Current Status of Intra-Vascular Imaging during Coronary Interventions

Most important interventional application of IVUS is plaque assessment, vessel sizing and stent implantation guidance. Image guided PCI is associated with decreased incidence of stent thrombosis and MACE rate as evident in recently published meta-analysis of IVUS guided PCI studies. Many imaging studies have shown very clearly under-expansion, edge-dissection, tissue-prolapse, mal apposition, and geographical miss are associated with adverse events following DES implantation, and IVI guides in optimization of stent implantation by identifying and rectifying these predictors of DES outcomes.

Speckle Noise Suppression in Ultrasound Images Using Modular Neural Networks

In spite of the advancement in computerized imaging,many image modalities produce images with commotion influencing both the visual quality and upsetting quantitative image analysis.In this way,the research in the zone of image denoising is very dynamic.Among an extraordinary assortment of image restoration and denoising techniques the neural network system-based noise sup-pression is a basic and productive methodology.In this paper,Bilateral Filter(BF)based Modular Neural Networks(MNN)has been utilized for speckle noise sup-pression in the ultrasound image.Initial step the BFfilter is used tofilter the input image.From the output of BF,statistical features such as mean,standard devia-tion,median and kurtosis have been extracted and these features are used to train the MNN.Then,thefiltered images from the BF are again denoised using MNN.The ultrasound dataset from the Kaggle site is used for the training and testing process.The simulation outcomes demonstrate that the BF-MNNfiltering method performs better for the multiplicative noise concealment in UltraSound(US)images.From the simulation results,it has been observed that BF-MNN performs better than the existing techniques in terms of peak signal to noise ratio(34.89),Structural Similarity Index(0.89)and Edge Preservation Index(0.67).

室内定位系统研究

近年来,随着无线网络和多媒体技术的迅速发展,开发位置感知服务提供灵活、自适应的个人服务和改善生活质量已经成为了市场需求,因此基于位置的服务应运而生。本文主要介绍了各种室内定位系统,并详细阐述了每种室内定位系统的网络架构和优缺点。

Ultrasound-assisted extraction of antioxidant polyphenolic compounds from Nephelium lappaceum L.(Mexican variety) husk

Objective: To reach the recovery and identification of antioxidant polyphenolic compounds from Nephelium lappaceum L.(Mexican variety) husk using ultrasound-assisted extraction and liquid chromatography/mass spectrometry as well as the in vitro antioxidant activity. Methods: Rambutan husk extracts were obtained by ultrasound-assisted extraction, mass/volume ratio, water/ethanol percentage and extraction time were evaluated. Once the best extraction condition of polyphenolic compounds was defined, a polyphenolic fraction was recovered using Ambetlite XAD-16. The total content of antioxidant polyphenolic compounds was determined by summation of the total hydrolysable polyphenol and total condensed polyphenol contents. Recovered compounds were identified by FTIR(ATR) spectroscopy and HPLC/ESI/MS. The antioxidant activity was carried out by ABTS, DPPH and lipid oxidation inhibition in vitro methods. Results: In Mexican variety rambutan husk, the total polyphenolic content was 487.67 mg/g, after ultrasound-assisted extraction. According to the HPLC/ESI/MS analysis 12 antioxidant polyphenolic compounds were identified, mostly ellagitannins such as geraniin, corilagin and ellagic acid. The antioxidant activity determined by ABTS, DPPH and lipid oxidation inhibition methods was demonstrated. The main functional groups of the identified compounds were determined by FTIR analysis. Conclusions: It was demonstrated that ultrasound-assisted extraction was effective and allowed the extraction and recovery of antioxidant polyphenolic compounds. Furthermore Mexican variety rambutan husk is an important source for recovering polyphenolic compounds with antioxidant activity, these compounds have potential application for the treatment/prevention of various diseases related to cancer and pathogenic microorganisms.

Evaluation of Ultrasound-based Surveillance for Hepatocellular Carcinoma in Patients at Risk:Results From a German Multicenter Retrospective Cohort Study

Background and Aims:Hepatocellular carcinoma(HCC)surveillance in patients at risk is strongly recommended and usually performed by ultrasound(US)semiannually with or without alfa-fetoprotein(AFP)measurements.Quality pa-rameters except for surveillance intervals have not been strictly defined.We aimed to evaluate surveillance success and risk factors for surveillance failure.Methods:Patients with≥1 US prior to HCC diagnosis performed at four tertiary referral hospitals in Germany between 2008 and 2019 were retrospectively analyzed.Surveillance success was defined as HCC detection within Milan criteria.Results:Only 47%of 156 patients,median age 63(interquartile range:57-70)years,56%male,and 96%with cirrhosis,received recom-mended surveillance modality and interval.Surveillance fail-ure occurred in 29%and was significantly associated with lower median model for end-stage liver disease(MELD)score odds ratio(OR)1.154,95%confidence interval(CI):1.027-1.297,p=0.025)and HCC localization within right liver lobe(OR:6.083,95%CI:1.303-28.407,p=0.022),but not with AFP≥200μg/L.Patients with surveillance failure had sig-nificantly more intermediate/advanced tumor stages(93%vs.6%,p<0.001),fewer curative treatment options(15%vs.75%,p<0.001)and lower survival at 1 year(54%vs.75%,p=0.041),2 years(32%vs.57%,p=0.019)and 5 years(0%vs.16%,p=0.009).Alcoholic and non-alcoholic fatty liver disease(OR:6.1,95%CI:1.7-21.3,p=0.005)and ascites(OR:3.9,95%CI:1.2-12.6,p=0.021)were in-dependently associated with severe visual limitations on US.Conclusions:US-based HCC surveillance in patients at risk frequently fails and its failure is associated with unfavorable patient-related outcomes.Lower MELD score and HCC lo-calization within right liver lobe were significantly associated with surveillance failure.

Optimization of percutaneous coronary intervention through lower frame rates angiogram

Background Coronary artery disease(CAD)is a leading cause of mortality worldwide.Percutaneous coronary intervention(PCI)is a standard treatment for CAD,yet the radiation exposure associated with this procedure can pose significant risks to both patients and healthcare professionals.With the aim to optimize this procedure,we studied the effects of different exposure rates on radiation dose,fluoroscopy time,and procedural complications.Methods A total of 441 consecutive patients who underwent coronary angiography and subsequent PCI treatment from January 2020 to December 2021 were included in this study.Baseon the fluoroscopy frame rates used during the procedure,patients were divided into two groups,which included a standard dose protocol(SDP)group that used15 frames per second(FPS)and a low dose protocol(LDP)group that used 7.5 FPS.Then the impact of different fluoroscopy frame rates on total air kerma(AK),procedure time,fluoroscopy times(FT),and procedural complications in patients undergoing PCI were evaluated.Results Our data indicated that LDP group had a significantly lower AK,indicative of a reduced radiation dose,in comparison to SDP group.Although the procedure time and FT were slightly longer in the LDP group,this increase was not statistically significant.Moreover,the rate of intraoperative complications in the LDP group was not higher than that in the SDP group.In a subgroup of patients who underwent intravascular ultrasound(IVUS)within the LDP group,we observed further reductions in radiation exposure and FT.Conclusions The use of reduced fluoroscopy frame rates and adjunctive IVUS during PCI procedures can be a viable approach to minimizing radiation exposure without compromising procedure success or patient safety.