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Regulatory Effects of Xylooligosaccharides on Intestinal Microbial Flora Proliferation and Defecation of BALB/c Mice
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作者 Tao WEI Hongtao SHANG +4 位作者 Zhaolan GAO Li WANG Siyu LI Xue HUANG Mengrui ZHENG 《Agricultural Biotechnology》 CAS 2013年第3期68-70,共3页
[ Objective] This study aimed to investigate the regulatory effects of xylooligesaccharides on intestinal microbial flora proliferation and defecation of BALB/c mice. [Method] In the intestinal microbial flora prolife... [ Objective] This study aimed to investigate the regulatory effects of xylooligesaccharides on intestinal microbial flora proliferation and defecation of BALB/c mice. [Method] In the intestinal microbial flora proliferation regulation experiment, microflom quantities of Bifidobacterium, Lactobacillus, Enterobacter and Enterococci in excrements of BALB/c mice were determined after continuous administration of high-dose[ 1.0 g/( kg ~ bw ) ] and low-dose[ 0.5 g/( kg ~ bw ) ] xylooligosaccharides for 14 d. In the defecation regulation experiment, constipation model of BALB/c mice was established with compound diphenexylate after con- tinuous administration of high-dose and low-dose xylooligosaccharides for 21 d, to determine the first defecation time of black excrement, weight of black excrements within 6 h and rate of intestinal propulsion of constipation mice. [ Result] Compared with the control group, after continuous administration of xyloolignsaccharides for 14 d, microflora quantifies of Lactobac//lus and B/fidobacter/um in excrements of BALB/c mice in low-dose and high-dose groups both increased significantly ( P 〈 0.05 ). After continuous administration of xylooligosaccharidos, microflora quantities of Enterococci and Lactobacillus in control group were significantly raised (P 〈 O. 05 and P 〈 0.01, respectively) compared with those before administration; mieroflora quantities of Enterococci in high-dose and low-dose groups were signif- icantly reduced (P 〈0.05), while microflora quantities of/zwtobac//lus and B/fidobacter/um and the B/E value increased significantly (P 〈0. 05, P 〈0.01 and P 〈 0.01, respectively). After continuous administration of xylooligosaccharides for 21 d, compared with the model group, the first defecation time of black excre- ment in high-dose and low-dose groups was significantly shortened ( P 〈 O. 05 ), the total weight of black.excrements within 6 h increased significantly ( P 〈 0.05 ) and the rate of intestinal propulsion was significantly enhanced ( P 〈0.01 ). [ Conclusion ] Low-dose (0.5 g/Kg. bw) and high-dose ( 1 g/Kg. bw) xylooligosac- charides can improve the proliferation of intestinal microbial flora and prevent mice from constipation. 展开更多
关键词 XYLOOLIGOSACCHARIDES BIFIDOBACTERIUM l.actobacillus rate of intestinal propulsion CONSTIPATION
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