Cancer cachexia is a multi-organ syndrome and closely related to changes in signal communication between organs,which is mediated by cancer cachexia factors.Cancer cachexia factors,being the general name of inflammato...Cancer cachexia is a multi-organ syndrome and closely related to changes in signal communication between organs,which is mediated by cancer cachexia factors.Cancer cachexia factors,being the general name of inflammatory factors,circulating proteins,metabolites,and microRNA secreted by tumor or host cells,play a role in secretory or other organs and mediate complex signal communication between organs during cancer cachexia.Cancer cachexia factors are also a potential target for the diagnosis and treatment.The pathogenesis of cachexia is unclear and no clear effective treatment is available.Thus,the treatment of cancer cachexia from the perspective of the tumor ecosystem rather than from the perspective of a single molecule and a single organ is urgently needed.From the point of signal communication between organs mediated by cancer cachexia factors,finding a deeper understanding of the pathogenesis,diagnosis,and treatment of cancer cachexia is of great significance to improve the level of diagnosis and treatment.This review begins with cancer cachexia factors released during the interaction between tumor and host cells,and provides a comprehensive summary of the pathogenesis,diagnosis,and treatment for cancer cachexia,along with a particular sight on multi-organ signal communication mediated by cancer cachexia factors.This summary aims to deepen medical community’s understanding of cancer cachexia and may conduce to the discovery of new diagnostic and therapeutic targets for cancer cachexia.展开更多
In recent years, considerable attention has been paid to exploring the complex gene regulatory networks involved in the development of the plant vascular system. Such information is crucial to our understanding of the...In recent years, considerable attention has been paid to exploring the complex gene regulatory networks involved in the development of the plant vascular system. Such information is crucial to our understanding of the molecular and cellular events which give rise to the integrated tissues of the xylem and phloem, leading to the formation of structurally continuous conduits that interconnect various organs of the plant. Vascular development begins in the embryo to form progenitor cells, and upon germination, these progenitor cells and their decedents in the shoot and root meristems will form phloem and xylem, and the cambium.展开更多
In this Special Issue, a focus is placed on the role of the xylem as an essential conduit for the long-distance delivery of water and mineral nutrients from the soil to the vegetative （above-ground） regions of the p...In this Special Issue, a focus is placed on the role of the xylem as an essential conduit for the long-distance delivery of water and mineral nutrients from the soil to the vegetative （above-ground） regions of the plant. Xylem cells destined to form tracheids or vessel members, which will make up the conduit for this water and mineral transport from the roots to the shoots, undergo apoptosis, a process of programmed cell death.展开更多
为揭示南水北调中线工程水体中溶解性有机质(Dissolved Organic Matter,DOM)的组成变化特征,采集南水北调中线总干渠沿线及丹江口水库水样,利用傅里叶变换离子回旋共振质谱(Fourier Transform Ion Cyclotron Resonance Mass Spectrometr...为揭示南水北调中线工程水体中溶解性有机质(Dissolved Organic Matter,DOM)的组成变化特征,采集南水北调中线总干渠沿线及丹江口水库水样,利用傅里叶变换离子回旋共振质谱(Fourier Transform Ion Cyclotron Resonance Mass Spectrometry,FT-ICR MS)分析了DOM的分子组成及其空间变化,并探讨了总干渠沿线DOM变化成因和环境意义。结果表明:丹江口水库和总干渠均检出DOM物质3200余种,仅含C、H和O的物质(CHOs)为主要组分,约占所有检出物质的61%,含C、H、O和N的物质(CHONs)占30.5%~31.5%,含C、H、O和S的物质(CHOSs)仅占7.3%~8.4%,结合O/C和H/C分类,丹江口水库和总干渠水体DOM主要组分为木质素(60%以上)。相较于丹江口水库,总干渠水体DOM组分发生了较大变化,蛋白质类组分占比由3.70%升至8.65%,表明总干渠中有蛋白质生成;稠环类物质占比由9.43%下降至4.77%,单宁酸类的变化趋势与稠环类物质类似。总干渠局部区域藻类增殖过程是引起总干渠中CHONs和CHOSs类DOM组分和占比升高的主要原因。研究成果可为科学认识南水北调中线工程水体水质变化过程提供科学依据。展开更多
基金supported by the High-Level Talent Introduction Funds from the First Hospital of Lanzhou University.
文摘Cancer cachexia is a multi-organ syndrome and closely related to changes in signal communication between organs,which is mediated by cancer cachexia factors.Cancer cachexia factors,being the general name of inflammatory factors,circulating proteins,metabolites,and microRNA secreted by tumor or host cells,play a role in secretory or other organs and mediate complex signal communication between organs during cancer cachexia.Cancer cachexia factors are also a potential target for the diagnosis and treatment.The pathogenesis of cachexia is unclear and no clear effective treatment is available.Thus,the treatment of cancer cachexia from the perspective of the tumor ecosystem rather than from the perspective of a single molecule and a single organ is urgently needed.From the point of signal communication between organs mediated by cancer cachexia factors,finding a deeper understanding of the pathogenesis,diagnosis,and treatment of cancer cachexia is of great significance to improve the level of diagnosis and treatment.This review begins with cancer cachexia factors released during the interaction between tumor and host cells,and provides a comprehensive summary of the pathogenesis,diagnosis,and treatment for cancer cachexia,along with a particular sight on multi-organ signal communication mediated by cancer cachexia factors.This summary aims to deepen medical community’s understanding of cancer cachexia and may conduce to the discovery of new diagnostic and therapeutic targets for cancer cachexia.
文摘In recent years, considerable attention has been paid to exploring the complex gene regulatory networks involved in the development of the plant vascular system. Such information is crucial to our understanding of the molecular and cellular events which give rise to the integrated tissues of the xylem and phloem, leading to the formation of structurally continuous conduits that interconnect various organs of the plant. Vascular development begins in the embryo to form progenitor cells, and upon germination, these progenitor cells and their decedents in the shoot and root meristems will form phloem and xylem, and the cambium.
文摘In this Special Issue, a focus is placed on the role of the xylem as an essential conduit for the long-distance delivery of water and mineral nutrients from the soil to the vegetative （above-ground） regions of the plant. Xylem cells destined to form tracheids or vessel members, which will make up the conduit for this water and mineral transport from the roots to the shoots, undergo apoptosis, a process of programmed cell death.
文摘为揭示南水北调中线工程水体中溶解性有机质(Dissolved Organic Matter,DOM)的组成变化特征,采集南水北调中线总干渠沿线及丹江口水库水样,利用傅里叶变换离子回旋共振质谱(Fourier Transform Ion Cyclotron Resonance Mass Spectrometry,FT-ICR MS)分析了DOM的分子组成及其空间变化,并探讨了总干渠沿线DOM变化成因和环境意义。结果表明:丹江口水库和总干渠均检出DOM物质3200余种,仅含C、H和O的物质(CHOs)为主要组分,约占所有检出物质的61%,含C、H、O和N的物质(CHONs)占30.5%~31.5%,含C、H、O和S的物质(CHOSs)仅占7.3%~8.4%,结合O/C和H/C分类,丹江口水库和总干渠水体DOM主要组分为木质素(60%以上)。相较于丹江口水库,总干渠水体DOM组分发生了较大变化,蛋白质类组分占比由3.70%升至8.65%,表明总干渠中有蛋白质生成;稠环类物质占比由9.43%下降至4.77%,单宁酸类的变化趋势与稠环类物质类似。总干渠局部区域藻类增殖过程是引起总干渠中CHONs和CHOSs类DOM组分和占比升高的主要原因。研究成果可为科学认识南水北调中线工程水体水质变化过程提供科学依据。
