BACKGROUND Intravascular papillary endothelial hyperplasia(IPEH)is a rare benign reactive vascular lesion that grows into an expansile compressing mass.It most commonly involves the skin and subcutaneous tissue.Spinal...BACKGROUND Intravascular papillary endothelial hyperplasia(IPEH)is a rare benign reactive vascular lesion that grows into an expansile compressing mass.It most commonly involves the skin and subcutaneous tissue.Spinal involvement is rare,with only 11 reported cases in the literature.We report,to our knowledge,the first case of IPEH in the cervicothoracic spinal canal and present a literature review.CASE SUMMARY A 27-year-old man presented with acute-onset neck pain,numbness,and weakness in his extremities.Magnetic resonance imaging showed an epidural mass in the cervicothoracic(C6-T1)spinal canal and vertebral hemangioma(VH)involving the C7 vertebral body.C6-T1 Laminectomy and radical excision of the mass were performed.Histopathological examinations revealed papillary proliferation of vascular endothelial cells with thrombus formation,and an IPEH diagnosis was made.By his 6-mo follow-up appointment,his symptoms were relieved without recurrence.The possible pathogenesis,clinical and imaging features,differential diagnosis,and management of IPEH were reviewed.CONCLUSION We report,to our knowledge,the first case of IPEH in the cervicothoracic spinal canal,treated via complete resection,and showing a favorable outcome.We found a causal relationship between spinal IPEH and VH;this partly explains the mechanism of IPEH.展开更多
Intravascular papillary endothelial hyperplasia is an unusual benign vascular lesion of the skin and subcutaneous tissue consisting of papillary formations lined with proliferative endothelial cells. The clinical char...Intravascular papillary endothelial hyperplasia is an unusual benign vascular lesion of the skin and subcutaneous tissue consisting of papillary formations lined with proliferative endothelial cells. The clinical characteristic is not specific and the diagnosis is based on histological examination. The lesion is often mistaken for angiosarcoma and a group of other benign and malignant vascular lesions. IPEH has been relatively rarely described in the head and neck region. An uncommon case located in the submandibular and sublingual region is presented which was misinterpreted as venous malformations and malignant tumors of vascular origin initially. A surgical excision was performed and no recurrences have been found after 5 years of follow-up.展开更多
Primary retroperitoneal tumors are rare, and benign retroperitoneal tumors are exceptionally rare. Herein, we present a very rare case of benign concomitant retroperitoneal intramuscular hemangioma and intravascular p...Primary retroperitoneal tumors are rare, and benign retroperitoneal tumors are exceptionally rare. Herein, we present a very rare case of benign concomitant retroperitoneal intramuscular hemangioma and intravascular papillary endothelial hyperplasia, with the unusual presentation of lumbosacral plexopathy. After surgical treatment and rehabilitation, the patient recovered uneventfully. This case report should serve to remind physicians of the rare condition of a retroperitoneal tumor leading to a neurological deficit.展开更多
报告1例血管内乳头状内皮细胞增生。患者女,42岁。左手小指近端肿物伴疼痛半年余。皮肤科检查:左手小指近端见一隆起于皮面、直径约2 cm 的结节,结节表面肤色正常,硬度适中,活动度小,与皮肤无明显粘连,压痛明显。皮损组织病理检查:皮下...报告1例血管内乳头状内皮细胞增生。患者女,42岁。左手小指近端肿物伴疼痛半年余。皮肤科检查:左手小指近端见一隆起于皮面、直径约2 cm 的结节,结节表面肤色正常,硬度适中,活动度小,与皮肤无明显粘连,压痛明显。皮损组织病理检查:皮下见大的血管管腔,并从管壁伸出乳头状突起,中轴为纤维组织增生,管腔内大量红细胞,并见大量内皮细胞增生,形成网状的血管管腔,可见深染略有多形的核,但无明显的核非典型性及有丝分裂象,团块中央部位可见含铁血黄素沉积,弹性纤维染色呈阳性。免疫组化染色 CD31、CD34、FⅧ阳性。组织病理诊断:血管内乳头状内皮细胞增生。展开更多
基金Guangdong Medical Science and Technology Research Fund Project,No.A2021454.
文摘BACKGROUND Intravascular papillary endothelial hyperplasia(IPEH)is a rare benign reactive vascular lesion that grows into an expansile compressing mass.It most commonly involves the skin and subcutaneous tissue.Spinal involvement is rare,with only 11 reported cases in the literature.We report,to our knowledge,the first case of IPEH in the cervicothoracic spinal canal and present a literature review.CASE SUMMARY A 27-year-old man presented with acute-onset neck pain,numbness,and weakness in his extremities.Magnetic resonance imaging showed an epidural mass in the cervicothoracic(C6-T1)spinal canal and vertebral hemangioma(VH)involving the C7 vertebral body.C6-T1 Laminectomy and radical excision of the mass were performed.Histopathological examinations revealed papillary proliferation of vascular endothelial cells with thrombus formation,and an IPEH diagnosis was made.By his 6-mo follow-up appointment,his symptoms were relieved without recurrence.The possible pathogenesis,clinical and imaging features,differential diagnosis,and management of IPEH were reviewed.CONCLUSION We report,to our knowledge,the first case of IPEH in the cervicothoracic spinal canal,treated via complete resection,and showing a favorable outcome.We found a causal relationship between spinal IPEH and VH;this partly explains the mechanism of IPEH.
文摘Intravascular papillary endothelial hyperplasia is an unusual benign vascular lesion of the skin and subcutaneous tissue consisting of papillary formations lined with proliferative endothelial cells. The clinical characteristic is not specific and the diagnosis is based on histological examination. The lesion is often mistaken for angiosarcoma and a group of other benign and malignant vascular lesions. IPEH has been relatively rarely described in the head and neck region. An uncommon case located in the submandibular and sublingual region is presented which was misinterpreted as venous malformations and malignant tumors of vascular origin initially. A surgical excision was performed and no recurrences have been found after 5 years of follow-up.
文摘Primary retroperitoneal tumors are rare, and benign retroperitoneal tumors are exceptionally rare. Herein, we present a very rare case of benign concomitant retroperitoneal intramuscular hemangioma and intravascular papillary endothelial hyperplasia, with the unusual presentation of lumbosacral plexopathy. After surgical treatment and rehabilitation, the patient recovered uneventfully. This case report should serve to remind physicians of the rare condition of a retroperitoneal tumor leading to a neurological deficit.
文摘报告1例血管内乳头状内皮细胞增生。患者女,42岁。左手小指近端肿物伴疼痛半年余。皮肤科检查:左手小指近端见一隆起于皮面、直径约2 cm 的结节,结节表面肤色正常,硬度适中,活动度小,与皮肤无明显粘连,压痛明显。皮损组织病理检查:皮下见大的血管管腔,并从管壁伸出乳头状突起,中轴为纤维组织增生,管腔内大量红细胞,并见大量内皮细胞增生,形成网状的血管管腔,可见深染略有多形的核,但无明显的核非典型性及有丝分裂象,团块中央部位可见含铁血黄素沉积,弹性纤维染色呈阳性。免疫组化染色 CD31、CD34、FⅧ阳性。组织病理诊断:血管内乳头状内皮细胞增生。
