The ability of human recombinant interleukin-6 (IL-6) to regulate the induction and cytotoxic function of lymphokine activated killer (LAK) cells from human fetal spleen was studied. The results showed that IL-6 alone...The ability of human recombinant interleukin-6 (IL-6) to regulate the induction and cytotoxic function of lymphokine activated killer (LAK) cells from human fetal spleen was studied. The results showed that IL-6 alone was unably to Induce fetal splenic mononuclear cells (FSMC) to develop functional LAK cells, nor was it able to affect the number of IL-2-induced LAK cells and to alter the lytic activity of LAK cells against tumor cells in effector phase. However, when IL-6 was used in combination with IL-2 during the induction phase , the resulting LAK cells displayed considerably greater lytic, activity than that with IL-2 alone (P<0. 01), and this effect was IL-6 dose-dependent. The possible machanism of the synergistic effect of IL-2 and IL-6 in LAK cell Induction from human fetal spleen is discussed.展开更多
In patients with gastric carcinoma the determination of the activities of some cellular and humoral factors may reflect the immunological state of the patient, the stage and extent of the disease, and help estimate th...In patients with gastric carcinoma the determination of the activities of some cellular and humoral factors may reflect the immunological state of the patient, the stage and extent of the disease, and help estimate the effects of treatment and prognosis. Moreover, experimental studies and preliminary clinical trials of some of these cellular elements and humoral factors in the treatment of gastric carcinoma have opened a new field of adoptive immunotherapy.展开更多
文摘The ability of human recombinant interleukin-6 (IL-6) to regulate the induction and cytotoxic function of lymphokine activated killer (LAK) cells from human fetal spleen was studied. The results showed that IL-6 alone was unably to Induce fetal splenic mononuclear cells (FSMC) to develop functional LAK cells, nor was it able to affect the number of IL-2-induced LAK cells and to alter the lytic activity of LAK cells against tumor cells in effector phase. However, when IL-6 was used in combination with IL-2 during the induction phase , the resulting LAK cells displayed considerably greater lytic, activity than that with IL-2 alone (P<0. 01), and this effect was IL-6 dose-dependent. The possible machanism of the synergistic effect of IL-2 and IL-6 in LAK cell Induction from human fetal spleen is discussed.
文摘In patients with gastric carcinoma the determination of the activities of some cellular and humoral factors may reflect the immunological state of the patient, the stage and extent of the disease, and help estimate the effects of treatment and prognosis. Moreover, experimental studies and preliminary clinical trials of some of these cellular elements and humoral factors in the treatment of gastric carcinoma have opened a new field of adoptive immunotherapy.
