Imidazo[1,2-a]pyridines are unique nitrogen-containing organic compounds with wide applications in pharma-ceuticals,natural products,material science and organometallics.Due to their significant biological and synthet...Imidazo[1,2-a]pyridines are unique nitrogen-containing organic compounds with wide applications in pharma-ceuticals,natural products,material science and organometallics.Due to their significant biological and synthetic value,the construction of imidazo[1,2-a]pyridine scaffolds has been a highly intriguing research topic,and substantial progress had been made in the past decades.In this review,we aim to summarize the current advances in direct C–H functionalization of imidazo[1,2-a]pyridines under transition-metal-free conditions.For the selected examples,we focused on the design and catalytic cycle mechanism,as well as on representative outcomes and applications.展开更多
基金support from the National Natural Science Foundation of China(Grant Nos.22101267)Natural Science Foundation of Henan Province(222300420084)application research plan of key scientific research projects in colleges and universities of Henan Province(22A150056).
文摘Imidazo[1,2-a]pyridines are unique nitrogen-containing organic compounds with wide applications in pharma-ceuticals,natural products,material science and organometallics.Due to their significant biological and synthetic value,the construction of imidazo[1,2-a]pyridine scaffolds has been a highly intriguing research topic,and substantial progress had been made in the past decades.In this review,we aim to summarize the current advances in direct C–H functionalization of imidazo[1,2-a]pyridines under transition-metal-free conditions.For the selected examples,we focused on the design and catalytic cycle mechanism,as well as on representative outcomes and applications.
