Baotou City is an industrial city developed in the farming-grazing transitional zone in northern China. The development of industry, farming and grazing is very fast. It has become a typical intergrated economic regio...Baotou City is an industrial city developed in the farming-grazing transitional zone in northern China. The development of industry, farming and grazing is very fast. It has become a typical intergrated economic region of industry, farming and grazing. Based on the analysis of utilization of land resources, this paper points out the main conflicts and problems on the utilization of land resources in the city, and puts forward a corresponding proposal.展开更多
Nowadays,huge consumption of fossil fuels brings about serious energy crisis and environmental problems,which urge researchers to explore novel sustainable energy sources and storage systems[1,2].
BACKGROUND： The core symptoms of attention deficit, impulsiveness, hyperactivity of attention deficit hyperactivity disorders （ADHD） can concurrently present in spontaneous hypertensive rats. Neuropathological, bio...BACKGROUND： The core symptoms of attention deficit, impulsiveness, hyperactivity of attention deficit hyperactivity disorders （ADHD） can concurrently present in spontaneous hypertensive rats. Neuropathological, biochemical and pharmacological studies also support it. Spontaneous hypertensive rats are one kind of best ADHD animal models, which has been accepted at present. Yizhining elixation can reinforce kidney and calm liver, strengthen spleen and nourish heart, benefit intelligence and focus attention, but its therapeutic effect on treatment of ADHD needs to be further investigated. OBJECTIVE： To observe the effect of Yizhining elixation on the persistent active attention deficit and impulsiveness of rats with spontaneous hypertension. DESIGN： Observational and controlled analysis. SETTING： Department of Pediatrics, the First Affiliated Hospital of Guangzhou University of Chinese Medicine. MATERIALS： Thirty-six male rats with spontaneous hypertension, of clean grade, were involved in this experiment. The involved rats were provided by Shanghai SLAC Laboratory Animal Co., Ltd., and they did not undergo any experiments; Yizhining elixation was composed by Guiban, Shenglonggu, Yuanzhi, Shichangpu, Yejiaoteng, Shudi, Dangshen, Yunling, Fuxiaomai, Wueizi. etc. Crude drug, provided by Outpatient Dispensary, Affiliated Hospital of Guangzhou University of Chinese Medicine, was prepared into water elixation, which contained crude drug of 1.154 g/mL. METHODS： This experiment was carried out in the Department of Pediatrics, First Affiliated Hospital of Guangzhou University of Chinese Medicine between March and July 2005. The involved rats were randomized into 3 groups： Yizhining high dose group, Yizhining low dose group and blank control group, with 12 rats in each. Changes in sustained attention and impulsiveness of rats were detected before and after administration of Yizhining elixation by ＂5-choice serial response time task＂ method. Following above-mentioned training and detection, rats in each group were daily drenched with Yizhining elixation once for 14 days successively. Rats in the Yizhining High-dose and low-dose groups we, e drenched with 12.6 mL/kg and 6.3 mL/kg Yizhining elixation （diluted to 25 mL/kg） respectively, and those in the blank control group were drenched with 12.5 mL/kg normal saline. On the 14^th day after administration, the ratios of correct and immature response of rats were re-detected for 3 days successively by formal detection method for later analysis. The sustained attention of rats was evaluated with ratio of correct response： Ratio of correct response=[times of correct response/（times of correct response ＋ times of incorrect response）]; impulsiveness was evaluated with the ratio of immature response： ratio of immature response=[times of immature response/ （times of correct response＋times of incorrect response＋times of omission＋times of immature response） ]. MAIN OUTCOME MEASURES： The effects of different doses of Yizhining elixation on the sustained attention （ratio of correct response） and impulsiveness （ratio of immature response） of spontaneous hypertensive rats. RESULTS： Thirty-six spontaneous hypertensive rats were involved in the final analysis. The ratio of correct response of rats in the Yizhining high dose and low dose groups after administration was （98.9±2.30）% and （96.6±4.00） %, respectively, which was significantly higher than that before administration [ （80.4±11.5 ） %, （839±8.90） %, P 〈 0.01] and that in the blank control group[ （83.3±6.30） %, P 〈 0.01]. The ratio of immature response of rats in the Yizhining high dose and low dose groups after adminisWafion was （5.04 ±1.04 ） %, （7.23 ± 1.22 ） %, respectively, which was lower than that before administration [ （9.85 ±2.50） %, （9.40±1.73 ） %, P 〈 0.05] and that in the blank control group [ （ 9.42 ±1.64） %, P 〈 0.01 ]. CONCLUSION： Yizhining elixation can improve the sustained attention and impulsiveness of spontaneous hypertensive rats.展开更多
As crucial negative regulatory small non-coding molecules, microRNAs (miRNAs), have multiple biological roles. The abnormal expression of specific miRNAs may contribute to the occurrence and development of tumor. Here...As crucial negative regulatory small non-coding molecules, microRNAs (miRNAs), have multiple biological roles. The abnormal expression of specific miRNAs may contribute to the occurrence and development of tumor. Here, based on HepG2 and L02 cells, we attempted to demonstrate the potential regulatory network of aberrantly expressed miRNA profiles, interaction between miRNA and mRNA, and potential functional correlation between different miRNAs. De-regulated miRNA and mRNA expression profiles were completely surveyed and identified by applying deep sequenc-ing and microarray techniques, respectively. The genome-wide and integrative analysis of miRNA-mRNA was performed based on their functional relationship according to experimentally validated and predicted targets. Nearly 50% targets were negatively regulated by at least 2 aberrantly expressed miRNAs. Similar results were obtained based on experimentally validated and predicted targets. Compared with abnormal miRNAs, their targets showed various expression patterns: stably expressed, down-regulated or up-regulated. Although the theoretical potential miRNA-mRNA interaction could be predicted, they showed consistent or inconsistent expression patterns. Both functional enrichment analysis of target mRNAs of dysregulated miRNAs and abnormal mRNA profiles suggested that corresponding pathways were involved in tumorigenesis. Moreover, to obtain potential functional relationships between different miRNAs, we also performed expression analysis of homologous miRNAs in gene families. Generally, they could co-regulate biological processes with similar roles. The integrative analysis of miRNA-mRNA indicated a complex and flexible regulatory network. The robust network mainly derived from multiple targets for a specific miRNA (and vice versa), each mRNA and co-regulation roles of different miRNAs.展开更多
This paper discussses the random singular integral of random process with second order moment, establishes the concepts of the random singular integral and proves that it's a linear bounded operator of space Ha(L)...This paper discussses the random singular integral of random process with second order moment, establishes the concepts of the random singular integral and proves that it's a linear bounded operator of space Ha(L)(m, s). Then Plemelj formula and some other properties for random singular integral are proved.展开更多
In the linguistic field,there are disputes on the view of contextual research and the goal of universality.Some scholars believe that common features of linguistic phenomena are significant while others are in favor o...In the linguistic field,there are disputes on the view of contextual research and the goal of universality.Some scholars believe that common features of linguistic phenomena are significant while others are in favor of the perception that it is more applicable and practical to carry out contextual researches.The author tends to analyze the reality and significance of contextual researches and with the goal of universality explained,the relationship between them and further suggestion will be discussed.展开更多
Gene finding, the accurate annotation of genomic DNA, has become one of the central topics in biological research. Although various computational methods (gene finders) have been proposed and developed, they all have ...Gene finding, the accurate annotation of genomic DNA, has become one of the central topics in biological research. Although various computational methods (gene finders) have been proposed and developed, they all have their own limitations in gene findings. In this paper, we introduce an integrating gene finder, which combines the results of several existing gene finders together, to improve the accuracy of gene finding. Four integration schemes, based on majority voting, are developed for the analysis of two datasets – the basic dataset and the testing dataset. The basic dataset consists of 1500 DNA sequences and the testing dataset consists of 103 DNA sequences. It is demonstrated that a simple integration (a simple voting for each nucleotide) can significantly improve the finding performance, and removing confusing gene finders, caused by poor performance or redundant results, is important for a further improvement of the integration. The best prediction results are obtained using weighted majority voting, aided by the mRMR (Minimum Redundancy Maximum Relevance) (Peng, 2005) method for the gene finder selection. The prediction accuracies are 84.16% and 90.06% for the basic dataset and testing dataset respectively, which are better than any individual gene finding software in our research.展开更多
The crustobody is a concept of tectonic element established for integrating the research airns, objects and methods of historic and dynamic geotectonics in order to study the tectonics of the earth in an all-round way...The crustobody is a concept of tectonic element established for integrating the research airns, objects and methods of historic and dynamic geotectonics in order to study the tectonics of the earth in an all-round way. It caTries the implications of both evolution and rnovernent, lying equal stress on both development viewpoint and connection viewpoint and giving consideration to both tirne and space. It has the nature, characteristics and functions of the above-mentioned two tectonic elements. On the one hand, though consisting of historic tectonic elernents such as geosynclinal, platform and geodepression (diwa) regions, it puts emphasis on their changing state in spatial rnigration, thus differing from them. On the other hand,though sirnilar in form to plate, a dynamic tectonic element, it places eruphasis on the changing state in its temporal evolution and has other distinguishing characteristics, thus differing from it.展开更多
基金Supported by the key project of Baotou Science and Technology Committee (No.973B2054)
文摘Baotou City is an industrial city developed in the farming-grazing transitional zone in northern China. The development of industry, farming and grazing is very fast. It has become a typical intergrated economic region of industry, farming and grazing. Based on the analysis of utilization of land resources, this paper points out the main conflicts and problems on the utilization of land resources in the city, and puts forward a corresponding proposal.
基金supported by the National Natural Science Foundation of China(21601089)Jiangsu Specially Appointed Professor Program。
文摘Nowadays,huge consumption of fossil fuels brings about serious energy crisis and environmental problems,which urge researchers to explore novel sustainable energy sources and storage systems[1,2].
基金Scientific Research Innovation of Guangzhou University of Chinese Medicine, No.K004052
文摘BACKGROUND： The core symptoms of attention deficit, impulsiveness, hyperactivity of attention deficit hyperactivity disorders （ADHD） can concurrently present in spontaneous hypertensive rats. Neuropathological, biochemical and pharmacological studies also support it. Spontaneous hypertensive rats are one kind of best ADHD animal models, which has been accepted at present. Yizhining elixation can reinforce kidney and calm liver, strengthen spleen and nourish heart, benefit intelligence and focus attention, but its therapeutic effect on treatment of ADHD needs to be further investigated. OBJECTIVE： To observe the effect of Yizhining elixation on the persistent active attention deficit and impulsiveness of rats with spontaneous hypertension. DESIGN： Observational and controlled analysis. SETTING： Department of Pediatrics, the First Affiliated Hospital of Guangzhou University of Chinese Medicine. MATERIALS： Thirty-six male rats with spontaneous hypertension, of clean grade, were involved in this experiment. The involved rats were provided by Shanghai SLAC Laboratory Animal Co., Ltd., and they did not undergo any experiments; Yizhining elixation was composed by Guiban, Shenglonggu, Yuanzhi, Shichangpu, Yejiaoteng, Shudi, Dangshen, Yunling, Fuxiaomai, Wueizi. etc. Crude drug, provided by Outpatient Dispensary, Affiliated Hospital of Guangzhou University of Chinese Medicine, was prepared into water elixation, which contained crude drug of 1.154 g/mL. METHODS： This experiment was carried out in the Department of Pediatrics, First Affiliated Hospital of Guangzhou University of Chinese Medicine between March and July 2005. The involved rats were randomized into 3 groups： Yizhining high dose group, Yizhining low dose group and blank control group, with 12 rats in each. Changes in sustained attention and impulsiveness of rats were detected before and after administration of Yizhining elixation by ＂5-choice serial response time task＂ method. Following above-mentioned training and detection, rats in each group were daily drenched with Yizhining elixation once for 14 days successively. Rats in the Yizhining High-dose and low-dose groups we, e drenched with 12.6 mL/kg and 6.3 mL/kg Yizhining elixation （diluted to 25 mL/kg） respectively, and those in the blank control group were drenched with 12.5 mL/kg normal saline. On the 14^th day after administration, the ratios of correct and immature response of rats were re-detected for 3 days successively by formal detection method for later analysis. The sustained attention of rats was evaluated with ratio of correct response： Ratio of correct response=[times of correct response/（times of correct response ＋ times of incorrect response）]; impulsiveness was evaluated with the ratio of immature response： ratio of immature response=[times of immature response/ （times of correct response＋times of incorrect response＋times of omission＋times of immature response） ]. MAIN OUTCOME MEASURES： The effects of different doses of Yizhining elixation on the sustained attention （ratio of correct response） and impulsiveness （ratio of immature response） of spontaneous hypertensive rats. RESULTS： Thirty-six spontaneous hypertensive rats were involved in the final analysis. The ratio of correct response of rats in the Yizhining high dose and low dose groups after administration was （98.9±2.30）% and （96.6±4.00） %, respectively, which was significantly higher than that before administration [ （80.4±11.5 ） %, （839±8.90） %, P 〈 0.01] and that in the blank control group[ （83.3±6.30） %, P 〈 0.01]. The ratio of immature response of rats in the Yizhining high dose and low dose groups after adminisWafion was （5.04 ±1.04 ） %, （7.23 ± 1.22 ） %, respectively, which was lower than that before administration [ （9.85 ±2.50） %, （9.40±1.73 ） %, P 〈 0.05] and that in the blank control group [ （ 9.42 ±1.64） %, P 〈 0.01 ]. CONCLUSION： Yizhining elixation can improve the sustained attention and impulsiveness of spontaneous hypertensive rats.
文摘As crucial negative regulatory small non-coding molecules, microRNAs (miRNAs), have multiple biological roles. The abnormal expression of specific miRNAs may contribute to the occurrence and development of tumor. Here, based on HepG2 and L02 cells, we attempted to demonstrate the potential regulatory network of aberrantly expressed miRNA profiles, interaction between miRNA and mRNA, and potential functional correlation between different miRNAs. De-regulated miRNA and mRNA expression profiles were completely surveyed and identified by applying deep sequenc-ing and microarray techniques, respectively. The genome-wide and integrative analysis of miRNA-mRNA was performed based on their functional relationship according to experimentally validated and predicted targets. Nearly 50% targets were negatively regulated by at least 2 aberrantly expressed miRNAs. Similar results were obtained based on experimentally validated and predicted targets. Compared with abnormal miRNAs, their targets showed various expression patterns: stably expressed, down-regulated or up-regulated. Although the theoretical potential miRNA-mRNA interaction could be predicted, they showed consistent or inconsistent expression patterns. Both functional enrichment analysis of target mRNAs of dysregulated miRNAs and abnormal mRNA profiles suggested that corresponding pathways were involved in tumorigenesis. Moreover, to obtain potential functional relationships between different miRNAs, we also performed expression analysis of homologous miRNAs in gene families. Generally, they could co-regulate biological processes with similar roles. The integrative analysis of miRNA-mRNA indicated a complex and flexible regulatory network. The robust network mainly derived from multiple targets for a specific miRNA (and vice versa), each mRNA and co-regulation roles of different miRNAs.
基金The project is supported by the NSF of China (10271098)Education Foundation of Fujian (JB02083) Science & Technical Development Foundation of Fuzhou University (2003xy-11).
文摘This paper discussses the random singular integral of random process with second order moment, establishes the concepts of the random singular integral and proves that it's a linear bounded operator of space Ha(L)(m, s). Then Plemelj formula and some other properties for random singular integral are proved.
文摘In the linguistic field,there are disputes on the view of contextual research and the goal of universality.Some scholars believe that common features of linguistic phenomena are significant while others are in favor of the perception that it is more applicable and practical to carry out contextual researches.The author tends to analyze the reality and significance of contextual researches and with the goal of universality explained,the relationship between them and further suggestion will be discussed.
文摘Gene finding, the accurate annotation of genomic DNA, has become one of the central topics in biological research. Although various computational methods (gene finders) have been proposed and developed, they all have their own limitations in gene findings. In this paper, we introduce an integrating gene finder, which combines the results of several existing gene finders together, to improve the accuracy of gene finding. Four integration schemes, based on majority voting, are developed for the analysis of two datasets – the basic dataset and the testing dataset. The basic dataset consists of 1500 DNA sequences and the testing dataset consists of 103 DNA sequences. It is demonstrated that a simple integration (a simple voting for each nucleotide) can significantly improve the finding performance, and removing confusing gene finders, caused by poor performance or redundant results, is important for a further improvement of the integration. The best prediction results are obtained using weighted majority voting, aided by the mRMR (Minimum Redundancy Maximum Relevance) (Peng, 2005) method for the gene finder selection. The prediction accuracies are 84.16% and 90.06% for the basic dataset and testing dataset respectively, which are better than any individual gene finding software in our research.
文摘The crustobody is a concept of tectonic element established for integrating the research airns, objects and methods of historic and dynamic geotectonics in order to study the tectonics of the earth in an all-round way. It caTries the implications of both evolution and rnovernent, lying equal stress on both development viewpoint and connection viewpoint and giving consideration to both tirne and space. It has the nature, characteristics and functions of the above-mentioned two tectonic elements. On the one hand, though consisting of historic tectonic elernents such as geosynclinal, platform and geodepression (diwa) regions, it puts emphasis on their changing state in spatial rnigration, thus differing from them. On the other hand,though sirnilar in form to plate, a dynamic tectonic element, it places eruphasis on the changing state in its temporal evolution and has other distinguishing characteristics, thus differing from it.
