A new phenylethanoid glycoside,seulponisidc（1） was isolated from the aerial parts of Isodon sculponeatus（Vaniot） Kudo, along with six known compounds martynoside（2）,verbascoside（3）,（＋）-hydroxypinoresinol-8-...A new phenylethanoid glycoside,seulponisidc（1） was isolated from the aerial parts of Isodon sculponeatus（Vaniot） Kudo, along with six known compounds martynoside（2）,verbascoside（3）,（＋）-hydroxypinoresinol-8-O- β-D-glucoside（4）,cedrusin（5）, 7-megastigmene-3S,5R,6R,7E,9S-tetrol（6） and 4-oxo- β-ionol- β-D-glucopyranoside（7）.Their chemical structures were elucidated from physieochemical data and by acidic hydrolysis.展开更多
b Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, China c Pharmaceutical Department of Dali College, Dali, Yunnan 671000, China Further investigation on the leaves of Isod...b Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, China c Pharmaceutical Department of Dali College, Dali, Yunnan 671000, China Further investigation on the leaves of Isodon sculponeatus afforded two new ent kaurane diterpenoids, sculponeatins J and K . Their structures were elucidated on the basis of their spectral properties, as well as X ray crystallographic analysis. The cytotoxicities of these two new compounds against human tumor cells K562 and T24 were also tested, and sculponeatin J showed significant inhibitory effects with IC 50 values less than 1.0 μg/mL.展开更多
基金supported financially by the NSFC(Nos.30772637 to H.D.Sun,and 30830119 to S.J.Chen)the NSFC-Joint Foundation of Yunnan Province(No.U0832602 to H.D.Sun)+2 种基金the Major State Basic Research Development Program of China(No.2009CB522300 and 2009CB940900)the Natural Science Foundation of Yunnan Province(No.2008CD162)the Science and technology plan project of Yunnan Province(No. 2008IF010)
文摘A new phenylethanoid glycoside,seulponisidc（1） was isolated from the aerial parts of Isodon sculponeatus（Vaniot） Kudo, along with six known compounds martynoside（2）,verbascoside（3）,（＋）-hydroxypinoresinol-8-O- β-D-glucoside（4）,cedrusin（5）, 7-megastigmene-3S,5R,6R,7E,9S-tetrol（6） and 4-oxo- β-ionol- β-D-glucopyranoside（7）.Their chemical structures were elucidated from physieochemical data and by acidic hydrolysis.
文摘b Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, China c Pharmaceutical Department of Dali College, Dali, Yunnan 671000, China Further investigation on the leaves of Isodon sculponeatus afforded two new ent kaurane diterpenoids, sculponeatins J and K . Their structures were elucidated on the basis of their spectral properties, as well as X ray crystallographic analysis. The cytotoxicities of these two new compounds against human tumor cells K562 and T24 were also tested, and sculponeatin J showed significant inhibitory effects with IC 50 values less than 1.0 μg/mL.
