Kashin-Beck disease(KBD)is a chronic,endemic,degenerative osteoarthropathic condition that is predominantly found in China's Mainland.KBD is a progressive disease,and the signs and symptoms become more severe in a...Kashin-Beck disease(KBD)is a chronic,endemic,degenerative osteoarthropathic condition that is predominantly found in China's Mainland.KBD is a progressive disease,and the signs and symptoms become more severe in adulthood owing to the continuous development of lesions in the joint cartilage[1].Although childhood KBD has largely been controlled,adult KBD is an important health concern in rural regions.Unfortunately,in the last century,many adult KBD patients still remain during serious epidemics.展开更多
Numerous instances of poisoning caused by the ingestion of mushrooms are reported annually worldwide,with most mushroom poisoning deaths caused by the ingestion of toxic amanita fungi.Amatoxin is the main toxic compon...Numerous instances of poisoning caused by the ingestion of mushrooms are reported annually worldwide,with most mushroom poisoning deaths caused by the ingestion of toxic amanita fungi.Amatoxin is the main toxic component of amanita,andα-amanitin is one of the most potent toxins present in amatoxin[1].展开更多
Alzheimer’s disease (AD) is the leading neurodegenerative disorder globally.Despite this,there is minimal effective therapeutics proven to reduce or prevent the progression of this disease.Glutamate is the main excit...Alzheimer’s disease (AD) is the leading neurodegenerative disorder globally.Despite this,there is minimal effective therapeutics proven to reduce or prevent the progression of this disease.Glutamate is the main excitatory neurotransmitter within the central nervous system and plays a crucial role in neuronal and synaptic functions.展开更多
Early blood-brain barrier(BBB) disturbance contributes to many different neurological diseases including Alzheimer 's disease, Parkinson's disease and stroke, particularly in the etiology and early stages(Abbo...Early blood-brain barrier(BBB) disturbance contributes to many different neurological diseases including Alzheimer 's disease, Parkinson's disease and stroke, particularly in the etiology and early stages(Abbott et al., 2010).展开更多
In recent years,many investigations have indicated that environmental endocrine disruptors(EEDs)may accelerate the development of obesity[1].One kind of EEDs,di-(2-ethylhexyl)phthalate(DEHP),is ubiquitous in natural e...In recent years,many investigations have indicated that environmental endocrine disruptors(EEDs)may accelerate the development of obesity[1].One kind of EEDs,di-(2-ethylhexyl)phthalate(DEHP),is ubiquitous in natural environments due to its role in the manufacture and use of plastic products[2].展开更多
Bone Mineral Content(BMC), serum cal-cium, phosphorus and AlP were measured in64 epileptic patients on long term treatmentwith one or two kinds of antiepileptic drugs(AEDs) ,and in 14 epileptic patients not tak-ing AE...Bone Mineral Content(BMC), serum cal-cium, phosphorus and AlP were measured in64 epileptic patients on long term treatmentwith one or two kinds of antiepileptic drugs(AEDs) ,and in 14 epileptic patients not tak-ing AEDs. In the epileptic patients takingAEDs, the BMC value was 0.645±0.020g/cm^2,significantly lower than 0.693±0.022g/cm^2, theBMC value of the control group (P【0.01).展开更多
基金supported by basic research projects of Qinghai province[2017-ZJ-770]projects of Qinghai province health and family planning commission[2017-wjzdx-38]+1 种基金the 2020"Kunlun TalentsHigh-tech Innovation and Entrepreneurial Talents"project to cultivate leading talents of Qinghai province。
文摘Kashin-Beck disease(KBD)is a chronic,endemic,degenerative osteoarthropathic condition that is predominantly found in China's Mainland.KBD is a progressive disease,and the signs and symptoms become more severe in adulthood owing to the continuous development of lesions in the joint cartilage[1].Although childhood KBD has largely been controlled,adult KBD is an important health concern in rural regions.Unfortunately,in the last century,many adult KBD patients still remain during serious epidemics.
基金financially supported by Guizhou Provincial Science and Technology Support Program[No.Qiankehe[2021]496]Science and Technology Fund of Guizhou Health Commission[No.gzwkj2021-407]+1 种基金National Major Research Project[No.2017YFC1601805]Guizhou Provincial Science and Technology Support Program[No.Qiankehe[2017]2972]。
文摘Numerous instances of poisoning caused by the ingestion of mushrooms are reported annually worldwide,with most mushroom poisoning deaths caused by the ingestion of toxic amanita fungi.Amatoxin is the main toxic component of amanita,andα-amanitin is one of the most potent toxins present in amatoxin[1].
文摘Alzheimer’s disease (AD) is the leading neurodegenerative disorder globally.Despite this,there is minimal effective therapeutics proven to reduce or prevent the progression of this disease.Glutamate is the main excitatory neurotransmitter within the central nervous system and plays a crucial role in neuronal and synaptic functions.
基金supported by a Swiss National Science Foundation,No.31003A_170129(to OOO)。
文摘Early blood-brain barrier(BBB) disturbance contributes to many different neurological diseases including Alzheimer 's disease, Parkinson's disease and stroke, particularly in the etiology and early stages(Abbott et al., 2010).
基金supported by the National Natural Science Foundation of China[Grant No.U2004102]the Natural Science Foundation of Henan Province[Grant No.202300410312]+1 种基金conducted in the laboratory of the Key Laboratory of Nutrition and Food Hygiene(Harbin Medical University)Heilongjiang Higher Education Institutions。
文摘In recent years,many investigations have indicated that environmental endocrine disruptors(EEDs)may accelerate the development of obesity[1].One kind of EEDs,di-(2-ethylhexyl)phthalate(DEHP),is ubiquitous in natural environments due to its role in the manufacture and use of plastic products[2].
文摘Bone Mineral Content(BMC), serum cal-cium, phosphorus and AlP were measured in64 epileptic patients on long term treatmentwith one or two kinds of antiepileptic drugs(AEDs) ,and in 14 epileptic patients not tak-ing AEDs. In the epileptic patients takingAEDs, the BMC value was 0.645±0.020g/cm^2,significantly lower than 0.693±0.022g/cm^2, theBMC value of the control group (P【0.01).
