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Establishing a mechanism for international cooperation for Fukushima nuclear-contaminated water monitoring
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作者 Shumei Yue Xiaodi Yang 《Chinese Journal of Population,Resources and Environment》 2024年第1期20-33,共14页
The Japanese government’s unilateral decision to discharge the nuclear-contaminated water from the Fukushima nuclear power plant into the ocean has caused immense nuclear safety risks.Monitoring the unclear contamina... The Japanese government’s unilateral decision to discharge the nuclear-contaminated water from the Fukushima nuclear power plant into the ocean has caused immense nuclear safety risks.Monitoring the unclear contaminated water is a starting point to combat these risks and seek remedies for the rights and interests of all concerned parties.The establishment of a mechanism for international cooperation in this respect is necessary to handle the risks of the Fukushima nuclear-contaminated water and to lay the foundation of a framework for tackling any future disposal of nuclear-contaminated water following Japan’s example.At present,the international legal systems in the spheres of nuclear safety and security,marine environmental protection,and other areas,as well as the questioning of the monitoring reports of the International Atomic Energy Agency(IAEA)by the relevant parties,the monitoring practices of historical nuclear accidents,and numerous radioactivity monitoring mechanisms have provided the institutional and practical basis for constructing such a mechanism.The mechanism can be promoted by the IAEA through its existing mechanisms or be jointly initiated by China,the Russian Federation,the Republic of Korea,the Democratic People’s Republic of Korea,and the Pacific Island countries,among other stakeholders.Specifically,this mechanism should consist of three levels:first,the framework of the basic legal system,including the cooperative principles of national sovereignty,interest-relatedness,and procedural fairness,and the signing of the Framework Convention on the Monitoring of Fukushima’s nuclear-contaminated water and its Optional Protocol;second,the organizational structure and its responsibilities,which may include the Conference of Parties as the decision-making body,the Secretariat as the central coordinating body,and the monitoring committees in various fields as specific implementing agencies;and third,specific administrative arrangements,which involve the standardization of monitoring,the management system of monitoring networks and stations,the rules for monitoring procedures,and the rules for the utilization of the monitoring data,etc.With the urgent need for the scientific and fair monitoring of Fukushima’s nuclear-contaminated water,China,as a stakeholder country,can promote the establishment of such a mechanism for monitoring nuclear-contaminated water through the following paths:①It is necessary to clarify the factors affecting the construction of an international cooperation mechanism for monitoring nuclear-contaminated water so as to ascertain the standpoints of the stakeholders,claims of their interests,contents of their cooperation,and the relevant international relations.②On the basis of existing practices,China should consider improving the monitoring mechanism to cope with the risks of the discharge of Fukushima’s nuclear-contaminated water by formulating targeted policies and systems,setting up specialized monitoring institutions,and establishing a systematic monitoring network system.③This is an effective way for China to actively promote the participation of stakeholders in the construction of an international cooperation mechanism for monitoring nuclear-contaminated water in Fukushima by further innovating the dissemination mechanism to address the risk of Fukushima’s nuclear-contaminated water discharging into the sea and facilitating the identification of issues for international cooperation in monitoring Fukushima’s nuclear-contaminated water based on the concept of a community with a shared future for mankind. 展开更多
关键词 Nuclear safety Fukushima nuclear-contaminated water Nuclear-contaminated water monitoring Mechanism for international cooperation
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Innovative Exploration and Research on International Exchange and Cooperation Mechanisms under the Background of Hainan Free Trade Port
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作者 Xiaochao Yao 《Proceedings of Business and Economic Studies》 2024年第1期150-154,共5页
In order to explore and foster innovation in international exchange and cooperation,this study focuses on the background of the construction of the Hainan Free Trade Port.It delves into the current development status,... In order to explore and foster innovation in international exchange and cooperation,this study focuses on the background of the construction of the Hainan Free Trade Port.It delves into the current development status,characteristic demands,and potential challenges of its international exchange and cooperation mechanisms.Through a comprehensive analysis of relevant cases,survey questionnaires,and literature,this study aims to provide feasible innovative models and recommendations to promote the sustained development of the Hainan Free Trade Port in the field of international exchange and cooperation,injecting new vitality into China’s economic globalization.This exploration contributes to a deeper understanding of the development of free trade ports and provides insights and references for other countries and regions. 展开更多
关键词 Free trade port international exchange Cooperation mechanism
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Analysis of International Cooperation Management Strategies of Enterprises under the Background of the“Belt and Road”
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作者 Nan Hua 《Proceedings of Business and Economic Studies》 2024年第4期238-243,共6页
With the deepening of the“Belt and Road”initiative,Chinese enterprises are facing unprecedented opportunities and challenges for international cooperation.This paper mainly analyzes the current situation,existing pr... With the deepening of the“Belt and Road”initiative,Chinese enterprises are facing unprecedented opportunities and challenges for international cooperation.This paper mainly analyzes the current situation,existing problems,and coping strategies of enterprise international cooperation management in the context of the“Belt and Road”.This article expounds on the importance of the“Belt and Road”initiative for international cooperation of enterprises and analyzes the key links of international cooperation management of enterprises from the aspects of internationalization strategy,cross-cultural management,risk prevention and control,and resource integration.Finally,combined with the case,this paper puts forward the management strategies and suggestions that enterprises should adopt in international cooperation,to provide a useful reference for Chinese enterprises in international cooperation in the construction of the“Belt and Road.” 展开更多
关键词 Belt and road international cooperation among enterprises Management strategy Cross-cultural management risk prevention and control
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Progress and Achievements of Fengyun Meteorological Satellite Program since 2022
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作者 GUAN Min WANG Jingsong +4 位作者 ZHAO Xiangang QIN Danyu FAN Cunqun XIAN Di LIU Chang 《空间科学学报》 CAS CSCD 北大核心 2024年第4期712-721,共10页
Fengyun meteorological satellites have undergone a series of significant developments over the past 50 years.Two generations,four types,and 21 Fengyun satellites have been developed and launched,with 9 currently opera... Fengyun meteorological satellites have undergone a series of significant developments over the past 50 years.Two generations,four types,and 21 Fengyun satellites have been developed and launched,with 9 currently operational in orbit.The data obtained from Fengyun satellites is employed in a multitude of applications,including weather forecasting,meteorological disaster prevention and reduction,climate change,global environmental monitoring,and space weather.These data products and services are made available to the global community,resulting in tangible social and economic benefits.In 2023,two Fengyun meteorological satellites were successfully launched.This report presents an overview of the two recently launched Fengyun satellites and currently in orbit Fengyun satellites,including an evaluation of their remote sensing instruments since 2022.Additionally,it addresses the subject of Fengyun satellite data archiving,data services,application services,international cooperation,and supporting activities.Furthermore,the development prospects have been outlined. 展开更多
关键词 Fengyun meteorological satellites data services and application international cooperation and support
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Promoting China-U.S.Arctic education cooperation:challenges,opportunities and recommendations
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作者 HE Liu SHAN Yanyan LIU Feichao 《Advances in Polar Science》 CSCD 2024年第2期264-274,共11页
Arctic education refers not only to the teaching,but also to research,communication,dissemination as well as popularization of knowledge related to the Arctic.This article reviews joint efforts between Chinese and Ame... Arctic education refers not only to the teaching,but also to research,communication,dissemination as well as popularization of knowledge related to the Arctic.This article reviews joint efforts between Chinese and American educators and researchers to promote cooperation and understanding in Arctic education and research,and examines the facing challenges of China-U.S.Arctic education cooperation which include current political or economic tensions between the two countries,the differing perspectives and priorities on Arctic policy,the disproportion in Arctic scientific research,different research methodologies and discourse system in social science.This article also argues that there are opportunities for the two countries to cooperate in Arctic education.Common goals and interests in the Arctic,Arctic-dedicated institutions with significant Arctic research capabilities and partnerships around the world provide foundations for Arctic education cooperation.The implementation of a new science-based Arctic treaty of the Arctic Council is an opportunity for China-U.S.Arctic education cooperation.As for future cooperation,it suggests that in addition to promoting the direct bilateral cooperation,cooperation within international cooperation platforms and mechanisms,especially within the Arctic Council also needs to be further promoted. 展开更多
关键词 China-U.S.relations Arctic education international cooperation Arctic policy
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Regulations for the Manufacture and Control of Live Poliovirus Vaccine: International Experience and China’s Path
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作者 Miao Wu 《Chinese Medical Sciences Journal》 CAS CSCD 2023年第4期315-320,共6页
The eradication of poliomyelitis is a landmark achievement in the history of public health, providing strong protection for children’s health. The introduction of the Chinese Regulations for the Manufacture and Contr... The eradication of poliomyelitis is a landmark achievement in the history of public health, providing strong protection for children’s health. The introduction of the Chinese Regulations for the Manufacture and Control of Live Poliovirus Vaccine is a prerequisite and safeguard for the large-scale production and use of domestically produced live poliovirus vaccines, serving as an indispensable component of vaccine safety. This article, based on archival documents, letters, collections of essays, and oral interviews, examines the historical experience of the development of Chinese Regulations for the Manufacture and Control of Live Poliovirus Vaccine. It contends that the emphasis on localization and the active engagement in international cooperation are critical factors in the swift introduction of Chinese Regulations for the Manufacture and Control of Live Poliovirus Vaccine. 展开更多
关键词 Chinese regulations for the Manufacture and Control of Live Poliovirus Vaccine international cooperation localization Gu Fang Zhou
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Building International Consensus and Working Together to Advance the Development of the Global Human Rights Cause—Summary of Academic Views at the Forum on Global Human Rights Governance
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作者 孙本雄 《The Journal of Human Rights》 2023年第4期915-933,共19页
On June 14-15,2023,the Forum on Global Human Rights Governance,jointly hosted by the State Council Information Office,the Ministry of Foreign Affairs,and the China International Development Cooperation Agency,was held... On June 14-15,2023,the Forum on Global Human Rights Governance,jointly hosted by the State Council Information Office,the Ministry of Foreign Affairs,and the China International Development Cooperation Agency,was held in Beijing under the theme of“Equality,Cooperation and Development:The 30th Anniversary of the Vienna Declaration and Programme of Action and Global Human Rights Governance.”Participants conducted in-depth discussions and exchanges on topics such as“International Cooperation and Global Human Rights Governance,”“Global Development Initiative and the Realization of the Right to Development”,“Global Security Initiative and Human Rights Protection,”“UN Human Rights Mechanisms and Global Human Rights Governance,”and“Human Rights Protection in the Digital Age.”The event helped build international consensus and yielded fruitful achievements. 展开更多
关键词 global human rights governance international cooperation a community with a shared future for mankind digital human rights
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Dilemma and Solutions of Greenhouse Gas Emission Reduction of International Shipping
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作者 Yanan Qu Jin Li 《Journal of Shipping and Ocean Engineering》 2023年第1期10-17,共8页
How to build an international maritime GHG(greenhouse gas)emission reduction cooperation mechanism is an important international issue at present.Firstly,we describe the current situation of maritime transport GHG emi... How to build an international maritime GHG(greenhouse gas)emission reduction cooperation mechanism is an important international issue at present.Firstly,we describe the current situation of maritime transport GHG emission reduction and analyze the problems that still exist in international maritime transport emission reduction from four aspects:political,economic,legal and technical.For example,geopolitical aggravation hinders the solution of the FOC(Flag of Convenience)issue;maritime emissions are not included in the carbon emission trading system;the synergy of maritime emission reduction principles under the IMO(International Maritime Organization)framework and the technical level of maritime emission reduction needs to be improved.The motivation and essence of the divergent international actions on maritime emission reduction are discussed.Finally,it is proposed to implement the“true linkage principle”to solve the problem of FOCs;to promote the development of regional carbon markets and link them to the international maritime carbon emission trading market economically;to implement the CBDR(the common but differentiated responsibilities)principle legally to promote the international emission reduction work in an orderly manner;and the technical innovation of ships and increase the technical support. 展开更多
关键词 Climate change SHIPPING GHG reduction international cooperation
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Southwest China and Southeast Asia: towards sustainability through cooperative development and management of international rivers
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作者 HE Daming Yunnan Institute of Geography, Yunnan, Kunming 650223 CHINA Dept. of Geography, the University of Memphis, Memphis, TN38152, USA Hsiange te Kung Dept. of Geography, the University of Memphis, Memphis, TN38152, USA 《Journal of Geographical Sciences》 SCIE CSCD 1998年第3期99-104,共6页
The western part of China borders on South and Southeast Asia. Of the numerous well known international rivers sharing with the two regions, the Lancang Mekong River has been most extensively studied in the world fo... The western part of China borders on South and Southeast Asia. Of the numerous well known international rivers sharing with the two regions, the Lancang Mekong River has been most extensively studied in the world for its important strategic position, rich resources, prosperous potential market as well as considerable opportunities for investment and development. The sustainable multipurpose development in this area has increasingly become the focus of international regional cooperation, and great attention has been paid to this area by the international society. Up to now, at least 10 major actions in the international regional cooperation are expected in this area. This paper intends, at the angle of geography and with the overall target of promoting the sustainable development in the basin through international cooperations, to study the international position, the potential and the prospects for development of the Lancang Mekong River, to analyze the main problems in this international cooperation, to propose targets and prospects for such cooperation, and to indicate the way for geographers to participate in such research. 展开更多
关键词 international rivers cooperation dEVELOPMENT Lancang Mekong river.
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Call for Papers The 6^(th) International Conference on Grid and Cooperative Computing
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《计算机科学》 CSCD 北大核心 2007年第4期148-148,共1页
Recent years have seen rapid advances in various grid-related technologies, middleware, and applications. The GCC conference has become one of the largest scientific events worldwide in grid and cooperative computing.... Recent years have seen rapid advances in various grid-related technologies, middleware, and applications. The GCC conference has become one of the largest scientific events worldwide in grid and cooperative computing. The 6th international conference on grid and cooperative computing (GCC2007) Sponsored by China Computer Federation (CCF),Institute of Computing Technology, Chinese Academy of Sciences (ICT) and Xinjiang University ,and in Cooperation with IEEE Computer Soceity ,is to be held from August 16 to 18, 2007 in Urumchi, Xinjiang, China. 展开更多
关键词 GCC GrId Call for Papers The 6 international Conference on Grid and cooperative Computing TH
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Influences on Excellent Course Network Teaching to Imported Courses Implementation of International Cooperative Education in Vocational Colleges
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作者 HUANG Shanshan 《International English Education Research》 2015年第10期95-97,共3页
Both the "Interim Provisions on Sino-foreign Cooperative Education" and the "Regulation of the People's Republic of China on Sino-Foreigu Cooperative Education" are not specifically mentioned the implementation p... Both the "Interim Provisions on Sino-foreign Cooperative Education" and the "Regulation of the People's Republic of China on Sino-Foreigu Cooperative Education" are not specifically mentioned the implementation proposals to the foreign imported courses.The implementation methods of those introduced courses of China are basically like someone crossing a river by feeling the stones, which lacks the mature theoretical guidance and successful practical experience.The release of "Implementation Proposal to Construction of Excellent Open Courses of Ministry of Education" and the "Notice of 'Construction Measures of the Top-quality Sharing Courses'" have pushed the excellent course construction of vocational colleges into a restructuring and upgrading stage. Focused on the poor teaching effect of current introduced courses appeared in the Sino-foreigu cooperative education, this paper aims to expand teaching time and space of the Sino-foreign cooperative education through the excellent courses construction and network sharing technology. 展开更多
关键词 Influence Excellent Course Network Teaching Imported Courses Implementation international cooperative Education
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To establish CMOC China as an important component of marine data and service international cooperation in China 被引量:2
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作者 杜琼玮 林绍花 王丰 《Marine Science Bulletin》 CAS 2013年第1期91-96,共6页
JCOMM has strategy to establish the network of WMO-IOC Centres for Marine-meteorological and Oceanographic Climate Data (CMOCs) under the new Marine Climate Data System (MCDS) in 2012 for improving the quality and... JCOMM has strategy to establish the network of WMO-IOC Centres for Marine-meteorological and Oceanographic Climate Data (CMOCs) under the new Marine Climate Data System (MCDS) in 2012 for improving the quality and timeliness of the marine-meteorological and oceanographic data, metadata and products available to end users. China as a candidate of CMOC China has been approved to run on a trial basis after the 4th Meeting of the Joint IOC/WMO Technical Commission for Oceanography and Marine Meteorology (JCOMM). This article states the developing intention of CMOC China in the next few years through the brief introduction to critical marine data, products and service system and cooperation projects in the world. 展开更多
关键词 MArINE data and service international cooperation future development
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INTERNATIONAL COOPERATIVE STUDIES ON THE QINGHAI-XIZANG PLATEAU
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作者 Zheng Du(Institute of Geography, the CAS, Beijing 100101)Deputy Director of the CAS Integrated Scientifie Expedition to the Qinghai-Xizang Plateau and Director of the CAS Institule of Geopgraphy 《Bulletin of the Chinese Academy of Sciences》 1995年第2期206-208,共3页
The Qinghai-Xizang Plateau is known as "the roof of the world".Its intensive uplifting has been one of the most important events in the past two million years of the earth history,which strongly affects the ... The Qinghai-Xizang Plateau is known as "the roof of the world".Its intensive uplifting has been one of the most important events in the past two million years of the earth history,which strongly affects the physical environment and human activities both in the plateau itself and in its nearby regions.As a natural laboratory in the fields of geo-science,biology,resources and environment,the Plateau has attracted worldwide attention from the academic circles.Because the main body of the plateau is located in China,Chinese scientists shoulder major responsibilities for 展开更多
关键词 international cooperative STUdIES ON THE QINGHAI-XIZANG PLATEAU
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RCEP背景下广西面向东盟的跨境电子商务高质量发展路径研究 被引量:1
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作者 刘丹羽 《中国商论》 2024年第7期37-40,共4页
广西是对接中国和东盟的“桥头堡”,同时东盟国家也是广西开展跨境电子商务的最重要贸易对象,RCEP背景下,东盟的跨境电子商务市场潜力愈发巨大。基于此,广西的跨境电子商务在新的营商环境中需进一步优化和完善,以实现高质量发展。当前,... 广西是对接中国和东盟的“桥头堡”,同时东盟国家也是广西开展跨境电子商务的最重要贸易对象,RCEP背景下,东盟的跨境电子商务市场潜力愈发巨大。基于此,广西的跨境电子商务在新的营商环境中需进一步优化和完善,以实现高质量发展。当前,广西面向东盟的跨境电子商务存在部分RCEP成员电商普及程度较低,区域内跨境电子商务平台交易规则参差不齐、物流体系不完善、交易支付体系未对接、复合型人才短缺等问题。因此,本文建议从加强区域内深度合作、整合成熟电商平台资源、优化物流网络体系、完善交易支付体系、培养新型跨境电子商务人才及政策保障支持等方面促进广西面向东盟的跨境电子商务的高质量发展。 展开更多
关键词 rCEP 广西 东盟 跨境电子商务 国际贸易 高质量发展 区域合作
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The Practice and Thinking of the Students'Exchange Program Under the Background of Internationalization
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作者 肖友兴 《海外英语》 2013年第5X期278-279,282,共3页
Based on the background of internationalization of higher education, the article analyzed the forms, size, significance and problems of the international students'exchange launched in Dali University of Yunnan Pro... Based on the background of internationalization of higher education, the article analyzed the forms, size, significance and problems of the international students'exchange launched in Dali University of Yunnan Province; and then provided the sustainable developing strategies for the program. 展开更多
关键词 practice and THINKING international EXCHANGE and c
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A Brief Introduction to the International Lunar Research Station Program and the Interstellar Express Mission 被引量:5
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作者 XU Lin LI Hui +2 位作者 PEI Zhaoyu ZOU Yongliao WANG Chi 《空间科学学报》 CAS CSCD 北大核心 2022年第4期511-513,共3页
China has planned and implemented a series of lunar and deep space exploration programs since the first lunar exploration satellite Chang’E-1 launched in 2007.In the future,China has initiated the international lunar... China has planned and implemented a series of lunar and deep space exploration programs since the first lunar exploration satellite Chang’E-1 launched in 2007.In the future,China has initiated the international lunar research station program,which aims to build a shared platform on the Moon jointly with many other countries for long-term and continuous lunar exploration,lunar-based observations and experiments,as well as in-situ resource utilization.In addition,China has also proposed an interstellar express mission to unveil the mysteries of the outer heliosphere,nearby interstellar space,and their interactions.This paper gives a brief introduction to the International Lunar Research Station program and the Interstellar Express mission. 展开更多
关键词 Lunar exploration deep space exploration international lunar research station Outer Heliospheric exploring international cooperation
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Research on the implementation of the Convention on Biological Diversity among the Shanghai Cooperation Organisation countries
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作者 HAO Yun WU Miao +2 位作者 ZHANG Xiaoyun WANG Lixian HE Jingjing 《Regional Sustainability》 2023年第3期322-331,共10页
The Shanghai Cooperation Organisation(SCO)is the most extensive and populous comprehensive regional cooperation organization in the world,covering about half of the world's population,with not only a huge consumer... The Shanghai Cooperation Organisation(SCO)is the most extensive and populous comprehensive regional cooperation organization in the world,covering about half of the world's population,with not only a huge consumer market,but also rich natural resources and strong productivity.As one of the important platforms for the implementation of the Green Belt and Road Initiative,it is an important opportunity for the SCO to actively participate in global governance and contribute to building a community of global life.To investigate the status of biodiversity conservation in the SCO countries,we used literature analysis approach.We surveyed the performance and international cooperation status of the SCO countries in the implementation of the Convention on Biological Diversity(CBD),listed facing problems and threats to biodiversity conservation,including not optimistic biodiversity conservation project implementation status,contradiction between ecological protection and economic development,impacts of human activities,lack of funds and talents,etc.,and analyzed the biodiversity protection needs of the SCO countries from the perspectives of project and policy implementation status and international cooperation.According to the cooperation between China and the other SCO countries on biodiversity conservation and the post-2020 global biodiversity framework goals,we gave some recommendations:(1)promoting access to genetic resources and benefit-sharing;(2)integrating multiple funds and innovating the implementation of funding mechanism;(3)developing talent training and exchange programs and deepening multilateral cooperation;(4)strengthening cross-border cooperation and improving cooperation network;and(5)establishing a coordination mechanism for biodiversity conservation within the framework of the SCO. 展开更多
关键词 Shanghai Cooperation Organisation(SCO) Biodiversity conservation Convention on Biological diversity(CBd) international cooperation Cross-border cooperation Multilateral cooperation
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Belt and Road Initiative and China’s International Energy Cooperation 被引量:1
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作者 Xu Qinhua Yuan Miao 《Contemporary International Relations》 2019年第4期66-74,共9页
In terms of energy supply, the Belt and Road Initiative has accelerated China’s international cooperation and has shaped, via that cooperation, the focus upon clean energy and low-carbon innovation.Under the Belt and... In terms of energy supply, the Belt and Road Initiative has accelerated China’s international cooperation and has shaped, via that cooperation, the focus upon clean energy and low-carbon innovation.Under the Belt and Road framework, the market will play an increased role as multilateral organizations engage in new models of international energy cooperation. As the largest energy consumer and public goods provider, China’s transition in energy cooperation will profoundly impact regional energy security and development. The economic growth of partners will also enhance results. 展开更多
关键词 BELT and rOAd INITIATIVE international energy COOPErATION ECONOMIC rELATIONS
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International carbon markets under the Paris Agreement:Basic form and development prospects 被引量:1
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作者 GAO Shuai LI Meng-Yu +1 位作者 DUAN Mao-Sheng WANG Can 《Advances in Climate Change Research》 SCIE CSCD 2019年第1期21-29,共9页
Article 6 of the Paris Agreement introduces two international carbon markets that receive extensive attention and are expected to play an important role in the post-2020 climate regime.Three key elements of the two in... Article 6 of the Paris Agreement introduces two international carbon markets that receive extensive attention and are expected to play an important role in the post-2020 climate regime.Three key elements of the two international carbon markets,including the scope,the types of tradable units and the governance,are identified,as the basis to clarify their basic forms.Based on the key issues and their different designs identified in negotiations,this study analyzes the contributions and challenges for China to participate in international carbon markets.Considering the inherent needs of climate change mitigation,climate finance,the development of a green"Belt and Road"and the China South-South cooperation in climate change,along with the existing domestic capacities on market mechanisms,this study puts forward the short-,medium-and long-term development prospects of the two international carbon markets. 展开更多
关键词 PArIS AGrEEMENT international carbon MArKETS cooperative approaches SUSTAINABLE development mechanism CLIMATE change
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International validation of the Chinese University Prognostic Index for staging of hepatocellular carcinoma: a joint United Kingdom and Hong Kong study 被引量:5
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作者 Stephen L.Chan Philip J.Johnson +8 位作者 Frankie Mo Sarah Berhane Mabel Teng Anthony W.H.Chan Ming C.Poon Paul B.S.Lai Simon Yu Anthony T.C.Chan Winnie Yeo 《Chinese Journal of Cancer》 SCIE CAS CSCD 2014年第10期481-491,共11页
The outcome of hepatocellular carcinoma(HCC) patients significantly differs between western and eastern population centers. Our group previously developed and validated the Chinese University Prognostic Index(CUPI) fo... The outcome of hepatocellular carcinoma(HCC) patients significantly differs between western and eastern population centers. Our group previously developed and validated the Chinese University Prognostic Index(CUPI) for the prognostication of HCC among the Asian HCC patient population. In the current study, we aimed to validate the CUPI using an international cohort of patients with HCC and to compare the CUPI to two widely used staging systems, the Barcelona Clinic Liver Cancer(BCLC) classification and the Cancer of the Liver Italian Program(CLIP). To accomplish this goal, two cohorts of patients were enrolled in the United Kingdom(UK; n = 567; 2006-2011) and Hong Kong(HK; n = 517; 2007-2012). The baseline clinical data were recorded. The performances of the CUPI, BCLC, and CLIP were compared in terms of a concordance index(C-index) and were evaluated in subgroups of patients according to treatment intent. The results revealed that the median follow-up durations of the UK and HK cohorts were 27.9 and 29.8 months, respectively. The median overall survival of the UK and HK cohorts were 22.9 and 8.6 months, respectively. The CUPI stratified the patients in both cohorts into three risk subgroups corresponding to distinct outcomes. The median overall survival of the CUPI low-, intermediate-, and high-risk subgroups were 3.15, 1.24, and 0.29 years, respectively, in the UK cohort and were 2.07, 0.32, and 0.10 years, respectively, in the HK cohort. For the patients who underwent curative treatment, the prognostic performance did not differ between the three staging systems, and all were suboptimal. For those who underwent palliative treatment, the CUPI displayed the highest C-index, indicating that this staging system was the most informative for both cohorts. In conclusion, the CUPI is applicable to both western and eastern HCC patient populations. The performances of the three staging systems differed according to treatment intent, and the CUPI was demonstrated to be optimal for those undergoing palliative treatment. A more precise staging system for early-stage disease patients is required. 展开更多
关键词 香港 英国 预后 肝癌 验证 国际 大学 中国
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