.The starting point for our discussion is how to incorporate more people,more SMEs,morewomen and more young entrepreneurs into global economic development.SMEs shall be involved in the global trade platform along a certain value chain.If this can be achieved,展开更多
The U(1)symmetry of the X X Z central spin model with an arbitrary central magnetic field B is broken,since its total spin in the z-direction is not conserved.We obtain the exact solutions of the system by using the o...The U(1)symmetry of the X X Z central spin model with an arbitrary central magnetic field B is broken,since its total spin in the z-direction is not conserved.We obtain the exact solutions of the system by using the off-diagonal Bethe ansatz method.The thermodynamic limit is investigated based on the solutions.We find that the contribution of the inhomogeneous term in the associated T-Q relation to the ground state energy satisfies an N^(-1)scaling law,where N is the total number of spins.This result makes it possible to investigate the properties of the system in the thermodynamic limit.By assuming the structural form of the Bethe roots in the thermodynamic limit,we obtain the contribution of the direction of B to the ground state energy.It is shown that the contribution of the direction of the central magnetic field is a finite value in the thermodynamic limit.This is the phenomenon caused by the U(1)symmetry breaking of the system.展开更多
We introduce the notion of the contraction integrated semigroups and give the Lumber-Phillips characterization of the generator, and also the charaterazied generators of isometric integrated semigroups. For their appl...We introduce the notion of the contraction integrated semigroups and give the Lumber-Phillips characterization of the generator, and also the charaterazied generators of isometric integrated semigroups. For their application, a necessary and sufficient condition for q-matrices Q generating a contraction integrated semigroup is given, and a necessary and sufficient condition for a transition function to be a Feller-Reuter-Riley transition function is also given in terms of its q-matrix.展开更多
We outline the smart manufacturing challenges for formulated products, which are typically multicom- ponent, structured, and multiphase. These challenges predominate in the food, pharmaceuticals, agricul- tural and sp...We outline the smart manufacturing challenges for formulated products, which are typically multicom- ponent, structured, and multiphase. These challenges predominate in the food, pharmaceuticals, agricul- tural and specialty chemicals, energy storage and energetic materials, and consumer goods industries, and are driven by fast-changing customer demand and, in some cases, a tight regulatory framework. This paper discusses progress in smart manufacturing namely, digitalization and the use of large data- sets with predictive models and solution- nding algorithms in these industries. While some progress has been achieved, there is a strong need for more demonstration of model-based tools on realistic prob- lems in order to demonstrate their bene ts and highlight any systemic weaknesses.展开更多
In this paper, the incorporation and use of ICT (Information and Communication Technologies) in organizations are recognized as a process that occurs in stages involving progressive levels of maturity towards the in...In this paper, the incorporation and use of ICT (Information and Communication Technologies) in organizations are recognized as a process that occurs in stages involving progressive levels of maturity towards the integration of the extended value chain. In the beginning, ICT are applied to the digitalization of tasks and processes within the organization that facilitates the transition to the stage of integration of information systems and internal communication. Once this level of maturity is reached, it is possible to extend the application oflCT in inter-organizational processes. The main objective of this work is to identify factors that encourage the integration of inter-organizational information systems and the development of the extended value chain. One of the difficulties that this kind of study has to face is on the lack of precise empirical tools that enable comparability of results, both in time and between sectors and countries. It is therefore necessary to perform specific works that shed light on whether the efforts of local organizations to integrate ICT enhance collaborative processes with the environment and the factors influencing these results. It was applied a mixed methodology that combines ad-hoc survey and Tool Assessment Websites, carried out on 23 industrial manufacturing companies located in Rosario and Cordoba Argentina. The search was oriented to the identification of a limited number of indicators, but with the advantage of being amenable to being followed in time, for a number of companies in the region under study. The results indicate that companies with customers and/or suppliers abroad denote a higher level of maturity in the application of ICT.展开更多
Metabolizing enzymes play important roles in the detoxification of various pollutants in aquatic organisms, thereby they can also be used to provide early-warning signals of environmental risks. Real-time quantitative...Metabolizing enzymes play important roles in the detoxification of various pollutants in aquatic organisms, thereby they can also be used to provide early-warning signals of environmental risks. Real-time quantitative reverse-transcription polymerase chain reaction assays were developed to quantify cytochrome P450 1A (CYP1A), superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT), and glutathione-S-transferase (GST) in crucian carp (Carassius auratus). The methods were then used to detect the respective mRNA expression levels in liver tissue in wild crucian carp from the Hun River, North China. CYP1A mRNA expression was significantly up-regulated in fish from stations $5, $6, and $8 (p 〈 0.05). SOD mRNA expression was significantly down-regulated in downstream areas relative to fish from upstream sites (p 〈 0.05); GPx and CAT mRNA expression levels were also down-regulated at $9 (p 〈 0.05). In contrast, GST mRNA expression showed no obvious change between fish collected from up- or downstream areas of the river. Finally, an integrated biomarker response was used to evaluate the integrated impact of pollutants in the Hun River and allow better comprehension of the real toxicological risk of these investigated sites.展开更多
Digital transformation provides companies with a productive approach to transforming and upgrading enterprise resources and capabilities and to exploiting external subject forces to unleash and magnify their potential...Digital transformation provides companies with a productive approach to transforming and upgrading enterprise resources and capabilities and to exploiting external subject forces to unleash and magnify their potential,thus advancing high-quality enterprise development.Therefore,using regression analysis of the data of China’s non-financial listed firms from 2007‒2019 obtained by Python,this paper finds that digital transformation has enormously improved enterprise performance.Furthermore,digital transformation has powerfully boosted supply chain integration,which has played a mediation role in the impact of digital transformation on enterprise performance.Finally,entrepreneurship plays a positive moderating effect on enterprise performance through supply chain integration during digital transformation.The further heterogeneity analysis finds that digital transformation performs better in large,public,state-owned,mature,and non-manufacturing(service industry)enterprises.However,the positive effect of digital transformation on enterprise performance and supply chain integration is not significant in small and medium-sized enterprises.Therefore,supply chain integration cannot play a mediating role in the impact of digital transformation of manufacturing enterprises upon their performance.This paper probes the realization mechanism and micro-foundation of digital transformation,and its conclusion contributes to high-quality digital transformation.展开更多
文摘The evolution and integration of ports in global logistics chains has altered their traditional role while has initiated restructuring processes in many ports worldwide. While most of the research addresses this issue by highlighting the need for re-positioning and redefining the role of the port within the supply chains, not much attention has been given to the structure, scope and reach as well as to the tools of regulation hat competent authorities could exploit in order to avert potential abusive actions of global powerful actors along the containerized transport chain, that would affect the competitive functioning of distinct segment or the integrity of supply chains. In this context, we propose the reconceptualization and reinforcement of the regulatory governance structures of ports on a national and international level as well as the extension of the scope of ports’ regulations along the supply chain to counterbalance the globalization, consolidation and integration of containerized transport actors.
基金supported by the National Natural Science Foundation of China(No.82174071).
文摘Objective:A typical case of Xianling Gubao(XLGB)Tablets-induced liver injury was systematically studied in the clinic and the laboratory.Methods:A patient with herb-induced liver injury(HILI)and a history of taking XLGB Tablets before disease onset was engaged as the study subject,and the case was diagnosed according to the updated Roussel Uclaf Causality Assessment Method(RUCAM)and the integrated evidence chain(iEC)method recommended by the Guidelines for Diagnosis and Treatment of Herb-induced Liver Injury(HILI Guidelines).Results:Clinical history,biochemical indexes and imaging tests were used to exclude the influence of fundamental diseases and confusing liver diseases such as viral,alcoholic and autoimmune liver diseases on the diagnosis.Based on an investigation of the patient’s medication history,she was suspected to have HILI caused by XLGB Tablets,as the patient was only taking an oral preparation of XLGB Tablets,and the influence of other drugs on the diagnosis was excluded.This patient with alanine aminotransferase(ALT)3 upper limit of normal(ULN)and a calculated R of 6 was diagnosed with possible acute drug-induced hepatocellular injury.The relationship was considered“highly probable”(score of 9)using the updated RUCAM of 2016.Moreover,the fingerprint similarity between the preparation taken by the patient and a commercially available preparation was 0.99,suggesting that the patient was consuming XLGB Tablets rather than another drug.LC-MS technology and the Agilent Fake TCM-Drugs database were used to investigate the drug,and no chemical additions were found.Examination of the drug for pesticide residues,heavy metals,aflatoxins and other exogenous substances indicated compliance with the content limits of the Chinese Pharmacopoeia.Conclusion:In summary,the final diagnosis of XLGB-induced liver injury reached the clinical diagnosis of HILI and was acute severe hepatocellular injury type by the updated RUCAM and iEC.Therefore,this study provides scientific evidence regarding the causality evaluation of compound preparations of traditional Chinese medicines-induced liver injury.
基金Project supported by the National Natural Science Foundation of China(Grant No.41474161)the National High-Technology Program of China(Grant No.2015AA123703)
文摘In order to satisfy the requirement of SI-traceable on-orbit absolute radiation calibration transfer with high accuracy for satellite remote sensors,a transfer chain consisting of a fiber coupling monochromator(FBM) and an integrating sphere transfer radiometer(ISTR) was designed in this paper.Depending on the Sun,this chain based on detectors provides precise spectral radiometric calibration and measurement to spectrometers in the reflective solar band(RSB) covering 300–2500 nm with a spectral bandwidth of 0.5–6 nm.It shortens the traditional chain based on lamp source and reduces the calibration uncertainty from 5% to 0.5% by using the cryogenic radiometer in space as a radiometric benchmark and trap detectors as secondary standard.This paper also gives a detailed uncertainty budget with reasonable distribution of each impact factor,including the weak spectral signal measurement with uncertainty of 0.28%.According to the peculiar design and comprehensive uncertainty analysis,it illustrates that the spectral radiance measurement uncertainty of the ISTR system can reach to 0.48%.The result satisfies the requirements of SI-traceable on-orbit calibration and has wider significance for expanding the application of the remote sensing data with high-quality.
基金supported by Basic Science Research Program through the National Research Foundation of Korea(NRF)funded by the Ministry of Education,Science and Technology(2010-0007325)
文摘A control problem of a chain of integrator system with measurement noise on feedback sensor is considered. We propose a gain-scaling controller for compensating measurement noise of feedback sensor. Because control systems operate via feedback sensor's signal, the measurement noise in sensor' signal results in performance degradation or even system failure. Therefore, control systems often demand on compensating measurement noise. Our controller is equipped with a compensator and gain-scaling factor in order to reduce the effect of measurement noise on feedback sensor.
文摘The food industry is evolving more towards new forms of organization much more complex and characterized by a greater degree of coordination, whether in the form of vertical integration of explicit or implicit contracts between players of different levels of the industry. Therefore, the aim of this work is the search for mechanisms that can provide value to the production phase to better increase competitiveness of the sector. For the first time, in fact, discussion about food chains have as reference a recognized legal entity, which is the integrated projects of food chain as a result of actions of agricultural policy at community, national and regional levels. The methodology is related to two steps: the administration of questionnaires to the three companies participating in food chain partnerships that have proposed a draft of integrated design of food chain in response to the notice of the Apulia region for the submission of the integrated projects of the food chain; and a cluster analysis in the wine sector of the Italian regions. The results showed, thanks to Network Analysis, the importance for the chain development of relationships formed by market relations and cooperation relations (formal and informal) and the need for more actions for the enhancement of products by research and development activities.
文摘We have talked about inclusiveness in many occasions in the SMEs taskforce working group.The starting point for our discussion is how to incorporate more people,more SMEs,morewomen and more young entrepreneurs into global economic development.SMEs shall be involved in the global trade platform along a certain value chain.If this can be achieved,
基金the National Natural Science Foundation of China(Grant Nos.11847245,11874393,and 12134015)the Doctoral Scientific Research Foundation of Yunnan Normal University(Grant No.00900205020503180)+2 种基金the National Natural Science Foundation of China(Grant Nos.12275214,11805152,12047502,and 11947301)the Natural Science Basic Research Program of Shaanxi Province(Grant Nos.2021JCW-19and 2019JQ-107)the Shaanxi Key Laboratory for Theoretical Physics Frontiers in China。
文摘The U(1)symmetry of the X X Z central spin model with an arbitrary central magnetic field B is broken,since its total spin in the z-direction is not conserved.We obtain the exact solutions of the system by using the off-diagonal Bethe ansatz method.The thermodynamic limit is investigated based on the solutions.We find that the contribution of the inhomogeneous term in the associated T-Q relation to the ground state energy satisfies an N^(-1)scaling law,where N is the total number of spins.This result makes it possible to investigate the properties of the system in the thermodynamic limit.By assuming the structural form of the Bethe roots in the thermodynamic limit,we obtain the contribution of the direction of B to the ground state energy.It is shown that the contribution of the direction of the central magnetic field is a finite value in the thermodynamic limit.This is the phenomenon caused by the U(1)symmetry breaking of the system.
文摘We introduce the notion of the contraction integrated semigroups and give the Lumber-Phillips characterization of the generator, and also the charaterazied generators of isometric integrated semigroups. For their application, a necessary and sufficient condition for q-matrices Q generating a contraction integrated semigroup is given, and a necessary and sufficient condition for a transition function to be a Feller-Reuter-Riley transition function is also given in terms of its q-matrix.
文摘We outline the smart manufacturing challenges for formulated products, which are typically multicom- ponent, structured, and multiphase. These challenges predominate in the food, pharmaceuticals, agricul- tural and specialty chemicals, energy storage and energetic materials, and consumer goods industries, and are driven by fast-changing customer demand and, in some cases, a tight regulatory framework. This paper discusses progress in smart manufacturing namely, digitalization and the use of large data- sets with predictive models and solution- nding algorithms in these industries. While some progress has been achieved, there is a strong need for more demonstration of model-based tools on realistic prob- lems in order to demonstrate their bene ts and highlight any systemic weaknesses.
文摘In this paper, the incorporation and use of ICT (Information and Communication Technologies) in organizations are recognized as a process that occurs in stages involving progressive levels of maturity towards the integration of the extended value chain. In the beginning, ICT are applied to the digitalization of tasks and processes within the organization that facilitates the transition to the stage of integration of information systems and internal communication. Once this level of maturity is reached, it is possible to extend the application oflCT in inter-organizational processes. The main objective of this work is to identify factors that encourage the integration of inter-organizational information systems and the development of the extended value chain. One of the difficulties that this kind of study has to face is on the lack of precise empirical tools that enable comparability of results, both in time and between sectors and countries. It is therefore necessary to perform specific works that shed light on whether the efforts of local organizations to integrate ICT enhance collaborative processes with the environment and the factors influencing these results. It was applied a mixed methodology that combines ad-hoc survey and Tool Assessment Websites, carried out on 23 industrial manufacturing companies located in Rosario and Cordoba Argentina. The search was oriented to the identification of a limited number of indicators, but with the advantage of being amenable to being followed in time, for a number of companies in the region under study. The results indicate that companies with customers and/or suppliers abroad denote a higher level of maturity in the application of ICT.
基金supported by the Water Pollution Control and Management(No.2009ZX07528)
文摘Metabolizing enzymes play important roles in the detoxification of various pollutants in aquatic organisms, thereby they can also be used to provide early-warning signals of environmental risks. Real-time quantitative reverse-transcription polymerase chain reaction assays were developed to quantify cytochrome P450 1A (CYP1A), superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT), and glutathione-S-transferase (GST) in crucian carp (Carassius auratus). The methods were then used to detect the respective mRNA expression levels in liver tissue in wild crucian carp from the Hun River, North China. CYP1A mRNA expression was significantly up-regulated in fish from stations $5, $6, and $8 (p 〈 0.05). SOD mRNA expression was significantly down-regulated in downstream areas relative to fish from upstream sites (p 〈 0.05); GPx and CAT mRNA expression levels were also down-regulated at $9 (p 〈 0.05). In contrast, GST mRNA expression showed no obvious change between fish collected from up- or downstream areas of the river. Finally, an integrated biomarker response was used to evaluate the integrated impact of pollutants in the Hun River and allow better comprehension of the real toxicological risk of these investigated sites.
基金This paper is supported by General Project of National Social Science Funds of China“Research on the Dynamic Coupling of Executive Incentives and Supervision of State-Owned Enterprises under the Big Data Context”(No.18BGL081).
文摘Digital transformation provides companies with a productive approach to transforming and upgrading enterprise resources and capabilities and to exploiting external subject forces to unleash and magnify their potential,thus advancing high-quality enterprise development.Therefore,using regression analysis of the data of China’s non-financial listed firms from 2007‒2019 obtained by Python,this paper finds that digital transformation has enormously improved enterprise performance.Furthermore,digital transformation has powerfully boosted supply chain integration,which has played a mediation role in the impact of digital transformation on enterprise performance.Finally,entrepreneurship plays a positive moderating effect on enterprise performance through supply chain integration during digital transformation.The further heterogeneity analysis finds that digital transformation performs better in large,public,state-owned,mature,and non-manufacturing(service industry)enterprises.However,the positive effect of digital transformation on enterprise performance and supply chain integration is not significant in small and medium-sized enterprises.Therefore,supply chain integration cannot play a mediating role in the impact of digital transformation of manufacturing enterprises upon their performance.This paper probes the realization mechanism and micro-foundation of digital transformation,and its conclusion contributes to high-quality digital transformation.