Exploring the aptitude of the human brain to compensate functional consequences of a lesion damaging its structural architecture is a key challenge to improve patient care in various neurological diseases,to optimize ...Exploring the aptitude of the human brain to compensate functional consequences of a lesion damaging its structural architecture is a key challenge to improve patient care in various neurological diseases,to optimize neuroscientifically-informed strategies of postlesional rehabilitation,and ultimately to develop innovative neuro-regenerative therapies.The term‘plasticity’,initially referring to the intrinsic propensity of neurons to modulate their synaptic transmission in a learning situation,was progressively transposed to brain injury research and clinical neurosciences.Indeed,in the event of brain damage,adaptive mechanisms of compensation allow a partial reshaping of the structure and activities of the central nervous system,thus permitting to some extent the maintenance of brain functions.展开更多
The poloidal magnetic field( B_(p)) plays a critical role in plasma equilibrium, confinement and transport of magnetic confinement devices. Multiple diagnostic methods are needed to complement each other to obtain a m...The poloidal magnetic field( B_(p)) plays a critical role in plasma equilibrium, confinement and transport of magnetic confinement devices. Multiple diagnostic methods are needed to complement each other to obtain a more accurate B_(p) profile. Recently, the laser-driven ion-beam trace probe(LITP) has been proposed as a promising tool for diagnosing B_(p) and radial electric field( E_(r)) profiles in tokamaks [Yang X Y et al 2014 Rev. Sci. Instrum. 85 11E429]. The spherical tokamak(ST) is a promising compact device with high plasma beta and naturally large elongation. However, when applying LITP to diagnosing B_(p) in STs, the larger B_(p) invalidates the linear reconstruction relationship for conventional tokamaks, necessitating the development of a nonlinear reconstruction principle tailored to STs. This novel approach employs an iterative reconstruction method based on Newton's method to solve the nonlinear equation. Subsequently,a simulation model to reconstruct the B_(p) profile of STs is developed and the experimental setup of LITP is designed for EXL-50, a middle-sized ST. Simulation results of the reconstruction show that the relative errors of B_(p) reconstruction are mostly below 5%. Moreover, even with 5 mm measurement error on beam traces or 1 cm flux surface shape error, the average relative error of reconstruction remains below 15%, initially demonstrating the robustness of LITP in diagnosing B_(p) profiles in STs.展开更多
Figurative sculpture and decorative elements belong to the same category of art;the development of sculpture art requires innovation and constant exploration of new development paths,while many characteristics of deco...Figurative sculpture and decorative elements belong to the same category of art;the development of sculpture art requires innovation and constant exploration of new development paths,while many characteristics of decorative elements can give the creation of sculpture works a variety of inspiration.This paper explores the significance of figurative sculpture and decorative elements,examining their intrinsic connections and historical practices.The study aims to uncover the potential of figurative sculpture in the creation of decorative elements,highlighting how the integration of these forms can contribute to the development of art and the creation of meaningful figurative sculptures.展开更多
In the field of contemporary sculpture creation,the rich culture and historical depth of Chinese ethnic minorities have attracted the widespread attention of artists.These creations not only emphasize external feature...In the field of contemporary sculpture creation,the rich culture and historical depth of Chinese ethnic minorities have attracted the widespread attention of artists.These creations not only emphasize external features such as ethnic costumes,totems,or life scenes but also touch deep spiritual contents including historical stories,religious beliefs,and living habits of ethnic minorities.This paper discusses the integration process of Chinese ethnic minority themes in figurative sculpture creation and the inheritance of the profound spirit of ethnic groups in this process.At the same time,this paper also places the diversified expression and innovative practice of these themes in sculpture art in the context of the new era for investigation and explores the far-reaching influence of its development on promoting cultural inheritance and artistic innovation.展开更多
Development of the telencephalon relies upon several signaling centers-localized cellular populations that supply secreted factors to pattern the cortical neuroepithelium.One such signaling center is the cortical hem,...Development of the telencephalon relies upon several signaling centers-localized cellular populations that supply secreted factors to pattern the cortical neuroepithelium.One such signaling center is the cortical hem,which arises during embryonic development at the telencephalic dorsal midline,adjacent to the choroid plexus and hippocampal primordium(Figure 1A).While the cortical hem has also been described in reptiles and birds,most of our knowledge about the developmental roles of the cortical hem is derived from the analysis in mice.The cortical hem produces several types of secreted molecules,including wingless-related integration site(Wnt)and bone morphogenetic(Bmp)proteins.The cortical hem is particularly important for the development of the hippocampus,which is involved in learning and memory,and the neocortex,which is the most complex brain region that mediates multiple types of behavior and higher cognitive functions(Mangale et al.,2008;Dal-Valle-Anton and Borrell,2022).展开更多
The neuromuscular junction(NMJ)is an essential synaptic structure composed of motor neurons,skeletal muscles,and glial cells that orchestrate the critical process of muscle contraction(Li et al.,2018).The typical NMJ ...The neuromuscular junction(NMJ)is an essential synaptic structure composed of motor neurons,skeletal muscles,and glial cells that orchestrate the critical process of muscle contraction(Li et al.,2018).The typical NMJ structure is classically described as having a“pretzel-like”shape in mice(Figure 1),whereas human NMJs have a smaller,fragmented structure throughout adulthood.Degenerated NMJs exhibit smaller or fragmented endplates,partial denervation,reduced numbers of synaptic vesicles,abnormal presynaptic mitochondria,and dysfunctional perisynaptic Schwann cells(Alhindi et al.,2022).展开更多
Adult microglia,by continuously sensing changes in their environment and communicating with nearly all brain cell types,are considered to be the immune sentinels of the brain.In the healthy central nervous system(CNS)...Adult microglia,by continuously sensing changes in their environment and communicating with nearly all brain cell types,are considered to be the immune sentinels of the brain.In the healthy central nervous system(CNS),microglia display a unique molecular homeostatic signature(i.e.,Tmem119,P2ry12,Sall1,Siglech,Gpr34,and Hexb)(Figure 1A).展开更多
At the request of the authors,Neural Regeneration Research is retracting the research article titled"The effects of exercise interventions on brain-derived neurotrophic factor levels in children and adolescents:a...At the request of the authors,Neural Regeneration Research is retracting the research article titled"The effects of exercise interventions on brain-derived neurotrophic factor levels in children and adolescents:a meta-analysis"(Shao et al.,2025;doi:10.4103/NRR.NRR-D-23-01296)due to erroneous data in Figure 4,which were produced during data extraction and synthesis.These erroneous analysis results lead to unreliable findings and misleading conclusions.展开更多
The metabolite lactate (L-lactate) can be generated and released by diverse brain cells,including neurons,astrocytes,and oligodendrocytes (Kann,2023;Rae et al.,2024).Lactate production usually requires the degradation...The metabolite lactate (L-lactate) can be generated and released by diverse brain cells,including neurons,astrocytes,and oligodendrocytes (Kann,2023;Rae et al.,2024).Lactate production usually requires the degradation of glucose (D-glucose)-and glycogen in astrocytes-to pyruvate by glycolysis and subsequent conversion of pyruvate to lactate by the enzyme lactate dehydrogenase(Figure 1A;Dienel,2019;Rae et al.,2024).展开更多
Based on the equivalent circuit model of a two-port optical receiver front-end,the relationship between the equivalent input noise current spectral density and the noise figure is analyzed. The derived relationship ha...Based on the equivalent circuit model of a two-port optical receiver front-end,the relationship between the equivalent input noise current spectral density and the noise figure is analyzed. The derived relationship has universal validity for determining the equivalent input noise current spectral density for optical receiver designs, as verified by measuring a 155Mb/s high-impedance optical receiver front.end. Good agreement between calculated and simulated results has been achieved.展开更多
The Song of Solomon is a series of love poems which contain 6 pieces of love poems and most part in the form of songs addressed by a man to a woman, and by the woman to the man, in order to express the love between th...The Song of Solomon is a series of love poems which contain 6 pieces of love poems and most part in the form of songs addressed by a man to a woman, and by the woman to the man, in order to express the love between them.Figures of speech are ways of making our language figurative. They can be divided into three parts, they are syntactical, semantic and phonetic rhetorical devices. These rhetorical devices can help us to heighten effect and to make the writing figuratively and vividly.These figures of speech used in the Song of Solomon make great contribution to the success description of these long songs.This essay will center on the figures of speech in the Song of Solomon.展开更多
文摘Exploring the aptitude of the human brain to compensate functional consequences of a lesion damaging its structural architecture is a key challenge to improve patient care in various neurological diseases,to optimize neuroscientifically-informed strategies of postlesional rehabilitation,and ultimately to develop innovative neuro-regenerative therapies.The term‘plasticity’,initially referring to the intrinsic propensity of neurons to modulate their synaptic transmission in a learning situation,was progressively transposed to brain injury research and clinical neurosciences.Indeed,in the event of brain damage,adaptive mechanisms of compensation allow a partial reshaping of the structure and activities of the central nervous system,thus permitting to some extent the maintenance of brain functions.
基金the support of National Key Research and Development Program of China (No. 2022YFA1604600)State Key Laboratory of Advanced Electromagnetic Technology。
文摘The poloidal magnetic field( B_(p)) plays a critical role in plasma equilibrium, confinement and transport of magnetic confinement devices. Multiple diagnostic methods are needed to complement each other to obtain a more accurate B_(p) profile. Recently, the laser-driven ion-beam trace probe(LITP) has been proposed as a promising tool for diagnosing B_(p) and radial electric field( E_(r)) profiles in tokamaks [Yang X Y et al 2014 Rev. Sci. Instrum. 85 11E429]. The spherical tokamak(ST) is a promising compact device with high plasma beta and naturally large elongation. However, when applying LITP to diagnosing B_(p) in STs, the larger B_(p) invalidates the linear reconstruction relationship for conventional tokamaks, necessitating the development of a nonlinear reconstruction principle tailored to STs. This novel approach employs an iterative reconstruction method based on Newton's method to solve the nonlinear equation. Subsequently,a simulation model to reconstruct the B_(p) profile of STs is developed and the experimental setup of LITP is designed for EXL-50, a middle-sized ST. Simulation results of the reconstruction show that the relative errors of B_(p) reconstruction are mostly below 5%. Moreover, even with 5 mm measurement error on beam traces or 1 cm flux surface shape error, the average relative error of reconstruction remains below 15%, initially demonstrating the robustness of LITP in diagnosing B_(p) profiles in STs.
文摘Figurative sculpture and decorative elements belong to the same category of art;the development of sculpture art requires innovation and constant exploration of new development paths,while many characteristics of decorative elements can give the creation of sculpture works a variety of inspiration.This paper explores the significance of figurative sculpture and decorative elements,examining their intrinsic connections and historical practices.The study aims to uncover the potential of figurative sculpture in the creation of decorative elements,highlighting how the integration of these forms can contribute to the development of art and the creation of meaningful figurative sculptures.
文摘In the field of contemporary sculpture creation,the rich culture and historical depth of Chinese ethnic minorities have attracted the widespread attention of artists.These creations not only emphasize external features such as ethnic costumes,totems,or life scenes but also touch deep spiritual contents including historical stories,religious beliefs,and living habits of ethnic minorities.This paper discusses the integration process of Chinese ethnic minority themes in figurative sculpture creation and the inheritance of the profound spirit of ethnic groups in this process.At the same time,this paper also places the diversified expression and innovative practice of these themes in sculpture art in the context of the new era for investigation and explores the far-reaching influence of its development on promoting cultural inheritance and artistic innovation.
基金supported by R01 NS093009 grant from NIH(to VVC).
文摘Development of the telencephalon relies upon several signaling centers-localized cellular populations that supply secreted factors to pattern the cortical neuroepithelium.One such signaling center is the cortical hem,which arises during embryonic development at the telencephalic dorsal midline,adjacent to the choroid plexus and hippocampal primordium(Figure 1A).While the cortical hem has also been described in reptiles and birds,most of our knowledge about the developmental roles of the cortical hem is derived from the analysis in mice.The cortical hem produces several types of secreted molecules,including wingless-related integration site(Wnt)and bone morphogenetic(Bmp)proteins.The cortical hem is particularly important for the development of the hippocampus,which is involved in learning and memory,and the neocortex,which is the most complex brain region that mediates multiple types of behavior and higher cognitive functions(Mangale et al.,2008;Dal-Valle-Anton and Borrell,2022).
基金funded by the Japan Society for the Promotion of Science,JSPS,23K07290(to MF).
文摘The neuromuscular junction(NMJ)is an essential synaptic structure composed of motor neurons,skeletal muscles,and glial cells that orchestrate the critical process of muscle contraction(Li et al.,2018).The typical NMJ structure is classically described as having a“pretzel-like”shape in mice(Figure 1),whereas human NMJs have a smaller,fragmented structure throughout adulthood.Degenerated NMJs exhibit smaller or fragmented endplates,partial denervation,reduced numbers of synaptic vesicles,abnormal presynaptic mitochondria,and dysfunctional perisynaptic Schwann cells(Alhindi et al.,2022).
基金supported by NIH grants(R01NS125074,R01AG083164,and R21NS127177)(to YL).
文摘Adult microglia,by continuously sensing changes in their environment and communicating with nearly all brain cell types,are considered to be the immune sentinels of the brain.In the healthy central nervous system(CNS),microglia display a unique molecular homeostatic signature(i.e.,Tmem119,P2ry12,Sall1,Siglech,Gpr34,and Hexb)(Figure 1A).
文摘At the request of the authors,Neural Regeneration Research is retracting the research article titled"The effects of exercise interventions on brain-derived neurotrophic factor levels in children and adolescents:a meta-analysis"(Shao et al.,2025;doi:10.4103/NRR.NRR-D-23-01296)due to erroneous data in Figure 4,which were produced during data extraction and synthesis.These erroneous analysis results lead to unreliable findings and misleading conclusions.
文摘The metabolite lactate (L-lactate) can be generated and released by diverse brain cells,including neurons,astrocytes,and oligodendrocytes (Kann,2023;Rae et al.,2024).Lactate production usually requires the degradation of glucose (D-glucose)-and glycogen in astrocytes-to pyruvate by glycolysis and subsequent conversion of pyruvate to lactate by the enzyme lactate dehydrogenase(Figure 1A;Dienel,2019;Rae et al.,2024).
文摘Based on the equivalent circuit model of a two-port optical receiver front-end,the relationship between the equivalent input noise current spectral density and the noise figure is analyzed. The derived relationship has universal validity for determining the equivalent input noise current spectral density for optical receiver designs, as verified by measuring a 155Mb/s high-impedance optical receiver front.end. Good agreement between calculated and simulated results has been achieved.
文摘The Song of Solomon is a series of love poems which contain 6 pieces of love poems and most part in the form of songs addressed by a man to a woman, and by the woman to the man, in order to express the love between them.Figures of speech are ways of making our language figurative. They can be divided into three parts, they are syntactical, semantic and phonetic rhetorical devices. These rhetorical devices can help us to heighten effect and to make the writing figuratively and vividly.These figures of speech used in the Song of Solomon make great contribution to the success description of these long songs.This essay will center on the figures of speech in the Song of Solomon.
