A multiple MIPS 4Kc processor cores based interrupt processing system is introduced. The interrupt controller plays a key role in the high definition television (HDTV) system-on-a-chip (SoC) platform, especially w...A multiple MIPS 4Kc processor cores based interrupt processing system is introduced. The interrupt controller plays a key role in the high definition television (HDTV) system-on-a-chip (SoC) platform, especially when it is a multiple processor system. Based on a general introduction to the whole HDTV SoC platform, a layered interrupt controller and its implementation are discussed in detail. The proposed scheme was implemented in our FPGA verification board. The results indicate that our scheme is reliable and efficient. Meanwhile, as a functional intellectual property (IP), the interrupt controller has reusability and expandability with the layered structure.展开更多
Highly Active Antiretroviral Therapy (HAART) has changed the course of human immunodeficiency virus (HIV) treatments since its introduction. However, for many patients, long term continuous HAART is expensive and can ...Highly Active Antiretroviral Therapy (HAART) has changed the course of human immunodeficiency virus (HIV) treatments since its introduction. However, for many patients, long term continuous HAART is expensive and can include problems with drug toxicity and side effects, as well as increased drug resistance. Because of these reasons, some HIV infected patients will voluntarily terminate HAART. Some of these patients will also interrupt the continuous prescribed therapies for short or long periods. After discontinuing HAART, patients will usually experience a rapid increase in viral load coupled with an immediate decline in CD4+ counts. The canonical example of a patient undergoing unsupervised breaks in HAART is that of the “Berlin patient”. In this case, the patient was able to control viral load in the absence of treatment by cycling HAART on and off due to non-related infections. Due to this patient, interest in the use of structured treatment interruptions (STI) as a mechanism to regulate an HIV infection piqued. This paper describes an optimal control approach to determine STI regimen for HIV patients. The optimal STI was implemented in the context of the receding horizon control (RHC) using a mathematical model for the in-vivo dynamics of an HIV type 1 infection. Using available clinical data, we calibrate the model by estimating on a patient specific basis, a best estimable set of parameters using sensitivity analysis and subset selection. We demonstrate how customized STI protocols can be designed through the variation of control parameters on a patient specific basis.展开更多
Investigations are reported into the use of an electromagnetically convoluted arc,external to a magnetic field(B-field)producing coil,in combination with a parallel R,L,C resonant circuit for interrupting quasi-steady...Investigations are reported into the use of an electromagnetically convoluted arc,external to a magnetic field(B-field)producing coil,in combination with a parallel R,L,C resonant circuit for interrupting quasi-steady currents.In order to elucidate the complex interactions between the arc,B-field and R,L,C circuit,the B-field producing coil is energised independently from the current to be interrupted and the R,L,C circuit.Experimental results are presented for the time variation of the currents flowing through the arc gap,the B-field coil and the parallel R,L,C circuit,along with the voltage across the arc gap.An insight is gained into the role of various effects,which are produced by the complex interactions and which might be used to advantage for direct current interruption.展开更多
针对通信中断下由智能网联车辆(Connected and Automated Vehicles,CAV)与人工驾驶车辆(Manually Driven Vehicles,MDV)所组成的混合编队的稳定性控制问题,考虑基于前车-领航车通信拓扑(Predecessor-Leader Following topology,PLF)和...针对通信中断下由智能网联车辆(Connected and Automated Vehicles,CAV)与人工驾驶车辆(Manually Driven Vehicles,MDV)所组成的混合编队的稳定性控制问题,考虑基于前车-领航车通信拓扑(Predecessor-Leader Following topology,PLF)和协同自适应巡航控制(Cooperative Adaptive Cruise Control,CACC)的混合编队,构建通信正常和通信中断状态下的车辆控制器.基于Routh-Hurwitz稳定性判据和频域分析方法设计稳定条件求解算法,计算控制器和MDV跟驰模型的稳定性条件,并提出针对两种控制器的平滑切换策略.案例分析表明:车队能够稳定安全行驶,各车速度标准差变化率均低于1.8%,平均加速度变化量和其平均值均低于0.016 m/s^(2),说明所提出的稳定性控制算法具有良好的有效性,可实现车辆及编队行驶状态的时空收敛;针对加速场景和减速场景,所提出的控制器切换策略能够分别减小车辆加速度波动幅度达37.1%和59.9%,控制器切换过程中的车辆状态稳定性得到显著提升.展开更多
文摘A multiple MIPS 4Kc processor cores based interrupt processing system is introduced. The interrupt controller plays a key role in the high definition television (HDTV) system-on-a-chip (SoC) platform, especially when it is a multiple processor system. Based on a general introduction to the whole HDTV SoC platform, a layered interrupt controller and its implementation are discussed in detail. The proposed scheme was implemented in our FPGA verification board. The results indicate that our scheme is reliable and efficient. Meanwhile, as a functional intellectual property (IP), the interrupt controller has reusability and expandability with the layered structure.
文摘Highly Active Antiretroviral Therapy (HAART) has changed the course of human immunodeficiency virus (HIV) treatments since its introduction. However, for many patients, long term continuous HAART is expensive and can include problems with drug toxicity and side effects, as well as increased drug resistance. Because of these reasons, some HIV infected patients will voluntarily terminate HAART. Some of these patients will also interrupt the continuous prescribed therapies for short or long periods. After discontinuing HAART, patients will usually experience a rapid increase in viral load coupled with an immediate decline in CD4+ counts. The canonical example of a patient undergoing unsupervised breaks in HAART is that of the “Berlin patient”. In this case, the patient was able to control viral load in the absence of treatment by cycling HAART on and off due to non-related infections. Due to this patient, interest in the use of structured treatment interruptions (STI) as a mechanism to regulate an HIV infection piqued. This paper describes an optimal control approach to determine STI regimen for HIV patients. The optimal STI was implemented in the context of the receding horizon control (RHC) using a mathematical model for the in-vivo dynamics of an HIV type 1 infection. Using available clinical data, we calibrate the model by estimating on a patient specific basis, a best estimable set of parameters using sensitivity analysis and subset selection. We demonstrate how customized STI protocols can be designed through the variation of control parameters on a patient specific basis.
文摘Investigations are reported into the use of an electromagnetically convoluted arc,external to a magnetic field(B-field)producing coil,in combination with a parallel R,L,C resonant circuit for interrupting quasi-steady currents.In order to elucidate the complex interactions between the arc,B-field and R,L,C circuit,the B-field producing coil is energised independently from the current to be interrupted and the R,L,C circuit.Experimental results are presented for the time variation of the currents flowing through the arc gap,the B-field coil and the parallel R,L,C circuit,along with the voltage across the arc gap.An insight is gained into the role of various effects,which are produced by the complex interactions and which might be used to advantage for direct current interruption.