The rising of aging and the declining of birth rates have forced the public to focus on the youth’s view on marriage.Based on critical discourse analysis and combined with Fairclough’s three-dimensional discourse an...The rising of aging and the declining of birth rates have forced the public to focus on the youth’s view on marriage.Based on critical discourse analysis and combined with Fairclough’s three-dimensional discourse analysis model,this paper builds a“Chinese media News Report Corpus on the topic of‘marriage’”whose news are collected from China Daily.It is found that the discourses are neutral and objective with regard to the advantages and disadvantages of marriage,but in general,it is still a traditional view of marriage that is inevitable and closely related to fertility.Although this is controlled by the policies and the social reasons including declining fertility rate,it deviates from the current view of the youth towards marriage,resulting in many serious consequences such as young people’s rejection.In addition,this research found that male and female have great differences in their views on marriage,and men’s resistance to marriage is far greater than that of women,which is departure from the public’s cognition.The reasons behind this need to be explored in order to solve the marriage and love problems of young people in today’s era and realize the healthy development of young marriage.展开更多
Rural marriage has characteristics such as close relationship with labor production,deep integration of traditional culture,shy and introverted expression of subjective emotions,and illegal and rough marriage.The civi...Rural marriage has characteristics such as close relationship with labor production,deep integration of traditional culture,shy and introverted expression of subjective emotions,and illegal and rough marriage.The civilization evolution of rural marriage forms is moving towards a path that is conducive to the development of production and the pursuit of happiness for farmers,the construction of rural spiritual civilization,and the comprehensive development of rural society.This study analyzes the direction of the evolution of rural marriage form civilization,predicts the trend of rural marriage form civilization evolution,and proposes the future path of rural marriage form civilization evolution,including adhering to human’s most original value expectations of marriage life,drawing nourishment from excellent traditional Chinese culture,and continuously adjusting marriage and family policy tools to keep up with changes in the world of life.展开更多
Introduction: In Nigeria, one of the major reasons for marriage is procreation and married couples look forward to having children within a year or two of marriage. The age of marriage is on the increase in this part ...Introduction: In Nigeria, one of the major reasons for marriage is procreation and married couples look forward to having children within a year or two of marriage. The age of marriage is on the increase in this part of the world. Many women are now increasingly getting engulfed in career and academic pursuits at the detriment of early marriage. Many men are also not interested in marrying women who have no job. There is age-related acceleration of primordial follicle depletion which is of great clinical importance because it is associated with a significant decrease in fecundity. Objective: This study assessed the ages of the marriage of women who attended Fertility and Antenatal clinics at the National Obstetric Fistula Centre and Smile Specialist Hospital, Abakaliki, and their relationship with the fertility pattern of these women. Methods: This was a cross-sectional study of 352 consenting married women who sought and received fertility and Antenatal care at the National Obstetric Fistula Centre and Smile Specialist Hospital Abakaliki, South-East Nigeria between February 1, 2022 and January 31, 2024. Semi-structured questionnaires were administered to the participants over a two-year period. Data was analyzed using IBM SPSS version 20. A test of statistical significance was done using Chi Square. Results: The age group with the highest education was 26 - 30. This was statistically significant (X2 = 90.893, P-value 2 = 294.555, P-value 2 = 173.007, p-value 2 = 129.494, P-value 2 = 169.300, p-value 2 = 279.230, p-value Conclusion: There is increased difficulty at conception at marriage age above 25 years. The major reasons for delayed marriage were academic pursuit and lack of gainful employment. Education of the masses and inclusion of biological dynamics of the female reproductive behaviours as part of the core school curriculum will help enlighten the female and the male folks alike to enable them to make informed decisions with regard to the timing of marriage and commencement of procreation. This will help reduce infertility and save millions of couples the agony associated with infertility.展开更多
This paper presents a comprehensive analysis and comparison of the existing literature on the phenomenon of non-marriage or staying unmarried in Asian countries such as China,Japan,South Korea,and Singapore,as well as...This paper presents a comprehensive analysis and comparison of the existing literature on the phenomenon of non-marriage or staying unmarried in Asian countries such as China,Japan,South Korea,and Singapore,as well as European and American countries such as Spain and the US,and explores the trends,characteristics as well as reasons behind such a phenomenon.Through analysis,the present study found that there is a growing trend of postponed marriage and parenthood as well as an increasing proportion of individuals who exhibit no enthusiasm towards matrimony or parenthood in the aforementioned countries.To some extent,non-marriage or postponed marriage has become a prevalent trend in developed countries and even some developing countries.Japan,South Korea,and several developed countries in Europe and America have exhibited this phenomenon since the middle to late 20th century,with a relatively long history.The emergence of this phenomenon in China,Malaysia,the Philippines,and other developing countries in Asia,however,was relatively late,exhibiting a gradual development process.The current marriage landscape in China is characterized by a growing number of non-marriage individuals and a significant level of marital stability.In terms of reasons for staying unmarried,the marriage rates in the aforementioned countries can be attributed to various factors at macro,meso,and micro levels.In China,the phenomenon of non-marriage is closely associated with a range of factors,including diverse values and attitudes towards romance and marriage,marriage squeeze,education expansion,and the rise in females’economic and social status.The emphasis in future research should be placed on predicting the phenomenon of non-marriage,with a specific focus on exploring the reasons for advocating non-marriage,examining the internal mechanisms underlying this phenomenon,analyzing the consequences of non-marriage,and proposing corresponding countermeasures while establishing the public identity towards marriage.展开更多
Marriage is a very important part in one's life.But different countries have different wedding ceremonies because of the culture difference.western wedding is simple while Chinese wedding is complex.No matter you ...Marriage is a very important part in one's life.But different countries have different wedding ceremonies because of the culture difference.western wedding is simple while Chinese wedding is complex.No matter you choose the Chinese style or the western style,you should marry the one you love best,and then you can enjoy a beautiful life.展开更多
At the very beginning of the book-Pride and Prejudice,the author said"It is universally acknowledged that a single man in possession of a good fortune must be want of a wife."From this line,we can find that ...At the very beginning of the book-Pride and Prejudice,the author said"It is universally acknowledged that a single man in possession of a good fortune must be want of a wife."From this line,we can find that marriage is the most important thing to women.Sometimes it even equals to men's career at that time.It seems like once a woman married to a rich single man,she succeed in her lifetime"career".The question is what is the standard of that"succeed"? Married to a rich man,or the man you really love,or a man you had a crush on? Everyone keep these questions in mind since very early time,and different people have different opinions.In her short life,Jane Austin,the great novelist,composed six novels and created lot of female characters.Women in her novel had different attitudes toward marriage.Speaking of marriage,Pride and Prejudice must be the most representative work of it,and it is also Jane's masterpiece.Through the different type of marriage of Mr.Bennet's daughters,we can find the Jane's atti tude towards marriage.In this article the author will discuss this issue based on Pride and Prejudice.展开更多
Pride and Prejudice is a great realistic novel of the 18th century, in which Jane Austen presents us a central topic on marriage: the plots of the novels and the actions of the characters revolve around marriage.The t...Pride and Prejudice is a great realistic novel of the 18th century, in which Jane Austen presents us a central topic on marriage: the plots of the novels and the actions of the characters revolve around marriage.The thesis analyzes women's opinion on marriage in different two times-the end of the 18th century, the beginning of the 19th century and modern society. How the novel influence the people's views of marriage in that period, and what we can learn about marriage from it.展开更多
Pride and Prejudice is the masterpiece of Jane Austen.In her novel,through description of four marriages,Jane Austen expressed such views on marriage:marriages based on economics or superficial qualities such as lust,...Pride and Prejudice is the masterpiece of Jane Austen.In her novel,through description of four marriages,Jane Austen expressed such views on marriage:marriages based on economics or superficial qualities such as lust,money,and appearance will inevitably lead to unhappiness,while those based on mutual understanding and true love will be happy and stable.展开更多
The present paper,by the novel Pride and Prejudice,shows Jane Austen's opinion of marriage.And from which we also can see the executive concern with money of relationship in the English society at that time.Marria...The present paper,by the novel Pride and Prejudice,shows Jane Austen's opinion of marriage.And from which we also can see the executive concern with money of relationship in the English society at that time.Marriage,a special relationship,is also based on money.We all know that love is the basis of marriage,but at that time,in such a historical social environment,a good eco-nomic situation is necessary.展开更多
Austin’s work-Pride and prejudice, demonstrates three key factors of marriage, namely, a certain economic condition is the guarantee to maintain a happy family, and Love is the foundation of a happy marriage, a ratio...Austin’s work-Pride and prejudice, demonstrates three key factors of marriage, namely, a certain economic condition is the guarantee to maintain a happy family, and Love is the foundation of a happy marriage, a rational and serious attitude towards the matrimonial issue.展开更多
Pride and Prejudice enjoys a worldwide appreciation for its readers. By showing different notions held by people in getting married, the author mainly intends to evoke the moral standards and principles beyond simple ...Pride and Prejudice enjoys a worldwide appreciation for its readers. By showing different notions held by people in getting married, the author mainly intends to evoke the moral standards and principles beyond simple love stories and instruct people's prudence in getting married.展开更多
Marriage is usually associated with happiness and harmony. But in Shakespear's Measure for Measure, it seems it is infused with power of law. Is it a clear-cut punishment or reward? Its qualities revolve around th...Marriage is usually associated with happiness and harmony. But in Shakespear's Measure for Measure, it seems it is infused with power of law. Is it a clear-cut punishment or reward? Its qualities revolve around the individual situations in which it occurs, which is interpreted and deployed by characters in the play in different ways.展开更多
This essay aims to discuss and analyse Jane Eyre and Mr. Rochester's attitude towards love and marriage. Struggling for theequality of human dignity crosses through their love from beginning to end. Therefore, we ...This essay aims to discuss and analyse Jane Eyre and Mr. Rochester's attitude towards love and marriage. Struggling for theequality of human dignity crosses through their love from beginning to end. Therefore, we can draw a conclusion--True love and happymarriage are based upon the equality of human dignity between a couple.展开更多
Pride and Prejudice is a masterpiece by Juan Austen.Generally,Austen is considered one of the two major novelists of the Romantic period in the history of British literature,the other is Walter Scott.But her view of l...Pride and Prejudice is a masterpiece by Juan Austen.Generally,Austen is considered one of the two major novelists of the Romantic period in the history of British literature,the other is Walter Scott.But her view of life is totally realistic.She shows the readers the daily life of middle class.This paper investigates different kinds of love and marriages in Pride and Prejudice with feminism,and comes to the conclusion that Jane Austen is a romantic writer as well as a realistic writer.展开更多
Jane Austen,one of the most influential female novelists in the history of world literature,is the first female to break up the monopoly of male writing.Her famous work Pride and Prejudice was created in 1813,which ga...Jane Austen,one of the most influential female novelists in the history of world literature,is the first female to break up the monopoly of male writing.Her famous work Pride and Prejudice was created in 1813,which gained her lasting fame and popularity.In this novel,the characters of the four ladies are impressive:Jane is mild;Charlotte is mediocre;Lydia is ignorant;Elizabeth is wise.Different characters result in different marriages which are moral marriage,utilitarian marriage,sex-oriented marriage and perfect marriage.Through the analysis of the characters and these four marriages,this thesis aims to conclude Jane Austen’s Perception of Marriage,that is,character determines marriage.展开更多
Bible, as one of the most significant sources of western literature, theology and philosophy has been illustrated in many different perspectives. This thesis is going to talk about the marriage philosophy in the Holy ...Bible, as one of the most significant sources of western literature, theology and philosophy has been illustrated in many different perspectives. This thesis is going to talk about the marriage philosophy in the Holy Bible(English and the new international version).展开更多
This paper,by reviewing Vanity Fair,attempts to illustrate the different marriages of the heroines--Becky's and Amelia's.Following that,there is a contrast between their values of love and marriage and analysi...This paper,by reviewing Vanity Fair,attempts to illustrate the different marriages of the heroines--Becky's and Amelia's.Following that,there is a contrast between their values of love and marriage and analysis about their relationships with different lovers.展开更多
Thalassemia is a group of genetically heterogeneous diseases characterized by hemolytic anemia.To investigate molecular characteristics ofα-andβ-thalassemia among young individuals of marriageable age in Guangdong P...Thalassemia is a group of genetically heterogeneous diseases characterized by hemolytic anemia.To investigate molecular characteristics ofα-andβ-thalassemia among young individuals of marriageable age in Guangdong Province,24,788 subjects with suspected thalassemia were genetically tested forα-andβ-thalassemia by GapPCR and reverse dot blot during 2018–2019.For suspected rare thalassemia cases,DNA sequencing was performed to identify rare and unknown thalassemia gene mutations.A total of 14,346 thalassemia carriers were detected,including 7,556 cases ofα-thalassemia with 25 genotypes and 8α-gene mutations identified,5,860 cases ofβ-thalassemia with 18 genotypes and 18β-gene mutations identified,and 930 cases of compoundα/β-thalassemia.Among them,the frequency of--SEA deletion was the highest inα-thalassemia(66.01%),followed by-α3.7(17.98%)and-α.24(8.22%),and the frequency of CD41-42(-TCTT)mutation was the highest inβ-thalassemia(38.38%),followed by IVS-II-654(C>T)(25.67%),-28(A>G)(15.76%),and CD17(10.01%).In addition,5 rare mutations(--THAI and HKαα,CD113,-90,and CD56)were found in the study population.Our results revealed molecular epidemiological background ofα-andβ-thalassemia in Guangdong Province,which can support optimization of thalassemia prevention and control strategies.We demonstrated that thalassemia is heterogeneous with significant geographical differences and population specificity.展开更多
AIM To assess the association of inter-ethnic vs intra-ethnic marriage with severity of coronary artery disease(CAD) in men undergoing angiography.METHODS We conducted a prospective multicenter,multi-ethnic,cross sect...AIM To assess the association of inter-ethnic vs intra-ethnic marriage with severity of coronary artery disease(CAD) in men undergoing angiography.METHODS We conducted a prospective multicenter,multi-ethnic,cross sectional observational study at five hospitals in Saudi Arabia and the United Arab Emirates,in which we used logistic regression analysis with and without adjustment for baseline differences. RESULTS Data were collected for 1068 enrolled patients undergoing coronary angiography for clinical indications during the period of April 1^(st),2013 to March 30^(th),2014. Ethnicities of spouses were available only for male patients. Of those enrolled,687 were married men and constituted the cohort for the present analysis. Intra-ethnic marriages were reported in 70% and inter-ethnic marriages in 30%. After adjusting for baseline differences,interethnic marriage was associated with lower odds of having significant CAD [adjusted odds ratio 0.52(95%CI:0.33,0.81)] or multi-vessel disease(MVD) [adjusted odds ratio 0.57(95%CI:0.37,0.86)]. The adjusted association with left main disease showed a similar trend,but was not statistically significant [adjusted odds ratio 0.74(95%CI:0.41,1.32)]. The association between interethnic marriage and the presence of significant CAD and MVD was not modified by number of concurrent wives(P interaction > 0.05 for both).CONCLUSION Among married men undergoing coronary angiography,inter-ethnic,as compared to intra-ethnic,marriage is associated with lower odds of significant CAD and MVD.展开更多
翻译活动就是一种伦理活动,自然要受到伦理的约束。同时,在不同的社会历史背景下,译者遵从翻译伦理模式呈现历时的动态变化。本文借用安德鲁.切斯特曼的翻译伦理模式对比分析Of Marriage andSingle Life的两个中译本,认为水天同译本遵...翻译活动就是一种伦理活动,自然要受到伦理的约束。同时,在不同的社会历史背景下,译者遵从翻译伦理模式呈现历时的动态变化。本文借用安德鲁.切斯特曼的翻译伦理模式对比分析Of Marriage andSingle Life的两个中译本,认为水天同译本遵循了再现的伦理,何新译本遵循了基于规范的伦理。展开更多
文摘The rising of aging and the declining of birth rates have forced the public to focus on the youth’s view on marriage.Based on critical discourse analysis and combined with Fairclough’s three-dimensional discourse analysis model,this paper builds a“Chinese media News Report Corpus on the topic of‘marriage’”whose news are collected from China Daily.It is found that the discourses are neutral and objective with regard to the advantages and disadvantages of marriage,but in general,it is still a traditional view of marriage that is inevitable and closely related to fertility.Although this is controlled by the policies and the social reasons including declining fertility rate,it deviates from the current view of the youth towards marriage,resulting in many serious consequences such as young people’s rejection.In addition,this research found that male and female have great differences in their views on marriage,and men’s resistance to marriage is far greater than that of women,which is departure from the public’s cognition.The reasons behind this need to be explored in order to solve the marriage and love problems of young people in today’s era and realize the healthy development of young marriage.
文摘Rural marriage has characteristics such as close relationship with labor production,deep integration of traditional culture,shy and introverted expression of subjective emotions,and illegal and rough marriage.The civilization evolution of rural marriage forms is moving towards a path that is conducive to the development of production and the pursuit of happiness for farmers,the construction of rural spiritual civilization,and the comprehensive development of rural society.This study analyzes the direction of the evolution of rural marriage form civilization,predicts the trend of rural marriage form civilization evolution,and proposes the future path of rural marriage form civilization evolution,including adhering to human’s most original value expectations of marriage life,drawing nourishment from excellent traditional Chinese culture,and continuously adjusting marriage and family policy tools to keep up with changes in the world of life.
文摘Introduction: In Nigeria, one of the major reasons for marriage is procreation and married couples look forward to having children within a year or two of marriage. The age of marriage is on the increase in this part of the world. Many women are now increasingly getting engulfed in career and academic pursuits at the detriment of early marriage. Many men are also not interested in marrying women who have no job. There is age-related acceleration of primordial follicle depletion which is of great clinical importance because it is associated with a significant decrease in fecundity. Objective: This study assessed the ages of the marriage of women who attended Fertility and Antenatal clinics at the National Obstetric Fistula Centre and Smile Specialist Hospital, Abakaliki, and their relationship with the fertility pattern of these women. Methods: This was a cross-sectional study of 352 consenting married women who sought and received fertility and Antenatal care at the National Obstetric Fistula Centre and Smile Specialist Hospital Abakaliki, South-East Nigeria between February 1, 2022 and January 31, 2024. Semi-structured questionnaires were administered to the participants over a two-year period. Data was analyzed using IBM SPSS version 20. A test of statistical significance was done using Chi Square. Results: The age group with the highest education was 26 - 30. This was statistically significant (X2 = 90.893, P-value 2 = 294.555, P-value 2 = 173.007, p-value 2 = 129.494, P-value 2 = 169.300, p-value 2 = 279.230, p-value Conclusion: There is increased difficulty at conception at marriage age above 25 years. The major reasons for delayed marriage were academic pursuit and lack of gainful employment. Education of the masses and inclusion of biological dynamics of the female reproductive behaviours as part of the core school curriculum will help enlighten the female and the male folks alike to enable them to make informed decisions with regard to the timing of marriage and commencement of procreation. This will help reduce infertility and save millions of couples the agony associated with infertility.
文摘This paper presents a comprehensive analysis and comparison of the existing literature on the phenomenon of non-marriage or staying unmarried in Asian countries such as China,Japan,South Korea,and Singapore,as well as European and American countries such as Spain and the US,and explores the trends,characteristics as well as reasons behind such a phenomenon.Through analysis,the present study found that there is a growing trend of postponed marriage and parenthood as well as an increasing proportion of individuals who exhibit no enthusiasm towards matrimony or parenthood in the aforementioned countries.To some extent,non-marriage or postponed marriage has become a prevalent trend in developed countries and even some developing countries.Japan,South Korea,and several developed countries in Europe and America have exhibited this phenomenon since the middle to late 20th century,with a relatively long history.The emergence of this phenomenon in China,Malaysia,the Philippines,and other developing countries in Asia,however,was relatively late,exhibiting a gradual development process.The current marriage landscape in China is characterized by a growing number of non-marriage individuals and a significant level of marital stability.In terms of reasons for staying unmarried,the marriage rates in the aforementioned countries can be attributed to various factors at macro,meso,and micro levels.In China,the phenomenon of non-marriage is closely associated with a range of factors,including diverse values and attitudes towards romance and marriage,marriage squeeze,education expansion,and the rise in females’economic and social status.The emphasis in future research should be placed on predicting the phenomenon of non-marriage,with a specific focus on exploring the reasons for advocating non-marriage,examining the internal mechanisms underlying this phenomenon,analyzing the consequences of non-marriage,and proposing corresponding countermeasures while establishing the public identity towards marriage.
文摘Marriage is a very important part in one's life.But different countries have different wedding ceremonies because of the culture difference.western wedding is simple while Chinese wedding is complex.No matter you choose the Chinese style or the western style,you should marry the one you love best,and then you can enjoy a beautiful life.
文摘At the very beginning of the book-Pride and Prejudice,the author said"It is universally acknowledged that a single man in possession of a good fortune must be want of a wife."From this line,we can find that marriage is the most important thing to women.Sometimes it even equals to men's career at that time.It seems like once a woman married to a rich single man,she succeed in her lifetime"career".The question is what is the standard of that"succeed"? Married to a rich man,or the man you really love,or a man you had a crush on? Everyone keep these questions in mind since very early time,and different people have different opinions.In her short life,Jane Austin,the great novelist,composed six novels and created lot of female characters.Women in her novel had different attitudes toward marriage.Speaking of marriage,Pride and Prejudice must be the most representative work of it,and it is also Jane's masterpiece.Through the different type of marriage of Mr.Bennet's daughters,we can find the Jane's atti tude towards marriage.In this article the author will discuss this issue based on Pride and Prejudice.
文摘Pride and Prejudice is a great realistic novel of the 18th century, in which Jane Austen presents us a central topic on marriage: the plots of the novels and the actions of the characters revolve around marriage.The thesis analyzes women's opinion on marriage in different two times-the end of the 18th century, the beginning of the 19th century and modern society. How the novel influence the people's views of marriage in that period, and what we can learn about marriage from it.
文摘Pride and Prejudice is the masterpiece of Jane Austen.In her novel,through description of four marriages,Jane Austen expressed such views on marriage:marriages based on economics or superficial qualities such as lust,money,and appearance will inevitably lead to unhappiness,while those based on mutual understanding and true love will be happy and stable.
文摘The present paper,by the novel Pride and Prejudice,shows Jane Austen's opinion of marriage.And from which we also can see the executive concern with money of relationship in the English society at that time.Marriage,a special relationship,is also based on money.We all know that love is the basis of marriage,but at that time,in such a historical social environment,a good eco-nomic situation is necessary.
文摘Austin’s work-Pride and prejudice, demonstrates three key factors of marriage, namely, a certain economic condition is the guarantee to maintain a happy family, and Love is the foundation of a happy marriage, a rational and serious attitude towards the matrimonial issue.
文摘Pride and Prejudice enjoys a worldwide appreciation for its readers. By showing different notions held by people in getting married, the author mainly intends to evoke the moral standards and principles beyond simple love stories and instruct people's prudence in getting married.
文摘Marriage is usually associated with happiness and harmony. But in Shakespear's Measure for Measure, it seems it is infused with power of law. Is it a clear-cut punishment or reward? Its qualities revolve around the individual situations in which it occurs, which is interpreted and deployed by characters in the play in different ways.
文摘This essay aims to discuss and analyse Jane Eyre and Mr. Rochester's attitude towards love and marriage. Struggling for theequality of human dignity crosses through their love from beginning to end. Therefore, we can draw a conclusion--True love and happymarriage are based upon the equality of human dignity between a couple.
文摘Pride and Prejudice is a masterpiece by Juan Austen.Generally,Austen is considered one of the two major novelists of the Romantic period in the history of British literature,the other is Walter Scott.But her view of life is totally realistic.She shows the readers the daily life of middle class.This paper investigates different kinds of love and marriages in Pride and Prejudice with feminism,and comes to the conclusion that Jane Austen is a romantic writer as well as a realistic writer.
文摘Jane Austen,one of the most influential female novelists in the history of world literature,is the first female to break up the monopoly of male writing.Her famous work Pride and Prejudice was created in 1813,which gained her lasting fame and popularity.In this novel,the characters of the four ladies are impressive:Jane is mild;Charlotte is mediocre;Lydia is ignorant;Elizabeth is wise.Different characters result in different marriages which are moral marriage,utilitarian marriage,sex-oriented marriage and perfect marriage.Through the analysis of the characters and these four marriages,this thesis aims to conclude Jane Austen’s Perception of Marriage,that is,character determines marriage.
文摘Bible, as one of the most significant sources of western literature, theology and philosophy has been illustrated in many different perspectives. This thesis is going to talk about the marriage philosophy in the Holy Bible(English and the new international version).
文摘This paper,by reviewing Vanity Fair,attempts to illustrate the different marriages of the heroines--Becky's and Amelia's.Following that,there is a contrast between their values of love and marriage and analysis about their relationships with different lovers.
基金the Data quality evaluation study of the national free preconception eugenics health screening program[No.C2018033]。
文摘Thalassemia is a group of genetically heterogeneous diseases characterized by hemolytic anemia.To investigate molecular characteristics ofα-andβ-thalassemia among young individuals of marriageable age in Guangdong Province,24,788 subjects with suspected thalassemia were genetically tested forα-andβ-thalassemia by GapPCR and reverse dot blot during 2018–2019.For suspected rare thalassemia cases,DNA sequencing was performed to identify rare and unknown thalassemia gene mutations.A total of 14,346 thalassemia carriers were detected,including 7,556 cases ofα-thalassemia with 25 genotypes and 8α-gene mutations identified,5,860 cases ofβ-thalassemia with 18 genotypes and 18β-gene mutations identified,and 930 cases of compoundα/β-thalassemia.Among them,the frequency of--SEA deletion was the highest inα-thalassemia(66.01%),followed by-α3.7(17.98%)and-α.24(8.22%),and the frequency of CD41-42(-TCTT)mutation was the highest inβ-thalassemia(38.38%),followed by IVS-II-654(C>T)(25.67%),-28(A>G)(15.76%),and CD17(10.01%).In addition,5 rare mutations(--THAI and HKαα,CD113,-90,and CD56)were found in the study population.Our results revealed molecular epidemiological background ofα-andβ-thalassemia in Guangdong Province,which can support optimization of thalassemia prevention and control strategies.We demonstrated that thalassemia is heterogeneous with significant geographical differences and population specificity.
文摘AIM To assess the association of inter-ethnic vs intra-ethnic marriage with severity of coronary artery disease(CAD) in men undergoing angiography.METHODS We conducted a prospective multicenter,multi-ethnic,cross sectional observational study at five hospitals in Saudi Arabia and the United Arab Emirates,in which we used logistic regression analysis with and without adjustment for baseline differences. RESULTS Data were collected for 1068 enrolled patients undergoing coronary angiography for clinical indications during the period of April 1^(st),2013 to March 30^(th),2014. Ethnicities of spouses were available only for male patients. Of those enrolled,687 were married men and constituted the cohort for the present analysis. Intra-ethnic marriages were reported in 70% and inter-ethnic marriages in 30%. After adjusting for baseline differences,interethnic marriage was associated with lower odds of having significant CAD [adjusted odds ratio 0.52(95%CI:0.33,0.81)] or multi-vessel disease(MVD) [adjusted odds ratio 0.57(95%CI:0.37,0.86)]. The adjusted association with left main disease showed a similar trend,but was not statistically significant [adjusted odds ratio 0.74(95%CI:0.41,1.32)]. The association between interethnic marriage and the presence of significant CAD and MVD was not modified by number of concurrent wives(P interaction > 0.05 for both).CONCLUSION Among married men undergoing coronary angiography,inter-ethnic,as compared to intra-ethnic,marriage is associated with lower odds of significant CAD and MVD.