Effects of Internet-Based Acceptance and Commitment Therapy (IACT) on Adolescents: A Systematic Review and Meta-Analysis

Objectives:This study reviewed published randomized controlled trials(RCTs)and evaluated the efficacy of internet-based acceptance and commitment therapy(IACT)on adolescent mental health.Methods:Searches were conducted in PubMed,ProQuest,APA(PsycNET/PsycINFO),and Web of Science from inception to Jan-uary 2022 to identify RCTs evaluating the effects of IACT on adolescents.The included studies were assessed for quality and risk of bias.This study was performed using the standard mean difference and associated 95%confidence interval of effective measures.Review Manager 5.4 software was adopted to calculate the effect size.Results:Compared to adolescents in control groups,those in the IACT groups showed some improvement in the efficacy of depression symptoms(SMD=−0.24,95%CI=[−0.44,−0.05],p=0.01)and had a small but sig-nificant effect on reducing experiential avoidance(SMD=−0.24,95%CI=[−0.46,−0.01],p=0.04).However,the effect size on anxiety did not reach the threshold(SMD=−0.18,95%CI=[−0.27,−0.09],p<0.0001).In addition,there were no significant differences in stress and well-being compared to those of the control group.Compared with universal adolescents,IACT was found to have a more significant therapeutic effect on targeted adolescents.Conclusions:IACT is effective in adolescent mental health interventions,but its clinical reliability and significant efficacy are limited,and more rigorous RCTs are needed in future studies.

Preferences for oral-vs blood-based human immunodeficiency virus self-testing:A scoping review of the literature

BACKGROUND The evidence on preferences for oral-vs blood-based human immunodeficiency virus self-testing(HIVST)has been heterogenous and inconclusive.In addition,most evaluations have relied on hypothetical or stated use cases using discreet choice experiments rather than actual preferences among experienced users,which are more objective and critical for the understanding of product uptake.Direct head-to-head comparison of consumer preferences for oral-versus bloodbased HIVST is lacking.AIM To examine the existing literature on preferences for oral-vs blood-based HIVST,determine the factors that impact these preferences,and assess the potential implications for HIVST programs.METHODS Databases such as PubMed,Medline,Google Scholar,and Web of Science were searched for articles published between January 2011 to October 2022.Articles must address preferences for oral-vs blood-based HIVST.The study used the Preferred Reporting Items for Systematic Reviews and Meta-Analyses checklist to ensure the quality of the study.RESULTS The initial search revealed 2424 records,of which 8 studies were finally included in the scoping review.Pooled preference for blood-based HIVST was 48.8%(9%-78.6%),whereas pooled preference for oral HIVST was 59.8%(34.2%-91%)across all studies.However,for male-specific studies,the preference for blood-based HIVST(58%-65.6%)was higher than that for oral(34.2%-41%).The four studies that reported a higher preference for blood-based HIVST were in men.Participants considered blood-based HIVST to be more accurate and rapid,while those with a higher preference for oral HIVST did so because these were considered non-invasive and easy to use.CONCLUSION Consistently in the literature,men preferred blood-based HIVST over oral HIVST due to higher risk perception and desire for a test that provides higher accuracy coupled with rapidity,autonomy,privacy,and confidentiality,whereas those with a higher preference for oral HIVST did so because these were considered non-invasive and easy to use.Misinformation and distrust need to be addressed through promotional messaging to maximize the diversity of this new biomedical technology.

Acceptability and strategies for enhancing uptake of human immunodeficiency virus self-testing in Nigeria

BACKGROUND In 2019,the Nigerian Ministry of Health published the first operational guidelines for human immunodeficiency virus self-testing(HIVST)to improve access to human immunodeficiency virus(HIV)testing services among undertested populations in the country.Also,as part of the campaign to increase HIV testing services in Nigeria,the Nigerian Ministry of Health developed standard operating procedures for using HIVST kits.AIM To systematically review the acceptability and strategies for enhancing the uptake of HIVST in Nigeria.METHODS The systematic review was conducted and reported in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses.Different databases were searched to get the necessary materials needed for this review.Standardized forms developed by the authors were used for data extraction to minimize the risk of bias and ensure that the articles used for the study were properly screened.Identified articles were first screened using the titles and their abstracts.The full papers were screened,and the similarities of the documents were determined.Qualitative,quantitative,and mixed-method studies were evaluated using the Critical Appraisal Skills Programme and Critical Appraisal Framework criteria.RESULTS All the publications reviewed were published between 2015 and 2022,with 33.3%published in 2021.Most(77.8%)of the studies were cross-sectional,43.3%were conducted in Lagos State,and 26.3%were conducted among young people.The study revealed a high level of acceptability of HIVST.Certain factors,such as gender,sexual activity,and previous testing experience,influence the acceptability of HIV self-testing,with some individuals more likely to opt-out.The cost of the kit was reported as the strongest factor for choosing HIVST services,and this ranged from 200 to 4000 Naira(approximately United States Dollar 0.55-11.07),with the majority willing to pay 500 Naira(approximately United States Dollar 1.38).Privately-owned,registered pharmacies,youthfriendly centres,supermarkets,and online stores were the most cited access locations for HIVST.The least influential attribute was the type of specimen needed for HIVST.Strategies addressing cost and preferred access points and diverse needs for social media promotion,local translation of product use instructions,and HIVST distribution led by key opinion leaders for key populations were found to significantly enhance HIVST uptake and linkage to care.CONCLUSION HIVST acceptability is generally high from an intention-to-use perspective.Targeted strategies are required to improve the acceptability of HIV self-testing,especially among males,sexually active individuals,and first-time testers.Identified and proposed uptake-enhancing strategies need to be investigated in controlled settings and among different populations and distribution models in Nigeria.

Uptake of HIV Self-testing among Men Who have Sex with Men in Beijing, China： a Cross-sectional Study

Objective To examine HIV self-testing uptake and its determinates among men who have sex with men （MSM） in Beijing, China. Methods A cross-sectional online survey was conducted in Beijing, China in 2016. Participants were users of a popular Chinese gay networking application and had an unknown or negative HIV status. Univariate and multivariate logistic regression analyses were conducted to examine factors associated with HIV self-testing based on adjusted odds ratio （AOR） and 95% confidence interval （CI）. Results Among the 5,996 MSM included in the study, 2,383 （39.7%） reported to have used HIV self-testing kits. Willingness to use an HIV self-test kit in the future was expressed by 92% of the participants. High monthly income （AOR = 1.49; CI = 1.10-2.02; P = 0.010）, large number of male sex partners （≥2： AOR = 1.24; CI = 2.09-1.43; P = 0.002）, sexual activity with commercial male sex partners （〉 2： AOR = 1.94; CI = 1.34 -2.82; P = 0.001）, long-term drug use （AOR = 1.42; CI = 1.23-1.62; P 〈 0.001）, and long-term HIV voluntary counseling and testing （VCT） attendance （AOR = 3.62; CI = 3.11-4.22; P 〈 0.001） were all associated with increased odds of HIV self-testing uptake. Conclusion The nearly 40% rate of HIV self-testing uptake among MSM in our sample was high. In addition, an over 90% willingness to use kits in the future was encouraging. HIV self-testing could be an important solution to help China achieve the global target of having 90% of all people living with HIV diagnosed by 2020.

The feasibility of an internet-based intervention for Chinese people with mental illness: A survey of willingness and attitude

Background:The easy accessibility,increasing usage,and low cost of internet make it a desirable way of providing health information and delivering interventions for health consumers.Studies in other countries have verified and confirmed the effectiveness of internet-based interventions among people with mental health problems.Similar programs have yet to commence in China.Purpose:This study investigated the willingness for,and attitude toward internet-based intervention in Chinese mental health service users and explored the feasibility of such an intervention.Methods:A cross-sectional survey utilizing a self-developed questionnaire was administered to 186 mental health service users in Beijing,between April and May 2011.Results:Most participants held a positive attitude toward online information and expressed interest in getting assistance from the internet.Some advice and suggestions were provided such as more ways of getting assistance,setting up more professional websites,increasing interaction,as well as having government funding and guidance.Conclusion:Internet-based programs are feasible and applicable,and worth implementing with Chinese people with mental illness.

Internet-Based Optimization and Choice of Insert Grooves for Face-Milling

Manufacture is facing more furiously competition in the new century. It tends to be globalized. Rapid response and technology innovation have become the key factor to the success of manufacture enterprise. At present, internet-based manufacturing develops rapidly. With the development of engineering material and machining techniques, better cutting properties of metal cutting tools are required. The world is paying more attention to the study of indexable carbide inserts with three-dimensional complex grooves which can affect cutting properties directly and chip-controlling. So the variety and specification of indexable insert develop quickly and the application of insert with three-dimensional complex chip-former becomes wider and wider. Because milling is an interrupted cutting, the process of milling is complicated and the failure of the milling inserts is severe. It is important to choose suitable milling inserts groove for particular machining conditions before actual machining, it will extend tool life and raise productivity. Optimization and choice of inserts with complex groove via internet may serve for manufacture enterprises all over the world. The milling inserts with three-dimensional complex grooves are optimized and chosen via Internet in this paper. The face-milling process is studied, with the mathematics models of cutting force for different shape of cutting edges established, the cutting forces predicted and stress-fields of different insert grooves analyzed by FEM, according to the predictable results and the most suitable insert groove for particular machining conditions are optimized and chosen. The complex groove optimization and choice are based on a client/server model, with the client and server being on different machines across the internet. Communication between the client and server uses the TCP/IP. The result of optimization and choice will be sent to the users via Internet. Manufacturers all over the world can get the desired insert groove without paying for expensive experiments. Thus, the cost and lead time of products are reduced.

Robustness self-testing of states and measurements in the prepare-and-measure scenario with 3 → 1 random access code

Recently, Tavakoli et al.proposed a self-testing scheme in the prepare-and-measure scenario, showing that self-testing is not necessarily based on entanglement and violation of a Bell inequality [Phys.Rev.A 98 062307(2018)].They realized the self-testing of preparations and measurements in an N → 1(N ≥ 2) random access code(RAC), and provided robustness bounds in a 2 → 1 RAC.Since all N → 1 RACs with shared randomness are combinations of 2 → 1 and 3 → 1 RACs, the3 → 1 RAC is just as important as the 2 → 1 RAC.In this paper, we find a set of preparations and measurements in the3 → 1 RAC, and use them to complete the robustness self-testing analysis in the prepare-and-measure scenario.The method is robust to small but inevitable experimental errors.

Efficient self-testing system for quantum computations based on permutations

Verification in quantum computations is crucial since quantum systems are extremely vulnerable to the environment.However,verifying directly the output of a quantum computation is difficult since we know that efficiently simulating a large-scale quantum computation on a classical computer is usually thought to be impossible.To overcome this difficulty,we propose a self-testing system for quantum computations,which can be used to verify if a quantum computation is performed correctly by itself.Our basic idea is using some extra ancilla qubits to test the output of the computation.We design two kinds of permutation circuits into the original quantum circuit:one is applied on the ancilla qubits whose output indicates the testing information,the other is applied on all qubits(including ancilla qubits) which is aiming to uniformly permute the positions of all qubits.We show that both permutation circuits are easy to achieve.By this way,we prove that any quantum computation has an efficient self-testing system.In the end,we also discuss the relation between our self-testing system and interactive proof systems,and show that the two systems are equivalent if the verifier is allowed to have some quantum capacity.

Feasibility of a finger prick-based self-testing kit in first- and second-degree relatives of children with coeliac disease

AIM:To assess feasibility of a finger prick-based kit as method for self-testing of first and second-degree relatives of coeliac disease (CD) patients. METHODS:A total number of 379 subjects were invited to participate in this study,consisting of 197 first- degree and 182 second-degree relatives of CD patients. The self-testing kit (BiocardTM) was sent out with included instructions for use. Completed tests were sent back to the study coordinator for assessment. RESULTS:One hundred and ninety-six invited relatives carried out the BiocardTM test at home. Amongst these,70% were children. In 97% of the cases the test was performed correctly. Three tests revealed a positive result,all of which were later confirmed by serology and histology as coeliac disease.CONCLUSION:Our study indicates that BiocardTM test is a reliable,easy to use and well-accepted tool for home testing of first- and second-degree relatives of CD patients.

Internet-Based Support and Coaching for Adolescents and Young Adults with Neuropsychiatric Disorders—The Implementation of an Intervention from an Organizational Perspective

There is a documented and often unmet need for interventions aimed at supporting young people with attention-deficit/hyperactivity disorder (ADHD) and/or autism spectrum disorder (ASD) in their transition between adolescence and adulthood. Difficulties with social interaction, initiation difficulties, and impairments in executive function can complicate visits at a clinic, i.e. traditional treatment, for individuals with neuropsychiatric disorders (NPD). A model for internet-based support and coaching aimed at young people with ASD and/or ADHD was developed and tested at three treatment sites in western Sweden. The implementation was analyzed against an inventory according to which implementations are more likely to be successful if an intervention: 1) has advantages compared to other existing methods, 2) matches the individual and organizational values, norms and work practices of its recipients, 3) is perceived as easy to use, and 4) is adaptable to local conditions and the recipients’ needs. Data were collected through group interviews with professionals involved in the implementation of the intervention. The implementation of the intervention showed promising results on measures such as access, delivery/quality of healthcare services, and equality of distribution of healthcare services. The identified impediments to successful implementation related to a wide range of factors and levels, including the design of the intervention, technical issues, attitudes of staff, organizational culture, and organizational structure at the implementation sites in terms of patient stock, work division, and resource allocation. The results are consistent with previous studies that stress the need for multi-component implementation strategies.

Internet-based event synchronization communication driven telerobotics

Based on QoS (quality of service) parameters: time delay, jitter, bandwidth and package loss. As time delay in the Internet is variable, it is hard to compensate it by traditional methods. Event synchronization communication driven method is proposed to overcome the negative effects induced by time delay. This method is a non-time based method and it can get rid of the effects of time in the control loop of telerobotics. Stability, transparency and synchronization can be maintained in it by event-driven method. Multimodal enhanced telerobotics is put forward with its feedback including force, video, audio and temperature etc. The use of multimodal feedback improves the efficiency and safety of the whole system. Synchronization in multimodal feedback is hard to ensure and event-driven method is also good for it. Experiments on an Internet-based shaft-hole assemblage system show good results by using event synchronization communication driven method and UDP protocol.

Research on customer knowledge transferring mode and mechanism in internet-based new product development

With the development of internet technology, customers play more and more important roles in new product development. The paper defines customer knowledge; then analyses the modes of customer knowledge transferring based on SECI model and information emission model. Finally customer knowledge transferring mechanism is discussed.

Assessing the Acceptability and Willingness to Use HIV Self-Testing among Student Nurses in a Private Nursing College, Gauteng Province, South Africa

Globally, there is increasing evidence that HIV self-testing (HIVST) is commonly practiced among health care workers (HCWs). Although HIVST kits are available in South Africa, their distribution and use remain unregulated and its acceptability, undocumented. The aim of the study was to explore the acceptability of HIV self-testing among student nurses, examine their willingness to use self-testing, and evaluate their views on the implementation of a regulated HIV self-testing programme. This was a qualitative explorative study, and six focus group discussions were conducted with 67 student nurses recruited from a private nursing college, in Pretoria, South Africa. Thematic analysis and NVivo10 qualitative software were used for data analysis. The nurses perceived HIVST as an acceptable option for HIV testing and most were willing to self-test. Self-testing will provide confidential and accessible HIV testing services, reduce the stigma associated with the condition, and increase partner testing and disclosure. HIVST is more likely to be practised if self-testing kits are easily accessible and affordable, and there are strategies to educate people before the adoption of HIVST. The lack of pre- and post-test counselling, the risk of inaccurate test results, and lack of strategies for the confirmation of self-testing results were the main arguments against HIVST. The high acceptance of HIVST among nurses suggests that HIVST is a feasible option to increase the uptake of HIV-testing among HCWs. However, pre- and post-test counselling should be considered important components in the implementation of self-testing services. Educational and awareness campaigns should precede the roll-out of the self-testing programs.

Phase-Coding Self-Testing Quantum Random Number Generator

How to estimate the randomness of the measurement outcomes generated by a given device is an important issue in quantum information theory. Recently, Brunner et al. [Phys. Rev. Lett. 112 （2014）140407] proposed a prepare-and-measure quantum random number generation scenario with device-independent assumption, which indicates a method to test the randomness of bit strings according to the generation process rather than the results. Based on this protocol, we implement a quantum random number generator with an intrinsic stable phase-encoded quantum key distribution system. The system has been continuously running for more than 200 h, a stable witness W with the average value of 0.9752 and a standard deviation of 0.0024 are obtained. More than 1 G random bits are generated and the results pass all items of NIST test suite.

A Dual-Channel Secure Transmission Scheme for Internet-Based Networked Control Systems

Two significant issues in Internet-based networked control systems （ INCSs）, transport performance of different protocols and security breach from Internet side, are investigated. First, for improving the performance of data transmission, user datagram protocol （UDP） is adopted as the main stand for controllers and plants using INCSs. Second, a dual-channel secure transmission scheme （DCSTS）based on data transmission characteristics of INCSs is proposed, in which a raw UDP channel and a secure TCP （transmission control protocol） connection making use of SSL/TLS （secure sockets layer/transport layer security） are included. Further, a networked control protocol （NCP） at application layer for supporting DCSTS between the controllers and plants in INCSs is designed, and it also aims at providing a universal communication mechanism for interoperability of devices among the networked control laboratories in Beijing Institute of Technology of China, Central South University of China and Tokyo University of Technology of Japan. By means of a networked single-degree-of-free- dom robot arm, an INCS under the new protocol and security environment is created. Compared with systems such as IPSec or SSL/TLS, which may cause more than 91% network throughput deduction, the new DCSTS protocol may yield results ten times better, being just 5.67%.

An Analysis of Internet-based Approaches to New Teacher Induction in Canada

Induction and mentoring programs aim to help new school teachers survive and thrive in their teaching profession.Among each juris-diction of Canada,there are different programs and most of them are characterized by Internet-based supports.On the websites of the provincial departments of education or teachers’organizations,well-designed webpages are set for induction programs,special portals are designed for new teachers,and documents relating to early career teaching are provided.Even on some local school districts’websites,induction programs and relevant documents are easily accessed.Based on the above facts,this paper also analyzes the advantages and limitations of those Internet-based approaches in Canadian teacher in-duction activities.

HIV Self-Testing Kits Uptake in Mashonaland West Province, Zimbabwe, 2019-2020: A Secondary Data Analysis

Background: Human Immuno-Deficiency Virus Self-Testing (HIVST) is a process where an individual who wants to know their HIV status collects a specimen, performs a test and interprets the result by themselves. HIVST data from the Zimbabwe AIDS and TB Program (ATP) directorate showed that between 2019-2020, only 31% of the target HIVST kits were distributed in the country. Mashonaland West Province was one of the least performing provinces in meeting targets for HIVST kits distribution. Gaps in the implementation of the HIVST in the province ultimately affect the nationwide scaleup of targeted testing, a key enabler in achieving HIV epidemic control. We analyzed HIVST trends in Mashonaland West Province to inform HIV testing services programming. Methods: We conducted a cross-sectional study using HIVST secondary data obtained from the District Health Information Software 2 (DHIS2) electronic database. We conducted regression analysis for trends using Epi Info 7.2 and tables, bar graphs, pie charts and linear graphs were used for data presentation. Results: A total of 31,070 clients accessed HIVST kits in Mashonaland West Province from 2019-2020. A slightly higher proportion (50.4% and 51.7%) of females as compared to males accessed HIVST kits in 2019 and 2020 respectively. Overall, an increase in the trend of HIVST kits uptake was recorded (males R2 = 0.3945, p-value = 0.003 and females R2 = 0.4739, p-value = 0.001). There was generally a decline in the trend of community-based distribution of HIVST kits from the third quarter of 2019 throughout 2020 (R2 = 0.2441, p-value = 0.006). Primary distribution of HIVST kits remained the dominant method of distribution, constituting more than half of the kits distributed in both 2019 (67%) and 2020 (86%). Conclusion: Mashonaland West Province was mainly utilising facility-based distribution model for HIVST over the community-based distribution model. We recommended training more community-based distribution agents to increase community distribution of HIVST kits.

On Applying Internet-based Teaching in College Oral English Teaching

Spoken language is such an important part in learning English that College English Curriculum Requirement considers promoting the students' spoken language as one of the most important goals in teaching English.However,at present,the students' oral expression competence is not so good in colleges.It is urgent to improve the quality of oral English classes and solve mute English of the students in colleges.Internet-based teaching is the new teaching mode adapting to the trend of the times.Internet provides excellent interactive methods for inquiry learning mode and provides the possibility for constructing an open learning environment.

An Adaptive Ramp Generator for ADC Built-in Self-Test

An adaptive ramp generator based on linear histogram was proposed for the built-in selftest (BIST) of analog to digital convertor (ADC) in CMOS image sensor. By comparing the generated ramp signal to a reference voltage and feeding back a calibration signal, the slope adjustment was implemented, and high linearity and precision of ramp slope were realized. By modulating the pulse width and reference voltage, sweep length varied from microsecond to second and signal swing could reach 3 V with 5.6 mW power consumption. The ramp was used as input to an ideal 10-bit single-slope ADC, and the corresponding DNL and INL were 0.032 LSB and 0.078 LSB, re-spectively.

Multicenter evaluation of a simple and sensitive nucleic acid self-testing for SARS-CoV-2

A rapid and accurate COVID-19 diagnosis is a prerequisite for blocking the source of infection as soon as possible and taking the appropriate medical action.Herein,we developed GeneClick,a device for nucleic acid self-testing of SARS-CoV-2,consisting of three modules:a sampling kit,a microfluidic chip-based disposable cartridge,and an amplification reader.In addition,we evaluated the clinical performance of GeneClick using 2162 nasal swabs collected at three medical institutions,using three commercial RT-qPCR kits and an antigen self-test as references.Compared to RT-qPCR,the sensitivity and specificity of the GeneClick assay were 97.93%and 99.72%,respectively,with a kappa value of 0.979(P<0.01).Of the 2162 samples,2076 were also tested for SARS-CoV-2 antigens.Among the 314 positive samples identified by GeneClick assay,63 samples were undetected by antigen tests.Overall,the GeneClick nucleic acid self-test demonstrated higher accuracy than the antigen-based detection.Based on the additional features,including simple operation,affordable price,portable device,and reliability of smartphone APP-driven sampling and result reporting,GeneClick offers a powerful tool for field-based SARS-CoV-2 detection in primary healthcare institutions or at-home use.