OBJECTIVE: To observe the effect of Qiangli Dingxuan Tablet on cerebral hemodynamics and brainstem auditory evoked potentials in vertigo patients with posterior circulation ischemia. METHODS: A total of 120 vertigo pa...OBJECTIVE: To observe the effect of Qiangli Dingxuan Tablet on cerebral hemodynamics and brainstem auditory evoked potentials in vertigo patients with posterior circulation ischemia. METHODS: A total of 120 vertigo patients with posterior circulation ischemia were randomly divided into observation group and control group. 60 patients in the control group were treated with conventional western medicine. 60 patients in the observation group were treated with Qiangli Dingxuan Tablet on the basis of the control group. After 2 weeks of treatment, the improvement of vertigo(dizziness handicap inventory(DHI), dizziness handicap inventory(DHI)), the hemodynamic index(Basilar artery blood flow velocity(BA), left vertebroarterial artery(LVA), and the average blood flow velocity of right vertebroarterial artery(RVA)) and the changes in brain stem auditory evoked potential(BAEP) of two groups were observed. And statistical analysis was conducted for the clinical efficacy and adverse reactions during treatment of two groups. RESULTS: The total effective rate of the observation group was significantly higher than that of the control group(P < 0.05). The DHI and DARS scores of the two groups were significantly lower than those before treatment(P < 0.05), and the degree of reduction was more obvious in the observation group(P < 0.05). The levels of BA, LVA and RVA in the two groups were significantly higher than those before treatment(P < 0.05), and the levels of BA, LVA and RVA in the observation group were significantly higher than those in the control group(P < 0.05). The indexes of BAEP latency I, II, III and indexes of BAEP peak latency I-III, III-V, IV were obviously lower than those before treatment(P < 0.05). Besides, the decrease of BAEP index in the observation group was significantly lower than that in the control group(P < 0.05). No adverse reactions occurred during the treatment of the two groups. CONCLUSION: Qiangli Dingxuan Tablet is able to significantly improve the cerebral hemodynamics and brainstem auditory evoked potentials of patients with PCIV, and quickly relieve vertigo. It is safe and reliable and worthy of clinical application.展开更多
Vertebral artery orifice stenting may improve blood supply of the posterior circulation of the brain to regions such as the cerebellum and brainstem. However, previous studies have mainly focused on recovery of cerebr...Vertebral artery orifice stenting may improve blood supply of the posterior circulation of the brain to regions such as the cerebellum and brainstem. However, previous studies have mainly focused on recovery of cerebral blood flow and perfusion in the posterior circulation after interventional therapy. This study examined the effects of functional recovery of local brain tissue on cerebellar function remodeling using blood oxygen level-dependent functional magnetic reso- nance imaging before and after interventional therapy. A total of 40 Chinese patients with severe unilateral vertebral artery orifice stenosis were enrolled in this study. Patients were equally and randomly assigned to intervention and control groups. The control group received drug treat- ment only. The intervention group received vertebral artery orifice angioplasty and stenting ＋ identical drug treatment to the control group. At 13 days after treatment, the Dizziness Handicap Inventory score was compared between the intervention and control groups. Cerebellar function remodeling was observed between the two groups using blood oxygen level-dependent functional magnetic resonance imaging. The improvement in dizziness handicap and cerebellar function was more obvious in the intervention group than in the control group. Interventional therapy for severe vertebral artery orifice stenosis may effectively promote cerebellar function remodeling and exert neuroprotective effects.展开更多
目的探讨老年后循环缺血性卒中患者预后及危险因素。方法选取河北省承德市中心医院老年后循环缺血性卒中患者120例,根据治疗后3个月预后情况进行分组,分析预后不良和良好患者临床一般资料、外周血空腹血糖、糖化血红蛋白(hemoglobin A_(...目的探讨老年后循环缺血性卒中患者预后及危险因素。方法选取河北省承德市中心医院老年后循环缺血性卒中患者120例,根据治疗后3个月预后情况进行分组,分析预后不良和良好患者临床一般资料、外周血空腹血糖、糖化血红蛋白(hemoglobin A_(1)c,HbA_(1)c)等差异,总结老年后循环缺血性卒中患者预后的影响因素。结果预后不良患者39例,预后不良发生率为32.50%。预后不良组年龄和入院期间最高美国国立卫生研究所卒中量表(National Institute of Health Stroke Scale,NIHSS)评分分别为(68.93±4.02)岁和(19.30±2.50)分,高于预后良好组(P<0.05)。预后不良组空腹血糖、HbA_(1)c、脂蛋白相关磷脂酶a2(lipoprotein associated phospholipase A2,LP-PLA2)、超敏C反应蛋白(high-sensitivity C-reactive protein,hs-CRP)和血小板活化因子(platelet activating factor,PAF)分别为(7.28±0.92)mmol/L、(7.02±0.86)%、(330.50±65.53)μg/L、(20.22±6.43)ng/L和(248.23±44.18)ng/L,高于预后良好组(P<0.05)。Logistic回归分析,显示年龄、入院期间最高NIHSS评分、空腹血糖、LP-PLA2、PAF是患者预后的影响因素(P<0.05)。构建的方程预测预后不良的ROC曲线下面积为0.884(95%CI:0.821~0.948),P<0.05,敏感度和特异度分别为84.60%和81.50%。结论老年后循环缺血性卒中患者预后不良比例高,预后情况受患者年龄、入院期间最高NIHSS评分、空腹血糖、LP-PLA2、PAF的影响,同时由此构建的模型对患者预后不良具有较高的预测价值。展开更多
文摘OBJECTIVE: To observe the effect of Qiangli Dingxuan Tablet on cerebral hemodynamics and brainstem auditory evoked potentials in vertigo patients with posterior circulation ischemia. METHODS: A total of 120 vertigo patients with posterior circulation ischemia were randomly divided into observation group and control group. 60 patients in the control group were treated with conventional western medicine. 60 patients in the observation group were treated with Qiangli Dingxuan Tablet on the basis of the control group. After 2 weeks of treatment, the improvement of vertigo(dizziness handicap inventory(DHI), dizziness handicap inventory(DHI)), the hemodynamic index(Basilar artery blood flow velocity(BA), left vertebroarterial artery(LVA), and the average blood flow velocity of right vertebroarterial artery(RVA)) and the changes in brain stem auditory evoked potential(BAEP) of two groups were observed. And statistical analysis was conducted for the clinical efficacy and adverse reactions during treatment of two groups. RESULTS: The total effective rate of the observation group was significantly higher than that of the control group(P < 0.05). The DHI and DARS scores of the two groups were significantly lower than those before treatment(P < 0.05), and the degree of reduction was more obvious in the observation group(P < 0.05). The levels of BA, LVA and RVA in the two groups were significantly higher than those before treatment(P < 0.05), and the levels of BA, LVA and RVA in the observation group were significantly higher than those in the control group(P < 0.05). The indexes of BAEP latency I, II, III and indexes of BAEP peak latency I-III, III-V, IV were obviously lower than those before treatment(P < 0.05). Besides, the decrease of BAEP index in the observation group was significantly lower than that in the control group(P < 0.05). No adverse reactions occurred during the treatment of the two groups. CONCLUSION: Qiangli Dingxuan Tablet is able to significantly improve the cerebral hemodynamics and brainstem auditory evoked potentials of patients with PCIV, and quickly relieve vertigo. It is safe and reliable and worthy of clinical application.
基金supported by the Natural Science Foundation of Yongchuan District of Chongqing in China,No.Ycstc,2013nc8031the Foundation of Chongqing Municipal Health Bureau in China,No.2010-2-250+1 种基金the Foundation of Chongqing Health and Family Planning Commission in China,No.20143001the Soft Science Foundation of Yongchuan District of Chongqing in China,No.Ycstc,2011BE5004
文摘Vertebral artery orifice stenting may improve blood supply of the posterior circulation of the brain to regions such as the cerebellum and brainstem. However, previous studies have mainly focused on recovery of cerebral blood flow and perfusion in the posterior circulation after interventional therapy. This study examined the effects of functional recovery of local brain tissue on cerebellar function remodeling using blood oxygen level-dependent functional magnetic reso- nance imaging before and after interventional therapy. A total of 40 Chinese patients with severe unilateral vertebral artery orifice stenosis were enrolled in this study. Patients were equally and randomly assigned to intervention and control groups. The control group received drug treat- ment only. The intervention group received vertebral artery orifice angioplasty and stenting ＋ identical drug treatment to the control group. At 13 days after treatment, the Dizziness Handicap Inventory score was compared between the intervention and control groups. Cerebellar function remodeling was observed between the two groups using blood oxygen level-dependent functional magnetic resonance imaging. The improvement in dizziness handicap and cerebellar function was more obvious in the intervention group than in the control group. Interventional therapy for severe vertebral artery orifice stenosis may effectively promote cerebellar function remodeling and exert neuroprotective effects.
文摘目的探讨老年后循环缺血性卒中患者预后及危险因素。方法选取河北省承德市中心医院老年后循环缺血性卒中患者120例,根据治疗后3个月预后情况进行分组,分析预后不良和良好患者临床一般资料、外周血空腹血糖、糖化血红蛋白(hemoglobin A_(1)c,HbA_(1)c)等差异,总结老年后循环缺血性卒中患者预后的影响因素。结果预后不良患者39例,预后不良发生率为32.50%。预后不良组年龄和入院期间最高美国国立卫生研究所卒中量表(National Institute of Health Stroke Scale,NIHSS)评分分别为(68.93±4.02)岁和(19.30±2.50)分,高于预后良好组(P<0.05)。预后不良组空腹血糖、HbA_(1)c、脂蛋白相关磷脂酶a2(lipoprotein associated phospholipase A2,LP-PLA2)、超敏C反应蛋白(high-sensitivity C-reactive protein,hs-CRP)和血小板活化因子(platelet activating factor,PAF)分别为(7.28±0.92)mmol/L、(7.02±0.86)%、(330.50±65.53)μg/L、(20.22±6.43)ng/L和(248.23±44.18)ng/L,高于预后良好组(P<0.05)。Logistic回归分析,显示年龄、入院期间最高NIHSS评分、空腹血糖、LP-PLA2、PAF是患者预后的影响因素(P<0.05)。构建的方程预测预后不良的ROC曲线下面积为0.884(95%CI:0.821~0.948),P<0.05,敏感度和特异度分别为84.60%和81.50%。结论老年后循环缺血性卒中患者预后不良比例高,预后情况受患者年龄、入院期间最高NIHSS评分、空腹血糖、LP-PLA2、PAF的影响,同时由此构建的模型对患者预后不良具有较高的预测价值。
