Dear Editor,The study by Mastropasqua et al[1]evaluated the efficacy and safety of ranibizumab(Lucentis;Genentech,Inc.,South San Francisco,CA,USA;RBZ group)and dexamethasone implant(Ozurdex;Allergan Irvine.,CA,USA;DEX...Dear Editor,The study by Mastropasqua et al[1]evaluated the efficacy and safety of ranibizumab(Lucentis;Genentech,Inc.,South San Francisco,CA,USA;RBZ group)and dexamethasone implant(Ozurdex;Allergan Irvine.,CA,USA;DEX group)intravitreal treatments in 50 patients with treatment-naive center involved diabetic macular edema(DME)by means of functional and morphological assessments during a 6-month follow-up.展开更多
Dear Sir,Iam Yonca A.Akova,MD-from the Department of Ophthalmology,Bayindir Kavaklidere Hospital,Turkey.I wrote this letter to evaluate the efficacy of 0.05%topical cyclosporine A（CsA）eye drops（Restasis Allergan,Ir...Dear Sir,Iam Yonca A.Akova,MD-from the Department of Ophthalmology,Bayindir Kavaklidere Hospital,Turkey.I wrote this letter to evaluate the efficacy of 0.05%topical cyclosporine A（CsA）eye drops（Restasis Allergan,Irvine,USA）in symptomatic patients with recurrent subepithelial infiltrates（SEIs）due to adenoviral keratoconjunctivitis following steroid eye drops tapering or discontinuation.展开更多
BACKGROUND AND OBJECTIVE: Older generation phacoemulsification units are widel y employed where economics do not permit frequent upgrades. Thermal effects on t he cornea while performing phacoemulsification with diffe...BACKGROUND AND OBJECTIVE: Older generation phacoemulsification units are widel y employed where economics do not permit frequent upgrades. Thermal effects on t he cornea while performing phacoemulsification with different generation machine s were evaluated. PATIENTS AND METHODS: The thermal effect on the clear corneal incision during uncomplicated phacoemulsification performed by the Series 10,000 (Alcon Laboratories, Fort Worth, TX) and the Diplomax (Allergan, Irvine, CA) ma chines was clinically evaluated and correlated with the effective phacoemulsific ation time required. The clinical outcome was analyzed with respect to wound clo sure and surgically induced corneal astigmatism. RESULTS: The average effective phacoemulsification time required to emulsify a grade IV cataract was 88.33 ±15 .81 seconds with the Series 10,000 machine and 61.67 ±21.79 seconds with the Di plomax machine. A grade 2 or more thermal effect was seen in 19.33%of patients operated on with the Series 10,000 machine and 3.22%of patients operated on wit h the Diplomax machine. The resultant tissue retraction affected wound closure a nd mean surgically induced corneal astigmatism (1.71 ±1.05 D with the Diplomax machine and 2.21 ±1.32 D with the Series 10,000 machine). CONCLUSIONS: Newer ge neration machines require less phacoemulsification power to emulsify hard catara cts, and the clinical outcomes are more favorable. Incision burns must be kept i n mind when working with older generation phacoemulsification machines.展开更多
Background Unruptured intracranial aneurysm treatment aims to reduce the risk of aneurysm rupture and bleeding,relieves symptoms and improve the quality of life for patients.This study aimed to assess the safety and e...Background Unruptured intracranial aneurysm treatment aims to reduce the risk of aneurysm rupture and bleeding,relieves symptoms and improve the quality of life for patients.This study aimed to assess the safety and efficacy of Pipeline Embolization Device(PED,Covidien/Medtronic,Irvine,CA)treatment for intracranial aneurysms presenting with mass effect in real-world settings.Methods We selected patients from the PED in China Post-Market Multi-Center Registry Study with mass effect presentation.The study endpoints included postoperative mass effect deterioration and mass effect relief at follow-up(3–36 months).We conducted multivariate analysis to identify factors associated with mass effect relief.Subgroup analyses by aneurysm location,size and form were also performed.Results This study included 218 patients with a mean age of 54.3±11.8 years and a female predominance of 74.0%(162/218).The postoperative mass effect deterioration rate was 9.6%(21/218).During a median follow-up period of 8.4 months,the mass effect relief rate was 71.6%(156/218).Notably,immediate aneurysm occlusion following treatment was significantly associated with mass effect relief(OR 0.392,95%CI,0.170 to 0.907,p=0.029).Subgroup analysis demonstrated that adjunctive coiling contributed to mass effect relief in cavernous aneurysms,while dense embolism impeded symptom relief in aneurysms<10mm and saccular aneurysms.Conclusions Our data confirmed the efficacy of PED in relieving mass effect.The findings of this study provide support for endovascular treatment to alleviate mass effect in unruptured intracranial aneurysms.Trial registration number NCT03831672.展开更多
Currently,transcatheter aortic valve implantation(TAVI)has become a feasible interventional technique for severe aortic stenosis in patients who deemed inoperable or are at high surgical risk.In China,the TAVI techniq...Currently,transcatheter aortic valve implantation(TAVI)has become a feasible interventional technique for severe aortic stenosis in patients who deemed inoperable or are at high surgical risk.In China,the TAVI technique started from 2010.Until now two domestic devices J Valve(Jie Cheng Medical Technologies,Suzhou,China)and Venus AValve(Venus MedTech,Hangzhou,China)have been allowed access into the market in 2017,since then most centers began to set up TAVI programs.Venus A-Valve is the only transfemoral transcatheter valve in China which approximately has been implanted 4000 times,till VitaFlow(MicroPort,Shanghai,China)and SAPIEN 3(Edwards Lifesciences,Irvine,CA,USA)entered the market in China a few months ago.展开更多
2007年9月23日-28日，中美职业健康和精神卫生学习班在北京大学医学部举办。学习班由北京大学第六附属医院、北京大学公共卫生学院、美国加利福尼亚大学尔湾校区职业与环境健康中心（Center for occupational and Environmental Medicin...2007年9月23日-28日，中美职业健康和精神卫生学习班在北京大学医学部举办。学习班由北京大学第六附属医院、北京大学公共卫生学院、美国加利福尼亚大学尔湾校区职业与环境健康中心（Center for occupational and Environmental Medicine．University of California，Irvine，CA）和美国纽约西奈山医学院（Mount Sinai School of Medicine．New York）联合举办，展开更多
With the support by the National Natural Science Foundation of China,Prof.Lei Jinzhi at Zhou PeiYuan Center of Applied Mathematics,Tsinghua University,and his collaborators,Prof.Simon Levin from Princeton University a...With the support by the National Natural Science Foundation of China,Prof.Lei Jinzhi at Zhou PeiYuan Center of Applied Mathematics,Tsinghua University,and his collaborators,Prof.Simon Levin from Princeton University and Prof.Qing Nie from the University of California Irvine,outline a general mathematical model that applied tools from optimization theory to understand stem cell dynamics。展开更多
文摘Dear Editor,The study by Mastropasqua et al[1]evaluated the efficacy and safety of ranibizumab(Lucentis;Genentech,Inc.,South San Francisco,CA,USA;RBZ group)and dexamethasone implant(Ozurdex;Allergan Irvine.,CA,USA;DEX group)intravitreal treatments in 50 patients with treatment-naive center involved diabetic macular edema(DME)by means of functional and morphological assessments during a 6-month follow-up.
文摘Dear Sir,Iam Yonca A.Akova,MD-from the Department of Ophthalmology,Bayindir Kavaklidere Hospital,Turkey.I wrote this letter to evaluate the efficacy of 0.05%topical cyclosporine A（CsA）eye drops（Restasis Allergan,Irvine,USA）in symptomatic patients with recurrent subepithelial infiltrates（SEIs）due to adenoviral keratoconjunctivitis following steroid eye drops tapering or discontinuation.
文摘BACKGROUND AND OBJECTIVE: Older generation phacoemulsification units are widel y employed where economics do not permit frequent upgrades. Thermal effects on t he cornea while performing phacoemulsification with different generation machine s were evaluated. PATIENTS AND METHODS: The thermal effect on the clear corneal incision during uncomplicated phacoemulsification performed by the Series 10,000 (Alcon Laboratories, Fort Worth, TX) and the Diplomax (Allergan, Irvine, CA) ma chines was clinically evaluated and correlated with the effective phacoemulsific ation time required. The clinical outcome was analyzed with respect to wound clo sure and surgically induced corneal astigmatism. RESULTS: The average effective phacoemulsification time required to emulsify a grade IV cataract was 88.33 ±15 .81 seconds with the Series 10,000 machine and 61.67 ±21.79 seconds with the Di plomax machine. A grade 2 or more thermal effect was seen in 19.33%of patients operated on with the Series 10,000 machine and 3.22%of patients operated on wit h the Diplomax machine. The resultant tissue retraction affected wound closure a nd mean surgically induced corneal astigmatism (1.71 ±1.05 D with the Diplomax machine and 2.21 ±1.32 D with the Series 10,000 machine). CONCLUSIONS: Newer ge neration machines require less phacoemulsification power to emulsify hard catara cts, and the clinical outcomes are more favorable. Incision burns must be kept i n mind when working with older generation phacoemulsification machines.
基金sponsored by the National Natural Science Foundation of China(82071302)Bai Qian Wan Talent Plan(2017A07)and Beijing Municipal Administration of Hospital Incubating Program(PX2016034).
文摘Background Unruptured intracranial aneurysm treatment aims to reduce the risk of aneurysm rupture and bleeding,relieves symptoms and improve the quality of life for patients.This study aimed to assess the safety and efficacy of Pipeline Embolization Device(PED,Covidien/Medtronic,Irvine,CA)treatment for intracranial aneurysms presenting with mass effect in real-world settings.Methods We selected patients from the PED in China Post-Market Multi-Center Registry Study with mass effect presentation.The study endpoints included postoperative mass effect deterioration and mass effect relief at follow-up(3–36 months).We conducted multivariate analysis to identify factors associated with mass effect relief.Subgroup analyses by aneurysm location,size and form were also performed.Results This study included 218 patients with a mean age of 54.3±11.8 years and a female predominance of 74.0%(162/218).The postoperative mass effect deterioration rate was 9.6%(21/218).During a median follow-up period of 8.4 months,the mass effect relief rate was 71.6%(156/218).Notably,immediate aneurysm occlusion following treatment was significantly associated with mass effect relief(OR 0.392,95%CI,0.170 to 0.907,p=0.029).Subgroup analysis demonstrated that adjunctive coiling contributed to mass effect relief in cavernous aneurysms,while dense embolism impeded symptom relief in aneurysms<10mm and saccular aneurysms.Conclusions Our data confirmed the efficacy of PED in relieving mass effect.The findings of this study provide support for endovascular treatment to alleviate mass effect in unruptured intracranial aneurysms.Trial registration number NCT03831672.
基金the grant from the National Key Technologies Research and Development Program(No.2015BAI12B03)。
文摘Currently,transcatheter aortic valve implantation(TAVI)has become a feasible interventional technique for severe aortic stenosis in patients who deemed inoperable or are at high surgical risk.In China,the TAVI technique started from 2010.Until now two domestic devices J Valve(Jie Cheng Medical Technologies,Suzhou,China)and Venus AValve(Venus MedTech,Hangzhou,China)have been allowed access into the market in 2017,since then most centers began to set up TAVI programs.Venus A-Valve is the only transfemoral transcatheter valve in China which approximately has been implanted 4000 times,till VitaFlow(MicroPort,Shanghai,China)and SAPIEN 3(Edwards Lifesciences,Irvine,CA,USA)entered the market in China a few months ago.
文摘2007年9月23日-28日，中美职业健康和精神卫生学习班在北京大学医学部举办。学习班由北京大学第六附属医院、北京大学公共卫生学院、美国加利福尼亚大学尔湾校区职业与环境健康中心（Center for occupational and Environmental Medicine．University of California，Irvine，CA）和美国纽约西奈山医学院（Mount Sinai School of Medicine．New York）联合举办，
文摘With the support by the National Natural Science Foundation of China,Prof.Lei Jinzhi at Zhou PeiYuan Center of Applied Mathematics,Tsinghua University,and his collaborators,Prof.Simon Levin from Princeton University and Prof.Qing Nie from the University of California Irvine,outline a general mathematical model that applied tools from optimization theory to understand stem cell dynamics。
