A new class of 3-phenyl-4-substituted-β-carbolines via iodine-mediated electrophilic cyclization as key step were synthesized and their inhibitory activity against three tumor cell lines was evaluated in vitro. It wa...A new class of 3-phenyl-4-substituted-β-carbolines via iodine-mediated electrophilic cyclization as key step were synthesized and their inhibitory activity against three tumor cell lines was evaluated in vitro. It was found that some of the tested compounds showed better cytotoxicity against HeLa and MCF-7 cells than harmine.展开更多
基金supported by NSFC(No.20602010)Scientific Research Fund of Hunan Provincial Education Department(No.10B061) and Program for Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province
文摘A new class of 3-phenyl-4-substituted-β-carbolines via iodine-mediated electrophilic cyclization as key step were synthesized and their inhibitory activity against three tumor cell lines was evaluated in vitro. It was found that some of the tested compounds showed better cytotoxicity against HeLa and MCF-7 cells than harmine.
