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The role of intraoperative neurophysiological monitoring in intramedullary spinal cord tumor surgery
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作者 Kai Liu Chengyuan Ma +6 位作者 Dapeng Li Haisong Li Xuechao Dong Bo Liu Ying Yu Yuxiang Fan Hongmei Song 《Chinese Neurosurgical Journal》 CAS CSCD 2024年第1期57-66,共10页
Intramedullary tumors are a class of central nervous system tumors with an incidence of 2 to 4%.As they are located very deep and frequently cause postoperative neurological complications,surgical resection is difficu... Intramedullary tumors are a class of central nervous system tumors with an incidence of 2 to 4%.As they are located very deep and frequently cause postoperative neurological complications,surgical resection is difficult.In recent years,many surgeons have performed electrophysiological monitoring to effectively reduce the occurrence of post-operative neurological complications.Modern electrophysiological monitoring technology has advanced considerably,leading to the development of many monitoring methods,such as SSEPs,MEPs,DCM,and EMG,to monitor intramedullary tumors.However,electrophysiological monitoring in tumor resection is still being studied.In this article,we discussed the different monitoring methods and their role in monitoring intramedullary tumors by reviewing previous studies.Intratumorally tumors need to be monitored for a summary of the condition of the patient.Only by using various monitoring methods flexibly and through clear communication between surgeons and neurophysiological experts can good decisions be made during surgery and positive surgical results be achieved. 展开更多
关键词 intramedullary spinal cord tumor Intraoperative neurophysiological monitoring D-WAVE
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Leveraging nano-engineered mesenchymal stem cells for intramedullary spinal cord tumor treatment 被引量:1
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作者 Lu Tang Mengying Xie +6 位作者 Jing Li Yijun Mei Yuqi Cao Qiaqia Xiao Haijuan Dong Yuhui Zhang Wei Wang 《Chinese Chemical Letters》 SCIE CAS CSCD 2023年第5期449-455,共7页
Intramedullary spinal cord tumor(IMSCT)is comparatively rare malignant tumor in the central nervous system and is very difficult accessible by conventional chemotherapy regimen.Currently,there are very limited researc... Intramedullary spinal cord tumor(IMSCT)is comparatively rare malignant tumor in the central nervous system and is very difficult accessible by conventional chemotherapy regimen.Currently,there are very limited researches for IMSCT treatment using nanomedicine.To fill this gap,we originally reported a targeted strategy by leveraging nano-engineered mesenchymal stem cells(MSCs)for synergistic antiIMSCT treatment.In this study,two mode drugs paclitaxel(PTX)and metformin(MET)were co-loaded in maleimide-modified poly(lactic-co-glycolicacid)(PLGA-MAL)nanoparticles,which were further conjugated onto MSCs surface via the thioether bond formed between PLGA-MAL and MSCs without affecting the migration ability of MSCs.Owing to the excellent tumor tropism and penetrability of MSCs and good biodegradability of PLGA,the designed drug delivery platform could accurately target IMSCT sites to exert long-term synergistic antitumor efficacy,exhibiting promising research value for alternative IMSCT management beyond surgery. 展开更多
关键词 Mesenchymal stem cell intramedullary spinal cord tumor METFORMIN Nanosystem Targeted drug delivery
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