Level of Copper Ion in Cervical Mucus of Various Duration after Inserting VCu200IUD

The purpose of the study was to test the effective period of VCu200 IUD.The concentration of copper ion was measured with non-flame atomic absorption spectrophotometer HITACHI-180.The average concentration of coPPer ion(x±s.)was 2.66±0.58μg/g cervical mucus wet weight(μg/g·M·W·W) in the first year,then gradually decreasing to 0.91±0.16μg/g·M·W·W in the fifteenth-year group of VCu200 IUD.There was an average of 0.35±0.08～0.56±0.14 μg/g·M·W·W in the control group.It showed that the concentration of copper ion was decreasing with prolongation of use of VCu200 IUD and there was statistically significant difference between VCu200 IUD group,on the one hand,and the stainless steel ring group and the control group(P<0.05～0.01)on the other hand.No difference was found between the stainless steel ring group and the control group(P>0.05).It was reported in the literature that the concentration Of copper ion in 1.0μg/ml had the action of antifertility,and it was found that the concentration of copper ion was higher than 1.0μg/ml in the tenth year after insertion of VCu200 IUD.It suggested that effective period of VCu200 IUD was at least ten years.

放置VCu200 IUD不同年限宫颈粘液含铜量

本文用无火焰原子吸收分光光度仪ＨＩＴＡＣＨＩ－１８０测试置ＶＣｕ２００ＩＵＤ妇女宫颈粘液含铜量２６７例。其结果为自第１年平均含铜量２．６６±０．５８μｇ／ｇ粘液湿重至第１５年降为０．９１±０．６μｇ／ｇ粘液湿重，显示宫颈粘液含铜量随放置时间延长而渐减少。金属圆环组２１４例，各不同年限宫颈粘液含铜量平均为０．３５±０．０８～０．５６±０．１４μｇ／ｇ粘液湿重。未带器组２１例宫颈粘液平均含铜量为０．４７±０．１１μｇ／ｇ粘液湿重，ＶＣｕ２００组与金属圆环组各年限相比均有显著差异（Ｐ＜０．０５～０．００１）。与未带器组比各年ｆＫ亦皆有显著差异（Ｐ＜０．０５～０．００１）。文献报道铜离子浓度达１．０μｇ／ｍｌ有杀死或抑制精子活动的作用，浓度为０．７μｇ／ｍｌ能使孕卵胚泡中毒。本文置ＶＣｕ１２００ＩＵＤ者第１０年时铜离子含量为１．１１μｇ／ｇ粘液湿重，第１５年为０．９１±０．１μｇ／ｇ粘液湿重，依此推测ＶＣｕ２００ＩＵＤ至少可放置１０年以上。

放置T_（Cu）200和T_（Cu）220宫内节育器后一年半内宫颈粘液中铜离子释放规律

用原子吸收法对使用Ｔ（Ｃｕ）２００和Ｔ（Ｃｕ）２２０型宫内节育器妇女的围排卵期宫颈粘液中铜离子浓度进行测定，以自身未带器前（Ｏ期）为对照。结果，带器者在第１，３，６，１２，１８个月宫颈粘液铜离子的平均浓度分别为；３．１８８，２．６９５，２．３２３，２．２４７，２．１１６μｇ／ｇ粘液湿重，与未带器前含铜量（０．８１８）相比，均有非常显著性差异（Ｐ＜０．０１），铜离子释放量随时间延长而逐渐减少。

含铜宫内节育器取出前后宫颈黏液铜离子浓度变化分析

目的:了解含铜宫内节育器(IUD)取出前后宫颈铜离子浓度的变化。方法:采用前瞻性队列研究的方法,暴露组为使用IUD 3个月以上妇女,对照组为使用避孕套避孕且从未放置过含铜IUD的妇女,测定并分析暴露组取器前及取器后1个月、6个月宫颈黏液铜离子浓度差异,并与对照组比较,测定使用IUD不同时间者和使用不同铜表面积IUD者宫颈黏液的铜离子浓度。结果:暴露组取器前宫颈黏液铜离子浓度为2.1(1.4,4.9)μg/g,显著高于对照组的0.2(0.1,0.3)μg/g(Z=-10.4,P<0.0001);取器后1个月铜离子浓度为0.2(0.1,0.3)μg/g,6个月为0.2(0.1,0.3)μg/g,与对照组结果相似(Z=-0.72,P=0.47;Z=-0.86,P=0.38);使用IUD不同时间者取器前宫颈黏液铜离子浓度无统计学差异(χ^2=3.35,P=0.34)。使用铜表面积≥300mm^2 IUD者取器前宫颈黏液铜离子浓度为2.2(1.0,15.3)μg/g,使用铜面积<300 mm^2 IUD者为2.1(1.4,3.9)μg/g,差异无统计学意义(Z=0.29,P=0.77)。结论:使用IUD妇女取器后1个月宫颈黏液的铜离子浓度即恢复到正常水平,且取器前宫颈黏液的铜离子浓度与IUD使用时长短与IUD铜表面积无关。