Role of Intra-Operative Nerve Monitoring in Thyroidectomies: An Institutional Review

Injury to the Recurrent Laryngeal Nerve (RLN) is a worrisome complication of a thyroidectomy. Intra-operative nerve monitoring (IONM) of the RLN has gained prevalence as an aid to prevent injury. We reviewed our series and other studies in literature for insight. A chart review was carried out to identify all patients who underwent a thyroidectomy between 2005 and 2010. IONM was implemented by the Otolaryngology service in 2007. All identified patients were separated into three groups: 1) Otolaryngology service with IONM, 2) Otolaryngology service without IONM, and 3) General Surgery service without IONM. Several factors were noted, including age, sex, thyroid disease, extent of thyroidectomy, and RLN injury along with recovery. 230 patients underwent thyroidectomy from 2005-2010. 60 patients were isolated in the IONM-Otolaryngology group with 3 patients suffering injury. 109 patients underwent a thyroidectomy by the Otolaryngology service without IONM with 8 patients suffering nerve damage. In the third group, 61 patients underwent a thyroidectomy by General Surgery without IONM with 4 patients suffering damage. Of the thyroid pathology, 10 patients had Multinodular Goiter while 4 had Papillary Cancer and 1 had a Follicular Adenoma. The most severe complication of a thyroidectomy is RLN injury. In order to further decrease the risk of RLN injury, IONM has been employed. From our review and other studies, there does not appear to be a significant difference in rates of RLN injury with or without use of nerve monitoring. An interesting note is the increased prevalence of nerve injuries in Multinodular Goiter—a finding that merits further study to evaluate the role of IONM.

Optic nerve sheath diameters in nontraumatic brain injury:A scoping review and role in the intensive care unit

BACKGROUND Neuromonitoring in medical intensive care units is challenging as most patients are unfit for invasive intracranial pressure(ICP)modalities or unstable to transport for imaging.Ultrasonography-based optic nerve sheath diameter(ONSD)is an attractive option as it is reliable,repeatable and easily performed at the bedside.It has been sufficiently validated in traumatic brain injury(TBI)to be incorporated into the guidelines.However,currently the data for non-TBI patients is inconsistent for a scientific recommendation to be made.AIM To compile the existing evidence for understanding the scope of ONSD in measuring ICP in adult non-traumatic neuro-critical patients.METHODS PubMed,Google Scholar and research citation analysis databases were searched for studies in adult patients with non-traumatic causes of raised ICP.Studies from 2010 to 2024 in English languages were included.RESULTS We found 37 articles relevant to our search.The cutoff for ONSD in predicting ICP varied from 4.1 to 6.3 mm.Most of the articles used cerebrospinal fluid opening pressure followed by raised ICP on computed tomography/magnetic resonance imaging as the comparator parameter.ONSD was also found to be a reliable outcome measure in cases of acute ischaemic stroke,intracerebral bleeding and intracranial infection.However,ONSD is of doubtful utility in septic metabolic encephalopathy,dysnatremias and aneurysmal subarachnoid haemorrhage.CONCLUSION ONSD is a useful tool for the diagnosis of raised ICP in non-traumatic neuro-critically ill patients and may also have a role in the prognostication of a subset of patients.

Clinical Benefits of Facial Nerve Monitoring during Cerebellopontine Angle Surgery

Background: The surgery of cerebellopontine angle tumours has remarkably progressed over the last 2 decades due to improved microsurgical techniques. The primary operative goals are microscopic total removal of the tumour while securing the adjacent cranial nerves. Facial Nerve plays a critical role in facial muscles function and one’s cosmetic appearance, and its weakness can have profound implications on a patient’s quality of life. Aim of the Study: To assess the impact of monitoring techniques on the preservation of facial nerve function during cerebellopontine angle tumours surgery. Patients and Methods: This is a prospective study. This study was conducted on 30 cases (2 groups, each had 15 patients) with CPA lesions that had undergone surgical excision of these lesions performed by retrosigmoid approach (Group A: the patients were operated under continuous intraoperative facial nerve monitoring (IOFNM) and Group B: the patients were operated without IOFNM). They were operated upon in neurosurgery departments at Al-Azhar university hospitals between August 2019 and August 2021. Results: This study showed that excellent facial nerve function (HB Grade I and II) was higher in group A than group B, immediately and at 6-month post op (80% and 93% VS 53.3% and 66.7%). Intermediate (HB Grade III and VI) and Poor (HB Grade V and VI) facial nerve function was higher in group B than group A;both immediately and 6-month postop (46.7% and 33.3% VS 20% and 6.6%). However, no statistically significant P-Value between both groups. Conclusion: We concluded that IOFNM can help, but cannot guarantee, the preservation of facial nerve. Furthermore, it is merely a technical adjunct and does not replace surgical skills, knowledge of anatomy and experience.

Surgical strategies for peripheral nerve schwannoma based on the intraoperative neurophysiological monitoring

Objective:To present our classification for peripheral nerve schwannomas as well as explore the surgical strategies and operative management of peripheral nerve schwannomas based on the intraoperative neurophysiological monitoring(INM)technique and to decrease the risk of postoperative neurological deficits in the management of these schwannomas.Materials and methods:A retrospective study was conducted on 92 cases of peripheral nerve microsurgery performed,using the INM technique.We also made the classification for peripheral nerve schwannomas into two types according to operative findings and proceeded corresponding surgical strategies.Results:All tumors were removed completely under microscopy and INM.Three patients developed residual neurological deficits at final follow-up.There were different results about temporary(18/92,19.6%)and permanent(3/92,3.3%)neurological deficits.The incidence of temporary and permanent neurological deficits in type II group was significantly higher than that in type I group(p<0.01).The incidence of permanent neurological deficits in larger size tumors was significantly higher than that of smaller size(p<0.01).Conclusions:We made the classification for peripheral nerve schwannomas according to operative findings based on INM that is helpful to our surgical strategies.Intracapsular enucleation was the preferred strategy with satisfactory results and low risk of nerve injury.The size and location of tumors seem to be related to the risk of fascicular injury.

An intraoperative lumbar neurological force monitoring system with high-density flexible pressure sensor array

In the surgery of lumbar disc herniation(LDH),the nerve root retractor is used to pull the nerve root to prevent damage.The traditional medical nerve root retractor cannot quantify the force on the nerve root.In order to improve the nerve root retractor,this paper proposes an intraoperative lumbar neurological force monitoring system.The core module of this system is the improved nerve root retractor equipped with the high density flexible pressure sensor array.The high density microneedle array and multiple pressure detection units are used in the pressure sensor to realise sensitive pressure monitoring in a narrow surgical operation area.The sensing area is 4 mm×17 mm,including 6 detection units.The sensitivity of sensor is 67.30%/N in the range of 0-5 N.This system is used for in vitro animal experiments,which can continuously detect pressure.

Facial nerve monitoring in parotid gland surgery:Design and feasibility assessment of a potential standardized technique

Background:Even though the use of nerve monitoring during parotid gland surgery is not the gold standard to prevent damage to the nerve,it surely offers some advantages over the traditional approach.Different from thyroid surgery,where a series of steps in intraoperative nerve monitoring have been described to confirm not only the integrity but—most importantly—the function of the recurrent laryngeal nerve,in parotid gland surgery,a formal guideline to follow while dissecting the facial nerve has yet to be described.Methods:A five‐year retrospective study was done reviewing the intraoperative records of patients who underwent parotid gland surgery under neural monitoring.The operative findings regarding the neuromonitoring process,particularly in regard to the amplitude of two main branches,were revised.A literature search was done to search for guidelines to follow when a facial nerve loss of signal is encountered.Results:Fifty‐five patients were operated on using the Nim 3 Nerve Monitoring System(Medtronic);31 were female patients,and 47 patients had benign lesions.Minimum changes were observed in the amplitude records after a comparison was made between the first and the last stimulation.There were only three articles discussing the term loss of signal during parotid gland surgery.Conclusion:Today,no sufficient attention has been given to the facial nerve monitoring process during parotidectomy.This study proposes a formal guideline to follow during this procedure as well as an instruction to consider when a loss of signal is observed to develop a uniform technique of facial nerve stimulation.

经皮针状电极在甲状腺术中喉返神经监测的研究

目的比较经皮针状电极和经口插管表面电极用于甲状腺术中神经监测的异同,并探讨在不适合经口插管或表面电极故障时,如何识别和保护喉返神经和迷走神经。方法收集并分析32例因甲状腺疾病接受手术治疗患者的临床资料,共计监测喉返神经和迷走神经各40侧,分别使用经口插管表面电极及经皮针状电极对神经进行监测,记录所获取的振幅及潜伏期。采用SPSS 26.0软件进行统计分析,采用配对t检验对潜伏期进行分析比较,采用秩和检验分析经皮针状电极与经口插管表面电极刺激所得振幅是否有差异。结果经皮针状电极用于甲状腺术中神经监测时,所有神经均被识别并获得与经口插管表面电极潜伏期和振幅相似的双相肌电信号,并可通过潜伏期有效鉴别喉返神经和迷走神经[(3.22±0.50)ms vs.(3.85±1.00)ms,P<0.05],与经口插管表面电极的监测效果[(3.04±0.58)ms vs.(3.89±1.07)ms,P<0.05]无明显差异;同时,经皮针状电极可视化操作度及安全性都更高,具有很大优势。结论经皮针状电极可有效辅助识别并保护喉返神经和迷走神经,是经口插管表面电极的重要补充。

食管癌术中喉返神经损伤因素的研究进展

食管癌患者淋巴结转移率高,其中双侧喉返神经旁淋巴结转移率高达19.8%~37.6%。在食管癌根治性淋巴结清扫过程中,喉返神经旁淋巴结的清扫可改善预后,同样也会增加喉返神经损伤风险,导致患者术后出现声音嘶哑及肺炎等并发症,降低术后生活质量。需要术者注重喉返神经的保护,完善术前检查,确定手术流程,合理使用术中仪器,提高术中操作水平。本文就术中神经检测、手术方式、淋巴结清扫范围、术者个人因素、喉返神经旁淋巴结的检查方式等对术中喉返神经损伤的影响展开综述。

盆腔自主神经监测对腹腔镜辅助中低位直肠癌根治术中男性患者排尿功能保护作用的研究

背景中低位直肠癌由于肿瘤位置较深,容易出现术中盆腔自主神经损伤从而导致患者术后出现排尿功能障碍,寻找降低术中自主神经损伤的方法至关重要。目的探讨术中盆腔自主神经监测对男性患者排尿功能的保护作用,及其降低术中盆腔自主神经损伤发生率的应用价值。方法回顾性分析2017年5月—2019年5月就诊于解放军总医院第一医学中心并接受腹腔镜辅助中低位直肠癌根治术的男性患者临床资料,根据是否行术中盆腔自主神经监测分为监测组和对照组。共纳入患者81例,其中监测组41例(双侧成功监测组31例,单侧成功监测组10例),对照组40例。比较患者围术期指标以及手术前后排尿功能变化。结果3组患者的年龄、肿瘤T分期、N分期、肿瘤直径、分化程度、肿瘤距肛门距离、手术时间、术中出血量、术式等指标差异无统计学意义(P>0.05)。双侧监测组和单侧监测组术后留置导尿管时间均小于对照组[(59.81±34.67)h和(84.50±25.43)h vs(115.73±50.53)h,P<0.05]。双侧监测组和单侧监测组的国际前列腺症状评分(international prostate symptom score,IPSS)术后1个月和术后1年均优于对照组[M(IQR):5.0(2.0~8.0)和4.0(1.3~6.8)vs6.0(1.0~11.0),P均<0.05;3.0(1.0~5.0)和3.0(0.5~5.5)vs 4.5(0.5~8.5),P均<0.05]。双侧监测组和单侧监测组术后1个月和术后1年生活质量评分(quality of life scores,QoL)均优于对照组[M(IQR):3.0(2.0~4.0)和2.5(1.3~3.8)vs 3.0(2.0~4.0),P均<0.05;2.0(1.0~3.0)和2.0(0.8~3.3)vs 3.0(2.0~4.0),P均<0.05]。此外,监测组术前和术后1年的IPSS评分和QoL评分差异无统计学意义(P>0.05),而对照组术前和术后1年的IPSS评分和QoL评分差异有统计学意义(P<0.05)。结论腹腔镜辅助中低位直肠癌根治术中应用盆腔自主神经监测对男性患者排尿功能具有保护作用,降低了患者术中盆腔自主神经损伤的风险,改善了患者的生活质量。

Pathogenesis, diagnosis, and treatment of epilepsy: electromagnetic stimulation-mediated neuromodulation therapy and new technologies

Epilepsy is a severe,relapsing,and multifactorial neurological disorder.Studies regarding the accurate diagnosis,prognosis,and in-depth pathogenesis are crucial for the precise and effective treatment of epilepsy.The pathogenesis of epilepsy is complex and involves alterations in variables such as gene expression,protein expression,ion channel activity,energy metabolites,and gut microbiota composition.Satisfactory results are lacking for conventional treatments for epilepsy.Surgical resection of lesions,drug therapy,and non-drug interventions are mainly used in clinical practice to treat pain associated with epilepsy.Non-pharmacological treatments,such as a ketogenic diet,gene therapy for nerve regeneration,and neural regulation,are currently areas of research focus.This review provides a comprehensive overview of the pathogenesis,diagnostic methods,and treatments of epilepsy.It also elaborates on the theoretical basis,treatment modes,and effects of invasive nerve stimulation in neurotherapy,including percutaneous vagus nerve stimulation,deep brain electrical stimulation,repetitive nerve electrical stimulation,in addition to non-invasive transcranial magnetic stimulation and transcranial direct current stimulation.Numerous studies have shown that electromagnetic stimulation-mediated neuromodulation therapy can markedly improve neurological function and reduce the frequency of epileptic seizures.Additionally,many new technologies for the diagnosis and treatment of epilepsy are being explored.However,current research is mainly focused on analyzing patients’clinical manifestations and exploring relevant diagnostic and treatment methods to study the pathogenesis at a molecular level,which has led to a lack of consensus regarding the mechanisms related to the disease.

近红外光谱监测在先天性心脏病患儿围术期应用的研究进展

先天性心脏病是儿童最常见的心脏病,大部分先天性心脏病患儿需及时进行手术治疗矫正畸形。然而,术后脑损伤和神经发育不良一直是心肺转流下先天性心脏病手术后常见的神经系统并发症,严重影响患儿的预后。有效的监测手段对于积极预防、尽早发现和及时处理神经系统并发症至关重要。应用近红外光谱(NIRS)监测局部脑组织氧饱和度(rScO 2),或联合其他脑神经功能监测手段进行多模式监测,有助于及时发现脑缺血缺氧不良事件,进而循序调整影响因素进行干预,有利于降低术后神经损伤的发生率,改善患儿预后。本文就NIRS的原理、影响因素及其在先天性心脏病患儿围术期单独应用和与其他监测方法联合应用进行综述,旨在为先天性心脏病患儿围术期脑神经功能监测提供参考。

麻醉药物对甲状腺术中喉返神经监测影响的研究进展

甲状腺疾病是一种常见的内分泌系统疾病,主要由于甲状腺功能分泌不足引起,目前手术切除是治疗甲状腺疾病的主要方法。喉返神经损伤是甲状腺术中一种严重的并发症,术后神经损伤可导致患者声音嘶哑,甚至呼吸困难,严重影响患者生活质量。术中神经电生理监测可以降低甚至避免喉返神经损伤风险,其中麻醉药物是影响术中神经电生理监测的主要因素。能否在保证术中神经监测正常实施前提下提供良好麻醉管理,甲状腺手术中麻醉药物的使用成为关键。本文主要介绍麻醉药物对甲状腺术中喉返神经监测的影响,优化术中麻醉管理、合理应用麻醉药物、避免麻醉药物对喉返神经监测的影响,从而提高手术质量、缩短康复时间。

超声动态监测神经鞘直径变化对急性高原脑水肿早期诊断的初步探讨

目的探讨超声监测视神经鞘直径(optic nerve sheath diameter,ONSD)指导治疗急性高原脑水肿(high altitude cerebral edema,HACE)可行性。方法对短时间进驻高原的40名健康成年男性(对照组)及3例急性HACE患者(HACE组),利用超声测定ONSD。以其阈值大于5.2mm诊断颅内压升高,在治疗过程中与出院1周后,动态监测ONSD。结果对照组双眼平均ONSD为(5.05±0.04)mm。HACE患者急诊就诊即刻双眼平均ONSD为(5.62±0.06)mm,经治疗出院时双眼平均ONSD为(5.00±0.17)mm,随访时双眼平均ONSD为(5.01±0.10)mm。与对照组比较,HACE患者急诊就诊即刻双眼平均ONSD差异具有统计学意义(P<0.01),出院时、随访时双眼ONSD差异无显著统计学意义(P>0.05)。HACE患者出院时、随访时双眼平均ONSD,小于急诊就诊即刻ONSD,差异具有统计学意义(P<0.05)。结论超声监测ONSD增宽是确诊急性HACE的一种便捷、简单且无创的方法,对急性HACE救治具有重要临床意义。

胸乳径路腔镜甲状腺切除术中应用神经监测的学习曲线分析

目的探讨胸乳径路腔镜甲状腺切除术中应用神经监测的学习曲线特点。方法回顾性分析42例行胸乳径路腔镜甲状腺切除术患者的资料,所有手术均由同一组术者实施。采用累积总和法计算每例患者的喉返神经识别时间,获得该组术者胸乳径路甲状腺切除术中应用神经监测的学习曲线。比较学习曲线不同阶段的喉返神经识别时间、喉返神经识别率、喉返神经损伤发生率、术中出血量、术后引流量、住院时间及并发症发生情况。结果手术例数在20例时喉返神经识别时间达到最大值,据此将曲线分为A、B两个阶段,A阶段(前20例)为早期学习阶段,B阶段(20例以后)为后期熟练阶段。B阶段患者喉返神经识别时间、术中出血量、术后引流量、住院时间均短于或少于A阶段患者,差异均有统计学意义(均P<0.05);B阶段患者喉返神经识别率、喉返神经损伤发生率和并发症发生率与A阶段差异均无统计学意义(均P>0.05)。结论术者能够熟练掌握胸乳径路腔镜甲状腺切除术须累积的最少手术例数为20例。后期熟练的手术操作可缩短腔镜甲状腺切除术中喉返神经识别时间、住院时间,减少术中出血量、术后引流量。

术中神经电生理监测技术在脊柱手术患者中的应用价值

目的研究术中神经电生理监测(IONM)技术在脊柱手术患者中的应用价值,旨在为提升脊柱手术的有效性与安全性提供指导依据。方法选取西安市红会医院和西安大兴医院2022年5月至2023年5月收治的200例拟行脊柱手术患者开展前瞻性研究。以电脑编号奇偶数字法随机分为术中监测组及参考组各100例。术中监测组男55例,女45例;年龄32~74(58.92±10.35)岁;体重指数(BMI)为18~30(23.15±2.09)kg/m^(2)。参考组男57例,女43例;年龄33~73(59.14±10.62)岁;BMI为18~30(23.27±2.15)kg/m^(2)。两组均开展常规脊柱手术,术中监测组术中应用IONM技术,而参考组术中不应用IONM技术。对比两组各项围手术期指标、脊髓神经功能(评估时机为术前1 d及术后7 d)、血清炎症因子水平(评估时机为术前1 d及术后1 d)、术后并发症。统计学方法采用χ^(2)检验、t检验。结果术中监测组术后肛门排气时间、下床活动时间及住院时间均短于参考组[(10.84±1.56)h比(15.20±2.30)h、(3.84±0.69)d比(5.71±0.83)d、(9.47±1.66)d比(12.84±2.30)d],差异均有统计学意义(t=15.69、17.33、11.88,均P<0.05)。两组术后7 d的日本骨科协会评估治疗分数(JOA)评分均较术前1 d高(均P<0.05),且术中监测组高于参考组[(25.94±2.30)分比(21.50±2.57)分],差异有统计学意义(t=12.87,P<0.05)。术中监测组术后并发症发生率低于参考组[6.00%(6/100)比20.00%(20/100)],差异有统计学意义(χ^(2)=8.67,P<0.05)。两组术后1 d血清炎症因子水平虽均较术前1 d高,但术中监测组均较参考组低(均P<0.05)。结论在脊柱手术中应用IONM技术可促进患者早日康复,改善脊髓神经功能,降低并发症发生风险,减轻炎症反应。

Intraoperative monitoring of the recurrent laryngeal nerve in surgeries for thyroid cancer: a review

Intraoperative nerve monitoring(IONM)has evolved into an objective tool not only for the identification but also for the preservation and prognostication of function of the recurrent laryngeal nerve in thyroid surgeries.Technical improvements have resulted in the increasing incorporation of IONM into operating rooms around the world.The importance of adherence to recommended standards is also recognized as being vital in optimizing the efficacy of IONM.The advent of continuous IONM has made real-time nerve monitoring possible,thus providing the surgeon with an ally in difficult surgeries.Additionally,as thyroid surgeries are evolving into remote access and minimally invasive procedures,so also is the applicability of IONM.This review focuses on the use of IONM for nerve monitoring in thyroidectomies for neoplastic conditions while discussing the rationale,technique,and interpretation of findings and their implications.

血糖波动与2型糖尿病亚临床周围神经病变的相关性

目的 分析血糖波动与2型糖尿病(T2DM)亚临床周围神经病变(sDPN)的相关性。方法 纳入T2DM sDPN患者153例为sDPN组,无DPN T2DM患者186例为非DPN组,比较两组患者临床指标及血糖波动。多因素Logistic回归分析T2DM患者并发sDPN与血糖波动的关系,ROC分析血糖波动对T2DM患者合并sDPN的预测价值。结果 与非DPN组相比,sDPN组空腹血糖、平均血糖(MBG)、血糖标准差(SDBG)、血糖变异系数(CV)、平均血糖波动幅度(MAGE)、最大血糖波动幅度(LAGE)及葡萄糖高于目标范围(TAR)的时间更高,葡萄糖目标范围内时间(TIR)更低(P<0.05)。多因素Logistic回归分析显示,MBG、SDBG、CV、MAGE、LAGE及TAR为T2DM并发sDPN的危险因素,TIR为其保护因素。ROC曲线显示危险因素MAGE曲线下面积最大。结论 血糖波动与T2DM患者合并sDPN密切相关,关注血糖波动有助于早期发现和治疗糖尿病神经病变。

神经探测技术在腔镜甲状腺手术中对喉返神经保护的临床研究

目的分析神经探测技术(IONM)在腔镜甲状腺手术中对喉返神经的保护作用。方法选取2017年7月至2020年7月甘肃省人民医院通过胸乳入路进行内镜下甲状腺大部分或全部切除的71例甲状腺肿瘤患者的临床资料,随机分为对照组(n=36)和神经探测组(n=35)。对照组采用常规性腔镜甲状腺手术,神经探测组在术中当靠近甲状腺背侧,即喉返神经所走行区域时,先用神经探测仪分别确定双侧喉返神经的位置,加以显露,予以保护。通过统计手术平均时间、术后平均住院时间、术后引流管拔除时间,术后24 h切口平均引流量、术中平均出血量、术中肌电图的响应幅度、术后并发症等指标比较研究IONM在腔镜甲状腺手术中对喉返神经保护效果。结果神经探测组手术时间、术后住院时间、术后引流管时间和术后24 h切口平均引流量均低于对照组,差异有统计学意义(P<0.05);神经探测组术中肌电图的平均响应幅度:V1为(800±345)μV,R1为(1120±219)μV,R^(2)为(1147±315)µV,V2为(1203±247)µV。神经探测组术后并发症(喉返神经损伤、声音嘶哑,呼吸困难、吞咽困难)的发生率均明显低于对照组,差异有统计学意义(P<0.05)。结论腔镜甲状腺手术结合IONM,可协助暴露和保护喉返神经,从而减少并发症的发生率,使手术更安全可靠。

遗传性压迫易感性神经病临床与神经电生理特征分析

目的总结分析遗传性压迫易感性神经病(HNPP)临床特征和神经电生理演变过程,以为临床早期诊断提供参考。方法与结果研究对象为2014年1月至2020年12月经北京医院基因检测确诊的3例男性HNPP患者,发病年龄(确诊年龄)分别为13(25)、57(57)和20(71)岁,至2020年12月随访时病程18、6和56年。致病基因均为PMP22,呈全基因杂合缺失突变。首发症状为腓总神经麻痹,早期发作后可自行恢复至正常状态;神经电生理改变以易嵌压部位的周围神经传导阻滞为核心特征,同时伴有多发性感觉和运动神经传导速度减慢、感觉神经电位波幅降低、远端潜伏期延长,受累神经数量超过临床症状范围;至疾病晚期,发作后症状可持续存在。结论HNPP患者病程早期呈现的神经电生理异常范围超过临床表现的特征有助于早期诊断,病程中出现易嵌压部位的周围神经传导阻滞有助于与吉兰-巴雷综合征、多灶性运动神经病、多灶性获得性脱髓鞘性感觉运动神经病和腓骨肌萎缩症1A型等疾病相鉴别。

神经电生理监测下显微切除术对听神经瘤患者的影响

目的:探讨神经电生理监测下显微切除术对听神经瘤患者的影响。方法:回顾性分析2017年12月—2022年12月蚌埠医学院第一附属医院行显微切除术治疗的62例听神经瘤患者的临床资料,根据是否使用神经电生理监测分为对照组31例与观察组31例。对照组常规行显微切除术治疗,观察组于神经电生理监测下行显微切除术。对比两组的手术情况、并发症发生情况、面神经功能保护情况及生活质量。结果:观察组手术时间短于对照组,术中出血量少于对照组,且观察组肿瘤全切除率为93.55%,高于对照组的64.52%,差异有统计学意义(P<0.05)。观察组并发症发生率为9.68%,低于对照组的35.48%,差异有统计学意义(P<0.05)。术后6个月,观察组面神经功能Ⅰ级率高于对照组,且观察组面部神经功能保留率为93.55%,高于对照组的70.97%,差异有统计学意义(P<0.05)。术后6个月,两组健康调查简表(SF-36)评分均高于术前,且观察组高于对照组,差异有统计学意义(P<0.05)。结论:神经电生理监测下显微切除术治疗听神经瘤患者,可有效缩短手术时间,减少术中出血量,提升肿瘤全切除率,降低并发症发生率,有效保护面神经功能,改善患者术后生活质量。