BACKGROUND： It has been reported that cerebrovascular disease causes changes in electrocardiogram results. OBJECTIVE： To investigate changes in electrocardiogram results in patients with intracerebral bematoma enlar...BACKGROUND： It has been reported that cerebrovascular disease causes changes in electrocardiogram results. OBJECTIVE： To investigate changes in electrocardiogram results in patients with intracerebral bematoma enlargement. DESIGN, TIME AND SETTING： The present case-retrospective analysis study was performed at the Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology from January 2005 to October 2006. PARTICIPANTS： A total of 225 intracerebral hemorrhage patients （142 males and 83 females） that were hospitalized at the Department of Neurology were enrolled the present study. The patient selection was in accordance with diagnostic criteria from the Fourth National Cerebrovascular Disease Congress of China in 1995, and diagnosis was confirmed using computed tomography. All patients underwent computed tomography twice within 24 hours following intracerebral hemorrhage, and were subjected to electrocardiogram examination after admission. METHODS： According to hematoma enlargement following intracerebral hemorrhage, all patients were divided into hematoma enlargement （n = 20） and non-hematoma enlargement （n = 205） groups. Because of the large patient number difference between the two groups, the hematoma enlargement group was matched with the non-hematoma enlargement group. Patients meeting these conditions were included in the non-hematoma enlargement group. Finally, 75 patients were included in the final analysis, 19 in the hematoma enlargement group and 56 in the non-hematoma enlargement group. Clinical data from the two groups were statistically analyzed. MAIN OUTCOME MEASURES： The incidence of electrocardiographic abnormalities between the hematoma enlargement and non-hematoma enlargement groups. RESULTS： In the hematoma enlargement group, 15 patients （79%） developed electrocardiographic abnormafities. In the non-hematoma enlargement group, 24 patients （43%） presented with electrocardiographic abnormalities. There were significant differences in electrocardiographic abnormalities between the groups （P 〈 0.01）. CONCLUSION： Patients with electrocardiographic abnormalities suffered from hematoma enlargement following admission.展开更多
目的:探讨颅脑CT平扫影像学征象对脑出血患者预后的预测价值。方法:选取103例脑出血患者为研究对象,根据预后不同分为预后良好组(n=67)和预后不良组(n=36)。比较两组患者一般资料、颅脑CT平扫影像学征象检出率,分析脑出血患者颅脑CT平...目的:探讨颅脑CT平扫影像学征象对脑出血患者预后的预测价值。方法:选取103例脑出血患者为研究对象,根据预后不同分为预后良好组(n=67)和预后不良组(n=36)。比较两组患者一般资料、颅脑CT平扫影像学征象检出率,分析脑出血患者颅脑CT平扫影像学征象与90 d Rankin评分量表(mRS)评分的相关性及其对脑出血患者预后的预测价值。结果:预后不良组患者出血体积大于预后良好组(P<0.05);除卫星征以外的各项颅脑CT平扫影像学征象检出率及检出≥2个颅脑CT平扫影像学征象发生率高于预后良好组(P<0.05);90 d mRS评分低于预后不良组(P<0.05)。相关性分析显示,漩涡征、黑洞征、海岛征、卫星征及检出≥2个颅脑CT平扫影像学征象均与90 d mRS评分呈正相关关系(P<0.05)。ROC曲线分析显示,漩涡征、海岛征及检出≥2个CT影像学征象预测脑出血患者预后的曲线下面积(AUC)分别为0.605、0.653、0.662,均对脑出血预后有预测价值(P<0.05)。结论:颅脑CT平扫影像学征象与脑出血患者90 d mRS评分相关,可用于预测脑出血患者的预后。展开更多
In Alzheimer’s disease and ischemic stroke,intranasal insulin can act as a neuroprotective agent.However,whether intranasal insulin has a neuroprotective effect in intracerebral hemorrhage and its potential mechanism...In Alzheimer’s disease and ischemic stroke,intranasal insulin can act as a neuroprotective agent.However,whether intranasal insulin has a neuroprotective effect in intracerebral hemorrhage and its potential mechanisms remain poorly understood.In this study,a mouse model of autologous blood-induced intracerebral hemorrhage was treated with 0.5,1,or 2 IU insulin via intranasal delivery,twice per day,until 24 or 72 hours after surgery.Compared with saline treatment,1 IU intranasal insulin treatment significantly reduced hematoma volume and brain edema after cerebral hemorrhage,decreased blood-brain barrier permeability and neuronal degeneration damage,reduced neurobehavioral deficits,and improved the survival rate of mice.Expression levels of p-AKT and p-GSK3βwere significantly increased in the perihematoma tissues after intranasal insulin therapy.Our findings suggest that intranasal insulin therapy can protect the neurological function of mice after intracerebral hemorrhage through the AKT/GSK3βsignaling pathway.The study was approved by the Ethics Committee of the North Sichuan Medical College of China(approval No.NSMC(A)2019(01))on January 7,2019.展开更多
目的探讨机器人引导下穿刺引流10~30 mL脑内小血肿的临床效果。方法采用回顾性病例对照研究。选取2019年1月至2022年12月在梅州市人民医院接受治疗的83例高血压脑出血患者,依据治疗方法不同分为机器人手术组(观察组)39例和保守治疗组(...目的探讨机器人引导下穿刺引流10~30 mL脑内小血肿的临床效果。方法采用回顾性病例对照研究。选取2019年1月至2022年12月在梅州市人民医院接受治疗的83例高血压脑出血患者,依据治疗方法不同分为机器人手术组(观察组)39例和保守治疗组(对照组)44例。比较两组患者临床效果、住院期间并发症发生情况、住院时间及住院费用、出院时及出院3个月时基础性日常生活能力量表(basic activity of daily living scale,BADL)评分及美国国立卫生研究院卒中量表(National Institute of Health stroke scale,NIHSS)评分。结果①入院时两组NIHSS评分和BADL评分无统计学差异(P>0.05);但出院时、出院3个月随访时观察组NIHSS评分更低(P<0.05),BADL评分更高(P<0.05)。②观察组和对照组的平均住院时间分别为(12.8±3.3)d和(13.8±4.0)d,两组比较无统计学差异(P=0.252)。观察组和对照组的住院费用分别为(38496.23±6369.06)元和(19258.36±4068.68)元,观察组高于对照组(P<0.05)。③观察组和对照组的并发症发生率分别为2.6%(1/39)和6.8%(3/44)。观察组发生穿刺行程区出血1例,对照组并发肺部感染3例,两组比较无统计学差异(P>0.05)。结论机器人引导下穿刺引流10~30 mL脑内小血肿的疗效较好,术后并发症少,操作便捷简单,可促进患者术后功能的恢复,有效提高患者的生活质量。展开更多
基金the National Natural Science Foundation of China, No. 30570628, 30770751
文摘BACKGROUND： It has been reported that cerebrovascular disease causes changes in electrocardiogram results. OBJECTIVE： To investigate changes in electrocardiogram results in patients with intracerebral bematoma enlargement. DESIGN, TIME AND SETTING： The present case-retrospective analysis study was performed at the Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology from January 2005 to October 2006. PARTICIPANTS： A total of 225 intracerebral hemorrhage patients （142 males and 83 females） that were hospitalized at the Department of Neurology were enrolled the present study. The patient selection was in accordance with diagnostic criteria from the Fourth National Cerebrovascular Disease Congress of China in 1995, and diagnosis was confirmed using computed tomography. All patients underwent computed tomography twice within 24 hours following intracerebral hemorrhage, and were subjected to electrocardiogram examination after admission. METHODS： According to hematoma enlargement following intracerebral hemorrhage, all patients were divided into hematoma enlargement （n = 20） and non-hematoma enlargement （n = 205） groups. Because of the large patient number difference between the two groups, the hematoma enlargement group was matched with the non-hematoma enlargement group. Patients meeting these conditions were included in the non-hematoma enlargement group. Finally, 75 patients were included in the final analysis, 19 in the hematoma enlargement group and 56 in the non-hematoma enlargement group. Clinical data from the two groups were statistically analyzed. MAIN OUTCOME MEASURES： The incidence of electrocardiographic abnormalities between the hematoma enlargement and non-hematoma enlargement groups. RESULTS： In the hematoma enlargement group, 15 patients （79%） developed electrocardiographic abnormafities. In the non-hematoma enlargement group, 24 patients （43%） presented with electrocardiographic abnormalities. There were significant differences in electrocardiographic abnormalities between the groups （P 〈 0.01）. CONCLUSION： Patients with electrocardiographic abnormalities suffered from hematoma enlargement following admission.
文摘目的:探讨颅脑CT平扫影像学征象对脑出血患者预后的预测价值。方法:选取103例脑出血患者为研究对象,根据预后不同分为预后良好组(n=67)和预后不良组(n=36)。比较两组患者一般资料、颅脑CT平扫影像学征象检出率,分析脑出血患者颅脑CT平扫影像学征象与90 d Rankin评分量表(mRS)评分的相关性及其对脑出血患者预后的预测价值。结果:预后不良组患者出血体积大于预后良好组(P<0.05);除卫星征以外的各项颅脑CT平扫影像学征象检出率及检出≥2个颅脑CT平扫影像学征象发生率高于预后良好组(P<0.05);90 d mRS评分低于预后不良组(P<0.05)。相关性分析显示,漩涡征、黑洞征、海岛征、卫星征及检出≥2个颅脑CT平扫影像学征象均与90 d mRS评分呈正相关关系(P<0.05)。ROC曲线分析显示,漩涡征、海岛征及检出≥2个CT影像学征象预测脑出血患者预后的曲线下面积(AUC)分别为0.605、0.653、0.662,均对脑出血预后有预测价值(P<0.05)。结论:颅脑CT平扫影像学征象与脑出血患者90 d mRS评分相关,可用于预测脑出血患者的预后。
基金supported by the National Natural Science Foundation of China,No.81971220a grant from the Science and Technology Department of Sichuan Province of China,No.2018JY0236(both to GHJ)。
文摘In Alzheimer’s disease and ischemic stroke,intranasal insulin can act as a neuroprotective agent.However,whether intranasal insulin has a neuroprotective effect in intracerebral hemorrhage and its potential mechanisms remain poorly understood.In this study,a mouse model of autologous blood-induced intracerebral hemorrhage was treated with 0.5,1,or 2 IU insulin via intranasal delivery,twice per day,until 24 or 72 hours after surgery.Compared with saline treatment,1 IU intranasal insulin treatment significantly reduced hematoma volume and brain edema after cerebral hemorrhage,decreased blood-brain barrier permeability and neuronal degeneration damage,reduced neurobehavioral deficits,and improved the survival rate of mice.Expression levels of p-AKT and p-GSK3βwere significantly increased in the perihematoma tissues after intranasal insulin therapy.Our findings suggest that intranasal insulin therapy can protect the neurological function of mice after intracerebral hemorrhage through the AKT/GSK3βsignaling pathway.The study was approved by the Ethics Committee of the North Sichuan Medical College of China(approval No.NSMC(A)2019(01))on January 7,2019.
文摘目的探讨机器人引导下穿刺引流10~30 mL脑内小血肿的临床效果。方法采用回顾性病例对照研究。选取2019年1月至2022年12月在梅州市人民医院接受治疗的83例高血压脑出血患者,依据治疗方法不同分为机器人手术组(观察组)39例和保守治疗组(对照组)44例。比较两组患者临床效果、住院期间并发症发生情况、住院时间及住院费用、出院时及出院3个月时基础性日常生活能力量表(basic activity of daily living scale,BADL)评分及美国国立卫生研究院卒中量表(National Institute of Health stroke scale,NIHSS)评分。结果①入院时两组NIHSS评分和BADL评分无统计学差异(P>0.05);但出院时、出院3个月随访时观察组NIHSS评分更低(P<0.05),BADL评分更高(P<0.05)。②观察组和对照组的平均住院时间分别为(12.8±3.3)d和(13.8±4.0)d,两组比较无统计学差异(P=0.252)。观察组和对照组的住院费用分别为(38496.23±6369.06)元和(19258.36±4068.68)元,观察组高于对照组(P<0.05)。③观察组和对照组的并发症发生率分别为2.6%(1/39)和6.8%(3/44)。观察组发生穿刺行程区出血1例,对照组并发肺部感染3例,两组比较无统计学差异(P>0.05)。结论机器人引导下穿刺引流10~30 mL脑内小血肿的疗效较好,术后并发症少,操作便捷简单,可促进患者术后功能的恢复,有效提高患者的生活质量。
